Grifolin (BioDeep_00000022258)

   

human metabolite Endogenous natural product


代谢物信息卡片


5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,3-diol

化学式: C22H32O2 (328.24021719999996)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1c(cc(c(c1O)C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C
InChI: InChI=1S/C22H32O2/c1-16(2)8-6-9-17(3)10-7-11-18(4)12-13-20-21(23)14-19(5)15-22(20)24/h8,10,12,14-15,23-24H,6-7,9,11,13H2,1-5H3/b17-10+,18-12+

描述信息

Grifolin is found in mushrooms. Grifolin is isolated from the edible maitake mushroom (Grifola confluens
Isolated from the edible maitake mushroom (Grifola confluens). Grifolin is found in mushrooms.

同义名列表

13 个代谢物同义名

5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,3-diol; 5-Methyl-2-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-1,3-benzenediol, 9ci; E,E,5-Methyl-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-1,3-benzenediol; Ammonium, hexadecyltrimethyl-, pentachlorophenoxide (8ci); Hexadecyltrimethylammonium pentachlorophenoxide (6ci,7ci); Ammonium, hexadecyltrimethyl-, pentachlorophenoxide; Ammonium, hexadecyltrimethyl-, pentachlorophenol; 3,8,12-Trimethyl-5,7,11-tridecatriene-3,4-diol; Hexadecyltrimethylammonium pentachlorophenol; Trimethylcetylammonium pentachlorophenate; 2-Farnesyl-5-methylresorcinol; DTXSID60342958; Grifolin



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aaron Boakye, Edward Ntim Gasu, Jehoshaphat Oppong Mensah, Lawrence Sheringham Borquaye. Computational studies on potential small molecule inhibitors of Leishmania pteridine reductase 1. Journal of biomolecular structure & dynamics. 2023 Jan; ?(?):1-14. doi: 10.1080/07391102.2023.2166119. [PMID: 36632757]
  • Almas Yaqoob, Wai Ming Li, Victor Liu, Chuyi Wang, Sebastian Mackedenski, Linda E Tackaberry, Hugues B Massicotte, Keith N Egger, Kerry Reimer, Chow H Lee. Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells. PloS one. 2020; 15(5):e0231948. doi: 10.1371/journal.pone.0231948. [PMID: 32369483]
  • Guang-Hui Huang, Zhu Hu, Chun Lei, Pei-Pei Wang, Jing Yang, Jing-Ya Li, Jia Li, Ai-Jun Hou. Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense. Journal of natural products. 2018 08; 81(8):1810-1818. doi: 10.1021/acs.jnatprod.8b00273. [PMID: 30067363]
  • Zijian Wu, Ying Li. Grifolin exhibits anti-cancer activity by inhibiting the development and invasion of gastric tumor cells. Oncotarget. 2017 Mar; 8(13):21454-21460. doi: 10.18632/oncotarget.15250. [PMID: 28206955]
  • Xiangjian Luo, Namei Li, Juanfang Zhong, Zheqiong Tan, Ying Liu, Xin Dong, Can Cheng, Zhijie Xu, Hongde Li, Lifang Yang, Min Tang, Xinxian Weng, Wei Yi, Jikai Liu, Ya Cao. Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1 / LSF- MMP2 / CD44 axes. Oncotarget. 2016 Oct; 7(42):68708-68720. doi: 10.18632/oncotarget.11929. [PMID: 27626695]
  • Xiaoxia Che, Hong Yan, Hengzi Sun, Samina Dongol, Yilin Wang, Qingtao Lv, Jie Jiang. Grifolin induces autophagic cell death by inhibiting the Akt/mTOR/S6K pathway in human ovarian cancer cells. Oncology reports. 2016 Aug; 36(2):1041-7. doi: 10.3892/or.2016.4840. [PMID: 27277722]
  • Xiangjian Luo, Lifang Yang, Lanbo Xiao, Xiaofeng Xia, Xin Dong, Juanfang Zhong, Ying Liu, Namei Li, Ling Chen, Hongde Li, Wei Li, Wenbin Liu, Xinfang Yu, Hanyong Chen, Min Tang, Xinxian Weng, Wei Yi, Ann Bode, Zigang Dong, Jikai Liu, Ya Cao. Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis. Oncotarget. 2015 Dec; 6(40):42704-16. doi: 10.18632/oncotarget.5678. [PMID: 26516701]
  • Xiangjian Luo, Xinfang Yu, Sufang Liu, Qipan Deng, Xiaolan Liu, Songling Peng, Hongde Li, Jikai Liu, Ya Cao. The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review). Oncology reports. 2015 Aug; 34(2):547-54. doi: 10.3892/or.2015.4029. [PMID: 26044950]
  • Liang-Yan Liu, Zheng-Hui Li, Zhi-Hui Ding, Ze-Jun Dong, Gen-Tao Li, Yan Li, Ji-Kai Liu. Meroterpenoid pigments from the basidiomycete Albatrellus ovinus. Journal of natural products. 2013 Jan; 76(1):79-84. doi: 10.1021/np300751m. [PMID: 23305465]
  • Maria José Alves, Isabel C F R Ferreira, Joana Dias, Vânia Teixeira, Anabela Martins, Manuela Pintado. A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds. Current topics in medicinal chemistry. 2013; 13(21):2648-59. doi: 10.2174/15680266113136660191. [PMID: 24083794]
  • Du-Qiang Luo, Hong-Jun Shao, Hua-Jie Zhu, Ji-Kai Liu. Activity in vitro and in vivo against plant pathogenic fungi of grifolin isolated from the basidiomycete Albatrellus dispansus. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2005 Jan; 60(1-2):50-6. doi: 10.1515/znc-2005-1-210. [PMID: 15787244]
  • Naoki Iwata, Naili Wang, Xinsheng Yao, Susumu Kitanaka. Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum. Journal of natural products. 2004 Jul; 67(7):1106-9. doi: 10.1021/np0303916. [PMID: 15270561]