Methyl hydrogen fumarate (BioDeep_00000020072)

   

human metabolite Endogenous PANOMIX_OTCML-2023


代谢物信息卡片


2-Butenedioic acid (e)-, monomethyl ester

化学式: C5H6O4 (130.0266)
中文名称: 富马酸单甲酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 77.48%

分子结构信息

SMILES: COC(=O)C=CC(=O)O
InChI: InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2-

描述信息

Methyl hydrogen fumarate is found in herbs and spices. Methyl hydrogen fumarate is found in Mexican marigold Tagetes minuta.
Found in Mexican marigold Tagetes minuta
Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

同义名列表

12 个代谢物同义名

2-Butenedioic acid (e)-, monomethyl ester; (2E)-4-Methoxy-4-oxo-2-butenoic acid; (2Z)-4-methoxy-4-oxobut-2-enoic acid; (Z)-4-methoxy-4-oxobut-2-enoic acid; Fumaric acid, monomethyl ester; Fumaric acid monomethyl ester; Methyl hydrogen fumaric acid; Fumaric acid, methyl ester; Methyl hydrogen fumarate; mono-Methyl fumarate; Monomethyl fumarate; Monomethyl fumarate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Julien Hanson, Andreas Gille, Stefan Offermanns. Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin. Pharmacology & therapeutics. 2012 Oct; 136(1):1-7. doi: 10.1016/j.pharmthera.2012.06.003. [PMID: 22743741]
  • Richard L Dunbar, Joel M Gelfand. Seeing red: flushing out instigators of niacin-associated skin toxicity. The Journal of clinical investigation. 2010 Aug; 120(8):2651-5. doi: 10.1172/jci44098. [PMID: 20664168]
  • Nirmal K Bairwa, Neeraj K Sethiya, S H Mishra. Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats. Pharmacognosy research. 2010 Jan; 2(1):26-30. doi: 10.4103/0974-8490.60584. [PMID: 21808535]
  • Thomas J Schmidt, Muharrem Ak, Ulrich Mrowietz. Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine--preparation of S-substituted thiosuccinic acid esters. Bioorganic & medicinal chemistry. 2007 Jan; 15(1):333-42. doi: 10.1016/j.bmc.2006.09.053. [PMID: 17049250]
  • Manfred Lehmann, Kirsten Risch, Horst Nizze, Jens Lutz, Uwe Heemann, Hans-Dieter Volk, Khusru Asadullah. Fumaric acid esters are potent immunosuppressants: inhibition of acute and chronic rejection in rat kidney transplantation models by methyl hydrogen fumarate. Archives of dermatological research. 2002 Dec; 294(9):399-404. doi: 10.1007/s00403-002-0347-6. [PMID: 12522577]
  • K Risch, H P Strebel, R K Joshi, J Lutz, J Brock, K Asadullah, H Volk, M Lehmann. Methyl hydrogen fumarate inhibits acute and chronic rejection in rat kidney transplantation models. Transplantation proceedings. 2001 Feb; 33(1-2):545-6. doi: 10.1016/s0041-1345(00)02134-5. [PMID: 11266950]