N-Methyl-1-deoxynojirimycin (BioDeep_00000022405)

   

human metabolite


代谢物信息卡片


2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol

化学式: C7H15NO4 (177.100103)
中文名称: N-甲基-1-脱氧野霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CC(C(C(C1CO)O)O)O
InChI: InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3

描述信息

N-Methyl-1-deoxynojirimycin is found in fruits. N-Methyl-1-deoxynojirimycin is an alkaloid from Morus alba (white mulberry
Alkaloid from Morus alba (white mulberry). N-Methyl-1-deoxynojirimycin is found in fruits.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D004791 - Enzyme Inhibitors

同义名列表

14 个代谢物同义名

2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol; 1,5-Dideoxy-1,5-(methylimino)-D-glucitol, 9ci; 1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol; 1,5-Dideoxy-1,5-(methylimino)-D-glucitol; N-Methyl-1-deoxynojirimycin; N-Methyldesoxynojirimycin; N-Methyldeoxy-nojirimycin; N-Methyldeoxynojirimycin; N-Methylmoranoline; N-Methylmoranolin; N-Methyl-DNJ; MOR-14; NMDNJ; Mednj



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tingting Liang, Shun Liu, Fang Wang, Jiamei Gu, Yang Lu, Weike Chen, Cunyu Li, Yunfeng Zheng, Guoping Peng. A UPLC-MS/MS method for simultaneous determination of 1-deoxynojirimycin and N-methyl-1-deoxynojirimycin in rat plasma and its application in pharmacokinetic and absolute bioavailability studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jan; 1072(?):205-210. doi: 10.1016/j.jchromb.2017.10.055. [PMID: 29179061]
  • K Murakami, J Aikawa, M Wada, S Horinouchi, T Beppu. A Mucor pusillus mutant defective in asparagine-linked glycosylation. Journal of bacteriology. 1994 May; 176(9):2635-9. doi: 10.1128/jb.176.9.2635-2639.1994. [PMID: 8169212]
  • E D Faber, J H Proost, R Oosting, D K Meijer. Disposition of glycosidase inhibitors in the isolated perfused rat liver: hepatobiliary and subcellular concentration gradients of 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin. Pharmaceutical research. 1994 Jan; 11(1):144-50. doi: 10.1023/a:1018970400323. [PMID: 8140045]
  • K Ishiwata, H Seki, T Sasaki, S Ishii, T Nozaki, M Senda. Synthesis and characteristics in tumor-bearing mice of N-[11C]methyl-1-deoxynojirimycin and N-[11C]methyl-1-deoxymannojirimycin. Nuclear medicine and biology. 1993 Oct; 20(7):843-7. doi: 10.1016/0969-8051(93)90150-s. [PMID: 8241996]
  • E D Faber, R Oosting, J J Neefjes, H L Ploegh, D K Meijer. Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo. Pharmaceutical research. 1992 Nov; 9(11):1442-50. doi: 10.1023/a:1015810913257. [PMID: 1475231]
  • P F Daniel, D L Sauls, R M Boustany. Evidence for processing of dolichol-linked oligosaccharides in patients with neuronal ceroid-lipofuscinosis. American journal of medical genetics. 1992 Feb; 42(4):586-92. doi: 10.1002/ajmg.1320420432. [PMID: 1609840]
  • G C Trudel, P C Holland. The glycoprotein-processing inhibitors bromoconduritol and N-methyl-1-deoxynojirimycin alter the adhesion phenotype of skeletal myoblasts. Biochemistry and cell biology = Biochimie et biologie cellulaire. 1990 Dec; 68(12):1411-8. doi: 10.1139/o90-204. [PMID: 2150751]
  • A J Verhoeven, H Jansen. Secretion of rat hepatic lipase is blocked by inhibition of oligosaccharide processing at the stage of glucosidase I. Journal of lipid research. 1990 Oct; 31(10):1883-93. doi: . [PMID: 2150412]
  • B S Stannard, N Gesundheit, N R Thotakura, P W Gyves, C Ronin, B D Weintraub. Differential effect of inhibitors of oligosaccharide processing on the secretion of thyrotropin from dispersed rodent pituitary cells. Biochemical and biophysical research communications. 1989 Dec; 165(2):788-94. doi: 10.1016/s0006-291x(89)80035-x. [PMID: 2532008]
  • R C Hughes, L Foddy, E Bause. Asparagine-linked oligosaccharides of BHK cells treated with inhibitors of oligosaccharide processing. The Biochemical journal. 1987 Nov; 247(3):537-45. doi: 10.1042/bj2470537. [PMID: 2962571]
  • D A Granato, J R Neeser. Effect of trimming inhibitors on the secretion and biological activity of a murine IgE monoclonal antibody. Molecular immunology. 1987 Aug; 24(8):849-55. doi: 10.1016/0161-5890(87)90187-8. [PMID: 3116410]
  • P A Romero, A Herscovics. Transfer of nonglucosylated oligosaccharide from lipid to protein in a mammalian cell. The Journal of biological chemistry. 1986 Dec; 261(34):15936-40. doi: 10.1016/s0021-9258(18)66656-6. [PMID: 3782099]
  • P A Romero, A Herscovics. Effects of tunicamycin, N-methyl-1-deoxynojirimycin, and manno-1-deoxynojirimycin on the biosynthesis of lactosaminoglycans in F9 teratocarcinoma cells. Carbohydrate research. 1986 Aug; 151(?):21-8. doi: 10.1016/s0008-6215(00)90326-4. [PMID: 2945635]
  • R Repp, T Tamura, C B Boschek, H Wege, R T Schwarz, H Niemann. The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles. The Journal of biological chemistry. 1985 Dec; 260(29):15873-9. doi: NULL. [PMID: 2999142]
  • P A Romero, P Friedlander, A Herscovics. Deoxynojirimycin inhibits the formation of Glc3Man9GlcNAc2-PP-dolichol in intestinal epithelial cells in culture. FEBS letters. 1985 Apr; 183(1):29-32. doi: 10.1016/0014-5793(85)80947-9. [PMID: 3156765]