Lacto-n-fucopentaose I (BioDeep_00000021941)

   

human metabolite Endogenous


代谢物信息卡片


N-[(2S,3R,5S,6R)-2-{[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-4-yl]oxy}-4-{[(2R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-6-(hydroxymethyl)oxan-3-yl]ethanimidate

化学式: C32H55NO25 (853.306302)
中文名称: 乳酰-N-岩藻五糖I
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC1C(OC2C(O)C(CO)OC(OC(C(O)CO)C(O)C(O)C=O)C2O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O
InChI: InChI=1S/C32H55NO25/c1-8-16(42)21(47)23(49)30(51-8)58-28-22(48)18(44)12(5-36)54-32(28)56-26-15(33-9(2)39)29(52-13(6-37)19(26)45)57-27-20(46)14(7-38)53-31(24(27)50)55-25(11(41)4-35)17(43)10(40)3-34/h3,8,10-32,35-38,40-50H,4-7H2,1-2H3,(H,33,39)/t8-,10-,11+,12+,13+,14+,15+,16+,17+,18-,19+,20-,21+,22-,23-,24+,25+,26?,27-,28?,29-,30-,31-,32-/m0/s1

描述信息

Lacto-n-fucopentaose I is an oligosaccharide found in human milk and other biofluids. Oligosaccharides of the blood group family decorate diverse glycoproteins and glycolipids on the surface of cells. Lacto-n-fucopentaose I and its sulfated and sialylated analogs, SuLNFPI and SLNFPI, are potent oligosaccharide ligands for the animal lectins, E- and L-selectin, and the natural killer cell receptor, NKR-P1. Burkinabe women show lower concentrations of lacto-n-fucopentaose I while Italian women show a higher concentrations of lacto-n-fucopentaose I. Lacto-n-fucopentaose I inhibits blastocyst attachment to uterine epithelial cells in vitro; component(s) carrying LNF-1 in the secretion might be regulatory molecules helping to secure the proper time for implantation. (PMID: 8639679, 16954962, 1802622, 3927775, 2988366) [HMDB]
Lacto-n-fucopentaose I is an oligosaccharide found in human milk and other biofluids. Oligosaccharides of the blood group family decorate diverse glycoproteins and glycolipids on the surface of cells. Lacto-n-fucopentaose I and its sulfated and sialylated analogs, SuLNFPI and SLNFPI, are potent oligosaccharide ligands for the animal lectins, E- and L-selectin, and the natural killer cell receptor, NKR-P1. Burkinabe women show lower concentrations of lacto-n-fucopentaose I while Italian women show a higher concentrations of lacto-n-fucopentaose I. Lacto-n-fucopentaose I inhibits blastocyst attachment to uterine epithelial cells in vitro; component(s) carrying LNF-1 in the secretion might be regulatory molecules helping to secure the proper time for implantation. (PMID: 8639679, 16954962, 1802622, 3927775, 2988366).

同义名列表

8 个代谢物同义名

N-[(2S,3R,5S,6R)-2-{[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-4-yl]oxy}-4-{[(2R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-6-(hydroxymethyl)oxan-3-yl]ethanimidate; N-[(2S,3R,5S,6R)-2-{[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-4-yl]oxy}-4-{[(2R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; lacto-N-fuco-Pentaose I; LACTO-N-FUCOPENTAOSE I; MCULE-3510536603; LNFP I; LNF 1; LNF I



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Shogo Matsumoto, Hiromi Nakao, Keiko Kawabe, Motohiro Nonaka, Hidenao Toyoda, Yuto Takishima, Kenji Kawabata, Tomoko Yamaguchi, Miho K Furue, Takao Taki, Takeshi Okumura, Yuzo Yamazaki, Shuuichi Nakaya, Nobuko Kawasaki, Toshisuke Kawasaki. A Cytotoxic Antibody Recognizing Lacto-N-fucopentaose I (LNFP I) on Human Induced Pluripotent Stem (hiPS) Cells. The Journal of biological chemistry. 2015 Aug; 290(33):20071-85. doi: 10.1074/jbc.m115.657692. [PMID: 26100630]
  • U Karsten, G Pilgrim, F G Hanisch, G Uhlenbruck, M Kasper, P Stosiek, G Papsdorf, G Pasternak. A new monoclonal antibody (A46-B/B10) highly specific for the blood group H type 2 epitope: generation, epitope analysis, serological and histological evaluation. British journal of cancer. 1988 Aug; 58(2):176-81. doi: 10.1038/bjc.1988.187. [PMID: 2458750]