3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid (BioDeep_00001876041)
代谢物信息卡片
3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
化学式: C10H14N2O4 (226.0954)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
InChI: InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D004791 - Enzyme Inhibitors > D065105 - Aromatic Amino Acid Decarboxylase Inhibitors
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:94430
- PubChem: 2563
- ChEMBL: CHEMBL1179357
- MeSH: Carbidopa
- CAS: 14585-65-0
- CAS: 302-53-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Journal of ethnopharmacology.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
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Parkinsonism & related disorders.
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Behavioural pharmacology.
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Annals of neurology.
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Cell reports.
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BMJ case reports.
2021 Mar; 14(3):. doi:
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Clinical pharmacology in drug development.
2021 02; 10(2):180-189. doi:
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CNS drugs.
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Journal of Parkinson's disease.
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The Medical letter on drugs and therapeutics.
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Scientific reports.
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Clinical neuropharmacology.
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Brain and behavior.
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Movement disorders : official journal of the Movement Disorder Society.
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Clinical therapeutics.
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Molecular pharmacology.
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Drugs.
2019 Oct; 79(15):1709-1718. doi:
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Biochimie.
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Parkinsonism & related disorders.
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Acta neurologica Scandinavica.
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Molecules (Basel, Switzerland).
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The Biochemical journal.
2017 11; 474(22):3763-3765. doi:
10.1042/bcj20170728. [PMID: 29109131] - Kirk L Pappan, Adam D Kennedy, Pilar L Magoulas, Neil A Hanchard, Qin Sun, Sarah H Elsea. Clinical Metabolomics to Segregate Aromatic Amino Acid Decarboxylase Deficiency From Drug-Induced Metabolite Elevations.
Pediatric neurology.
2017 Oct; 75(?):66-72. doi:
10.1016/j.pediatrneurol.2017.06.014. [PMID: 28823629] - Nico C van de Merbel, Kees J Bronsema, Steven H Gorman, Ray Bakhtiar. Sensitivity improvement of the LC-MS/MS quantification of carbidopa in human plasma and urine by derivatization with 2,4-pentanedione.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Oct; 1064(?):62-67. doi:
10.1016/j.jchromb.2017.09.010. [PMID: 28915419] - Aravind Mittur, Suneel Gupta, Nishit B Modi. Pharmacokinetics of Rytary®, An Extended-Release Capsule Formulation of Carbidopa-Levodopa.
Clinical pharmacokinetics.
2017 09; 56(9):999-1014. doi:
10.1007/s40262-017-0511-y. [PMID: 28236251] - Trisha M Kesar, Samir R Belagaje, Paola Pergami, Marc W Haut, Gerald Hobbs, Cathrin M Buetefisch. Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults.
Brain research.
2017 Sep; 1670(?):106-117. doi:
10.1016/j.brainres.2017.06.015. [PMID: 28633996] - Rejko Krüger, Paul Lingor, Triantafyllos Doskas, Johanna M L Henselmans, Erik H Danielsen, Oriol de Fabregues, Alessandro Stefani, Sven-Christian Sensken, Juan Carlos Parra, Koray Onuk, Ashley Yegin, Angelo Antonini. An Observational Study of the Effect of Levodopa-Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson's Disease Patients.
Advances in therapy.
2017 07; 34(7):1741-1752. doi:
10.1007/s12325-017-0571-2. [PMID: 28631218] - Jingduan Chi, Yonghua Ling, Rand Jenkins, Fumin Li. Quantitation of levodopa and carbidopa in rat plasma by LC-MS/MS: The key role of ion-pairing reversed-phase chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jun; 1054(?):1-9. doi:
10.1016/j.jchromb.2017.04.001. [PMID: 28412665] - Erin M Hill-Burns, Justine W Debelius, James T Morton, William T Wissemann, Matthew R Lewis, Zachary D Wallen, Shyamal D Peddada, Stewart A Factor, Eric Molho, Cyrus P Zabetian, Rob Knight, Haydeh Payami. Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome.
Movement disorders : official journal of the Movement Disorder Society.
2017 05; 32(5):739-749. doi:
10.1002/mds.26942. [PMID: 28195358] - Sebastian Loens, Elena Chorbadzhieva, Alexandra Kleimann, Dirk Dressler, Christoph Schrader. Effects of levodopa/carbidopa intestinal gel versus oral levodopa/carbidopa on B vitamin levels and neuropathy.
Brain and behavior.
2017 05; 7(5):e00698. doi:
10.1002/brb3.698. [PMID: 28523235] - James Tetrud, Paul Nausieda, David Kreitzman, Grace S Liang, Anette Nieves, Andrew P Duker, Robert A Hauser, Eric S Farbman, Aaron Ellenbogen, Ann Hsu, Sherron Kell, Sarita Khanna, Robert Rubens, Suneel Gupta. Conversion to carbidopa and levodopa extended-release (IPX066) followed by its extended use in patients previously taking controlled-release carbidopa-levodopa for advanced Parkinson's disease.
Journal of the neurological sciences.
2017 Feb; 373(?):116-123. doi:
10.1016/j.jns.2016.11.047. [PMID: 28131167] - Marina Senek, Elisabet I Nielsen, Dag Nyholm. Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study.
Movement disorders : official journal of the Movement Disorder Society.
2017 02; 32(2):283-286. doi:
10.1002/mds.26855. [PMID: 27987231] - Ahmed A Othman, Matthew Rosebraugh, Krai Chatamra, Charles Locke, Sandeep Dutta. Levodopa-Carbidopa Intestinal Gel Pharmacokinetics: Lower Variability than Oral Levodopa-Carbidopa.
Journal of Parkinson's disease.
2017; 7(2):275-278. doi:
10.3233/jpd-161042. [PMID: 28211816] - Prashant P Raut, Shrikant Y Charde, Pradeep Bishnoi. Simultaneous estimation of levodopa, carbidopa and 3-oxymethyldopa in rat plasma using HPLC-ECD.
Biomedical chromatography : BMC.
2016 Oct; 30(10):1696-700. doi:
10.1002/bmc.3713. [PMID: 26910491] - Jonathan Timpka, Ulrika Mundt-Petersen, Per Odin. Continuous dopaminergic stimulation therapy for Parkinson's disease - recent advances.
Current opinion in neurology.
2016 Aug; 29(4):474-9. doi:
10.1097/wco.0000000000000354. [PMID: 27272976] - Daphne Atlas. DopAmide: Novel, Water-Soluble, Slow-Release l-dihydroxyphenylalanine (l-DOPA) Precursor Moderates l-DOPA Conversion to Dopamine and Generates a Sustained Level of Dopamine at Dopaminergic Neurons.
CNS neuroscience & therapeutics.
2016 Jun; 22(6):461-7. doi:
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European review for medical and pharmacological sciences.
2016 06; 20(11):2413-7. doi:
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Clinical pharmacology in drug development.
2016 May; 5(3):232-40. doi:
10.1002/cpdd.217. [PMID: 27163503] - Khichar Shubhakaran. Restless leg syndrome and its treatment.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2016 May; 27(3):621. doi:
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Neurology.
2016 Apr; 86(14 Suppl 1):S13-24. doi:
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Journal of neural transmission (Vienna, Austria : 1996).
2016 Apr; 123(4):401-6. doi:
10.1007/s00702-016-1519-4. [PMID: 26880022] - Philip Cordery, Lewis J James, Nick Peirce, Ronald J Maughan, Phillip Watson. A Catecholamine Precursor Does Not Influence Exercise Performance in Warm Conditions.
Medicine and science in sports and exercise.
2016 Mar; 48(3):536-42. doi:
10.1249/mss.0000000000000791. [PMID: 26460629] - Yasuhiro Nagashima, Tomoyoshi Kondo, Mayumi Sakata, Jinsoo Koh, Hidefumi Ito. Effects of soybean ingestion on pharmacokinetics of levodopa and motor symptoms of Parkinson's disease--In relation to the effects of Mucuna pruriens.
Journal of the neurological sciences.
2016 Feb; 361(?):229-34. doi:
10.1016/j.jns.2016.01.005. [PMID: 26810548] - Masakatsu Kanazawa, Hiroyuki Ohba, Norihiro Harada, Takeharu Kakiuchi, Shin-Ichi Muramatsu, Hideo Tsukada. Evaluation of 6-11C-Methyl-m-Tyrosine as a PET Probe for Presynaptic Dopaminergic Activity: A Comparison PET Study with β-11C-l-DOPA and 18F-FDOPA in Parkinson Disease Monkeys.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 Feb; 57(2):303-8. doi:
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Clinical neuropharmacology.
2016 Jan; 39(1):10-7. doi:
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Clinical neuropharmacology.
2015 Sep; 38(5):201-3. doi:
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Clinical pharmacokinetics.
2015 Sep; 54(9):975-84. doi:
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Movement disorders : official journal of the Movement Disorder Society.
2015 Aug; 30(9):1222-8. doi:
10.1002/mds.26219. [PMID: 25847690] - Vandana S Nade, Laxman A Kawale, Shankar S Zambre, Amit B Kapure. Neuroprotective potential of Beta vulgaris L. in Parkinson's disease.
Indian journal of pharmacology.
2015 Jul; 47(4):403-8. doi:
10.4103/0253-7613.161263. [PMID: 26288473] - Morteza Hosseini, Nooshin Mirzanasiri, Morteza Rezapour, Mohammad Hasan Sheikhha, Farnoush Faridbod, Parviz Norouzi, Mohammad Reza Ganjali. Sensitive determination of carbidopa through the electrochemiluminescence of luminol at graphene-modified electrodes.
Luminescence : the journal of biological and chemical luminescence.
2015 Jun; 30(4):376-81. doi:
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Expert opinion on drug safety.
2015 May; 14(5):761-7. doi:
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Movement disorders : official journal of the Movement Disorder Society.
2015 Apr; 30(4):500-9. doi:
10.1002/mds.26123. [PMID: 25545465] - Cheryl H Waters, Paul Nausieda, Lyudmila Dzyak, Joerg Spiegel, Monika Rudzinska, Dee E Silver, Elena S Tsurkalenko, Sherron Kell, Ann Hsu, Sarita Khanna, Suneel Gupta. Long-Term Treatment with Extended-Release Carbidopa-Levodopa (IPX066) in Early and Advanced Parkinson's Disease: A 9-Month Open-Label Extension Trial.
CNS drugs.
2015 Apr; 29(4):341-50. doi:
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Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2015 Mar; 26(2):271-8. doi:
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Expert opinion on pharmacotherapy.
2015; 16(18):2807-17. doi:
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Bioanalysis.
2015; 7(2):207-20. doi:
10.4155/bio.14.230. [PMID: 25587837] - Fabrizio Stocchi, Ann Hsu, Sarita Khanna, Aaron Ellenbogen, Andreas Mahler, Grace Liang, Ulrich Dillmann, Robert Rubens, Sherron Kell, Suneel Gupta. Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients.
Parkinsonism & related disorders.
2014 Dec; 20(12):1335-40. doi:
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Human & experimental toxicology.
2014 Dec; 33(12):1217-31. doi:
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Journal of neural transmission (Vienna, Austria : 1996).
2014 Nov; 121(11):1357-66. doi:
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Journal of neural transmission (Vienna, Austria : 1996).
2014 Oct; 121(10):1269-72. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Sep; 967(?):41-9. doi:
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International journal of biological macromolecules.
2014 Aug; 69(?):369-81. doi:
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Pharmacogenetics and genomics.
2014 Jul; 24(7):370-3. doi:
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British journal of clinical pharmacology.
2014 Jul; 78(1):94-105. doi:
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