Primapterin (BioDeep_00000020949)

   

human metabolite Endogenous


代谢物信息卡片


2-amino-7-(1,2-dihydroxypropyl)-1,4-dihydropteridin-4-one

化学式: C9H11N5O3 (237.0861856)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 2.04%

分子结构信息

SMILES: CC(C(C1=CN=C2C(=O)NC(=NC2=N1)N)O)O
InChI: InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-5-7(12-4)13-9(10)14-8(5)17/h2-3,6,15-16H,1H3,(H3,10,12,13,14,17)

描述信息

Primapterin and anapterin are present in very low concentrations in every human urine, as well as in the liver of man. - PMID: 3382399 [HMDB]
Primapterin and anapterin are present in very low concentrations in every human urine, as well as in the liver of man. - PMID: 3382399.

同义名列表

7 个代谢物同义名

2-amino-7-(1,2-dihydroxypropyl)-1,4-dihydropteridin-4-one; 2-amino-7-(1,2-dihydroxypropyl)-1H-pteridin-4-one; Primapterin, (L-erythro)-isomer; L-erythro-7-Isobiopterin; 7-Isobiopterin; 7-Biopterin; Primapterin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gabriella Allegri, Heleno José Bezerra Costa Netto, Luiz Nelson Lopes Ferreira Gomes, Maria Lúcia Costa de Oliveira, Fernanda Bertão Scalco, Francisco Radler de Aquino Neto. Determination of six pterins in urine by LC-MS/MS. Bioanalysis. 2012 Jul; 4(14):1739-46. doi: 10.4155/bio.12.131. [PMID: 22877220]
  • Ayse Basak Engin, Aylin Sepici-Dincel, Ipek Isik Gonul, Atilla Engin. Oxidative stress-induced endothelial cell damage in thyroidectomized rat. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2012 Jul; 64(5):481-5. doi: 10.1016/j.etp.2010.11.002. [PMID: 21130634]
  • Angel L Pey, Aurora Martinez, Ramamurthy Charubala, Derek J Maitland, Knut Teigen, Ana Calvo, Wolfgang Pfleiderer, John M Wood, Karin U Schallreuter. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Oct; 20(12):2130-2. doi: 10.1096/fj.06-5835fje. [PMID: 16935936]
  • J E Ayling, S W Bailey, S R Boerth, R Giugliani, C P Braegger, B Thöny, N Blau. Hyperphenylalaninemia and 7-pterin excretion associated with mutations in 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH: analysis of enzyme activity in intestinal biopsies. Molecular genetics and metabolism. 2000 Jul; 70(3):179-88. doi: 10.1006/mgme.2000.3016. [PMID: 10924272]
  • B Thöny, F Neuheiser, L Kierat, M Blaskovics, P H Arn, P Ferreira, I Rebrin, J Ayling, N Blau. Hyperphenylalaninemia with high levels of 7-biopterin is associated with mutations in the PCBD gene encoding the bifunctional protein pterin-4a-carbinolamine dehydratase and transcriptional coactivator (DCoH). American journal of human genetics. 1998 Jun; 62(6):1302-11. doi: 10.1086/301887. [PMID: 9585615]
  • N Blau, L Kierat, H C Curtius, M Blaskovics, T Giudici. Hyperphenylalaninaemia presumably due to carbinolamine dehydratase deficiency: loading tests with pterin derivatives. Journal of inherited metabolic disease. 1992; 15(3):409-12. doi: 10.1007/bf02435990. [PMID: 1405481]
  • H C Curtius, C Adler, C Heizmann, N Blau, I Rebrin, S Ghisla. 7-substituted pterins: formation and occurrence. Journal of nutritional science and vitaminology. 1992; Spec No(?):501-4. doi: 10.3177/jnsv.38.special_501. [PMID: 1297797]
  • N Blau, H C Curtius, T Kuster, A Matasovic, G Schoedon, J L Dhondt, P Guibaud, T Giudici, M Blaskovics. Primapterinuria: a new variant of atypical phenylketonuria. Journal of inherited metabolic disease. 1989; 12 Suppl 2(?):335-8. doi: 10.1007/bf03335415. [PMID: 2512438]
  • N Blau, J L Dhondt, P Guibaud, T Kuster, H C Curtius. New variant of hyperphenylalaninaemia with excretion of 7-substituted pterins. European journal of pediatrics. 1988 Nov; 148(2):176. doi: 10.1007/bf00445941. [PMID: 3234449]
  • H C Curtius, T Kuster, A Matasovic, N Blau, J L Dhondt. Primapterin, anapterin, and 6-oxo-primapterin, three new 7-substituted pterins identified in a patient with hyperphenylalaninemia. Biochemical and biophysical research communications. 1988 Jun; 153(2):715-21. doi: 10.1016/s0006-291x(88)81153-7. [PMID: 3382399]