Metyrapol (BioDeep_00000020867)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


2-methyl-1,2-bis(pyridin-3-yl)propan-1-ol

化学式: C14H16N2O (228.12625659999998)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 16.09%

分子结构信息

SMILES: CC(C)(C(O)C1=CN=CC=C1)C1=CN=CC=C1
InChI: InChI=1S/C14H16N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10,13,17H,1-2H3

描述信息

Metyrapol is a metabolite of metyrapone. Metyrapone (trade name Metopirone) is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushings syndrome (hypercortisolism). (Wikipedia)

同义名列表

5 个代谢物同义名

2-methyl-1,2-bis(pyridin-3-yl)propan-1-ol; Metyrapol, 3H-labeled; Metyrapol, (-)-isomer; Metyrapol (mpol); Metyrapol



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hideyuki Murata, Toshiyuki Higuchi, Masaki Otagiri. Oral pharmacokinetics and in-vitro metabolism of metyrapone in male rats. The Journal of pharmacy and pharmacology. 2016 Aug; 68(8):970-9. doi: 10.1111/jphp.12560. [PMID: 27265478]
  • Neila M Cassiano, Quezia B Cass, Ana Luiza G Degani, Irving W Wainer. Determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography. Chirality. 2002 Oct; 14(9):731-5. doi: 10.1002/chir.10133. [PMID: 12237834]
  • S Nagamine, E Horisaka, Y Fukuyama, K Maetani, R Matsuzawa, S Iwakawa, S Asada. Stereoselective reductive metabolism of metyrapone and inhibitory activity of metyrapone metabolites, metyrapol enantiomers, on steroid 11 beta-hydroxylase in the rat. Biological & pharmaceutical bulletin. 1997 Feb; 20(2):188-92. doi: 10.1248/bpb.20.188. [PMID: 9057984]
  • J A Chiarotto, I W Wainer. Determination of metyrapone and the enantiomers of its chiral metabolite metyrapol in human plasma and urine using coupled achiral-chiral liquid chromatography. Journal of chromatography. B, Biomedical applications. 1995 Mar; 665(1):147-54. doi: 10.1016/0378-4347(94)00500-5. [PMID: 7795785]
  • J I Usansky, L A Damani. The urinary metabolic profile of metyrapone in the rat. Identification of two novel isomeric metyrapol N-oxide metabolites. Drug metabolism and disposition: the biological fate of chemicals. 1992 Jan; 20(1):64-9. doi: NULL. [PMID: 1346999]
  • E Maser, K J Netter. Reductive metabolism of metyrapone by a quercitrin-sensitive ketone reductase in mouse liver cytosol. Biochemical pharmacology. 1991 Jun; 41(11):1595-9. doi: 10.1016/0006-2952(91)90159-3. [PMID: 2043149]
  • J I Usansky, L A Damani. Assay of metyrapone, metyrapol and the isomeric mono-N-oxides of metyrapone in biological fluids by high-performance liquid chromatography. Journal of chromatography. 1991 Feb; 563(2):283-98. doi: 10.1016/0378-4347(91)80035-b. [PMID: 2055992]