2,5-Dimethylfuran (BioDeep_00000020662)

   

human metabolite blood metabolite


代谢物信息卡片


2,5-Dimethyl-furan

化学式: C6H8O (96.0575118)
中文名称: 2,5-二甲基呋喃
谱图信息: 最多检出来源 Homo sapiens(blood) 96.77%

分子结构信息

SMILES: CC1=CC=C(C)O1
InChI: InChI=1S/C6H8O/c1-5-3-4-6(2)7-5/h3-4H,1-2H3

描述信息

2,5-Dimethylfuran is a derivative of furan. It is a heterocyclic compound of the formula C6H8O. While it may be abbreviated DMF, it should not be confused with dimethylformamide. 2,5-Dimethylfuran is a maillard product. 2,5-Dimethylfuran has been identified as one of the components of cigar smoke with low cilatoxicity (ability to adversely affect the cilia in the respiratory tract that are responsible for removing foreign particles). Its blood concentration can be used as a biomarker for smoking. 2,5-Dimethylfuran, together with 2,5-hexanedione and 4,5-dihydroxy-2-hexanone, is one of the main metabolites of hexane in humans, which play a role in the mechanism for the neurotoxicity of hexane.Recent advances have increased its attractiveness as a biofuel.
Maillard product

同义名列表

3 个代谢物同义名

2,5-Dimethyl-furan; 2,5-Dimethylfurane; 2,5-DIMETHYLFURAN



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shinji Takasu, Yuji Ishii, Moeka Namiki, Kenji Nakamura, Tatsuya Mitsumoto, Norifumi Takimoto, Takehiko Nohmi, Kumiko Ogawa. Comprehensive analysis of the general toxicity, genotoxicity, and carcinogenicity of 3-acetyl-2,5-dimethylfuran in male gpt delta rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Feb; 172(?):113544. doi: 10.1016/j.fct.2022.113544. [PMID: 36464108]
  • Xiang Li, Likang Zhang, Qiang Deng, Shixia Chen, Jun Wang, Zheling Zeng, Shuguang Deng. Promoted Hydrogenolysis of Furan Aldehydes to 2,5-Dimethylfuran by Defect Engineering on Pd/NiCo2 O4. ChemSusChem. 2022 Jul; 15(13):e202102532. doi: 10.1002/cssc.202102532. [PMID: 34997695]
  • Jeonghwan Lee, Sohee Oh, Habyeong Kang, Sunmi Kim, Gowoon Lee, Lilin Li, Clara Tammy Kim, Jung Nam An, Yun Kyu Oh, Chun Soo Lim, Dong Ki Kim, Yon Su Kim, Kyungho Choi, Jung Pyo Lee. Environment-Wide Association Study of CKD. Clinical journal of the American Society of Nephrology : CJASN. 2020 06; 15(6):766-775. doi: 10.2215/cjn.06780619. [PMID: 32628126]
  • Mar Castellanos, Rosa Suñer, José M Fernández-Real, Juan M Sanchez. 2,5-Dimethylfuran as a Validated Biomarker of Smoking Status. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2019 05; 21(6):828-834. doi: 10.1093/ntr/nty078. [PMID: 29697832]
  • Anja Hortemo Høie, Camilla Svendsen, Gunnar Brunborg, Hansruedi Glatt, Jan Alexander, Walter Meinl, Trine Husøy. Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environmental and molecular mutagenesis. 2015 Oct; 56(8):709-14. doi: 10.1002/em.21963. [PMID: 26270892]
  • Jimmy Phuong, Simon Kim, Reuben Thomas, Luoping Zhang. Predicted toxicity of the biofuel candidate 2,5-dimethylfuran in environmental and biological systems. Environmental and molecular mutagenesis. 2012 Jul; 53(6):478-87. doi: 10.1002/em.21702. [PMID: 22730190]
  • Arati A Inamdar, Prakash Masurekar, Joan Wennstrom Bennett. Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Oct; 117(2):418-26. doi: 10.1093/toxsci/kfq222. [PMID: 20643751]
  • Monica Alonso, Mar Castellanos, Juan M Sanchez. Evaluation of potential breath biomarkers for active smoking: assessment of smoking habits. Analytical and bioanalytical chemistry. 2010 Apr; 396(8):2987-95. doi: 10.1007/s00216-010-3524-z. [PMID: 20186536]
  • Carol S Rubin, Adrianne K Holmes, Martin G Belson, Robert L Jones, W Dana Flanders, Stephanie M Kieszak, John Osterloh, George E Luber, Benjamin C Blount, Dana B Barr, Karen K Steinberg, Glen A Satten, Michael A McGeehin, Randall L Todd. Investigating childhood leukemia in Churchill County, Nevada. Environmental health perspectives. 2007 Jan; 115(1):151-7. doi: 10.1289/ehp.9022. [PMID: 17366836]
  • Franklin Vargas, Carlos Rivas, Yrene Díaz, Alberto Fuentes. Photodegradation pathways and the in vitro phototoxicity of pyrazinamide, a phototoxic antitubercular drug. Journal of photochemistry and photobiology. B, Biology. 2003 Dec; 72(1-3):87-94. doi: 10.1016/j.jphotobiol.2003.09.010. [PMID: 14644570]
  • Luigi Perbellini, Andrea Princivalle, Marzia Cerpelloni, Francesco Pasini, Francesco Brugnone. Comparison of breath, blood and urine concentrations in the biomonitoring of environmental exposure to 1,3-butadiene, 2,5-dimethylfuran, and benzene. International archives of occupational and environmental health. 2003 Jul; 76(6):461-6. doi: 10.1007/s00420-003-0436-7. [PMID: 12687377]
  • F Vargas, H Méndez, A Fuentes, J Sequera, G Fraile, M Velásquez, G Cáceres, K Cuello. Photosensitizing activity of thiocolchicoside: photochemical and in vitro phototoxicity studies. Die Pharmazie. 2001 Jan; 56(1):83-8. doi: . [PMID: 11210677]
  • R Agarwal, S I Zaidi, M Athar, D R Bickers, H Mukhtar. Photodynamic effects of chloroaluminum phthalocyanine tetrasulfonate are mediated by singlet oxygen: in vivo and in vitro studies utilizing hepatic microsomes as a model membrane source. Archives of biochemistry and biophysics. 1992 Apr; 294(1):30-7. doi: 10.1016/0003-9861(92)90132-g. [PMID: 1550355]
  • G Ekström, M Ingelman-Sundberg. Mechanisms of lipid peroxidation dependent upon cytochrome P-450 LM2. European journal of biochemistry. 1986 Jul; 158(1):195-201. doi: 10.1111/j.1432-1033.1986.tb09738.x. [PMID: 3015607]
  • M Iwata, Y Takeuchi, N Hisanaga, Y Ono. Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK. International archives of occupational and environmental health. 1983; 53(1):1-8. doi: 10.1007/bf00406172. [PMID: 6654498]
  • M Iwata, Y Takeuchi, N Hisanaga, Y Ono. A study on biological monitoring of n-hexane exposure. International archives of occupational and environmental health. 1983; 51(3):253-60. doi: 10.1007/bf00377756. [PMID: 6852931]