p-Cresol sulfate (BioDeep_00000018635)

 

Secondary id: BioDeep_00000229602, BioDeep_00000416065, BioDeep_00000605311

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin


代谢物信息卡片


Sulfuric acid, mono(4-methylphenyl) ester

化学式: C7H8O4S (188.0143288)
中文名称: 对甲酚硫酸, 硫酸对甲酚
谱图信息: 最多检出来源 Homo sapiens(feces) 0.52%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

p-Cresol sulfate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/p-cresol_sulfate (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000018635). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1=CC=C(C=C1)OS(=O)(=O)O
InChI: InChI=1S/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)

描述信息

p-Cresol sulfate is a microbial metabolite that is found in urine and likely derives from secondary metabolism of p-cresol. It appears to be elevated in the urine of individuals with progressive multiple sclerosis (PMID:10775436). p-Cresol sulfate is the major component of urinary MBPLM (myelin basic protein-like material). p-Cresol sulfate is a small protein-bound molecule that is poorly cleared with dialysis. It has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID:22626821). Uremic toxins include other low-molecular-weight compounds such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, and asymmetric dimethylarginine (PMID:18941347). It has also been linked to cardiovascular disease and oxidative injury. Higher levels are associated with overgrowth of intestinal bacteria from Clostridia species, including C. difficile. p-Cresol is generated by the partial breakdown of tyrosine and phenylalanine by a wide range of intestinal obligate or facultative anaerobes, including the genera Bacteroides, Lactobacillus, Enterobacter, Bifidobacterium, and especially Clostridium (PMID:2394806).
p-Cresol sulfate is a microbial metabolite that is found in urine and likely derives from secondary metabolism of p-cresol. It appears to be elevated in the urine of individuals with progressive multiple sclerosis (PMID: 10775436). p-Cresol sulfate is the major component of urinary MBPLM (myelin basic protein-like material). p-Cresol sulfate is a small protein-bound molecule that is poorly cleared with dialysis and is often considered to be a uremic toxin. Uremic toxins include low-molecular-weight compounds such as indoxyl sulfate, p-cresol sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and asymmetric dimethylarginine (PMID: 18941347). It has been linked to cardiovascular disease and oxidative injury. [HMDB]

p-Cresol sulfate. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=3233-58-7 (retrieved 2024-07-01) (CAS RN: 3233-58-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
p-Cresyl Sulfate, a major uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver, existed in the blood of patients with chronic kidney disease (CKD).

同义名列表

28 个代谢物同义名

Sulfuric acid, mono(4-methylphenyl) ester; Sulfuric acid mono(p-tolyl) ester (8ci); (4-methylphenyl)oxidanesulfonic acid; Sulphuric acid mono-p-tolyl ester; Sulfuric acid mono-p-tolyl ester; mono(4-Methylphenyl) sulfate; Sulphate mono-p-tolyl ester; Sulfate mono-p-tolyl ester; p-Tolyl sulphate (6ci,7ci); p-Tolyl sulfate (6ci,7ci); 4-Cresol sulphuric acid; p-Cresol sulphuric acid; p-Cresol sulfuric acid; 4-Cresol sulfuric acid; Para-cresol sulphate; Para-cresol sulfate; 4-Cresol sulphate; p-Cresol sulphate; p-Cresyl-sulphate; p-Cresyl sulphate; p-Cresyl sulfate; p-Cresyl-sulfate; p-Cresylsulphate; 4-Cresol sulfate; p-Cresol sulfate; p-Cresylsulfate; p-Cresyl sulfate; p-Tolyl sulfate



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Cheng Chen, Caidie Xie, Yiqing Xiong, Hanzhang Wu, Lin Wu, Jingfeng Zhu, Changying Xing, Huijuan Mao. Damage of uremic myocardium by p-cresyl sulfate and the ameliorative effect of Klotho by regulating SIRT6 ubiquitination. Toxicology letters. 2022 Aug; 367(?):19-31. doi: 10.1016/j.toxlet.2022.06.006. [PMID: 35839976]
  • Yan Rong, Penny Colbourne, Sita Gourishankar, Tony K L Kiang. Significant Correlations between p-Cresol Sulfate and Mycophenolic Acid Plasma Concentrations in Adult Kidney Transplant Recipients. Clinical drug investigation. 2022 Mar; 42(3):207-219. doi: 10.1007/s40261-022-01121-1. [PMID: 35182318]
  • Xiao Tan, Jianzhou Zou, Fangfang Xiang, Pan Zhang, Bo Shen, Yaqiong Wang, Xiaoqiang Ding, Xuesen Cao. p-Cresyl Sulfate Predicts Ischemic Stroke among Patients on Hemodialysis: A Prospective Cohort Study. Disease markers. 2022; 2022(?):1358419. doi: 10.1155/2022/1358419. [PMID: 35140818]
  • Kenshiro Hirata, Tokunori Ikeda, Hiroshi Watanabe, Toru Maruyama, Motoko Tanaka, Victor Tuan Giam Chuang, Yuji Uchida, Keiki Sakurama, Koji Nishi, Keishi Yamasaki, Masaki Otagiri. The Binding of Aripiprazole to Plasma Proteins in Chronic Renal Failure Patients. Toxins. 2021 11; 13(11):. doi: 10.3390/toxins13110811. [PMID: 34822595]
  • Laetitia Koppe, Marine L Croze, Elisa B Monteiro, Bérengère Benoit, Emilie Bres, Fitsum Guebre-Egziabher, Julio B Daleprane, Denis Fouque, Christophe O Soulage. The protein-bound uremic toxin p-cresyl-sulfate promotes intracellular ROS production and lipid peroxidation in 3T3-L1 adipose cells. Biochimie. 2021 Oct; 189(?):137-143. doi: 10.1016/j.biochi.2021.06.020. [PMID: 34217821]
  • Kullaya Takkavatakarn, Pongpratch Puapatanakul, Jeerath Phannajit, Warumphon Sukkumme, Pajaree Chariyavilaskul, Patita Sitticharoenchai, Asada Leelahavanichkul, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong. Protein-Bound Uremic Toxins Lowering Effect of Sevelamer in Pre-Dialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized Controlled Trial. Toxins. 2021 09; 13(10):. doi: 10.3390/toxins13100688. [PMID: 34678981]
  • Giane Favretto, Regiane Stafim da Cunha, Andressa Flores Santos, Amanda Leitolis, Elberth Manfron Schiefer, Paulo Cézar Gregório, Célia Regina Cavichiolo Franco, Ziad Massy, Maria Aparecida Dalboni, Andréa Emilia Marques Stinghen. Uremic endothelial-derived extracellular vesicles: Mechanisms of formation and their role in cell adhesion, cell migration, inflammation, and oxidative stress. Toxicology letters. 2021 Sep; 347(?):12-22. doi: 10.1016/j.toxlet.2021.04.019. [PMID: 33945863]
  • Yan Rong, Tony K L Kiang. Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification. Toxicology and applied pharmacology. 2021 08; 425(?):115553. doi: 10.1016/j.taap.2021.115553. [PMID: 33915121]
  • Yan Chen, Leila R Zelnick, Matthew P Huber, Ke Wang, Nisha Bansal, Andrew N Hoofnagle, Rajan K Paranji, Susan R Heckbert, Noel S Weiss, Alan S Go, Chi-Yuan Hsu, Harold I Feldman, Sushrut S Waikar, Rupal C Mehta, Anand Srivastava, Stephen L Seliger, James P Lash, Anna C Porter, Dominic S Raj, Bryan R Kestenbaum. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 08; 78(2):226-235.e1. doi: 10.1053/j.ajkd.2020.12.005. [PMID: 33421453]
  • Jia-Feng Chang, Chih-Yu Hsieh, Jian-Chiun Liou, Kuo-Cheng Lu, Cai-Mei Zheng, Mai-Szu Wu, Shu-Wei Chang, Ting-Ming Wang, Chang-Chin Wu. Circulating p-Cresyl Sulfate, Non-Hepatic Alkaline Phosphatase and Risk of Bone Fracture Events in Chronic Kidney Disease-Mineral Bone Disease. Toxins. 2021 07; 13(7):. doi: 10.3390/toxins13070479. [PMID: 34357951]
  • Roberta T Salarolli, Livia Alvarenga, Ludmila F M F Cardozo, Karla T R Teixeira, Laís de S G Moreira, Jordana D Lima, Silvia D Rodrigues, Lia S Nakao, Denis Fouque, Denise Mafra. Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study. International urology and nephrology. 2021 Jun; 53(6):1231-1238. doi: 10.1007/s11255-020-02760-z. [PMID: 33438085]
  • Yung-Chuan Lu, Cheng-Ching Wu, I-Ting Tsai, Wei-Chin Hung, Thung-Lip Lee, Chin-Feng Hsuan, Teng-Hung Yu, Ching-Ting Wei, Fu-Mei Chung, Yau-Jiunn Lee, Chao-Ping Wang. Associations among total p-cresylsulfate, indoxyl sulfate and hippuric acid levels with hemodialysis quality indicators in maintenance hemodialysis patients. Clinica chimica acta; international journal of clinical chemistry. 2021 May; 516(?):83-91. doi: 10.1016/j.cca.2021.01.015. [PMID: 33508250]
  • Robin Pla, Estelle Pujos-Guillot, Stéphanie Durand, Marion Brandolini-Bunlon, Delphine Centeno, David B Pyne, Jean-François Toussaint, Philippe Hellard. Non-targeted metabolomics analyses by mass spectrometry to explore metabolic stress after six training weeks in high level swimmers. Journal of sports sciences. 2021 May; 39(9):969-978. doi: 10.1080/02640414.2020.1851933. [PMID: 33320058]
  • Ping-Hsun Wu, Yi-Ting Lin, Yi-Wen Chiu, Gabriel Baldanzi, Jiun-Chi Huang, Shih-Shin Liang, Su-Chu Lee, Szu-Chia Chen, Ya-Ling Hsu, Mei-Chuan Kuo, Shang-Jyh Hwang. The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients. Scientific reports. 2021 02; 11(1):3786. doi: 10.1038/s41598-021-83383-x. [PMID: 33589722]
  • Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, Ichiei Narita. pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro. Toxins. 2021 02; 13(2):. doi: 10.3390/toxins13020116. [PMID: 33557434]
  • Koji Nishi, Keiki Sakurama, Hiroshi Watanabe, Toru Maruyama, Keishi Yamasaki, Masaki Otagiri. Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin. Biological & pharmaceutical bulletin. 2021; 44(3):437-441. doi: 10.1248/bpb.b20-00929. [PMID: 33642552]
  • Ebru Melekoglu, M Alper Cetinkaya, S Evrim Kepekci-Tekkeli, Oguz Kul, Gulhan Samur. Effects of prebiotic oligofructose-enriched inulin on gut-derived uremic toxins and disease progression in rats with adenine-induced chronic kidney disease. PloS one. 2021; 16(10):e0258145. doi: 10.1371/journal.pone.0258145. [PMID: 34614017]
  • Maria Teresa Rocchetti, Carmela Cosola, Elena Ranieri, Loreto Gesualdo. Protein-Bound Uremic Toxins and Immunity. Methods in molecular biology (Clifton, N.J.). 2021; 2325(?):215-227. doi: 10.1007/978-1-0716-1507-2_15. [PMID: 34053061]
  • Chiao-Yin Sun, Jian-Ri Li, Ya-Yu Wang, Shih-Yi Lin, Yen-Chuan Ou, Cheng-Jui Lin, Jiaan-Der Wang, Su-Lan Liao, Chun-Jung Chen. p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation. International journal of molecular sciences. 2020 Sep; 21(18):. doi: 10.3390/ijms21186687. [PMID: 32932690]
  • Kiana Ashley West, Chidimma Kanu, Tanya Maric, Julie Anne Kathryn McDonald, Jeremy K Nicholson, Jia V Li, Mark R Johnson, Elaine Holmes, Makrina D Savvidou. Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery. Gut. 2020 08; 69(8):1452-1459. doi: 10.1136/gutjnl-2019-319620. [PMID: 31964751]
  • Akira Iguchi, Suguru Yamamoto, Akira Oda, Kenichi Tanaka, Junichiro James Kazama, Takako Saeki, Hajime Yamazaki, Ken Ishioka, Tatsuo Suzutani, Ichiei Narita. Effect of sucroferric oxyhydroxide on gastrointestinal microbiome and uremic toxins in patients with chronic kidney disease undergoing hemodialysis. Clinical and experimental nephrology. 2020 Aug; 24(8):725-733. doi: 10.1007/s10157-020-01892-x. [PMID: 32285213]
  • Tien-Hung Huang, Hon-Kan Yip, Cheuk-Kwan Sun, Yi-Ling Chen, Chih-Chao Yang, Fan-Yen Lee. P-cresyl sulfate causes mitochondrial hyperfusion in H9C2 cardiomyoblasts. Journal of cellular and molecular medicine. 2020 08; 24(15):8379-8390. doi: 10.1111/jcmm.15303. [PMID: 32639656]
  • Yu-Sen Peng, Jhih-Pu Syu, Sheng-De Wang, Pie-Chun Pan, Hsiu-Ni Kung. BSA-bounded p-cresyl sulfate potentiates the malignancy of bladder carcinoma by triggering cell migration and EMT through the ROS/Src/FAK signaling pathway. Cell biology and toxicology. 2020 08; 36(4):287-300. doi: 10.1007/s10565-019-09509-0. [PMID: 31873818]
  • Jia-Feng Chang, Chih-Yu Hsieh, Jian-Chiun Liou, Shih-Hao Liu, Chi-Feng Hung, Kuo-Cheng Lu, Chih-Cheng Lin, Chang-Chin Wu, Shuk-Man Ka, Li-Li Wen, Mai-Szu Wu, Cai-Mei Zheng, Wen-Chin Ko. Scavenging Intracellular ROS Attenuates p-Cresyl Sulfate-Triggered Osteogenesis through MAPK Signaling Pathway and NF-κB Activation in Human Arterial Smooth Muscle Cells. Toxins. 2020 07; 12(8):. doi: 10.3390/toxins12080472. [PMID: 32722241]
  • Isabelle Six, Nadia Flissi, Gaëlle Lenglet, Loïc Louvet, Said Kamel, Marlène Gallet, Ziad A Massy, Sophie Liabeuf. Uremic Toxins and Vascular Dysfunction. Toxins. 2020 06; 12(6):. doi: 10.3390/toxins12060404. [PMID: 32570781]
  • Jia-Feng Chang, Chih-Yu Hsieh, Kuo-Cheng Lu, Yue-Wen Chen, Shih-Shin Liang, Chih-Cheng Lin, Chi-Feng Hung, Jian-Chiun Liou, Mai-Szu Wu. Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease. Toxins. 2020 06; 12(6):. doi: 10.3390/toxins12060364. [PMID: 32498221]
  • Wendy J Dahl, Wei-Lun Hung, Amanda L Ford, Joon Hyuk Suh, Jerémié Auger, Varuni Nagulesapillai, Yu Wang. In older women, a high-protein diet including animal-sourced foods did not impact serum levels and urinary excretion of trimethylamine-N-oxide. Nutrition research (New York, N.Y.). 2020 06; 78(?):72-81. doi: 10.1016/j.nutres.2020.05.004. [PMID: 32544852]
  • Maxime Espi, Laetitia Koppe, Denis Fouque, Olivier Thaunat. Chronic Kidney Disease-Associated Immune Dysfunctions: Impact of Protein-Bound Uremic Retention Solutes on Immune Cells. Toxins. 2020 05; 12(5):. doi: 10.3390/toxins12050300. [PMID: 32384617]
  • Tae-Hee Lee, Dongsun Park, Yang Ji Kim, Isaac Lee, Suae Kim, Chang-Taek Oh, Joem-Yong Kim, Jihyun Yang, Sang-Kyung Jo. Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis. International journal of molecular medicine. 2020 Apr; 45(4):1130-1140. doi: 10.3892/ijmm.2020.4495. [PMID: 32124946]
  • Tessa Gryp, Geert R B Huys, Marie Joossens, Wim Van Biesen, Griet Glorieux, Mario Vaneechoutte. Isolation and Quantification of Uremic Toxin Precursor-Generating Gut Bacteria in Chronic Kidney Disease Patients. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21061986. [PMID: 32183306]
  • Maria Teresa Rocchetti, Carmela Cosola, Ighli di Bari, Stefania Magnani, Vanessa Galleggiante, Letizia Scandiffio, Giuseppe Dalfino, Giuseppe Stefano Netti, Mauro Atti, Roberto Corciulo, Loreto Gesualdo. Efficacy of Divinylbenzenic Resin in Removing Indoxyl Sulfate and P-Cresol Sulfate in Hemodialysis Patients: Results From an In Vitro Study and An In Vivo Pilot Trial (xuanro4-Nature 3.2). Toxins. 2020 03; 12(3):. doi: 10.3390/toxins12030170. [PMID: 32164382]
  • Silvia D Rodrigues, Sabrina S Santos, Tassiana Meireles, Natalia Romero, Griet Glorieux, Roberto Pecoits-Filho, Donna D Zhang, Lia S Nakao. Uremic toxins promote accumulation of oxidized protein and increased sensitivity to hydrogen peroxide in endothelial cells by impairing the autophagic flux. Biochemical and biophysical research communications. 2020 02; 523(1):123-129. doi: 10.1016/j.bbrc.2019.12.022. [PMID: 31837804]
  • Cheng-Jui Lin, Chiao-Yin Sun, Chih-Jen Wu, Chau-Chung Wu, Vincent Wu, Feng-Huei Lin. CharXgen-Activated Bamboo Charcoal Encapsulated in Sodium Alginate Microsphere as the Absorbent of Uremic Toxins to Retard Kidney Function Deterioration. International journal of molecular sciences. 2020 Feb; 21(4):. doi: 10.3390/ijms21041257. [PMID: 32070049]
  • Yan Rong, Tony K L Kiang. Mechanisms of Metabolism Interaction Between p-Cresol and Mycophenolic Acid. Toxicological sciences : an official journal of the Society of Toxicology. 2020 02; 173(2):267-279. doi: 10.1093/toxsci/kfz231. [PMID: 31742356]
  • Bartłomiej Sankowski, Karolina Księżarczyk, Emilia Raćkowska, Stanisław Szlufik, Dariusz Koziorowski, Joanna Giebułtowicz. Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. 2020 Feb; 501(?):165-173. doi: 10.1016/j.cca.2019.10.038. [PMID: 31726035]
  • Shih-Chieh Chen, Shin-Yin Huang, Chia-Chun Wu, Chiung-Fang Hsu. P-Cresylsulfate, the Protein-Bound Uremic Toxin, Increased Endothelial Permeability Partly Mediated by Src-Induced Phosphorylation of VE-Cadherin. Toxins. 2020 01; 12(2):. doi: 10.3390/toxins12020062. [PMID: 31973024]
  • Britt Opdebeeck, Patrick C D'Haese, Anja Verhulst. Molecular and Cellular Mechanisms that Induce Arterial Calcification by Indoxyl Sulfate and P-Cresyl Sulfate. Toxins. 2020 01; 12(1):. doi: 10.3390/toxins12010058. [PMID: 31963891]
  • Christiane Ishikawa Ramos, Rachel Gatti Armani, Maria Eugenia Canziani, Carla Juliana Ribeiro Dolenga, Lia Sumie Nakao, Katrina Louise Campbell, Lilian Cuppari. Bowel Habits and the Association With Uremic Toxins in Non-Dialysis-Dependent Chronic Kidney Disease Patients. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2020 01; 30(1):31-35. doi: 10.1053/j.jrn.2019.02.004. [PMID: 30956092]
  • I-Wen Wu, Chan-Yu Lin, Lun-Ching Chang, Chin-Chan Lee, Chih-Yung Chiu, Heng-Jung Hsu, Chiao-Yin Sun, Yuen-Chan Chen, Yu-Lun Kuo, Chi-Wei Yang, Sheng-Siang Gao, Wen-Ping Hsieh, Wen-Hung Chung, Hsin-Chih Lai, Shih-Chi Su. Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study. International journal of biological sciences. 2020; 16(3):420-434. doi: 10.7150/ijbs.37421. [PMID: 32015679]
  • Thatsanapong Pongking, Ornuma Haonon, Rungtiwa Dangtakot, Sudarat Onsurathum, Apinya Jusakul, Kitti Intuyod, Arunnee Sangka, Sirirat Anutrakulchai, Ubon Cha'on, Somchai Pinlaor, Porntip Pinlaor. A combination of monosodium glutamate and high-fat and high-fructose diets increases the risk of kidney injury, gut dysbiosis and host-microbial co-metabolism. PloS one. 2020; 15(4):e0231237. doi: 10.1371/journal.pone.0231237. [PMID: 32267892]
  • Johannes Holle, Marietta Kirchner, Jürgen Okun, Aysun K Bayazit, Lukasz Obrycki, Nur Canpolat, Ipek Kaplan Bulut, Karolis Azukaitis, Ali Duzova, Bruno Ranchin, Rukshana Shroff, Cengiz Candan, Jun Oh, Günter Klaus, Francesca Lugani, Charlotte Gimpel, Rainer Büscher, Alev Yilmaz, Esra Baskin, Hakan Erdogan, Ariane Zaloszyc, Gül Özcelik, Dorota Drozdz, Augustina Jankauskiene, Francois Nobili, Anette Melk, Uwe Querfeld, Franz Schaefer. Serum indoxyl sulfate concentrations associate with progression of chronic kidney disease in children. PloS one. 2020; 15(10):e0240446. doi: 10.1371/journal.pone.0240446. [PMID: 33108385]
  • Stacie Summers, Jessica M Quimby, Robert Kyle Phillips, Jonathan Stockman, Anitha Isaiah, Jonathan A Lidbury, Joerg M Steiner, Jan Suchodolski. Preliminary evaluation of fecal fatty acid concentrations in cats with chronic kidney disease and correlation with indoxyl sulfate and p-cresol sulfate. Journal of veterinary internal medicine. 2020 Jan; 34(1):206-215. doi: 10.1111/jvim.15634. [PMID: 31693251]
  • Yu-Hsien Lai, Chih-Hsien Wang, Chiu-Huang Kuo, Yu-Li Lin, Jen-Pi Tsai, Bang-Gee Hsu. Serum P-Cresyl Sulfate Is a Predictor of Central Arterial Stiffness in Patients on Maintenance Hemodialysis. Toxins. 2019 12; 12(1):. doi: 10.3390/toxins12010010. [PMID: 31877718]
  • Johannes Holle, Uwe Querfeld, Marietta Kirchner, Alexandros Anninos, Jürgen Okun, Daniela Thurn-Valsassina, Aysun Bayazit, Ana Niemirska, Nur Canpolat, Ipek Kaplan Bulut, Ali Duzova, Ali Anarat, Rukshana Shroff, Yelda Bilginer, Salim Caliskan, Cengiz Candan, Jerome Harambat, Zeynep Birsin Özcakar, Oguz Soylemezoglu, Sibylle Tschumi, Sandra Habbig, Ebru Yilmaz, Ayse Balat, Aleksandra Zurowska, Nilgun Cakar, Birgitta Kranz, Pelin Ertan, Anette Melk, Karolis Azukaitis, Franz Schaefer. Indoxyl sulfate associates with cardiovascular phenotype in children with chronic kidney disease. Pediatric nephrology (Berlin, Germany). 2019 12; 34(12):2571-2582. doi: 10.1007/s00467-019-04331-6. [PMID: 31428929]
  • Rita Paroni, Silvana Casati, Michele Dei Cas, Monica Bignotto, Federico Maria Rubino, Pierangela Ciuffreda. Unambiguous Characterization of p-Cresyl Sulfate, a Protein-Bound Uremic Toxin, as Biomarker of Heart and Kidney Disease. Molecules (Basel, Switzerland). 2019 Oct; 24(20):. doi: 10.3390/molecules24203704. [PMID: 31618977]
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