Piperidines (BioDeep_00000227739)
human metabolite
代谢物信息卡片
3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-ium
化学式: C6H14NO4+ (164.0923)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(C(C([NH2+]1)CO)O)O)O
InChI: InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/p+1
描述信息
Piperidines is soluble (in water) and a very weakly acidic compound (based on its pKa). Piperidines can be found in pomegranate, which makes piperidines a potential biomarker for the consumption of this food product. Piperidines is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless Liquid with an odor described as objectionable, and typical of amines. the name comes from the genus name Piper, which is the Latin word for pepper. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids .
Piperidines is soluble (in water) and a very weakly acidic compound (based on its pKa). Piperidines can be found in pomegranate, which makes piperidines a potential biomarker for the consumption of this food product. Piperidines is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor described as objectionable, and typical of amines. the name comes from the genus name Piper, which is the Latin word for pepper. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids .
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 44237242
- HMDB: HMDB0302905
- MeSH: Piperidines
- foodb: FDB006805
- chemspider: 21235529
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Phanit Songvut, Tussapon Boonyarattanasoonthorn, Nitra Nuengchamnong, Thammaporn Junsai, Teetat Kongratanapasert, Kittitach Supannapan, Phisit Khemawoot. Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs.
Pharmaceutical biology.
2024 Dec; 62(1):183-194. doi:
10.1080/13880209.2024.2311201. [PMID: 38351624] - Wenjie Deng, Liyuan Shen, Jia Zeng, Jianxin Gao, Jiachun Luo, Jingwen Xu, Yihai Wang, Xiangjiu He. Antiproliferative piperidine alkaloids from the leaves of Alocasia macrorrhiza.
Phytochemistry.
2024 Jun; 222(?):114069. doi:
10.1016/j.phytochem.2024.114069. [PMID: 38548035] - Liang Lai, Mengyao Zhang, Tong Li, Jiahuan Qu, Dongsheng Xu, Pei Yu, Zhengjin Jiang. Preparation and evaluation of a piperidinium-sulfonate based zwitterionic monolith for HILIC separation.
Journal of chromatography. A.
2024 May; 1722(?):464864. doi:
10.1016/j.chroma.2024.464864. [PMID: 38598890] - Kazuki Hashiba, Masamitsu Taguchi, Sachiko Sakamoto, Ayaka Otsu, Yoshiki Maeda, Hirofumi Ebe, Arimichi Okazaki, Hideyoshi Harashima, Yusuke Sato. Overcoming thermostability challenges in mRNA-lipid nanoparticle systems with piperidine-based ionizable lipids.
Communications biology.
2024 May; 7(1):556. doi:
10.1038/s42003-024-06235-0. [PMID: 38730092] - Yangchen Tang, Mengli Yan, Zemin Fang, Song Jin, Tingjuan Xu. Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice.
BMJ open diabetes research & care.
2024 May; 12(3):. doi:
10.1136/bmjdrc-2023-003837. [PMID: 38719505] - Lucas F F Albuquerque, Fernanda V Lins, Elizabete C I Bispo, Ellyêssa N Borges, Mateus T Silva, Taís Gratieri, Marcílio Cunha-Filho, Antonio Alonso, Juliana L Carvalho, Felipe Saldanha-Araujo, Guilherme M Gelfuso. Ibrutinib topical delivery for melanoma treatment: The effect of nanostructured lipid carriers' composition on the controlled drug skin deposition.
Colloids and surfaces. B, Biointerfaces.
2024 May; 237(?):113875. doi:
10.1016/j.colsurfb.2024.113875. [PMID: 38547795] - Qianqian Dai, Yanfeng Zhang, Qian Liu, Chijin Zhang. Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials.
Clinical rheumatology.
2024 May; 43(5):1605-1613. doi:
10.1007/s10067-024-06940-5. [PMID: 38517652] - Yifei Wu, Jiayu Zhang, Sha Du, Xiaochuan Wang, Jinrong Li, Yi Chen, Hongying Zhou, Su Gao, Yongrong Li, Xiuhong Liu. Combination of 308-nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR-328/SFRP1 axis.
Photodermatology, photoimmunology & photomedicine.
2024 May; 40(3):e12970. doi:
10.1111/phpp.12970. [PMID: 38685665] - Sichun Xiang, Rongbin Shen, Jingjing Xiang, Ni Zhu, Jianyou Gu, Jianping Shen, Yu Zhang, Hangping Ge. A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for Bruton's tyrosine kinase inhibitors (BTKis) single and its combination therapy.
Expert opinion on drug safety.
2024 May; 23(5):627-636. doi:
10.1080/14740338.2024.2327507. [PMID: 38456691] - Kangyun Zhao, Siwei Zhang, Chunhong Piao, Fei Xu, Yutong Zhang, Xu Wang, Jiyue Zhang, Chunxia Zhao, Sang Guan You, Yanjun Zhang. Investigation of the formation mechanism of the pepper starch-piperine complex.
International journal of biological macromolecules.
2024 May; 268(Pt 1):131777. doi:
10.1016/j.ijbiomac.2024.131777. [PMID: 38663710] - Enrica Flori, Alessia Cavallo, Sarah Mosca, Daniela Kovacs, Carlo Cota, Marco Zaccarini, Anna Di Nardo, Grazia Bottillo, Miriam Maiellaro, Emanuela Camera, Giorgia Cardinali. JAK/STAT Inhibition Normalizes Lipid Composition in 3D Human Epidermal Equivalents Challenged with Th2 Cytokines.
Cells.
2024 Apr; 13(9):. doi:
10.3390/cells13090760. [PMID: 38727296] - Xiyue Wang, Wei Zhao, Xinhe Wei, Shuang Song, Shoukun Dong. The application potential of mepiquat chloride in soybean: improvement of yield characteristics and drought resistance.
BMC plant biology.
2024 Apr; 24(1):310. doi:
10.1186/s12870-024-05028-1. [PMID: 38649811] - Bin Tang, Shangrong Hu, Yujia Luo, Dongmei Shi, Xiangyu Liu, Fan Zhong, Xinyi Jiang, Gao Hu, Can Li, Hongxia Duan, Yan Wu. Impact of Three Thiazolidinone Compounds with Piperine Skeletons on Trehalase Activity and Development of Spodoptera frugiperda Larvae.
Journal of agricultural and food chemistry.
2024 Apr; 72(15):8423-8433. doi:
10.1021/acs.jafc.3c08898. [PMID: 38565327] - Asmaa Badawy Darwish, Amira Mohamed Mohsen, Shaimaa ElShebiney, Rania Elgohary, Mostafa Mohamed Younis. Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats.
Scientific reports.
2024 04; 14(1):8247. doi:
10.1038/s41598-024-58601-x. [PMID: 38589438] - Lan Yu, Xiaolu Hu, Rongrong Xu, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Xing Wang, Xiaoqing Chen, Yinying Ba, Zhikai Xing, Chongye Guo, Shuangli Mi, Xia Wu. Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats.
Journal of ethnopharmacology.
2024 Mar; 322(?):117628. doi:
10.1016/j.jep.2023.117628. [PMID: 38158101] - Meghana N Kumar, Sreeram Peringattu Kalarikkal, Yashaswini Jayaram, Janakiraman Narayanan, Gopinath M Sundaram. Protocol to produce plant-based hybrid nanovesicles from fresh turmeric and pepper using polyethylene glycol.
STAR protocols.
2024 Mar; 5(1):102924. doi:
10.1016/j.xpro.2024.102924. [PMID: 38430518] - Atsushi Sawamoto, Madoka Okada, Nanako Matsuoka, Satoshi Okuyama, Mitsunari Nakajima. Tipepidine activates AMPK and improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2024 Mar; 38(5):e23542. doi:
10.1096/fj.202301861rr. [PMID: 38466234] - Michail Saragatsis, Eleni Pontiki. Synthesis and Antioxidant Activities of Novel Pyrimidine Acrylamides as Inhibitors of Lipoxygenase: Molecular Modeling and In Silico Physicochemical Studies.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061189. [PMID: 38542826] - Jingyuan Chen, Shuhao Fan, Jianhua Guo, Jian Yang, Le Pan, Yong Xia. Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells.
Toxicology and applied pharmacology.
2024 Mar; 484(?):116878. doi:
10.1016/j.taap.2024.116878. [PMID: 38431229] - Qiao Wu, Na Jiang, Yao Wang, Guini Song, Ping Li, Yongkang Fang, Li Xu, Wei Wang, Minjie Xie. Soluble epoxide hydrolase inhibitor (TPPU) alleviates ferroptosis by regulating CCL5 after intracerebral hemorrhage in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Mar; 172(?):116301. doi:
10.1016/j.biopha.2024.116301. [PMID: 38377737] - Baiyinzi Du, Shudan Luo, Xujun Zhu, Maqing Hu, Xianzhang Feng, Qianjun Yu, Bin Bai, Jian Xu, Jun Wang. WAY-262611 ameliorates the inflammatory bowel disease by activating Wnt/β-catenin pathway.
In vitro cellular & developmental biology. Animal.
2024 Mar; 60(2):128-138. doi:
10.1007/s11626-023-00809-8. [PMID: 38393664] - Protha Biswas, Devendra Kumar Pandey, Mahipal S Shekhawat, Abhijit Dey, Tabarak Malik. Tissue-specific variations of piperine in ten populations of Piper longum L.: bioactivities and toxicological profile.
Scientific reports.
2024 03; 14(1):5062. doi:
10.1038/s41598-024-52297-9. [PMID: 38424458] - Junping Zhu, Jiaming Wei, Ye Lin, Yuanyuan Tang, Zhaoli Su, Liqing Li, Bin Liu, Xiong Cai. Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.
BMC complementary medicine and therapies.
2024 Feb; 24(1):105. doi:
10.1186/s12906-024-04397-2. [PMID: 38413973] - Robert B Shultz, Nan Hai, Yinghui Zhong. Local delivery of AdipoRon from self-assembled microparticles to inhibit myelin lipid uptake and to promote lipid efflux from rat macrophages.
Journal of neural engineering.
2024 02; 21(1):. doi:
10.1088/1741-2552/ad29d5. [PMID: 38359460] - Cheng Jiang, Jiancheng Qian, Xin Jiang, Shuohan Zhang, Junxian Zheng, Hongwei Wang. Is pitolisant safe for clinical use? A retrospective pharmacovigilance study focus on the post-marketing safety.
Pharmacology research & perspectives.
2024 Feb; 12(1):e1161. doi:
10.1002/prp2.1161. [PMID: 38174838] - Yumei Li, Shijin Lu, Ping Yao, Wenchuang Huang, Yong Huang, Ying Zhou, Ying Yuan, Shaochen Cheng, Fasheng Wu. Lung adenocarcinoma with brain metastasis detected dual fusion of LOC399815-ALK and ALK-EML4 in combined treatment of Alectinib and CyberKnife: A case report.
Medicine.
2024 Jan; 103(3):e36992. doi:
10.1097/md.0000000000036992. [PMID: 38241569] - Abigail L Brewer, Claire E Felter, Anna R Sternitzky, Sade M Spencer. Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212-2.
Pharmacology, biochemistry, and behavior.
2024 Jan; ?(?):173707. doi:
10.1016/j.pbb.2024.173707. [PMID: 38244864] - Hany S M Ali, Nader Namazi, Hossein M Elbadawy, Abdelaziz A A El-Sayed, Sameh A Ahmed, Rawan Bafail, Mohannad A Almikhlafi, Yaser M Alahmadi. Repaglinide-Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box-Behnken Design, Characterization, and In Vivo Evaluation.
International journal of nanomedicine.
2024; 19(?):209-230. doi:
10.2147/ijn.s438564. [PMID: 38223883] - Lei Mao, Lingying Jiang, Hangyu Zhao, Jie Lin, Lihong Huang, Zebei Liu, Qunan Cheng, Xiaoyan Dai, Xiaofen Wang. A validated high-performance liquid chromatography method for detecting geniposide, ellagic acid, piperine, costunolide and dehydrocostus lactone in Liuwei Muxiang capsules.
Pakistan journal of pharmaceutical sciences.
2024 Jan; 37(1(Special)):205-213. doi:
". [PMID: 38747271] - Sakineh Rezaei, Hoda-Sadat Meftah, Yasamin Ebtehajpour, Hamid Reza Rahimi, Jamshidkhan Chamani. Investigation on the Effect of Fluorescence Quenching of Calf Thymus DNA by Piperine: Caspase Activation in the Human Breast Cancer Cell Line Studies.
DNA and cell biology.
2024 Jan; 43(1):26-38. doi:
10.1089/dna.2023.0269. [PMID: 38079271] - Miaohe Zhang, Shuang Feng, Shuai Chen, Yuanxiang Zhou, Chenyu Gong, Wei Xue. Synthesis, antibacterial and antifungal activity of myricetin derivatives containing piperidine and amide fragments.
Pest management science.
2023 Dec; 79(12):4795-4808. doi:
10.1002/ps.7675. [PMID: 37477984] - Ying-Jun Wang, Hai-Zhen Hui, Jia-Rong Cheng, Han Mao, Qing-Chun Diao, Bing-Jun Shi. Improvement of Refractory Chronic Actinic Dermatitis During Tofacitinib Treatment.
American journal of therapeutics.
2023 Nov; 30(6):e547-e548. doi:
10.1097/mjt.0000000000001616. [PMID: 36856587] - Muhammed Majeed, Kalyanam Nagabhushanam, Avinash Murali, Devarajan T Vishwanathan, Ramamohan V Mamidala, Lakshmi Mundkur. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study.
Journal of integrative and complementary medicine.
2023 Oct; ?(?):. doi:
10.1089/jicm.2023.0279. [PMID: 37878284] - Pu Jian, Takuto Kumano, Mio Kimura, Makoto Kurisaki, Yoshiteru Hashimoto, Michihiko Kobayashi. Biodegradation of the methylenedioxyphenyl group in piperine and its derivatives: discovery of a novel methylenetransferase in an actinomycete.
Applied and environmental microbiology.
2023 Oct; ?(?):e0114523. doi:
10.1128/aem.01145-23. [PMID: 37874289] - Yuanyuan Lv, Jinjin Zhu, Sihui Huang, Xiaoli Xing, Shen Zhou, Hui Yao, Zhuang Yang, Ling Liu, Sishu Huang, Yuanyuan Miao, Xianqing Liu, Alisdair R Fernie, Yuanhao Ding, Jie Luo. Metabolome profiling and transcriptome analysis filling the early crucial missing steps of piperine biosynthesis in Piper nigrum L.
The Plant journal : for cell and molecular biology.
2023 Sep; ?(?):. doi:
10.1111/tpj.16476. [PMID: 37753665] - Maria Pia Adorni, Bianca Papotti, Maria Orietta Borghi, Elena Raschi, Francesca Zimetti, Franco Bernini, Pier Luigi Meroni, Nicoletta Ronda. Effect of the JAK/STAT Inhibitor Tofacitinib on Macrophage Cholesterol Metabolism.
International journal of molecular sciences.
2023 Aug; 24(16):. doi:
10.3390/ijms241612571. [PMID: 37628747] - Xiaolu Hu, Lan Yu, Yatong Li, Xiaoxi Li, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Qijun Chen, Xing Wang, Xiaoqing Chen, Yinying Ba, Yaonan Wang, Xia Wu. Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase.
CNS neuroscience & therapeutics.
2023 Aug; ?(?):. doi:
10.1111/cns.14383. [PMID: 37528534] - Zhaoyang Hu, Jiaxue Li, Quanhua Liu, Rían W Manville, Geoffrey W Abbott. The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 Jul; 37(7):e22999. doi:
10.1096/fj.202300253r. [PMID: 37249366] - Sharmistha Das, Ritwik Roy, Payel Paul, Poulomi Chakraborty, Sudipta Chatterjee, Moumita Malik, Sarita Sarkar, Anirban Das Gupta, Debasish Maiti, Prosun Tribedi. Piperine, a Plant Alkaloid, Exhibits Efficient Disintegration of the Pre-existing Biofilm of Staphylococcus aureus: a Step Towards Effective Management of Biofilm Threats.
Applied biochemistry and biotechnology.
2023 Jun; ?(?):. doi:
10.1007/s12010-023-04610-x. [PMID: 37389724] - Renxiang Xie, Sujun Yan, Xiaoling Zhou, Yunyi Gao, Yu Qian, Jingyu Hou, Zhanghui Chen, Kairan Lai, Xiangwei Gao, Saisai Wei. Activation of METTL3 promotes white adipose tissue beiging and combats obesity.
Diabetes.
2023 May; ?(?):. doi:
10.2337/db22-0775. [PMID: 37224383] - Basma G Eid, Thikryat Neamatallah, Lenah S Binmahfouz, Amina M Bagher, Abdulmohsin J Alamoudi, Hibah Mubarak Aldawsari, Abeer Hanafy, Atif Hasan, Hany M El-Bassossy, Ashraf B Abdel-Naim, Kiran Vemuri, Alexandros Makriyannis. Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats.
Biomolecules and biomedicine.
2023 May; ?(?):. doi:
10.17305/bb.2023.9173. [PMID: 37212036] - Hongxia Li, Yanan Liu, Jiachao Xiao, Jin Huang, Yue Zhang. Preclinical pharmacokinetics and metabolism study of SCO-267, a GPR40 full agonist, in beagle dogs using ultra-high performance liquid chromatography coupled to tandem mass spectrometry.
Biomedical chromatography : BMC.
2023 May; ?(?):e5685. doi:
10.1002/bmc.5685. [PMID: 37189222] - Jiao Xie, Zhou-Qing Long, Ai-Qun Chen, Ying-Guo Ding, Shi-Tao Liu, Xiang Zhou, Li-Wei Liu, Song Yang. Novel Sulfonamide Derivatives Containing a Piperidine Moiety as New Bactericide Leads for Managing Plant Bacterial Diseases.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065861. [PMID: 36982936] - Shuai-Shuai Liu, Dan Zeng, Tai-Hong Zhang, Jin-Hong Hu, Bin-Xin Yang, Jie Yang, Xiang Zhou, Pei-Yi Wang, Li-Wei Liu, Zhi-Bing Wu, Song Yang. Novel spiro[chromanone-2,4'-piperidine]-4-one derivatives as potential inhibitors of fatty acid synthesis in pathogens: Design, synthesis, and biological evaluation.
European journal of medicinal chemistry.
2023 Mar; 250(?):115215. doi:
10.1016/j.ejmech.2023.115215. [PMID: 36812655] - Shu-Rong Chen, Yih-Fung Chen, Jue-Jun Lin, Tzu-Yi Ke, Yun-Sheng Lin, Yuan-Bin Cheng. 2,6-Disubstituted Piperidine Alkaloids with Neuroprotective Activity from Hippobroma longiflora.
Planta medica.
2023 Mar; 89(3):308-315. doi:
10.1055/a-1903-2663. [PMID: 36482147] - Richard Bade, Geoff Eaglesham, Katja M Shimko, Jochen Mueller. Quantification of new psychoactive substances in Australian wastewater utilising direct injection liquid chromatography coupled to tandem mass spectrometry.
Talanta.
2023 Jan; 251(?):123767. doi:
10.1016/j.talanta.2022.123767. [PMID: 35973252] - Jiali Ni, Xiaoying Li, Xiaodi Tu, Haiyan Zhu, Shiqi Wang, Yayi Hou, Huan Dou. Halofuginone ameliorates systemic lupus erythematosus by targeting Blk in myeloid-derived suppressor cells.
International immunopharmacology.
2023 Jan; 114(?):109487. doi:
10.1016/j.intimp.2022.109487. [PMID: 36493694] - Shaochen Li, Min Lv, Hui Xu. Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships.
Mini reviews in medicinal chemistry.
2023; 23(8):917-940. doi:
10.2174/1389557522666220726121012. [PMID: 35894471] - Liang Dai, Qian Wang, Pengfei Wang, Shangran Zhang, Luyang Tai, Xiangrui Xu, Gang Sun, Mengyu Duan, Haoliang Yuan, Zhiqi Feng. Discovery of novel AdipoRon analogues as potent anti-inflammatory agents against nonalcoholic steatohepatitis.
European journal of medicinal chemistry.
2022 Dec; 244(?):114800. doi:
10.1016/j.ejmech.2022.114800. [PMID: 36215862] - Hema Murugesan, Gauthaman Cs, H Sadiqa Nasreen, Sham Santhanam, Gowrishankar M, Sailatha Ravi, Sharanya Shre Es. An Evaluation of Efficacy and Safety of Tofacitinib, A JAK Inhibitor in the Management of Hospitalized Patients with Mild to Moderate COVID-19 - An Open-Label Randomized Controlled Study.
The Journal of the Association of Physicians of India.
2022 Dec; 69(12):11-12. doi:
NULL. [PMID: 35057599] - Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist. The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats.
Pharmaceutical biology.
2022 Dec; 60(1):96-107. doi:
10.1080/13880209.2021.2018470. [PMID: 34962450] - Yuqing Qian, Mingtao Ao, Boqun Li, Zhijian Kuang, Xiumei Wang, Yin Cao, Jiayi Li, Yingkun Qiu, Kaiqiang Guo, Meijuan Fang, Zhen Wu. Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors.
Bioorganic chemistry.
2022 Dec; 129(?):106119. doi:
10.1016/j.bioorg.2022.106119. [PMID: 36116323] - Demin Ma, Ling Zhong, Zhenzhen Yan, Jing Yao, Yan Zhang, Fan Ye, Yuan Huang, Dongwu Lai, Wei Yang, Panpan Hou, Jiangtao Guo. Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers.
Proceedings of the National Academy of Sciences of the United States of America.
2022 11; 119(45):e2207067119. doi:
10.1073/pnas.2207067119. [PMID: 36763058] - Muhammad Junaid Rao, Mingzheng Duan, Xiaoshuang Wei, Hou Zuo, Li Ma, Muhammad Tahir Ul Qamar, Min Li, Shijian Han, Lihua Hu, Lingqiang Wang. LC-MS/MS-based metabolomics approach revealed novel phytocompounds from sugarcane rind with promising pharmacological value.
Journal of the science of food and agriculture.
2022 Nov; 102(14):6632-6642. doi:
10.1002/jsfa.12030. [PMID: 35603546] - S O Vanegas, A M Reck, C E Rodriguez, J A Marusich, O Yassin, G Sotzing, J L Wiley, S G Kinsey. Assessment of dependence potential and abuse liability of Δ8-tetrahydrocannabinol in mice.
Drug and alcohol dependence.
2022 11; 240(?):109640. doi:
10.1016/j.drugalcdep.2022.109640. [PMID: 36179506] - Georgios Papagiouvannis, Panagiotis Theodosis-Nobelos, Eleni A Rekka. Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27206984. [PMID: 36296574] - Liang-Wei Tseng, John Wen-Cheng Chang, Chiao-En Wu. Safety of Tepotinib Challenge after Capmatinib-Induced Pneumonitis in a Patient with Non-Small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation: A Case Report.
International journal of molecular sciences.
2022 Oct; 23(19):. doi:
10.3390/ijms231911809. [PMID: 36233109] - Rui Li, Yanqing Zhang, Yanhong Li, Zihao Chen, Zhen Wang, Minghua Wang. An Innovative Chiral UPLC-MS/MS Method for Enantioselective Determination and Dissipation in Soil of Fenpropidin Enantiomers.
Molecules (Basel, Switzerland).
2022 Oct; 27(19):. doi:
10.3390/molecules27196530. [PMID: 36235065] - Liaoxi Tan, Yixin Hu, Xinyi Zhang, Chunlei Zhang, Chuchu Xi, Zhao Yang, Zhengyu Cao, Fang Zhao. Corydecumine G inhibits microglia activation via MAPK pathway in a rat model of neuropathic pain.
Journal of chemical neuroanatomy.
2022 10; 124(?):102124. doi:
10.1016/j.jchemneu.2022.102124. [PMID: 35752418] - Luiza V Vieira, Maria Eduarda M Juvenato, Maiara Krause, Otávio A Heringer, Juliano S Ribeiro, Geisamanda P Brandão, Ricardo M Kuster, Maria Tereza W D Carneiro. The effects of drying methods and harvest season on piperine, essential oil composition, and multi-elemental composition of black pepper.
Food chemistry.
2022 Oct; 390(?):133148. doi:
10.1016/j.foodchem.2022.133148. [PMID: 35551027] - Xiaohe Li, Yuli Wei, Shimeng Li, Jingjing Liang, Zhichao Liu, Yunyao Cui, Jingjing Gao, Zhongyi Yang, Lei Li, Honggang Zhou, Shanshan Chen, Cheng Yang. Zanubrutinib ameliorates lipopolysaccharide-induced acute lung injury via regulating macrophage polarization.
International immunopharmacology.
2022 Oct; 111(?):109138. doi:
10.1016/j.intimp.2022.109138. [PMID: 35973369] - Peter Obi, Senthil Natesan. Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of Cannabinoid CB1 Receptor Bound to a Negative Allosteric Modulator, ORG27569, and Analogs.
Journal of medicinal chemistry.
2022 09; 65(18):12240-12255. doi:
10.1021/acs.jmedchem.2c00946. [PMID: 36066412] - Chenchen Guo, Ying Chen, Dengyun Wu, Yu Du, Mengyue Wang, Cunqi Liu, Jianzhou Chu, Xiaoqin Yao. Transcriptome Analysis Reveals an Essential Role of Exogenous Brassinolide on the Alkaloid Biosynthesis Pathway in Pinellia Ternata.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810898. [PMID: 36142812] - Li Lin, Yuan Wang, Sennan Shao, Wen Lin, Dan Huang, Yue Dai, Yufeng Xia. Herb-drug interaction between Shaoyao-Gancao-Fuzi decoction and tofacitinib via CYP450 enzymes.
Journal of ethnopharmacology.
2022 Sep; 295(?):115437. doi:
10.1016/j.jep.2022.115437. [PMID: 35667582] - Jameel Mohammed Al-Khayri, Vinayak Upadhya, Sandeep Ramachandra Pai, Poornananda Madhava Naik, Muneera Qassim Al-Mssallem, Fatima Mohammed Alessa. Comparative Quantification of the Phenolic Compounds, Piperine Content, and Total Polyphenols along with the Antioxidant Activities in the Piper trichostachyon and P. nigrum.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185965. [PMID: 36144701] - Jeff K Kerkovius, Andrea Stegner, Aneta Turlik, Pik Hoi Lam, Kendall N Houk, Sarah E Reisman. A Pyridine Dearomatization Approach to the Matrine-Type Lupin Alkaloids.
Journal of the American Chemical Society.
2022 09; 144(35):15938-15943. doi:
10.1021/jacs.2c06584. [PMID: 36006400] - Jasmita Gill, Amit Sharma. Prospects of halofuginone as an antiprotozoal drug scaffold.
Drug discovery today.
2022 09; 27(9):2586-2592. doi:
10.1016/j.drudis.2022.05.020. [PMID: 35636724] - Roham Foroumadi, Maryam Baeeri, Sara Asgarian, Zahra Emamgholipour, Fereshteh Goli, Loghman Firoozpour, Mohammad Keykhaei, Mahdi Gholami, Ahmad R Dehpour, Mohammad Abdollahi, Alireza Foroumadi. Antidiabetic and neuroprotective effects of a novel repaglinide analog.
Journal of biochemical and molecular toxicology.
2022 Sep; 36(9):e23125. doi:
10.1002/jbt.23125. [PMID: 35702883] - Hae Jin Kim, In Kyung Jeong, Kyu Yeon Hur, Soo-Kyung Kim, Jung Hyun Noh, Sung Wan Chun, Eun Seok Kang, Eun-Jung Rhee, Sung Hee Choi. Comparison of Efficacy of Glimepiride, Alogliptin, and Alogliptin-Pioglitazone as the Initial Periods of Therapy in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Open-Label, Multicenter, Randomized, Controlled Study.
Diabetes & metabolism journal.
2022 09; 46(5):689-700. doi:
10.4093/dmj.2021.0183. [PMID: 35295073] - Lúcio R Lima, Ruan S Bastos, Elenilze F B Ferreira, Rozires P Leão, Pedro H F Araújo, Samuel S da R Pita, Humberto F De Freitas, José M Espejo-Román, Edla L V S Dos Santos, Ryan da S Ramos, Williams J C Macêdo, Cleydson B R Santos. Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach.
International journal of molecular sciences.
2022 Sep; 23(17):. doi:
10.3390/ijms23179927. [PMID: 36077329] - Masakazu Ishii, Haruka Miyata, Nao Ikeda, Takashi Tagawa, Masahiro Nishimura. Piper retrofractum extract and its component piperine promote lymphangiogenesis via an AKT- and ERK-dependent mechanism.
Journal of food biochemistry.
2022 09; 46(9):e14233. doi:
10.1111/jfbc.14233. [PMID: 35567300] - Larisse Borges Sousa, Mara Lúcia Albuquerque Pereira, Herymá Giovane de Oliveira Silva, Leandro Borges Sousa, Leandro Santos E Silva, Fernanda Samarini Machado, Thierry Ribeiro Tomich, Daniela Batista Oss, Alexandre Lima Ferreira, Mariana Magalhães Campos, Isabela Carvalho Costa, Luiz Gustavo Ribeiro Pereira. Prosopis juliflora piperidine alkaloid extract levels in diet for sheep change energy and nitrogen metabolism and affect enteric methane yield.
Journal of the science of food and agriculture.
2022 Sep; 102(12):5132-5140. doi:
10.1002/jsfa.11864. [PMID: 35279834] - Zhiyang Jiang, Dongmei Shi, Huilin Li, Danchan He, Kai Zhu, Jingyi Li, Yunjiang Zi, Zhijian Xu, Jiaxing Huang, Hongxia Duan, Qing Yang. Rational Design and Identification of Novel Piperine Derivatives as Multichitinase Inhibitors.
Journal of agricultural and food chemistry.
2022 Aug; 70(33):10326-10336. doi:
10.1021/acs.jafc.2c03751. [PMID: 35960858] - Aya Saad Radwan, Mahmoud M Elkhoudary, Ghada M Hadad, Fathalla Belal, Mohamed M Salim. A highly sensitive spectrofluorimetric method for the determination of bilastine in its pharmaceutical preparations and biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Aug; 276(?):121246. doi:
10.1016/j.saa.2022.121246. [PMID: 35429867] - Ziteng Wang, Eric Chun Yong Chan. Physiologically-Based Pharmacokinetic Modelling to Investigate Baricitinib and Tofacitinib Dosing Recommendations for COVID-19 in Geriatrics.
Clinical pharmacology and therapeutics.
2022 Aug; 112(2):291-296. doi:
10.1002/cpt.2600. [PMID: 35380176] - Luise Jäckel, Arianne Schnabel, Hagen Stellmach, Ulrike Klauß, Susanne Matschi, Gerd Hause, Thomas Vogt. The terminal enzymatic step in piperine biosynthesis is co-localized with the product piperine in specialized cells of black pepper (Piper nigrum L.).
The Plant journal : for cell and molecular biology.
2022 08; 111(3):731-747. doi:
10.1111/tpj.15847. [PMID: 35634755] - Zhongnan Xu, Yanli Wang, Zhengzhi Liu, Renjie Zhang, Yannan Zhou, Jing Yu, Jing Lan, Wenzhong Liang, Guangwen Liu, Xinyao Qu, Jiahui Chen, Zhengjie Su, Shuang Yu, Yang Cheng, Wanhua Wang, Qing Ren, Qiaohuan Deng, Yicheng Zhao, Haimiao Yang. A randomized, crossover, phase I clinical study to evaluate bioequivalence and safety of tofacitinib and Xeljanz® in Chinese healthy subjects.
International immunopharmacology.
2022 Aug; 109(?):108780. doi:
10.1016/j.intimp.2022.108780. [PMID: 35461158] - Ying Zhu, Ting Wang, Na Zhao, Wenya Jiang. High-resolution accurate mass approach to characterization of SCO-267 metabolites using liquid chromatography hybrid quadrupole Orbitrap mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2022 Jul; 36(14):e9325. doi:
10.1002/rcm.9325. [PMID: 35560672] - Nasser A Hassan, Asma K Alshamari, Allam A Hassan, Mohamed G Elharrif, Abdullah M Alhajri, Mohammed Sattam, Reham R Khattab. Advances on Therapeutic Strategies for Alzheimer's Disease: From Medicinal Plant to Nanotechnology.
Molecules (Basel, Switzerland).
2022 Jul; 27(15):. doi:
10.3390/molecules27154839. [PMID: 35956796] - Zhenming Kang, Guoshao Zhu, Changsheng Su, Kai Zeng, Shunyuan Li, Xiaodan Wu. Differential effects of remifentanil and sufentanil anesthesia on post-operative pain and cognitive functions.
International immunopharmacology.
2022 Jul; 108(?):108888. doi:
10.1016/j.intimp.2022.108888. [PMID: 35729829] - J M van Berge Henegouwen, H van der Wijngaart, L J Zeverijn, L R Hoes, M Meertens, A D R Huitema, L A Devriese, M Labots, H M W Verheul, E E Voest, H Gelderblom. Efficacy and toxicity of vemurafenib and cobimetinib in relation to plasma concentrations, after administration via feeding tube in patients with BRAF-mutated thyroid cancer: a case series and review of literature.
Cancer chemotherapy and pharmacology.
2022 07; 90(1):97-104. doi:
10.1007/s00280-022-04437-z. [PMID: 35598186] - Samantha Smith, Jordan Sergio, Michael Coyle, Kayla Elder, Ashley Centner, Sophie Cohen, Michelle Terry, Natalie Lipari, John Glinski, Emily Wheelis, Carla Budrow, Christopher Bishop. The effects of Vilazodone, YL-0919 and Vortioxetine in hemiparkinsonian rats.
Psychopharmacology.
2022 Jul; 239(7):2119-2132. doi:
10.1007/s00213-022-06078-9. [PMID: 35275226] - Rajinder Bhardwaj, Julie L Collins, Joseph Stringfellow, Jennifer Madonia, Matt S Anderson, Jeri-Anne Finley, David A Stock, Vladimir Coric, Robert Croop, Richard Bertz. P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects.
Clinical pharmacology in drug development.
2022 07; 11(7):889-897. doi:
10.1002/cpdd.1088. [PMID: 35304977] - Ulrich Kintscher, George L Bakris, Peter Kolkhof. Novel non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease.
British journal of pharmacology.
2022 07; 179(13):3220-3234. doi:
10.1111/bph.15747. [PMID: 34811750] - Panagiotis I Georgianos, Rajiv Agarwal. Management of hypertension in advanced kidney disease.
Current opinion in nephrology and hypertension.
2022 07; 31(4):374-379. doi:
10.1097/mnh.0000000000000812. [PMID: 35727171] - Weina Ma, Man Zhu, Bo Wang, Zhengyan Gong, Xia Du, Tianfeng Yang, Xianpeng Shi, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang, Yanhong Ji, Yang Wang, Song Li, Yanmin Zhang. Vandetanib drives growth arrest and promotes sensitivity to imatinib in chronic myeloid leukemia by targeting ephrin type-B receptor 4.
Molecular oncology.
2022 07; 16(14):2747-2765. doi:
10.1002/1878-0261.13270. [PMID: 35689424] - Arnab Mukherjee, Shinichi Tsuchiwata, Timothy Nicholas, Jack A Cook, Irene Modesto, Chinyu Su, Geert R D'Haens, William J Sandborn. Exposure-Response Characterization of Tofacitinib Efficacy in Moderate to Severe Ulcerative Colitis: Results From Phase II and Phase III Induction and Maintenance Studies.
Clinical pharmacology and therapeutics.
2022 Jul; 112(1):90-100. doi:
10.1002/cpt.2601. [PMID: 35380740] - Wei Gao, Yi Wang, Ru Wang, Yi-Hai Wang, Jing-Wen Xu, Xiang-Jiu He. Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza).
Chinese journal of natural medicines.
2022 Jul; 20(7):541-550. doi:
10.1016/s1875-5364(22)60165-1. [PMID: 35907653] - Daisuke Hiraoka, Jun Ishizaki, Kenta Horie, Takuya Matsumoto, Koichiro Suemori, Katsuto Takenaka, Hitoshi Hasegawa. A case of clinically amyopathic dermatomyositis that was refractory to intensive immunosuppressive therapy including tofacitinib, but successfully treated with plasma exchange therapy.
Modern rheumatology case reports.
2022 06; 6(2):194-198. doi:
10.1093/mrcr/rxab054. [PMID: 34984465] - Siamak Beheshti, Mohammad Wasil Wesal. Anticonvulsant activity of the histamine H3 receptor inverse agonist pitolisant in an electrical kindling model of epilepsy.
Neuroscience letters.
2022 06; 782(?):136685. doi:
10.1016/j.neulet.2022.136685. [PMID: 35598693] - Gholamreza Askari, Amirhossein Sahebkar, Davood Soleimani, Atena Mahdavi, Sahar Rafiee, Muhammed Majeed, Farzin Khorvash, Bijan Iraj, Mahshid Elyasi, Mohammad Hossein Rouhani, Mohammad Bagherniya. The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial.
Trials.
2022 Jun; 23(1):472. doi:
10.1186/s13063-022-06375-w. [PMID: 35668500] - Shining Wang, Grace Chen, Emilio Merlo Pich, John Affinito, Michael Cwik, Hélène M Faessel. Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers.
British journal of clinical pharmacology.
2022 06; 88(6):2899-2908. doi:
10.1111/bcp.15225. [PMID: 35001412] - Joice Guilherme de Oliveira, Harry Luiz Pilz-Júnior, Alessandra Bittencourt de Lemos, Felipe Allan da Silva da Costa, Millena Fernandes, Douglas Zelinger Gonçalves, Paula Fassicolo Variza, Fernanda Mendes de Moraes, Fernando Dal Pont Morisso, Rachel Faverzani Magnago, Karine Modolon Zepon, Luiz Alberto Kanis, Onilda Santos da Silva, Josiane Somariva Prophiro. Polymer-based nanostructures loaded with piperine as a platform to improve the larvicidal activity against Aedes aegypti.
Acta tropica.
2022 Jun; 230(?):106395. doi:
10.1016/j.actatropica.2022.106395. [PMID: 35278367] - Nayyer Islam, Muhammad Irfan, Talib Hussain, Maria Mushtaq, Ikram Ullah Khan, Abid Mehmood Yousaf, Muhammad Usman Ghori, Yasser Shahzad. Piperine phytosomes for bioavailability enhancement of domperidone.
Journal of liposome research.
2022 Jun; 32(2):172-180. doi:
10.1080/08982104.2021.1918153. [PMID: 33944662] - Junmei Weng, Lian Chen, Huicheng Liu, Xiang-Ping Yang, Liu Huang. Ferroptosis Markers Predict the Survival, Immune Infiltration, and Ibrutinib Resistance of Diffuse Large B cell Lymphoma.
Inflammation.
2022 Jun; 45(3):1146-1161. doi:
10.1007/s10753-021-01609-6. [PMID: 35064379] - Zhiquan Xiang, Klaudia Kuranda, William Quinn, Areski Chekaoui, Robert Ambrose, Mohadeseh Hasanpourghai, Mikhail Novikov, Dakota Newman, Christina Cole, Xiangyang Zhou, Federico Mingozzi, Hildegund C J Ertl. The Effect of Rapamycin and Ibrutinib on Antibody Responses to Adeno-Associated Virus Vector-Mediated Gene Transfer.
Human gene therapy.
2022 06; 33(11-12):614-624. doi:
10.1089/hum.2021.258. [PMID: 35229644] - Yueting Li, Yihan Cao, Chen Li, Wen Zhang. Response to: 'Off-label use of tofacitinib: a potential treatment option for SAPHO syndrome' by Xie et al.
Annals of the rheumatic diseases.
2022 06; 81(6):e92. doi:
10.1136/annrheumdis-2020-217956. [PMID: 32527867] - Cihan Yurdaydin, Onur Keskin, Esra Yurdcu, Aysun Çalişkan, Soner Önem, Fatih Karakaya, Çağdaş Kalkan, Ersin Karatayli, Senem Karatayli, Ingrid Choong, David Apelian, Christopher Koh, Theo Heller, Ramazan Idilman, A Mithat Bozdayi, Jeffrey S Glenn. A phase 2 dose-finding study of lonafarnib and ritonavir with or without interferon alpha for chronic delta hepatitis.
Hepatology (Baltimore, Md.).
2022 06; 75(6):1551-1565. doi:
10.1002/hep.32259. [PMID: 34860418] - Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist. Low Piperine Fractional Piper nigrum Extract Enhanced the Antitumor Immunity via Regulating the Th1/Th2/Treg Cell Subsets on NMU-Induced Tumorigenesis Rats.
Planta medica.
2022 Jun; 88(7):527-537. doi:
10.1055/a-1458-5646. [PMID: 33902130]
