Benzoxazole (BioDeep_00001873801)
代谢物信息卡片
Benzoxazole
化学式: C7H5NO (119.03711200000001)
中文名称: 苯并恶唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)N=CO2
InChI: InChI=1S/C7H5NO/c1-2-4-7-6(3-1)8-5-9-7/h1-5H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo. Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome.
Heart and vessels.
2024 Jun; 39(6):486-495. doi:
10.1007/s00380-024-02363-z. [PMID: 38393377] - Rui Ge, Jiaqi Song, Zhen Cao, Shurong Ban, Li Tang, Qing-Shan Li. Discovery of 6-Acylamino/Sulfonamido Benzoxazolone with IL-6 Inhibitory Activity as Promising Therapeutic Agents for Ulcerative Colitis.
Chemistry & biodiversity.
2024 May; 21(5):e202400031. doi:
10.1002/cbdv.202400031. [PMID: 38448389] - Rimi Izumihara, Hiroshi Nomoto, Kenichi Kito, Yuki Yamauchi, Kazuno Omori, Yui Shibayama, Shingo Yanagiya, Aika Miya, Hiraku Kameda, Kyu Yong Cho, So Nagai, Ichiro Sakuma, Akinobu Nakamura, Tatsuya Atsumi. Switching from Conventional Fibrates to Pemafibrate Has Beneficial Effects on the Renal Function of Diabetic Subjects with Chronic Kidney Disease.
Diabetes & metabolism journal.
2024 May; 48(3):473-481. doi:
10.4093/dmj.2023.0370. [PMID: 38419467] - Yukino Katakura, Masashi Shimoda, Mana Ohnishi, Takashi Kusano, Kazunori Dan, Hayato Isobe, Ryo Wamata, Yuichiro Iwamoto, Yoshiro Fushimi, Junpei Sanada, Atsushi Obata, Tomohiko Kimura, Fuminori Tatsumi, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto. Efficacy and safety of pemafibrate in patients with hypertriglyceridemia in clinical settings: A retrospective study.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2023 Jul; 33(7):1444-1452. doi:
10.1016/j.numecd.2023.02.011. [PMID: 37246074] - Huiying Bai, Zhen Cao, Sha Meng, Rui Ge, Shurong Ban, Yuanlin Zhang, Li Tang, Qing-Shan Li. Synthesis and Anti-Inflammatory Activity Evaluation of Benzoxazole Derivatives as New Myeloid Differentiation Protein 2 Inhibitors.
Chemistry & biodiversity.
2023 Jun; 20(6):e202201145. doi:
10.1002/cbdv.202201145. [PMID: 37080925] - Elena Chugunova, Victoria Matveeva, Alena Tulesinova, Emil Iskanderov, Nurgali Akylbekov, Alexey Dobrynin, Ayrat Khamatgalimov, Nurbol Appazov, Lyazat Boltayeva, Bakhytzhan Duisembekov, Mukhtar Zhanakov, Yulia Aleksandrova, Tatyana Sashenkova, Elena Klimanova, Ugulzhan Allayarova, Anastasia Balakina, Denis Mishchenko, Alexander Burilov, Margarita Neganova. Water-Soluble Salts Based on Benzofuroxan Derivatives-Synthesis and Biological Activity.
International journal of molecular sciences.
2022 Nov; 23(23):. doi:
10.3390/ijms232314902. [PMID: 36499230] - Feng Zhao, Mengyu Guo, Mengna Zhang, Manman Duan, Junyue Zheng, Yinchi Liu, Lihong Qiu. Sub-lethal concentration of metamifop exposure impair gut health of zebrafish (Danio rerio).
Chemosphere.
2022 Sep; 303(Pt 2):135081. doi:
10.1016/j.chemosphere.2022.135081. [PMID: 35636611] - Li-Yun Lin, Yi-Lun Liao, Min-Hung Chen, Shih-Feng Chang, Kuan-Chou Chen, Robert Y Peng. Molecular Action Mechanism of Coixol from Soft-Shelled Adlay on Tyrosinase: The Future of Cosmetics.
Molecules (Basel, Switzerland).
2022 Jul; 27(14):. doi:
10.3390/molecules27144626. [PMID: 35889498] - Helen Usansky, Esther Yoon, Ariel Teper, Jun Zou, Carlos Fernandez. Safety, Tolerability, and Pharmacokinetic Evaluation of Single and Multiple Doses of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib in Healthy Japanese and White Adults.
Clinical pharmacology in drug development.
2022 Jul; 11(7):832-842. doi:
10.1002/cpdd.1094. [PMID: 35411669] - Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo. Efficacy and Safety of Pemafibrate Versus Bezafibrate to Treat Patients with Hypertriglyceridemia: A Randomized Crossover Study.
Journal of atherosclerosis and thrombosis.
2022 Jun; ?(?):. doi:
10.5551/jat.63659. [PMID: 35768226] - Yuri Ochi, Toru Kubo, Yuichi Baba, Kenta Sugiura, Kazuya Miyagawa, Tatsuya Noguchi, Takayoshi Hirota, Tomoyuki Hamada, Naohito Yamasaki, Hiroaki Kitaoka. Early Experience of Tafamidis Treatment in Japanese Patients With Wild-Type Transthyretin Cardiac Amyloidosis From the Kochi Amyloidosis Cohort.
Circulation journal : official journal of the Japanese Circulation Society.
2022 Jun; 86(7):1121-1128. doi:
10.1253/circj.cj-21-0965. [PMID: 35599003] - Henry N Ginsberg, Neil J Hounslow, Yusuke Senko, Hideki Suganami, Pawel Bogdanski, Richard Ceska, Akos Kalina, Roman A Libis, Tatiana V Supryadkina, G Kees Hovingh. Efficacy and Safety of K-877 (Pemafibrate), a Selective PPARα Modulator, in European Patients on Statin Therapy.
Diabetes care.
2022 04; 45(4):898-908. doi:
10.2337/dc21-1288. [PMID: 35238894] - Atsushi Kimura, Kenya Kamimura, Marina Ohkoshi-Yamada, Yoko Shinagawa-Kobayashi, Ryo Goto, Takashi Owaki, Chiyumi Oda, Osamu Shibata, Shinichi Morita, Norihiro Sakai, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai. Effects of a novel selective PPARα modulator, statin, sodium-glucose cotransporter 2 inhibitor, and combinatorial therapy on the liver and vasculature of medaka nonalcoholic steatohepatitis model.
Biochemical and biophysical research communications.
2022 03; 596(?):76-82. doi:
10.1016/j.bbrc.2022.01.086. [PMID: 35121372] - Ebtehal F Anwer, Deena A M Nour El-Deen, Sayed M Derayea, Mahmoud A Omar. Benzofurazan -based fluorophore for the spectrofluorimetric determination of 6-Aminocaproic acid: Application to spiked human plasma and urine.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Mar; 268(?):120723. doi:
10.1016/j.saa.2021.120723. [PMID: 34915229] - Kentaro Murakami, Yusuke Sasaki, Masato Asahiyama, Wataru Yano, Toshiaki Takizawa, Wakana Kamiya, Yoshihiro Matsumura, Motonobu Anai, Tsuyoshi Osawa, Jean-Charles Fruchart, Jamila Fruchart-Najib, Hiroyuki Aburatani, Juro Sakai, Tatsuhiko Kodama, Toshiya Tanaka. Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis.
Cells.
2022 02; 11(4):. doi:
10.3390/cells11040720. [PMID: 35203369] - Bradley A McGregor, Wanling Xie, Elio Adib, Walter M Stadler, Yousef Zakharia, Aijai Alva, M Dror Michaelson, Shilpa Gupta, Elaine T Lam, Subrina Farah, Amin H Nassar, Xiao X Wei, Kerry L Kilbridge, Lauren Harshman, Sabina Signoretti, Lynette Sholl, David J Kwiatkowski, Rana R McKay, Toni K Choueiri. Biomarker-Based Phase II Study of Sapanisertib (TAK-228): An mTORC1/2 Inhibitor in Patients With Refractory Metastatic Renal Cell Carcinoma.
JCO precision oncology.
2022 02; 6(?):e2100448. doi:
10.1200/po.21.00448. [PMID: 35171658] - Tatsuya Fujikawa, Yuka Sogabe. Lipid Metabolic Disorder with Varied Clinical Manifestations.
The American journal of medicine.
2022 02; 135(2):e42-e43. doi:
10.1016/j.amjmed.2021.09.011. [PMID: 34655537] - Laura Laschke, Vadim Schütz, Oliver Schackow, Dieter Sicker, Lothar Hennig, Diana Hofmann, Peter Dörmann, Margot Schulz. Survival of Plants During Short-Term BOA-OH Exposure: ROS Related Gene Expression and Detoxification Reactions Are Accompanied With Fast Membrane Lipid Repair in Root Tips.
Journal of chemical ecology.
2022 Feb; 48(2):219-239. doi:
10.1007/s10886-021-01337-z. [PMID: 34988771] - Masao Takahashi, Nobuhiro Ooba, Marina Nagamura, Makoto Ushida, Eiji Kawakami, Masaomi Kimura, Tsugumichi Sato, Yoshinori Takahashi, Junichi Tokuyoshi, Hajime Hashiba, Miwako Kamei, Choichiro Miyazaki, Mitsuaki Shimada. Event Monitoring and Evaluation by Community Pharmacists in Japan: A Pilot Study on Fenofibrate and Pemafibrate.
Current drug safety.
2022; 17(4):350-356. doi:
10.2174/1574886317666220224142511. [PMID: 35209830] - Ziyu Li, Wei Yang, Yong Yang, Jianbo Wu, Pei Luo, Yong Liu. The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy.
Drug design, development and therapy.
2022; 16(?):647-664. doi:
10.2147/dddt.s346546. [PMID: 35308255] - Kumiko Suto, Daiju Fukuda, Masakazu Shinohara, Byambasuren Ganbaatar, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Ken-Ichi Hirata, Masataka Sata. Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice.
Journal of atherosclerosis and thrombosis.
2021 Dec; 28(12):1349-1360. doi:
10.5551/jat.61101. [PMID: 33775978] - Jason W Carter, Thomas R Gordon. Tolerance of 2-Benzoxazolinone and Interactions with Grass and Pine Hosts in a Population of Fusarium circinatum.
Plant disease.
2021 Dec; 105(12):3880-3888. doi:
10.1094/pdis-01-21-0203-re. [PMID: 34232056] - Yuji Tanaka, Toshinori Kamisako. Regulation of the expression of cholesterol transporters by lipid-lowering drugs ezetimibe and pemafibrate in rat liver and intestine.
Biochimica et biophysica acta. Molecular basis of disease.
2021 11; 1867(11):166215. doi:
10.1016/j.bbadis.2021.166215. [PMID: 34265370] - Atsushi Nakajima, Yuichiro Eguchi, Masato Yoneda, Kento Imajo, Nobuharu Tamaki, Hideki Suganami, Toshiaki Nojima, Ryohei Tanigawa, Masakazu Iizuka, Yuki Iida, Rohit Loomba. Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), versus placebo in patients with non-alcoholic fatty liver disease.
Alimentary pharmacology & therapeutics.
2021 11; 54(10):1263-1277. doi:
10.1111/apt.16596. [PMID: 34528723] - Kazufumi Dohmen, Shin-Ya Onohara, Shigeru Harada. Effects of Switching from Fenofibrate to Pemafibrate for Asymptomatic Primary Biliary Cholangitis.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi.
2021 10; 78(4):227-234. doi:
10.4166/kjg.2021.092. [PMID: 34697277] - Elena Chugunova, Almir Gazizov, Daut Islamov, Alexander Burilov, Alena Tulesinova, Sergey Kharlamov, Victor Syakaev, Vasily Babaev, Nurgali Akylbekov, Nurbol Appazov, Konstantin Usachev, Rakhmetulla Zhapparbergenov. The Reactivity of Azidonitrobenzofuroxans towards 1,3-Dicarbonyl Compounds: Unexpected Formation of Amino Derivative via the Regitz Diazo Transfer and Tautomerism Study.
International journal of molecular sciences.
2021 Sep; 22(17):. doi:
10.3390/ijms22179646. [PMID: 34502553] - Rui Liu, Yinan Qin, Jinling Diao, Hongjun Zhang. Xenopus laevis tadpoles exposed to metamifop: Changes in growth, behavioral endpoints, neurotransmitters, antioxidant system and thyroid development.
Ecotoxicology and environmental safety.
2021 Sep; 220(?):112417. doi:
10.1016/j.ecoenv.2021.112417. [PMID: 34126306] - Toshinori Komatsu, Takashi Miura, Kensuke Joko, Daisuke Sunohara, Tomoaki Mochidome, Toshio Kasai, Uichi Ikeda. Real-world Profile of a Selective Peroxisome Proliferator-activated Receptor α Modulator (SPPARMα) in Japanese Patients with Renal Impairment and Dyslipidemia.
Internal medicine (Tokyo, Japan).
2021 Sep; 60(17):2741-2748. doi:
10.2169/internalmedicine.6871-20. [PMID: 33776008] - Yeamin Huh, Steve Riley, Lutz Harnisch, Timothy Nicholas. Population pharmacokinetic modelling and simulation of tafamidis in healthy subjects and patients with transthyretin amyloidosis.
British journal of clinical pharmacology.
2021 09; 87(9):3574-3587. doi:
10.1111/bcp.14773. [PMID: 33586186] - Shizuya Yamashita, Mitsuyo Okazaki, Takeshi Okada, Daisaku Masuda, Koutaro Yokote, Hidenori Arai, Eiichi Araki, Shun Ishibashi. Distinct Differences in Lipoprotein Particle Number Evaluation between GP-HPLC and NMR: Analysis in Dyslipidemic Patients Administered a Selective PPARα Modulator, Pemafibrate.
Journal of atherosclerosis and thrombosis.
2021 Sep; 28(9):974-996. doi:
10.5551/jat.60764. [PMID: 33536398] - Deokho Lee, Yohei Tomita, Heonuk Jeong, Yukihiro Miwa, Kazuo Tsubota, Kazuno Negishi, Toshihide Kurihara. Pemafibrate Prevents Retinal Dysfunction in a Mouse Model of Unilateral Common Carotid Artery Occlusion.
International journal of molecular sciences.
2021 Aug; 22(17):. doi:
10.3390/ijms22179408. [PMID: 34502311] - Elena Chugunova, Gabriele Micheletti, Dario Telese, Carla Boga, Daut Islamov, Konstantin Usachev, Alexander Burilov, Alena Tulesinova, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Tatiana Gerasimova, Aisylu Gilfanova, Victor Syakaev. Novel Hybrid Compounds Containing Benzofuroxan and Aminothiazole Scaffolds: Synthesis and Evaluation of Their Anticancer Activity.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147497. [PMID: 34299115] - Naoki Tanaka, Kazutaka Mukaiyama, Akio Morikawa, Satoshi Kawakami, Yasuyuki Ichise, Takefumi Kimura, Akira Horiuchi. Pemafibrate, a novel selective PPARα modulator, attenuates tamoxifen-induced fatty liver disease.
Clinical journal of gastroenterology.
2021 Jun; 14(3):846-851. doi:
10.1007/s12328-021-01386-7. [PMID: 33751406] - Xin Zhang, Huan Chen, Yanqi Lei, Xiaonan Zhang, Long Xu, Wenchao Liu, Zhenya Fan, Zequn Ma, Zhechang Yin, Lingyun Li, Changjin Zhu, Bing Ma. Multifunctional agents based on benzoxazolone as promising therapeutic drugs for diabetic nephropathy.
European journal of medicinal chemistry.
2021 Apr; 215(?):113269. doi:
10.1016/j.ejmech.2021.113269. [PMID: 33588177] - J Acharya, T C Kaspar, A E Robertson. Effect of 6-Methoxy-2-Benzoxazolinone (MBOA) on Pythium Species and Corn Seedling Growth and Disease.
Plant disease.
2021 Apr; 105(4):752-757. doi:
10.1094/pdis-04-20-0824-sc. [PMID: 33048595] - Lily K Stern, Michelle M Kittleson. Updates in Cardiac Amyloidosis Diagnosis and Treatment.
Current oncology reports.
2021 03; 23(4):47. doi:
10.1007/s11912-021-01028-8. [PMID: 33725199] - Emmanuelle Soleilhac, Marjorie Comte, Anaelle da Costa, Caroline Barette, Christèle Picoli, Magda Mortier, Laurence Aubry, Franck Mouthon, Marie-Odile Fauvarque, Mathieu Charvériat. Quantitative Automated Assays in Living Cells to Screen for Inhibitors of Hemichannel Function.
SLAS discovery : advancing life sciences R & D.
2021 03; 26(3):420-427. doi:
10.1177/2472555220954388. [PMID: 32914684] - Luke T Nelson, Ryan J Paxman, Jin Xu, Bill Webb, Evan T Powers, Jeffery W Kelly. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2021 Mar; 28(1):24-29. doi:
10.1080/13506129.2020.1808783. [PMID: 32811187] - Ichiro Komiya, Akira Yamamoto, Suguru Sunakawa, Tamio Wakugami. Pemafibrate decreases triglycerides and small, dense LDL, but increases LDL-C depending on baseline triglycerides and LDL-C in type 2 diabetes patients with hypertriglyceridemia: an observational study.
Lipids in health and disease.
2021 Feb; 20(1):17. doi:
10.1186/s12944-021-01434-8. [PMID: 33610176] - Dai Heng, Xiaoyan Sheng, Chenglei Tian, Jie Li, Linlin Liu, Mo Gou, Lin Liu. Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice.
Aging cell.
2021 02; 20(2):e13304. doi:
10.1111/acel.13304. [PMID: 33448083] - Li Tang, Jie-Ran Luo, Xiao-Yan Wang, Bei Zhao, Rui Ge, Tai-Gang Liang, Shu-Rong Ban, Qing-Shan Li. 4-Sulfonyloxy/alkoxy benzoxazolone derivatives with high anti-inflammatory activities: Synthesis, biological evaluation, and mechanims of action via p38/ERK-NF-κB/iNOS pathway.
Chemical biology & drug design.
2021 02; 97(2):200-209. doi:
10.1111/cbdd.13784. [PMID: 32915501] - Jean-Charles Fruchart, Michel P Hermans, Jamila Fruchart-Najib, Tatsuhiko Kodama. Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARMα) in the Metabolic Syndrome: Is Pemafibrate Light at the End of the Tunnel?.
Current atherosclerosis reports.
2021 01; 23(1):3. doi:
10.1007/s11883-020-00897-x. [PMID: 33392801] - Masataka Kusunoki, Takahiko Sakazaki, Kazuhiko Tsutsumi, Tetsuro Miyata, Yoshiharu Oshida. The Effects of Pemafibrate in Japanese Patients with Type 2 Diabetes Receiving HMG-CoA Reductase Inhibitors.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(5):919-924. doi:
10.2174/1871530320999200818135553. [PMID: 32819242] - Mansi L Patil, Swati S Gaikwad, Naresh J Gaikwad. Anti-nociceptive and Anti-inflammatory Activity of Synthesized Novel Benzoxazole Derivatives.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2021; 20(4):333-343. doi:
10.2174/1871523020666210203103433. [PMID: 33535962] - Wojciech Szlasa, Aleksander Kiełbik, Anna Szewczyk, Nina Rembiałkowska, Vitalij Novickij, Mounir Tarek, Jolanta Saczko, Julita Kulbacka. Oxidative Effects during Irreversible Electroporation of Melanoma Cells-In Vitro Study.
Molecules (Basel, Switzerland).
2020 Dec; 26(1):. doi:
10.3390/molecules26010154. [PMID: 33396317] - Shin-Ichiro Ogawa, Makiko Shimizu, Hiroshi Yamazaki. Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Dec; 50(12):1413-1422. doi:
10.1080/00498254.2020.1793030. [PMID: 32628085] - Himi Tripathi, Ahmed Al-Darraji, Mohamed Abo-Aly, Hsuan Peng, Elica Shokri, Lakshman Chelvarajan, Renee R Donahue, Bryana M Levitan, Erhe Gao, Gabriela Hernandez, Andrew J Morris, Susan S Smyth, Ahmed Abdel-Latif. Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
Journal of molecular and cellular cardiology.
2020 12; 149(?):95-114. doi:
10.1016/j.yjmcc.2020.09.011. [PMID: 33017574] - Chie Iitake, Daisaku Masuda, Masahiro Koseki, Shizuya Yamashita. Marked effects of novel selective peroxisome proliferator-activated receptor α modulator, pemafibrate in severe hypertriglyceridemia: preliminary report.
Cardiovascular diabetology.
2020 11; 19(1):201. doi:
10.1186/s12933-020-01172-8. [PMID: 33246467] - Elena Chugunova, Almir Gazizov, Marina Sazykina, Nurgali Akylbekov, Anastasiya Gildebrant, Ivan Sazykin, Alexander Burilov, Nurbol Appazov, Shorena Karchava, Maria Klimova, Alexandra Voloshina, Anastasia Sapunova, Syumbelya Gumerova, Ayrat Khamatgalimov, Tatiana Gerasimova, Alexey Dobrynin, Olga Gogoleva, Vladimir Gorshkov. Design of Novel 4-Aminobenzofuroxans and Evaluation of Their Antimicrobial and Anticancer Activity.
International journal of molecular sciences.
2020 Nov; 21(21):. doi:
10.3390/ijms21218292. [PMID: 33167439] - Takuya Minamizuka, Junji Kobayashi, Hayato Tada, Kazuya Miyashita, Masaya Koshizaka, Yoshiro Maezawa, Hiraku Ono, Koutaro Yokote. Detailed analysis of lipolytic enzymes in a Japanese woman of familial lipoprotein lipase deficiency - Effects of pemafibrate treatment.
Clinica chimica acta; international journal of clinical chemistry.
2020 Nov; 510(?):216-219. doi:
10.1016/j.cca.2020.07.031. [PMID: 32682802] - Li Tang, Xiao-Hui Gao, Bei Zhao, Jie-Ran Luo, Xin-Yang Shi, Rui Ge, Shu-Rong Ban, Qing-Shan Li. Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI).
Bioorganic & medicinal chemistry.
2020 11; 28(21):115733. doi:
10.1016/j.bmc.2020.115733. [PMID: 33065432] - David Adams, Michel Slama. Hereditary transthyretin amyloidosis: current treatment.
Current opinion in neurology.
2020 10; 33(5):553-561. doi:
10.1097/wco.0000000000000852. [PMID: 32796279] - Masatoki Yoshida, Kazufumi Nakamura, Toru Miyoshi, Masashi Yoshida, Megumi Kondo, Kaoru Akazawa, Tomonari Kimura, Hiroaki Ohtsuka, Yuko Ohno, Daiji Miura, Hiroshi Ito. Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet.
Cardiovascular diabetology.
2020 09; 19(1):149. doi:
10.1186/s12933-020-01132-2. [PMID: 32979918] - Naohiro Okano, Kiyomi Hana, Daisuke Naruge, Kirio Kawai, Takaaki Kobayashi, Fumio Nagashima, Hitoshi Endou, Junji Furuse. Biomarker Analyses in Patients With Advanced Solid Tumors Treated With the LAT1 Inhibitor JPH203.
In vivo (Athens, Greece).
2020 Sep; 34(5):2595-2606. doi:
10.21873/invivo.12077. [PMID: 32871789] - Shin-Ichiro Ogawa, Makiko Shimizu, Hiroshi Yamazaki. Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Sep; 50(9):1023-1031. doi:
10.1080/00498254.2019.1709133. [PMID: 31900032] - Yohei Tomita, Deokho Lee, Yukihiro Miwa, Xiaoyan Jiang, Masayuki Ohta, Kazuo Tsubota, Toshihide Kurihara. Pemafibrate Protects Against Retinal Dysfunction in a Murine Model of Diabetic Retinopathy.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21176243. [PMID: 32872333] - Daniel O Pinto, Catherine DeMarino, Thy T Vo, Maria Cowen, Yuriy Kim, Michelle L Pleet, Robert A Barclay, Nicole Noren Hooten, Michele K Evans, Alonso Heredia, Elena V Batrakova, Sergey Iordanskiy, Fatah Kashanchi. Low-Level Ionizing Radiation Induces Selective Killing of HIV-1-Infected Cells with Reversal of Cytokine Induction Using mTOR Inhibitors.
Viruses.
2020 08; 12(8):. doi:
10.3390/v12080885. [PMID: 32823598] - Shin-Ichiro Ogawa, Makiko Shimizu, Yusuke Kamiya, Shotaro Uehara, Hiroshi Suemizu, Hiroshi Yamazaki. Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):354-360. doi:
10.1016/j.dmpk.2020.03.005. [PMID: 32601018] - Jean-Charles Fruchart, Michel P Hermans, Jamila Fruchart-Najib. Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARMα): New Opportunities to Reduce Residual Cardiovascular Risk in Chronic Kidney Disease?.
Current atherosclerosis reports.
2020 07; 22(8):43. doi:
10.1007/s11883-020-00860-w. [PMID: 32671476] - Morie A Gertz, Angela Dispenzieri. Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review.
JAMA.
2020 07; 324(1):79-89. doi:
10.1001/jama.2020.5493. [PMID: 32633805] - Mahmoud A Omar, Hytham M Ahmed, Hany A Batakoushy, Mohamed A Abdel Hamid. New spectrofluorimetric analysis of empagliflozin in its tablets and human plasma using two level full factorial design.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Jul; 235(?):118307. doi:
10.1016/j.saa.2020.118307. [PMID: 32247255] - Shin-Ichiro Ogawa, Shotaro Uehara, Yoshihiko Tsunenari, Hiroyuki Kawai, Hiroshi Suemizu, Hiroshi Yamazaki. Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Jul; 50(7):769-775. doi:
10.1080/00498254.2019.1694198. [PMID: 31766940] - Terry J McGenity, Amare Gessesse, John E Hallsworth, Esther Garcia Cela, Carol Verheecke-Vaessen, Fengping Wang, Max Chavarría, Max M Haggblom, Søren Molin, Antoine Danchin, Eddy J Smid, Cédric Lood, Charles S Cockell, Corinne Whitby, Shuang-Jiang Liu, Nancy P Keller, Lisa Y Stein, Seth R Bordenstein, Rup Lal, Olga C Nunes, Lone Gram, Brajesh K Singh, Nicole S Webster, Cindy Morris, Sharon Sivinski, Saskia Bindschedler, Pilar Junier, André Antunes, Bonnie K Baxter, Paola Scavone, Kenneth Timmis. Visualizing the invisible: class excursions to ignite children's enthusiasm for microbes.
Microbial biotechnology.
2020 07; 13(4):844-887. doi:
10.1111/1751-7915.13576. [PMID: 32406115] - Magdalena Markowicz-Piasecka, Johanna Huttunen, Ahmed Montaser, Kristiina M Huttunen. Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.
Apoptosis : an international journal on programmed cell death.
2020 06; 25(5-6):426-440. doi:
10.1007/s10495-020-01603-7. [PMID: 32405891] - Yujin Kang, Na Young Cheon, Jongjin Cha, Ayoung Kim, Hyung-Il Kim, Luda Lee, Kang O Kim, Kyubong Jo, Ja Yil Lee. High-throughput single-molecule imaging system using nanofabricated trenches and fluorescent DNA-binding proteins.
Biotechnology and bioengineering.
2020 06; 117(6):1640-1648. doi:
10.1002/bit.27331. [PMID: 32162675] - Yusuke Sasaki, Masato Asahiyama, Toshiya Tanaka, Shogo Yamamoto, Kentaro Murakami, Wakana Kamiya, Yoshihiro Matsumura, Tsuyoshi Osawa, Motonobu Anai, Jean-Charles Fruchart, Hiroyuki Aburatani, Juro Sakai, Tatsuhiko Kodama. Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content.
Scientific reports.
2020 05; 10(1):7818. doi:
10.1038/s41598-020-64902-8. [PMID: 32385406] - Xiao-Yan Zhi, Ling-Yun Jiang, Ting Li, Li-Li Song, Yi Wang, Hui Cao, Chun Yang. Semisynthesis and insecticidal bioactivities of benzoxazole and benzoxazolone derivatives of honokiol, a naturally occurring neolignan derived from Magnolia officinalis.
Bioorganic & medicinal chemistry letters.
2020 05; 30(9):127086. doi:
10.1016/j.bmcl.2020.127086. [PMID: 32165043] - Atsushi Tanaka, Tsukasa Nakamura, Eiichi Sato, Atsuko Chihara, Koichi Node. Effect of pemafibrate, a novel selective peroxisome proliferator-activated receptor-alpha modulator (SPPARMα), on urinary protein excretion in IgA nephropathy with hypertriglyceridemia.
CEN case reports.
2020 05; 9(2):141-146. doi:
10.1007/s13730-020-00444-2. [PMID: 31950425] - Shinji Kobuchi, Atsushi Shigemura, Yukako Ito, Toshiyuki Sakaeda. A validated LC-MS/MS method for the low-level determination of pemafibrate, a novel SPPARMα, in plasma.
Bioanalysis.
2020 May; 12(10):683-692. doi:
10.4155/bio-2020-0081. [PMID: 32489112] - Simona Di Martino, Piero Tardia, Vincenzo Cilibrasi, Samantha Caputo, Marco Mazzonna, Debora Russo, Ilaria Penna, Natalia Realini, Natasha Margaroli, Marco Migliore, Daniela Pizzirani, Giuliana Ottonello, Sine Mandrup Bertozzi, Andrea Armirotti, Duc Nguyen, Ying Sun, Ernesto R Bongarzone, Peter Lansbury, Min Liu, Renato Skerlj, Rita Scarpelli. Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.
Journal of medicinal chemistry.
2020 04; 63(7):3634-3664. doi:
10.1021/acs.jmedchem.9b02004. [PMID: 32176488] - Kento Ogawa, Takashi Yagi, Tingting Guo, Katsushi Takeda, Hideomi Ohguchi, Hiroyuki Koyama, Daisuke Aotani, Kenro Imaeda, Hiromi Kataoka, Tomohiro Tanaka. Pemafibrate, a selective PPARα modulator, and fenofibrate suppress microglial activation through distinct PPARα and SIRT1-dependent pathways.
Biochemical and biophysical research communications.
2020 04; 524(2):385-391. doi:
10.1016/j.bbrc.2020.01.118. [PMID: 32005522] - Helen L Miller, Sonia Contera, Adam J M Wollman, Adam Hirst, Katherine E Dunn, Sandra Schröter, Deborah O'Connell, Mark C Leake. Biophysical characterisation of DNA origami nanostructures reveals inaccessibility to intercalation binding sites.
Nanotechnology.
2020 Mar; 31(23):235605. doi:
10.1088/1361-6528/ab7a2b. [PMID: 32125281] - Maria Chatzopoulou, Tim D W Claridge, Kay E Davies, Stephen G Davies, David J Elsey, Enrico Emer, Ai M Fletcher, Shawn Harriman, Neil Robinson, Jessica A Rowley, Angela J Russell, Jonathon M Tinsley, Richard Weaver, Isabel V L Wilkinson, Nicky J Willis, Francis X Wilson, Graham M Wynne. Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
Journal of medicinal chemistry.
2020 03; 63(5):2547-2556. doi:
10.1021/acs.jmedchem.9b01547. [PMID: 31599580] - Yusheng Hu, Qilyu Zhou, Tianlong Liu, Zhongjie Liu. Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells.
Molecules (Basel, Switzerland).
2020 Feb; 25(4):. doi:
10.3390/molecules25040894. [PMID: 32085388] - Shizuya Yamashita, Daisaku Masuda, Yuji Matsuzawa. Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases.
Current atherosclerosis reports.
2020 01; 22(1):5. doi:
10.1007/s11883-020-0823-5. [PMID: 31974794] - Hiroshi Kawanishi, Koji Ohashi, Hayato Ogawa, Naoya Otaka, Tomonobu Takikawa, Lixin Fang, Yuta Ozaki, Mikito Takefuji, Toyoaki Murohara, Noriyuki Ouchi. A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.
PloS one.
2020; 15(6):e0235362. doi:
10.1371/journal.pone.0235362. [PMID: 32584895] - Hei-Nga Chan, See-Lok Ho, Dinggeng He, Hung-Wing Li. Direct and sensitive detection of circulating miRNA in human serum by ligase-mediated amplification.
Talanta.
2020 Jan; 206(?):120217. doi:
10.1016/j.talanta.2019.120217. [PMID: 31514897] - Hirokazu Konishi, Katsumi Miyauchi, Akira Onishi, Shunichi Suzuki, Daiichiro Fuchimoto, Jun Shitara, Hirohisa Endo, Hideki Wada, Shinichiro Doi, Ryo Naito, Manabu Ogita, Tomotaka Dohi, Takatoshi Kasai, Hiroyuki Daida. Effect of pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor α modular (SPPARMα), in atherosclerosis model using low density lipoprotein receptor knock-out swine with balloon injury.
PloS one.
2020; 15(11):e0241195. doi:
10.1371/journal.pone.0241195. [PMID: 33201888] - Samiha A Hussein, Baher I Salman, Marwa F B Ali, Mostafa A Marzouq. Development of sensitive benzofurazan-based spectrometric methods for analysis of spectinomycin in vials and human biological samples.
Luminescence : the journal of biological and chemical luminescence.
2019 Dec; 34(8):895-902. doi:
10.1002/bio.3688. [PMID: 31379072] - D M Paton. Tafamidis: a selective transthyretin stabilizer to treat wild-type ATTR amyloidosis and hereditary ATTR amyloidosis with cardiomyopathy.
Drugs of today (Barcelona, Spain : 1998).
2019 Dec; 55(12):727-734. doi:
10.1358/dot.2019.55.12.3078389. [PMID: 31942875] - Jean-Charles Fruchart, Raul D Santos. SPPARM alpha: the Lazarus effect.
Current opinion in lipidology.
2019 12; 30(6):419-427. doi:
10.1097/mol.0000000000000640. [PMID: 31577610] - Kosuke Higuchi, Shinichi Sakamoto, Keisuke Ando, Maihulan Maimaiti, Nobushige Takeshita, Kentaro Okunushi, Yoshie Reien, Yusuke Imamura, Tomokazu Sazuka, Kazuyoshi Nakamura, Jun Matsushima, Tomomi Furihata, Yuzuru Ikehara, Tomohiko Ichikawa, Naohiko Anzai. Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma.
Scientific reports.
2019 11; 9(1):16776. doi:
10.1038/s41598-019-53397-7. [PMID: 31748583] - Shizuya Yamashita, Hidenori Arai, Koutaro Yokote, Eiichi Araki, Mitsunori Matsushita, Toshiaki Nojima, Hideki Suganami, Shun Ishibashi. Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Patients with or without Statin Combination.
International journal of molecular sciences.
2019 Nov; 20(22):. doi:
10.3390/ijms20225537. [PMID: 31698825] - Fei Ding, Ling-Xu Li, Wei Peng, Yu-Kui Peng, Bing-Qi Liu. Molecular basis for the resistance of American sloughgrass to aryloxyphenoxypropionic acid pesticides and its environmental relevance: A combined experimental and computational study.
Chemosphere.
2019 Nov; 235(?):1030-1040. doi:
10.1016/j.chemosphere.2019.07.044. [PMID: 31561292] - Francesco Muntoni, Bina Tejura, Stefan Spinty, Helen Roper, Imelda Hughes, Gary Layton, Kay E Davies, Shawn Harriman, Jonathon Tinsley. A Phase 1b Trial to Assess the Pharmacokinetics of Ezutromid in Pediatric Duchenne Muscular Dystrophy Patients on a Balanced Diet.
Clinical pharmacology in drug development.
2019 10; 8(7):922-933. doi:
10.1002/cpdd.642. [PMID: 30650257] - Sk Abdul Amin, Nilanjan Adhikari, Shovanlal Gayen, Tarun Jha. Reliable structural information for rational design of benzoxazole type potential cholesteryl ester transfer protein (CETP) inhibitors through multiple validated modeling techniques.
Journal of biomolecular structure & dynamics.
2019 10; 37(17):4528-4541. doi:
10.1080/07391102.2018.1552895. [PMID: 30488780] - Xu Yuan, Qingyi Yang, Tongyan Liu, Ke Li, Yuwen Liu, Changcheng Zhu, Zhiyun Zhang, Linghua Li, Conghai Zhang, Mingjin Xie, Jun Lin, Jihong Zhang, Yi Jin. Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase.
European journal of medicinal chemistry.
2019 Oct; 179(?):147-165. doi:
10.1016/j.ejmech.2019.06.054. [PMID: 31252306] - Lucas Falarz, Yang Xu, Stacy D Singer, Guanqun Chen. A Fluorescence-Based Assay for Quantitative Analysis of Phospholipid:Diacylglycerol Acyltransferase Activity.
Lipids.
2019 09; 54(9):571-579. doi:
10.1002/lipd.12190. [PMID: 31478204] - Bingqi Liu, Fei Ding, Mingliang Wang, Fei Wang, Xiaoyong Luo, Lingxu Li. Cross-resistance pattern to ACCase-inhibiting herbicides in a novel Trp1999Leu mutation American sloughgrass (Beckmannia syzigachne) population.
Pesticide biochemistry and physiology.
2019 Sep; 159(?):80-84. doi:
10.1016/j.pestbp.2019.05.019. [PMID: 31400787] - Ming-Xia Song, Yuping Huang, Shiben Wang, Zeng-Tao Wang, Xian-Qing Deng. Design, synthesis, and evaluation of anticonvulsant activities of benzoxazole derivatives containing the 1,2,4-triazolone moiety.
Archiv der Pharmazie.
2019 Aug; 352(8):e1800313. doi:
10.1002/ardp.201800313. [PMID: 31330092] - Mengli Zi, Feifei Liu, Di Wu, Ke Li, Da Zhang, Changcheng Zhu, Zhiyun Zhang, Linghua Li, Conghai Zhang, Mingjin Xie, Jun Lin, Jihong Zhang, Yi Jin. Discovery of 6-Arylurea-2-arylbenzoxazole and 6-Arylurea-2-arylbenzimidazole Derivatives as Angiogenesis Inhibitors: Design, Synthesis and in vitro Biological Evaluation.
ChemMedChem.
2019 07; 14(13):1291-1302. doi:
10.1002/cmdc.201900216. [PMID: 31131561] - Chirag G Patel, Lakshmi Rangachari, Mark Patti, Celina Griffin, Yaping Shou, Karthik Venkatakrishnan. Characterizing the Sources of Pharmacokinetic Variability for TAK-117 (Serabelisib), an Investigational Phosphoinositide 3-Kinase Alpha Inhibitor: A Clinical Biopharmaceutics Study to Inform Development Strategy.
Clinical pharmacology in drug development.
2019 07; 8(5):637-646. doi:
10.1002/cpdd.613. [PMID: 30168905] - Xuemei Sun, Xiukun Huang, Xunshuai Zhu, Lin Liu, Siyan Mo, Hongyuan Wang, Xiugui Wei, Shunyu Lu, Facheng Bai, Dandan Wang, Xing Lin, Jun Lin. HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108901. doi:
10.1016/j.biopha.2019.108901. [PMID: 31079002] - Eiichi Araki, Shizuya Yamashita, Hidenori Arai, Koutaro Yokote, Jo Satoh, Toyoshi Inoguchi, Jiro Nakamura, Hiroshi Maegawa, Narihito Yoshioka, Yukio Tanizawa, Hirotaka Watada, Hideki Suganami, Shun Ishibashi. Efficacy and safety of pemafibrate in people with type 2 diabetes and elevated triglyceride levels: 52-week data from the PROVIDE study.
Diabetes, obesity & metabolism.
2019 07; 21(7):1737-1744. doi:
10.1111/dom.13686. [PMID: 30830727] - Cecília Monteiro, Jaleh S Mesgazardeh, João Anselmo, Joana Fernandes, Marta Novais, Carla Rodrigues, Gabriel J Brighty, David L Powers, Evan T Powers, Teresa Coelho, Jeffery W Kelly. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy.
JCI insight.
2019 06; 4(12):. doi:
10.1172/jci.insight.126526. [PMID: 31217346] - Jean-Charles Fruchart, Raul D Santos, Carlos Aguilar-Salinas, Masanori Aikawa, Khalid Al Rasadi, Pierre Amarenco, Philip J Barter, Richard Ceska, Alberto Corsini, Jean-Pierre Després, Patrick Duriez, Robert H Eckel, Marat V Ezhov, Michel Farnier, Henry N Ginsberg, Michel P Hermans, Shun Ishibashi, Fredrik Karpe, Tatsuhiko Kodama, Wolfgang Koenig, Michel Krempf, Soo Lim, Alberto J Lorenzatti, Ruth McPherson, Jesus Millan Nuñez-Cortes, Børge G Nordestgaard, Hisao Ogawa, Chris J Packard, Jorge Plutzky, Carlos I Ponte-Negretti, Aruna Pradhan, Kausik K Ray, Željko Reiner, Paul M Ridker, Massimiliano Ruscica, Shaukat Sadikot, Hitoshi Shimano, Piyamitr Sritara, Jane K Stock, Ta-Chen Su, Andrey V Susekov, André Tartar, Marja-Riitta Taskinen, Alexander Tenenbaum, Lale S Tokgözoğlu, Brian Tomlinson, Anne Tybjærg-Hansen, Paul Valensi, Michal Vrablík, Walter Wahli, Gerald F Watts, Shizuya Yamashita, Koutaro Yokote, Alberto Zambon, Peter Libby. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.
Cardiovascular diabetology.
2019 06; 18(1):71. doi:
10.1186/s12933-019-0864-7. [PMID: 31164165] - Xing-Yan Luo, Hong Zhou, Si-Yu Wang, Jing Xiong, Chun-Fen Mo, Hui-Jie Guo, Yan-Tang Wang, Shu-Xia Yang, Li-Mei Li, Qiang Zou, Yang Liu. A benzoxazole derivative PO-296 inhibits T lymphocyte proliferation by the JAK3/STAT5 signal pathway.
Journal of cellular biochemistry.
2019 06; 120(6):9193-9202. doi:
10.1002/jcb.28195. [PMID: 30506723] - Joel N Buxbaum. Treatment of hereditary and acquired forms of transthyretin amyloidosis in the era of personalized medicine: the role of randomized controlled trials.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2019 Jun; 26(2):55-65. doi:
10.1080/13506129.2019.1575201. [PMID: 30907141] - Shizuya Yamashita, Daisaku Masuda, Yuji Matsuzawa. Clinical Applications of a Novel Selective PPARα Modulator, Pemafibrate, in Dyslipidemia and Metabolic Diseases.
Journal of atherosclerosis and thrombosis.
2019 May; 26(5):389-402. doi:
10.5551/jat.48918. [PMID: 30930344]