(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid (BioDeep_00000022472)

   

human metabolite


代谢物信息卡片


(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid

化学式: C13H14N2O2 (230.1055)
中文名称: 1,2,3,4-四氢哈尔满-3-羧酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C2=C(CC(N1)C(=O)O)C3=CC=CC=C3N2
InChI: InChI=1S/C13H14N2O2/c1-7-12-9(6-11(14-7)13(16)17)8-4-2-3-5-10(8)15-12/h2-5,7,11,14-15H,6H2,1H3,(H,16,17)

描述信息

(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid is found in alcoholic beverages. (1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid is widespread in many foodstuffs especially fruit juices, jams and fermented foods or beverages including beer and soy sauce. Also present in the toxic fly agaric mushroom (Amanita muscaria). (1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid is formed by Pictet-Spengler condensation between acetaldehyde and L-tryptophan in nature or during food processing.
Widespread in many foodstuffs especially fruit juices, jams and fermented foods or beverages including beer and soy sauceand is) also present in the toxic fly agaric mushroom (Amanita muscaria). Formed by Pictet-Spengler condensation between acetaldehyde and L-tryptophan in nature or during food processing. (1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid is found in many foods, some of which are alcoholic beverages, herbs and spices, fruits, and mushrooms.

同义名列表

12 个代谢物同义名

(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid; 1H-Pyrido[3,4-b]indole-3-carboxylicacid, 2,3,4,9-tetrahydro-1-methyl-; (1XI,3xi)-1,2,3,4-tetrahydro-1-methyl-β-carboline-3-carboxylic acid; (1XI,3xi)-1,2,3,4-tetrahydro-1-methyl-b-carboline-3-carboxylic acid; (1XI,3xi)-1,2,3,4-tetrahydro-1-methyl-beta-carboline-3-carboxylate; (1XI,3xi)-1,2,3,4-tetrahydro-1-methyl-b-carboline-3-carboxylate; (1XI,3xi)-1,2,3,4-tetrahydro-1-methyl-β-carboline-3-carboxylate; 1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid; 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid; 1-Methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate; Tetrahydroharman-3-carboxylic acid; MTCA



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Xiaoming Lu, Ningyang Li, Xuguang Qiao, Zhichang Qiu, Pengli Liu. Composition analysis and antioxidant properties of black garlic extract. Journal of food and drug analysis. 2017 04; 25(2):340-349. doi: 10.1016/j.jfda.2016.05.011. [PMID: 28911676]
  • Per M Hellström, Panu Hendolin, Pertti Kaihovaara, Leif Kronberg, Axel Meierjohann, Anders Millerhovf, Lea Paloheimo, Heidi Sundelin, Kari Syrjänen, Dominic-Luc Webb, Mikko Salaspuro. Slow-release L-cysteine capsule prevents gastric mucosa exposure to carcinogenic acetaldehyde: results of a randomised single-blinded, cross-over study of Helicobacter-associated atrophic gastritis. Scandinavian journal of gastroenterology. 2017 Feb; 52(2):230-237. doi: 10.1080/00365521.2016.1249403. [PMID: 27806647]
  • Xiaomin Wang, Rui Liu, Yukun Yang, Min Zhang. Isolation, purification and identification of antioxidants in an aqueous aged garlic extract. Food chemistry. 2015 Nov; 187(?):37-43. doi: 10.1016/j.foodchem.2015.03.109. [PMID: 25976995]
  • Tomás Herraiz, Juan Galisteo. Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases. Biochemical and biophysical research communications. 2014 Aug; 451(1):42-7. doi: 10.1016/j.bbrc.2014.07.047. [PMID: 25035927]
  • Gustavo F Gonzales, Cynthia Gonzales-Castañeda. The Methyltetrahydro-{beta}-Carbolines in Maca (Lepidium meyenii). Evidence-based complementary and alternative medicine : eCAM. 2009 Sep; 6(3):315-6. doi: 10.1093/ecam/nen041. [PMID: 18955346]
  • H Tsuchiya. Biphasic effects of acetaldehyde-biogenic amine condensation products on membrane fluidity. The Journal of pharmacy and pharmacology. 2001 Jan; 53(1):121-7. doi: 10.1211/0022357011775109. [PMID: 11206186]
  • H Tsuchiya, M Sato, I Watanabe. Antiplatelet activity of soy sauce as functional seasoning. Journal of agricultural and food chemistry. 1999 Oct; 47(10):4167-74. doi: 10.1021/jf990147d. [PMID: 10552785]
  • J Adachi, Y Ueno, Y Tatsuno, M Gomez, C C Smith, E M Sternberg. A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome. Advances in experimental medicine and biology. 1996; 398(?):365-70. doi: 10.1007/978-1-4613-0381-7_56. [PMID: 8906290]
  • H Tsuchiya, S Ohtani, K Yamada, N Takagi, H Todoriki, T Hayashi. Quantitation of urinary 1,2,3,4-tetrahydro-beta-carboline and 1-methyl-1,2,3,4-tetrahydro-beta-carboline by high-performance liquid chromatography. Journal of pharmaceutical sciences. 1994 Mar; 83(3):415-8. doi: 10.1002/jps.2600830330. [PMID: 8207693]
  • J Adachi, Y Ueno, Y Ogawa, S Hishida, K Yamamoto, H Ouchi, Y Tatsuno. Acetaldehyde-induced formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in rats. Biochemical pharmacology. 1993 Feb; 45(4):935-41. doi: 10.1016/0006-2952(93)90179-z. [PMID: 8452569]
  • J Adachi, T Naito, Y Ueno, Y Ogawa, I Ninomiya, Y Tatsuno. Metabolism and distribution in the rat of peak E substance, a constituent in L-tryptophan product implicated in eosinophilia-myalgia syndrome. Archives of toxicology. 1993; 67(4):284-9. doi: 10.1007/bf01974348. [PMID: 8517785]
  • Y Ogawa, J Adachi, Y Tatsuno. Accumulation of 1-methyl-tetrahydro-beta-carboline-3-carboxylic acid in blood and organs of rat. A possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. Archives of toxicology. 1993; 67(4):290-3. doi: 10.1007/bf01974349. [PMID: 8517786]
  • A Nagahara, S Kumagai. Excretion and distribution of nitrite-treated or untreated 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1991 Apr; 29(4):243-7. doi: 10.1016/0278-6915(91)90021-x. [PMID: 2040486]
  • J Adachi, K Yamamoto, Y Ogawa, Y Ueno, Y Mizoi, Y Tatsuno. Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. Archives of toxicology. 1991; 65(6):505-9. doi: 10.1007/bf01977365. [PMID: 1929872]