4'-Hydroxy-3',5,6,7,8-pentamethoxyflavone (BioDeep_00000019653)

   

human metabolite Endogenous


代谢物信息卡片


2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one

化学式: C20H20O8 (388.115812)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)O
InChI: InChI=1S/C20H20O8/c1-23-14-8-10(6-7-11(14)21)13-9-12(22)15-16(24-2)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,21H,1-5H3

描述信息

4-Hydroxy-3,5,6,7,8-pentamethoxyflavone is found in citrus. 4-Hydroxy-3,5,6,7,8-pentamethoxyflavone is a constituent of mandarin orange peel (Citrus reticulata)

同义名列表

5 个代谢物同义名

2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one; 2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one; 4-Hydroxy-5,6,7,8,3-pentamethoxyflavone; 4-Hydroxy-3,5,6,7,8-pentamethoxyflavone; 4-Demethylnobiletin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Xian Wu, Mingyue Song, Peiju Qiu, Fang Li, Minqi Wang, Jinkai Zheng, Qi Wang, Fei Xu, Hang Xiao. A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. Food & function. 2018 Jan; 9(1):87-95. doi: 10.1039/c7fo01155e. [PMID: 29063088]
  • Ichiro Kawahata, Tatsuya Suzuki, Evelyn Gutiérrez Rico, Shuichi Kusano, Hiroshi Tamura, Yoshihiro Mimaki, Tohru Yamakuni. Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment. Journal of natural medicines. 2017 Oct; 71(4):617-631. doi: 10.1007/s11418-017-1091-8. [PMID: 28488113]
  • Md Al Rahim, Akira Nakajima, Daisuke Saigusa, Naomi Tetsu, Yuji Maruyama, Masatoshi Shibuya, Hiroyuki Yamakoshi, Yoshihisa Tomioka, Yoshiharu Iwabuchi, Yasushi Ohizumi, Tohru Yamakuni. 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry. 2009 Aug; 48(32):7713-21. doi: 10.1021/bi901088w. [PMID: 19601643]
  • Shiming Li, Shengmin Sang, Min-Hsiung Pan, Ching-Shu Lai, Chih-Yu Lo, Chung S Yang, Chi-Tang Ho. Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. Bioorganic & medicinal chemistry letters. 2007 Sep; 17(18):5177-81. doi: 10.1016/j.bmcl.2007.06.096. [PMID: 17644380]
  • Shiming Li, Min-Hsiung Pan, Ching-Shu Lai, Chih-Yu Lo, Slavik Dushenkov, Chi-Tang Ho. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorganic & medicinal chemistry. 2007 May; 15(10):3381-9. doi: 10.1016/j.bmc.2007.03.021. [PMID: 17391969]
  • Zhenyu Wang, Shiming Li, Malgorzata Jonca, Ted Lambros, Stephen Ferguson, Robert Goodnow, Chi-Tang Ho. Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases. Biomedical chromatography : BMC. 2006 Nov; 20(11):1206-15. doi: 10.1002/bmc.686. [PMID: 16799930]
  • Takaaki Yasuda, Yukako Yoshimura, Hisako Yabuki, Takahiro Nakazawa, Keisuke Ohsawa, Yoshihiro Mimaki, Yutaka Sashida. Urinary metabolites of nobiletin orally administered to rats. Chemical & pharmaceutical bulletin. 2003 Dec; 51(12):1426-8. doi: 10.1248/cpb.51.1426. [PMID: 14646323]