Methadone (BioDeep_00000002181)

 

Secondary id: BioDeep_00000405895

human metabolite blood metabolite


代谢物信息卡片


GlaxoSmithKline brand OF methadone hydrochloride

化学式: C21H27NO (309.20925320000003)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.41%

分子结构信息

SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3

描述信息

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
CONFIDENCE standard compound; INTERNAL_ID 513; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8112; ORIGINAL_PRECURSOR_SCAN_NO 8110
CONFIDENCE standard compound; INTERNAL_ID 513; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8059; ORIGINAL_PRECURSOR_SCAN_NO 8057
CONFIDENCE standard compound; INTERNAL_ID 513; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8114; ORIGINAL_PRECURSOR_SCAN_NO 8112
CONFIDENCE standard compound; INTERNAL_ID 513; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8021; ORIGINAL_PRECURSOR_SCAN_NO 8016
CONFIDENCE standard compound; INTERNAL_ID 513; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8067; ORIGINAL_PRECURSOR_SCAN_NO 8064
CONFIDENCE standard compound; INTERNAL_ID 513; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8100; ORIGINAL_PRECURSOR_SCAN_NO 8098
N - Nervous system > N07 - Other nervous system drugs > N07B - Drugs used in addictive disorders > N07BC - Drugs used in opioid dependence
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2828
CONFIDENCE standard compound; INTERNAL_ID 1628

同义名列表

40 个代谢物同义名

GlaxoSmithKline brand OF methadone hydrochloride; Pharmascience brand OF methadone hydrochloride; Mallinckrodt brand OF methadone hydrochloride; Martindale brand OF methadone hydrochloride; Yamanouchi brand OF methadone hydrochloride; 6-(dimethylamino)-4,4-diphenylheptan-3-one; 6-(Dimethylamino)-4,4-diphenyl-3-heptanone; AddiCare brand OF methadone hydrochloride; Pinewood brand OF methadone hydrochloride; Rosemont brand OF methadone hydrochloride; Generics brand OF methadone hydrochloride; 6-dimethylamino-4,4-Diphenyl-3-heptanone; Roxane brand OF methadone hydrochloride; Esteve brand OF methadone hydrochloride; Biomet brand OF methadone hydrochloride; (+/-)-methadone hydrochloride; DL-Methadone hydrochloride; Hydrochloride, methadone; Methadone hydrochloride; Phenadone hydrochloride; (+/-)-methadone; (+-)-Methadone; Methadone HCL; DL-Methadone; Methadonum; Methaddict; Physeptone; Dolophine; methadone; Phenadone; Metasedin; Methadose; Pinadone; Methadon; Symoron; Metadol; Amidone; Biodone; Phymet; Methex



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Marco Carnevale Miino, Tomáš Macsek, Taťána Halešová, Tomáš Chorazy, Petr Hlavínek. Pharmaceutical and narcotics monitoring in Brno wastewater system and estimation of seasonal effect on the abuse of illicit drugs by a wastewater-based epidemiology approach. The Science of the total environment. 2023 May; ?(?):164386. doi: 10.1016/j.scitotenv.2023.164386. [PMID: 37263433]
  • Taja Verovšek, Ariana Šuštarič, Maria Laimou-Geraniou, Ivona Krizman-Matasic, Helena Prosen, Tina Eleršek, Vlasta Kramarič Zidar, Vesna Mislej, Boštjan Mišmaš, Marjeta Stražar, Marjetka Levstek, Bernardka Cimrmančič, Simon Lukšič, Nataša Uranjek, Tjaša Kozlovič-Bobič, Tina Kosjek, David Kocman, David Heath, Ester Heath. Removal of residues of psychoactive substances during wastewater treatment, their occurrence in receiving river waters and environmental risk assessment. The Science of the total environment. 2023 Mar; 866(?):161257. doi: 10.1016/j.scitotenv.2022.161257. [PMID: 36608822]
  • Hossein Zhaleh, Hamed Mahdizadeh, Shahab Khoshkhoy. Punica granatum Seed Essential Oil Suppressed Methadone-Induced Cell Death by Natural Antioxidant Activity. Asian Pacific journal of cancer prevention : APJCP. 2023 Mar; 24(3):801-810. doi: 10.31557/apjcp.2023.24.3.801. [PMID: 36974531]
  • Tim Boogaerts, Maarten Quireyns, Hans De Loof, Xander Bertels, Natan Van Wichelen, Bram Pussig, Jan Saevels, Lies Lahousse, Pauline Bonmariage, Wouter Hamelinck, Bert Aertgeerts, Adrian Covaci, Alexander L N van Nuijs. Do the lockdown-imposed changes in a wastewater treatment plant catchment's socio-demographics impact longitudinal temporal trends in psychoactive pharmaceutical use?. The Science of the total environment. 2023 Feb; ?(?):162342. doi: 10.1016/j.scitotenv.2023.162342. [PMID: 36842581]
  • Gholamreza Kheirabadi, Masoud Asadi, Mohammad Niroumand Sarvandani, Alireza Jamshidi, Faezeh Mahdavi. Risk and Protective Factors Affecting Drug Craving among Patients with Substance Use Disorders Undergoing Opioid Agonists Maintenance Therapy. Substance use & misuse. 2023; 58(13):1742-1750. doi: 10.1080/10826084.2023.2247068. [PMID: 37602742]
  • NULL. A Patient With Sepsis-Induced Multiorgan Failure and Increasing Serum Methadone Concentration: A Case Study: Erratum. Therapeutic drug monitoring. 2022 Aug; 44(4):597. doi: 10.1097/ftd.0000000000000999. [PMID: 35821591]
  • Ria Garg, Sophie A Kitchen, Siyu Men, Tonya J Campbell, Nikki Bozinoff, Mina Tadrous, Tony Antoniou, Jennifer Wyman, Dan Werb, Charlotte Munro, Tara Gomes. Impact of the COVID-19 pandemic on the prevalence of opioid agonist therapy discontinuation in Ontario, Canada: A population-based time series analysis. Drug and alcohol dependence. 2022 Jul; 236(?):109459. doi: 10.1016/j.drugalcdep.2022.109459. [PMID: 35489179]
  • Gabriel Vallecillo, Juan Pedro-Botet, Silvia Fernandez, Irene Román, Roberto Elosua, Anna Camps, Marta Torrens, Jaume Marrugat. High cardiovascular risk in older patients with opioid use disorder: Differences with the general population. Drug and alcohol review. 2022 07; 41(5):1078-1084. doi: 10.1111/dar.13449. [PMID: 35178806]
  • Zachary Bouck, Ayden I Scheim, Tara Gomes, Vicki Ling, Alexander Caudarella, Dan Werb. Evaluating interventions to facilitate opioid agonist treatment access among people who inject drugs in Toronto, Ontario during COVID-19 pandemic restrictions. The International journal on drug policy. 2022 06; 104(?):103680. doi: 10.1016/j.drugpo.2022.103680. [PMID: 35447476]
  • Gro Helen Dale, Gunhild Holmaas, Jon A Berg, Bettina Riedel, Jan Schjøtt, Tormod K Bjånes. A Patient With Sepsis-Induced Multiorgan Failure and Increasing Serum Methadone Concentration: A Case Study. Therapeutic drug monitoring. 2022 06; 44(3):366-368. doi: 10.1097/ftd.0000000000000963. [PMID: 35067668]
  • Mohammad Mehdi Habibi, Jahan B Ghasemi, Alireza Badiei, Parviz Norouzi. Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration. Scientific reports. 2022 05; 12(1):8270. doi: 10.1038/s41598-022-12506-9. [PMID: 35585173]
  • Monireh Isazad, Maliheh Amirzehni, Maryam Akhgari. Highly efficient dispersive liquid-liquid microextraction assisted by magnetic porous carbon composite-based dispersive micro solid-phase extraction for determination of tramadol and methadone in urine samples by gas chromatography-mass spectrometry. Journal of chromatography. A. 2022 May; 1670(?):462989. doi: 10.1016/j.chroma.2022.462989. [PMID: 35349917]
  • Tung-Hsia Liu, Hsiao-Hui Tsou, Ren-Hua Chung, Shu Chih Liu, Sheng-Chang Wang, Hsiang-Wei Kuo, Chiu-Ping Fang, Andrew C H Chen, Yu-Li Liu. Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment. Journal of human genetics. 2022 May; 67(5):273-278. doi: 10.1038/s10038-021-01008-7. [PMID: 34983973]
  • Mahmoud Abdelwahab, Michelle Petrich, Heather Wang, Erin Walker, Erin M Cleary, Kara M Rood. Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. American journal of obstetrics & gynecology MFM. 2022 05; 4(3):100582. doi: 10.1016/j.ajogmf.2022.100582. [PMID: 35123110]
  • Alexandra Bisch, Manon Ceelen, Tina Dorn, Udo Reijnders, Karen van den Hondel, Joris Stomp, Jeroen den Burger, Eric Franssen. Performance of an on-site urine multidrug test used by forensic physicians in determining the cause of death. Journal of forensic and legal medicine. 2022 May; 88(?):102346. doi: 10.1016/j.jflm.2022.102346. [PMID: 35417849]
  • Sophie A Kitchen, Tonya J Campbell, Siyu Men, Nikki Bozinoff, Mina Tadrous, Tony Antoniou, Jennifer Wyman, Dan Werb, Charlotte Munro, Tara Gomes. Impact of the COVID-19 pandemic on the provision of take-home doses of opioid agonist therapy in Ontario, Canada: A population-based time-series analysis. The International journal on drug policy. 2022 05; 103(?):103644. doi: 10.1016/j.drugpo.2022.103644. [PMID: 35272107]
  • R Fernández-Tobar, C Chamorro-Jambrina, M Pérez-Torres, B Castiñeiras-Amor, S Alcántara-Carmona, M A Romera-Ortega. Methadone as a rescue drug for difficult-to-sedate critically ill patients suffering from ARDS related to SARS-CoV-2 infection. Medicina intensiva. 2022 05; 46(5):279-281. doi: 10.1016/j.medine.2022.02.016. [PMID: 35292199]
  • Le Minh Giang, Nguyen Thu Trang, Nguyen Bich Diep, Dao Thi Dieu Thuy, Dinh Thanh Thuy, Han Dinh Hoe, Hoang Thi Hai Van, Thai Thanh Truc, Hoa H Nguyen, Nguyen Ly Lai, Pham Thi Dan Linh, Vu Thi Tuong Vi, Cathy J Reback, Arleen Leibowitz, Li Li, Chunqing Lin, Michael Li, Do Van Dung, Steve Shoptaw. An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial. Trials. 2022 Apr; 23(1):342. doi: 10.1186/s13063-022-06278-w. [PMID: 35461300]
  • Ida V Stalund, Heidi Grønseth, Finn P Reinholt, Einar Svarstad, Hans-Peter Marti, Sabine Leh. Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use. Clinical journal of the American Society of Nephrology : CJASN. 2022 04; 17(4):518-526. doi: 10.2215/cjn.13681021. [PMID: 35296512]
  • Paul J Joudrey, Marynia Kolak, Qinyun Lin, Susan Paykin, Vidal Anguiano, Emily A Wang. Assessment of Community-Level Vulnerability and Access to Medications for Opioid Use Disorder. JAMA network open. 2022 04; 5(4):e227028. doi: 10.1001/jamanetworkopen.2022.7028. [PMID: 35438757]
  • Kim Corace, Kelly Suschinsky, Jennifer Wyman, Pamela Leece, Sue Cragg, Sarah Konefal, Priscille Pana, Susan Barrass, Amy Porath, Brian Hutton. Evaluating how has care been affected by the Ontario COVID-19 Opioid Agonist Treatment Guidance: Patients' and prescribers' experiences with changes in unsupervised dosing. The International journal on drug policy. 2022 04; 102(?):103573. doi: 10.1016/j.drugpo.2021.103573. [PMID: 35123246]
  • Miriam T H Harris, Audrey M Lambert, Ariel D Maschke, Sarah M Bagley, Alexander Y Walley, Christine M Gunn. 'No home to take methadone to': Experiences with addiction services during the COVID-19 pandemic among survivors of opioid overdose in Boston. Journal of substance abuse treatment. 2022 04; 135(?):108655. doi: 10.1016/j.jsat.2021.108655. [PMID: 34772604]
  • John Arianda Owiti, Molli Benson, Mandisa Maplanka, Lasekan Oluseye, Debora Carvalho. Is Methadone Safe for Patients With Opioid Use Disorder and Coronavirus Disease 2019 Infection?. Journal of addictions nursing. 2022 Apr; 33(2):86-94. doi: 10.1097/jan.0000000000000457. [PMID: 35640212]
  • Christopher Welsh, Suzanne Doyon, Katherine Hart. Methadone exposures reported to poison control centers in the United States following the COVID-19-related loosening of federal methadone regulations. The International journal on drug policy. 2022 04; 102(?):103591. doi: 10.1016/j.drugpo.2022.103591. [PMID: 35085855]
  • Ilan Volkov, Shaul Schreiber, Miriam Adelson, Stacy Shoshan, Einat Peles. Cannabis use is associated with lower retention in methadone maintenance treatment, but not among schizophrenic- and other chronically psychotic patients. Journal of addictive diseases. 2022 Apr; 40(2):183-191. doi: 10.1080/10550887.2021.1962209. [PMID: 34379049]
  • Leslie W Suen, William H Coe, Janan P Wyatt, Zoe M Adams, Mona Gandhi, Hannah M Batchelor, Stacy Castellanos, Neena Joshi, Shannon Satterwhite, Rafael Pérez-Rodríguez, Esther Rodríguez-Guerra, Carmen E Albizu-Garcia, Kelly R Knight, Ayana Jordan. Structural Adaptations to Methadone Maintenance Treatment and Take-Home Dosing for Opioid Use Disorder in the Era of COVID-19. American journal of public health. 2022 04; 112(S2):S112-S116. doi: 10.2105/ajph.2021.306654. [PMID: 35349324]
  • Nessreen Ghanem, Devin Dromgoole, Ahmad Hussein, Richard T Jermyn. Review of medication-assisted treatment for opioid use disorder. Journal of osteopathic medicine. 2022 Mar; 122(7):367-374. doi: 10.1515/jom-2021-0163. [PMID: 35285220]
  • Alyssa Peterkin, Corey S Davis, Zoe Weinstein. Permanent Methadone Treatment Reform Needed to Combat the Opioid Crisis and Structural Racism. Journal of addiction medicine. 2022 Mar; 16(2):127-129. doi: 10.1097/adm.0000000000000841. [PMID: 33758114]
  • Leslie Roberts. Surge of HIV, tuberculosis and COVID feared amid war in Ukraine. Nature. 2022 03; 603(7902):557-558. doi: 10.1038/d41586-022-00748-6. [PMID: 35292767]
  • Linda Peng, David Lawrence, Ximena A Levander. Challenges of Diagnosing and Managing Designer Benzodiazepine Dependence and Withdrawal: A Case Report. Journal of addiction medicine. 2022 Mar; 16(2):249-251. doi: 10.1097/adm.0000000000000869. [PMID: 34001772]
  • Tara Gomes, Tonya J Campbell, Sophie A Kitchen, Ria Garg, Nikki Bozinoff, Siyu Men, Mina Tadrous, Charlotte Munro, Tony Antoniou, Dan Werb, Jennifer Wyman. Association Between Increased Dispensing of Opioid Agonist Therapy Take-Home Doses and Opioid Overdose and Treatment Interruption and Discontinuation. JAMA. 2022 03; 327(9):846-855. doi: 10.1001/jama.2022.1271. [PMID: 35230394]
  • Elizabeth Wambui Ngarachu, Sarah Kanana Kiburi, Frederick R Owiti, Rachel Kangethe. The prevalence and pattern of cannabis use among patients attending a methadone treatment clinic in Nairobi, Kenya. Substance abuse treatment, prevention, and policy. 2022 02; 17(1):12. doi: 10.1186/s13011-022-00437-7. [PMID: 35168646]
  • Ofer Amram, Solmaz Amiri, Emily L Thorn, Robert Lutz, Paul J Joudrey. Changes in methadone take-home dosing before and after COVID-19. Journal of substance abuse treatment. 2022 02; 133(?):108552. doi: 10.1016/j.jsat.2021.108552. [PMID: 34304950]
  • Gavin Bart, Solvejg Wastvedt, James S Hodges, Rebecca Rosenthal. Did drug use increase following COVID-19 relaxation of methadone take-out regulations? 2020 was a complicated year. Journal of substance abuse treatment. 2022 02; 133(?):108590. doi: 10.1016/j.jsat.2021.108590. [PMID: 34373169]
  • Li-Tzy Wu, William S John, Eric D Morse, Steve Adkins, Jennifer Pippin, Robert K Brooner, Robert P Schwartz. Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial. Addiction (Abingdon, England). 2022 02; 117(2):444-456. doi: 10.1111/add.15641. [PMID: 34286886]
  • Leslie W Suen, Stacy Castellanos, Neena Joshi, Shannon Satterwhite, Kelly R Knight. 'The idea is to help people achieve greater success and liberty': A qualitative study of expanded methadone take-home access in opioid use disorder treatment. Substance abuse. 2022; 43(1):1143-1150. doi: 10.1080/08897077.2022.2060438. [PMID: 35499469]
  • Damir Suljević, Amra Šiljak, Muhamed Fočak. Different outcomes of methadone maintenance therapy in rehabilitated and relapsed drug addicts: significance of liver and renal biomarkers. Drug and chemical toxicology. 2022 Jan; 45(1):470-475. doi: 10.1080/01480545.2020.1722157. [PMID: 32013636]
  • Brian Chan, Christina Bougatsos, Kelsey C Priest, Dennis McCarty, Sara Grusing, Roger Chou. Opioid treatment programs, telemedicine and COVID-19: A scoping review. Substance abuse. 2022; 43(1):539-546. doi: 10.1080/08897077.2021.1967836. [PMID: 34520702]
  • Kelsey C Priest, Caroline A King, Honora Englander, Travis I Lovejoy, Dennis McCarty. Differences in the delivery of medications for opioid use disorder during hospitalization by racial categories: A retrospective cohort analysis. Substance abuse. 2022; 43(1):1251-1259. doi: 10.1080/08897077.2022.2074601. [PMID: 35670778]
  • Siri Shastry, Ishak Nobel, Lisa R Allen, Lynne D Richardson, Kavey Vidal, Alex F Manini. Prior use of medications for opioid use disorder in ED patients with opioid overdose: prevalence, misuse and overdose severity. The American journal of emergency medicine. 2022 Jan; 51(?):114-118. doi: 10.1016/j.ajem.2021.10.012. [PMID: 34735968]
  • Ximena A Levander, Jarratt D Pytell, Kenneth B Stoller, P Todd Korthuis, Geetanjali Chander. COVID-19-related policy changes for methadone take-home dosing: A multistate survey of opioid treatment program leadership. Substance abuse. 2022; 43(1):633-639. doi: 10.1080/08897077.2021.1986768. [PMID: 34666636]
  • Suzan M Walters, David C Perlman, Honoria Guarino, Pedro Mateu-Gelabert, David Frank. Lessons from the First Wave of COVID-19 for Improved Medications for Opioid Use Disorder (MOUD) Treatment: Benefits of Easier Access, Extended Take Homes, and New Delivery Modalities. Substance use & misuse. 2022; 57(7):1144-1153. doi: 10.1080/10826084.2022.2064509. [PMID: 35443862]
  • Nader Molavi, Morad Rasouli-Azad, Hamed Mirzaei, Amir Hassan Matini, Hamid Reza Banafshe, Marjan Valiollahzadeh, Majid Hassanzadeh, Ahmad Reza Saghazade, Samira Abbaszadeh-Mashkani, Peyman Mamsharifi, Amir Ghaderi. The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs. International journal of clinical practice. 2022; 2022(?):1206914. doi: 10.1155/2022/1206914. [PMID: 35685534]
  • Ximena A Levander, Kim A Hoffman, John W McIlveen, Dennis McCarty, Javier Ponce Terashima, P Todd Korthuis. Rural opioid treatment program patient perspectives on take-home methadone policy changes during COVID-19: a qualitative thematic analysis. Addiction science & clinical practice. 2021 12; 16(1):72. doi: 10.1186/s13722-021-00281-3. [PMID: 34895346]
  • Alex Harocopos, Michelle L Nolan, Gail P Goldstein, Shivani Mantha, Madeleine O'Neill, Denise Paone. Implementing a Methadone Delivery System in New York City in Response to COVID-19. American journal of public health. 2021 Dec; 111(12):2115-2117. doi: 10.2105/ajph.2021.306523. [PMID: 34878865]
  • Jianbo Zhang, Yajuan Fan, Jinting Zhou, Tengfei Ma, Keqiang Gao, Min Xu, Yifan Xiao, Yongsheng Zhu. Methylation quantitative trait locus rs5326 is associated with susceptibility and effective dosage of methadone maintenance treatment for heroin use disorder. Psychopharmacology. 2021 Dec; 238(12):3511-3518. doi: 10.1007/s00213-021-05968-8. [PMID: 34476566]
  • Sarah Brothers, Adam Viera, Robert Heimer. Changes in methadone program practices and fatal methadone overdose rates in Connecticut during COVID-19. Journal of substance abuse treatment. 2021 12; 131(?):108449. doi: 10.1016/j.jsat.2021.108449. [PMID: 34098303]
  • Caroul Chawar, Alannah Hillmer, Stephanie Sanger, Alessia D'Elia, Balpreet Panesar, Lucy Guan, Dave Xiaofei Xie, Nandini Bansal, Aamna Abdullah, Flavio Kapczinski, Guillaume Pare, Lehana Thabane, Zainab Samaan. A systematic review of GWAS identified SNPs associated with outcomes of medications for opioid use disorder. Addiction science & clinical practice. 2021 11; 16(1):70. doi: 10.1186/s13722-021-00278-y. [PMID: 34838141]
  • Ofer Amram, Solmaz Amiri, Victoria Panwala, Robert Lutz, Paul J Joudrey, Eugenia Socias. The impact of relaxation of methadone take-home protocols on treatment outcomes in the COVID-19 era. The American journal of drug and alcohol abuse. 2021 11; 47(6):722-729. doi: 10.1080/00952990.2021.1979991. [PMID: 34670453]
  • Jamey J Lister, Holly H Lister. Improving methadone access for rural communities in the USA: lessons learned from COVID-19 adaptations and international models of care. Rural and remote health. 2021 11; 21(4):6770. doi: 10.22605/rrh6770. [PMID: 34757760]
  • Leila Ahmad-Molaei, Mahsa Pourhamzeh, Reza Ahadi, Fariba Khodagholi, Hossein Hassanian-Moghaddam, Abbas Haghparast. Time-Dependent Changes in the Serum Levels of Neurobiochemical Factors After Acute Methadone Overdose in Adolescent Male Rat. Cellular and molecular neurobiology. 2021 Nov; 41(8):1635-1649. doi: 10.1007/s10571-020-00931-1. [PMID: 32712727]
  • Erin Fanning Madden, Bryson T Christian, Pooja A Lagisetty, Bradley R Ray, Sandra H Sulzer. Treatment provider perceptions of take-home methadone regulation before and during COVID-19. Drug and alcohol dependence. 2021 11; 228(?):109100. doi: 10.1016/j.drugalcdep.2021.109100. [PMID: 34600251]
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  • Gavin Bart, Le Minh Giang, Hoang Yen, James S Hodges, Richard C Brundage. Effect of HIV, antiretrovirals, and genetics on methadone pharmacokinetics: Results from the methadone antiretroviral pharmacokinetics study. Drug and alcohol dependence. 2021 10; 227(?):109025. doi: 10.1016/j.drugalcdep.2021.109025. [PMID: 34482033]
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