PC(18:2(9Z,12Z)/18:2(9Z,12Z)) (BioDeep_00000019232)

 

Secondary id: BioDeep_00001871460

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2R)-2,3-Bis{[(9Z,12Z)-octadeca-9,12-dienoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphoric acid

化学式: C44H80NO8P (781.562125)
中文名称: 1,2-二亚油酰基-sn-甘油-3-磷酸胆碱
谱图信息: 最多检出来源 Homo sapiens(blood) 0.1%

分子结构信息

SMILES: CCCCCC=CCC=CCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
InChI: InChI=1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h14-17,20-23,42H,6-13,18-19,24-41H2,1-5H3/b16-14-,17-15-,22-20-,23-21-/t42-/m1/s1

描述信息

PC(18:2(9Z,12Z)/18:2(9Z,12Z)) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(18:2(9Z,12Z)/18:2(9Z,12Z)), in particular, consists of two chains of linoleic acid at the C-1 and C-2 positions. The linoleic acid moieties are derived from seed oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.
1-18:2-2-18:2-sn-glycerol-3-phosphocholine, also known as dilinoleoylphosphatidylcholine or L-dilinoleoyllecithin, is a member of the class of compounds known as phosphatidylcholines. Phosphatidylcholines are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage. Thus, 1-18:2-2-18:2-sn-glycerol-3-phosphocholine is considered to be a glycerophosphocholine lipid molecule. 1-18:2-2-18:2-sn-glycerol-3-phosphocholine is practically insoluble (in water) and a moderately acidic compound (based on its pKa). 1-18:2-2-18:2-sn-glycerol-3-phosphocholine can be found in a number of food items such as green bean, malabar spinach, peach, and swede, which makes 1-18:2-2-18:2-sn-glycerol-3-phosphocholine a potential biomarker for the consumption of these food products. 1-18:2-2-18:2-sn-glycerol-3-phosphocholine can be found primarily in blood, saliva, and urine, as well as throughout all human tissues. In humans, 1-18:2-2-18:2-sn-glycerol-3-phosphocholine is involved in a couple of metabolic pathways, which include phosphatidylcholine biosynthesis PC(18:2(9Z,12Z)/18:2(9Z,12Z)) and phosphatidylethanolamine biosynthesis PE(18:2(9Z,12Z)/18:2(9Z,12Z)).

同义名列表

41 个代谢物同义名

(2R)-2,3-Bis{[(9Z,12Z)-octadeca-9,12-dienoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphoric acid; (2R)-2,3-Bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl 2-(trimethylammonio)ethyl phosphoric acid; (2-{[(2R)-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium; (2R)-2,3-Bis{[(9Z,12Z)-octadeca-9,12-dienoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate; (R)-2,3-Bis((9Z,12Z)-octadeca-9,12-dienoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate; (2R)-2,3-Bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl 2-(trimethylammonio)ethyl phosphate; 1,2-Linoleoylphosphatidylcholine, 14C-labeled CPD, (R-(all Z))-isomer; 1,2-Di(9Z,12Z-octadecadienoyl)-rac-glycero-3-phosphocholine; 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine; 1,2-Linoleoylphosphatidylcholine, (R-(all Z))-isomer; 1,2-Di-O-linoleoyl-sn-glycero-3-phosphocholine; 1,2-Dilinoleoyl-rac-glycero-3-phosphocholine; 1,2-dilinoleoyl-sn-glycero-3-phosphocholine; 1-18:2-2-18:2-sn-glycerol-3-phosphocholine; 1,2-Linoleoyl-sn-glycero-3-phosphocholine; 1,2-Dilinoleoyl-3-glycerophosphocholine; DI-linoleoyl-3-sn-phosphatidylcholine; Phosphatidylcholine(18:2W6/18:2W6); Phosphatidylcholine(18:2n6/18:2n6); 1,2-Linoleoylphosphatidylcholine; Dilinoleoyl phosphatidylcholine; Phosphatidylcholine(18:2/18:2); Dilinoleoylphosphatidylcholine; PC(18:2(9Z,12Z)/18:2(9Z,12Z)); Phosphatidylcholine(36:4); L-Dilinoleoyllecithin; GPCho(18:2W6/18:2W6); GPCho(18:2n6/18:2n6); 1,2-Dilinoleoyl-GPC; Dilinoleoyllecithin; PC(18:2n6/18:2n6); PC(18:2W6/18:2W6); GPCho(18:2/18:2); PC(18:2/18:2); GPCho(36:4); DLPC Lipid; PC(36:4); Lecithin; DL-PC; DLNPC; DLPC



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

33 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

  • phospholipid desaturation: 1-linoleoyl-2-linoleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-α-linolenoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-linoleoyl-2-linoleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-α-linolenoyl-2-linoleoyl-phosphatidylcholine + H2O + a ferricytochrome b5

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(20)

  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-linoleoyl-2-oleoyl-phosphatidylcholine + H2O + a ferricytochrome b5
  • phospholipid desaturation: 1-oleoyl-2-oleoyl-phosphatidylcholine + H+ + O2 + a ferrocytochrome b5 ⟶ 1-oleoyl-2-linoleoyl-phosphatidylcholine + H2O + a ferricytochrome b5

COVID-19 Disease Map(0)

PathBank(11)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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