2-Hydroxy-4-oxopentanoic acid (BioDeep_00000020926)

   

human metabolite


代谢物信息卡片


PENTANOIC ACID, 2-HYDROXY-4-OXO-

化学式: C5H8O4 (132.0423)
中文名称: 2-羟基-4-氧代-2-戊酸
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC(=O)CC(C(=O)O)O
InChI: InChI=1S/C5H8O4/c1-3(6)2-4(7)5(8)9/h4,7H,2H2,1H3,(H,8,9)

描述信息

2-Hydroxy-4-oxopentanoic acid is found in alcoholic beverages. 2-Hydroxy-4-oxopentanoic acid is formed in beer wort fermentation Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposis sarcoma. Alitretinoin inhibits the growth of Kaposis sarcoma (KS) cells in vitro. Retinoic acid is the oxidized form of Vitamin A. It functions in determining position along embryonic anterior/posterior axis in chordates. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages. Retinoic acid acts by binding to heterodimers of the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), which then bind to retinoic acid response elements (RAREs) in the regulatory regions of direct targets (including Hox genes), thereby activating gene transcription. Retinoic acid receptors mediate transcription of different sets of genes of cell differentiation, thus it also depends on the target cells. 2-Hydroxy-4-oxopentanoic acid is one of the target genes is the gene of the retinoic acid receptor itself which occurs during positive regulation. Control of retinoic acid levels is maintained by a suite of proteins. Retinoic acid is the oxidized form of Vitamin A. It functions in determining position along embryonic anterior/posterior axis in chordates. It acts through Hox genes, which ultimately controls anterior/posterior patterning in early developmental stages (PMID: 17495912). It is an important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth and embryonic development. 2-Hydroxy-4-oxopentanoic acid is an excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute).
Formed in beer wort fermentation

同义名列表

7 个代谢物同义名

PENTANOIC ACID, 2-HYDROXY-4-OXO-; a-Hydroxy-b-acetylpropionic acid; 2-Hydroxy-4-oxopentanoic acid; 2-Hydroxy-4-oxovaleric acid; 2-Hydroxy-4-oxopentanoate; a-Hydroxylevulinic acid; Acetolactic acid



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hyejin Lee, Steven E Ullrich, Ian C Burke, Joseph Yenish, Timothy C Paulitz. Interactions between the root pathogen Rhizoctonia solani AG-8 and acetolactate-synthase-inhibiting herbicides in barley. Pest management science. 2012 Jun; 68(6):845-52. doi: 10.1002/ps.2336. [PMID: 22307918]
  • Lewis H Ziska, David R Gealy, Martha B Tomecek, Aaron K Jackson, Howard L Black. Recent and projected increases in atmospheric CO2 concentration can enhance gene flow between wild and genetically altered rice (Oryza sativa). PloS one. 2012; 7(5):e37522. doi: 10.1371/journal.pone.0037522. [PMID: 22649533]
  • Qin Yu, Heping Han, Martin M Vila-Aiub, Stephen B Powles. AHAS herbicide resistance endowing mutations: effect on AHAS functionality and plant growth. Journal of experimental botany. 2010 Sep; 61(14):3925-34. doi: 10.1093/jxb/erq205. [PMID: 20627897]
  • Fanny Ramel, Cécile Sulmon, Matthieu Bogard, Ivan Couée, Gwenola Gouesbet. Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets. BMC plant biology. 2009 Mar; 9(?):28. doi: 10.1186/1471-2229-9-28. [PMID: 19284649]
  • J McNaughton, M Roberts, B Smith, D Rice, M Hinds, T Rood, R Layton, I Lamb, B Delaney. Comparison of broiler performance and carcass yields when fed diets containing transgenic maize grains from event DP-O9814O-6 (Optimum GAT), near-isogenic control maize grain, or commercial reference maize grains. Poultry science. 2008 Dec; 87(12):2562-72. doi: 10.3382/ps.2008-00017. [PMID: 19038812]
  • Rong Zhou, Timothy M Squires, Stephen J Ambrose, Suzanne R Abrams, Andrew R S Ross, Adrian J Cutler. Rapid extraction of abscisic acid and its metabolites for liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2003 Aug; 1010(1):75-85. doi: 10.1016/s0021-9673(03)01029-x. [PMID: 14503817]
  • Moshe Sibony, Baruch Rubin. Molecular basis for multiple resistance to acetolactate synthase-inhibiting herbicides and atrazine in Amaranthus blitoides (prostrate pigweed). Planta. 2003 Apr; 216(6):1022-7. doi: 10.1007/s00425-002-0955-6. [PMID: 12687370]