Ginsenoside Rg5 (BioDeep_00000019020)
human metabolite Endogenous
代谢物信息卡片
2-{[4,5-dihydroxy-2-({16-hydroxy-2,6,6,10,11-pentamethyl-14-[(2Z)-6-methylhepta-2,5-dien-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-yl}oxy)-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
化学式: C42H70O12 (766.486702)
中文名称: 人参皂苷Rg5
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)=CCC=C(C)C1CCC2(C)C1C(O)CC1C3(C)CCC(OC4OC(CO)C(O)C(O)C4OC4OC(CO)C(O)C(O)C4O)C(C)(C)C3CCC12C
InChI: InChI=1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10-11,23-38,43-50H,9,12-20H2,1-8H3/b22-11-
描述信息
Ginsenoside Rg5 is found in tea. Ginsenoside Rg5 is isolated from ginsen
Isolated from ginseng. Ginsenoside Rg5 is found in tea.
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 72985464
- HMDB: HMDB0031830
- KNApSAcK: C00033875
- foodb: FDB008508
- CAS: 74964-14-0
- PMhub: MS000014148
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 44685 - Panax japonicus: 10.1021/NP100851S
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guoqing Zhang, Jinpeng Hu, Ao Li, Haiying Zhang, Zhengting Guo, Xinqiao Li, Zinan You, Yongfeng Wang, Zhitao Jing. Ginsenoside Rg5 inhibits glioblastoma by activating ferroptosis via NR3C1/HSPB1/NCOA4.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155631. doi:
10.1016/j.phymed.2024.155631. [PMID: 38640858] - Na Li, Chenhui Zhu, Rongzhan Fu, Xiaoxuan Ma, Zhiguang Duan, Daidi Fan. Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Feb; 124(?):155287. doi:
10.1016/j.phymed.2023.155287. [PMID: 38176268] - Ming-Yang Liu, Dong-Xin Jiang, Xiang Zhao, Liang Zhang, Yu Zhang, Zhen-Dong Liu, Run-Ze Liu, Hai-Jun Li, Xiao-Yu Rong, Yan-Zheng Gao. Exploration in the Mechanism of Ginsenoside Rg5 for the Treatment of Osteosarcoma by Network Pharmacology and Molecular Docking.
Orthopaedic surgery.
2024 Feb; 16(2):462-470. doi:
10.1111/os.13971. [PMID: 38086608] - Wenxiang Fan, Qi Liao, Linhong Fan, Qi Li, Longchan Liu, Ziying Wang, Yuqi Mei, Linnan Li, Li Yang, Zhengtao Wang. An innovative processing driven efficient transformation of rare ginsenosides enhances anti-platelet aggregation potency of notoginseng by integrated analyses of processing-(chemical) profiling-pharmacodynamics.
Journal of ethnopharmacology.
2024 Jan; 319(Pt 1):117126. doi:
10.1016/j.jep.2023.117126. [PMID: 37716488] - Caidie Zhang, Yan Jin. Ginsenoside Rg5 induces NSCLC cell apoptosis and autophagy through PI3K/Akt/mTOR signaling pathway.
Human & experimental toxicology.
2024 Jan; 43(?):9603271241229140. doi:
10.1177/09603271241229140. [PMID: 38289222] - Chenxi Wang, Chenyang Huang, Jiali Wang, Jianfeng Ye, Zhiqiang Xue, Jian Zhang, Yuke Ren. Ginsenoside Rg5 attenuates hypoxia-induced cardiomyocyte apoptosis via regulating the Akt pathway.
Chemical biology & drug design.
2023 06; 101(6):1348-1355. doi:
10.1111/cbdd.14217. [PMID: 36762503] - Ziyu Chen, Gaorui Wang, Xueqing Xie, Heng Liu, Jun Liao, Hailian Shi, Min Chen, Shusheng Lai, Zhengtao Wang, Xiaojun Wu. Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by counteracting neutrophil NETosis and inflammatory response.
Frontiers in immunology.
2022; 13(?):918476. doi:
10.3389/fimmu.2022.918476. [PMID: 36032109] - Xu-Fei Gao, Jun-Jie Zhang, Xiao-Jie Gong, Ke-Ke Li, Lian-Xue Zhang, Wei Li. Ginsenoside Rg5: A Review of Anticancer and Neuroprotection with Network Pharmacology Approach.
The American journal of Chinese medicine.
2022; 50(8):2033-2056. doi:
10.1142/s0192415x22500872. [PMID: 36222119] - Chao Ma, Qiyan Lin, Yafu Xue, Zhengcai Ju, Gang Deng, Wei Liu, Yuting Sun, Huida Guan, Xuemei Cheng, Changhong Wang. Pharmacokinetic studies of ginsenosides Rk1 and Rg5 in rats by UFLC-MS/MS.
Biomedical chromatography : BMC.
2021 Aug; 35(8):e5108. doi:
10.1002/bmc.5108. [PMID: 33650162] - Chao Ma, Huida Guan, Qiyan Lin, Chang Liu, Zhengcai Ju, Yafu Xue, Xuemei Cheng, Changhong Wang. Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng.
Biomedical chromatography : BMC.
2021 Jun; 35(6):e5077. doi:
10.1002/bmc.5077. [PMID: 33475178] - Jingjing Shao, Xiaoyan Zheng, Linlin Qu, Hui Zhang, Huifang Yuan, Junfeng Hui, Yu Mi, Pei Ma, Daidi Fan. Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model.
Food & function.
2020 Feb; 11(2):1245-1257. doi:
10.1039/c9fo02248a. [PMID: 32052003] - Kyu Sup An, Yeo Ok Choi, So Min Lee, Hyeon Yeol Ryu, Su Jin Kang, Yong Yeon, Yu Ri Kim, Jae Geun Lee, Chul Joong Kim, Ye Ji Lee, Byeong Ju Kang, Jee Eun Choi, Kyung Seuk Song. Ginsenosides Rg5 and Rk1 Enriched Cultured Wild Ginseng Root Extract Bioconversion of Pediococcus pentosaceus HLJG0702: Effect on Scopolamine-Induced Memory Dysfunction in Mice.
Nutrients.
2019 May; 11(5):. doi:
10.3390/nu11051120. [PMID: 31137483] - Zhekang Cheng, Meng Zhang, Chengli Ling, Ying Zhu, Hongwei Ren, Chao Hong, Jing Qin, Tongxiang Liu, Jianxin Wang. Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Molecules (Basel, Switzerland).
2019 Mar; 24(6):. doi:
10.3390/molecules24061102. [PMID: 30897756] - Yanan Dong, Rongzhan Fu, Jing Yang, Pei Ma, Lihua Liang, Yu Mi, Daidi Fan. Folic acid-modified ginsenoside Rg5-loaded bovine serum albumin nanoparticles for targeted cancer therapy in vitro and in vivo.
International journal of nanomedicine.
2019; 14(?):6971-6988. doi:
10.2147/ijn.s210882. [PMID: 31507319] - Chao Hong, Ping Yang, Shuping Li, Yizhen Guo, Dan Wang, Jianxin Wang. In Vitro/In Vivo Metabolism of Ginsenoside Rg5 in Rat Using Ultra-Performance Liquid Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry.
Molecules (Basel, Switzerland).
2018 Aug; 23(9):. doi:
10.3390/molecules23092113. [PMID: 30135411] - Guilin Chen, Haijun Li, Yugang Gao, Lianxue Zhang, Yan Zhao. Flavored black ginseng exhibited antitumor activity via improving immune function and inducing apoptosis.
Food & function.
2017 May; 8(5):1880-1889. doi:
10.1039/c6fo01870j. [PMID: 28426048] - Ping Zhang. Ginsenoside‑Rg5 treatment inhibits apoptosis of chondrocytes and degradation of cartilage matrix in a rat model of osteoarthritis.
Oncology reports.
2017 Mar; 37(3):1497-1502. doi:
10.3892/or.2017.5392. [PMID: 28112382] - Wei Li, Meng-Han Yan, Ying Liu, Zhi Liu, Zi Wang, Chen Chen, Jing Zhang, Yin-Shi Sun. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis.
Nutrients.
2016 Sep; 8(9):. doi:
10.3390/nu8090566. [PMID: 27649238] - Dan Huang, Yang Li, Min Zhang, Shengli Ruan, Hongyang Zhang, Yuerong Wang, Ping Hu. Tartaric acid induced conversion of protopanaxadiol to ginsenosides Rg3 and Rg5 and their in situ recoveries by integrated expanded bed adsorption chromatography.
Journal of separation science.
2016 Aug; 39(15):2995-3001. doi:
10.1002/jssc.201600269. [PMID: 27288199]