N,N-Dimethyl-4-(3-pyridin-4-ylprop-1-enyl)aniline (BioDeep_00000185416)

   

human metabolite blood metabolite


代谢物信息卡片


N,N-dimethyl-4-[3-(pyridin-4-yl)prop-1-en-1-yl]aniline

  化学式: C16H18N2 (238.147)
中文名称:
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)C1=CC=C(C=CCC2=CC=NC=C2)C=C1
InChI: InChI=1S/C16H18N2/c1-18(2)16-8-6-14(7-9-16)4-3-5-15-10-12-17-13-11-15/h3-4,6-13H,5H2,1-2H3


描述信息

同义名列表

2 个代谢物同义名

N,N-dimethyl-4-[3-(pyridin-4-yl)prop-1-en-1-yl]aniline; N,N-Dimethyl-4-(3-pyridin-4-ylprop-1-enyl)aniline



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Murat Oz, Dmytro Isaev, Dietrich E Lorke, Muhammed Hasan, Georg Petroianu, Toni S Shippenberg. Methylene blue inhibits function of the 5-HT transporter. British journal of pharmacology. 2012 May; 166(1):168-76. doi: 10.1111/j.1476-5381.2011.01462.x. [PMID: 21542830]
  • Hao-Jie Zhu, David I Appel, Dirk Gründemann, Elliott Richelson, John S Markowitz. Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action. Pharmacological research. 2012 Apr; 65(4):491-6. doi: 10.1016/j.phrs.2012.01.008. [PMID: 22342816]
  • Sabine Brast, Alexander Grabner, Sonja Sucic, Harald H Sitte, Edwin Hermann, Hermann Pavenstädt, Eberhard Schlatter, Giuliano Ciarimboli. The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Mar; 26(3):976-86. doi: 10.1096/fj.11-180679. [PMID: 22085643]
  • G Ahlin, L Chen, L Lazorova, Y Chen, A G Ianculescu, R L Davis, K M Giacomini, P Artursson. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions. The pharmacogenomics journal. 2011 Dec; 11(6):400-11. doi: 10.1038/tpj.2010.54. [PMID: 20567254]
  • Svenja K Holle, Giuliano Ciarimboli, Bayram Edemir, Ute Neugebauer, Hermann Pavenstädt, Eberhard Schlatter. Properties and regulation of organic cation transport in freshly isolated mouse proximal tubules analyzed with a fluorescence reader-based method. Pflugers Archiv : European journal of physiology. 2011 Aug; 462(2):359-69. doi: 10.1007/s00424-011-0969-7. [PMID: 21523352]
  • Murat Oz, Therissa Libby, Bronwyn Kivell, Vanaja Jaligam, Sammanda Ramamoorthy, Toni S Shippenberg. Real-time, spatially resolved analysis of serotonin transporter activity and regulation using the fluorescent substrate, ASP+. Journal of neurochemistry. 2010 Aug; 114(4):1019-29. doi: 10.1111/j.1471-4159.2010.06828.x. [PMID: 20524964]
  • Hao-Jie Zhu, David I Appel, Dirk Gründemann, John S Markowitz. Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. Journal of neurochemistry. 2010 Jul; 114(1):142-9. doi: 10.1111/j.1471-4159.2010.06738.x. [PMID: 20402963]
  • Murat Oz, Vanaja Jaligam, Sehamuddin Galadari, George Petroianu, Yaroslav M Shuba, Toni S Shippenberg. The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. Journal of neurochemistry. 2010 Mar; 112(6):1454-64. doi: 10.1111/j.1471-4159.2009.06557.x. [PMID: 20050977]
  • Martijn J Wilmer, Moin A Saleem, Rosalinde Masereeuw, Lan Ni, Thea J van der Velden, Frans G Russel, Peter W Mathieson, Leo A Monnens, Lambertus P van den Heuvel, Elena N Levtchenko. Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell and tissue research. 2010 Feb; 339(2):449-57. doi: 10.1007/s00441-009-0882-y. [PMID: 19902259]
  • S Wilde, E Schlatter, H Koepsell, B Edemir, S Reuter, H Pavenstädt, U Neugebauer, R Schröter, S Brast, G Ciarimboli. Calmodulin-associated post-translational regulation of rat organic cation transporter 2 in the kidney is gender dependent. Cellular and molecular life sciences : CMLS. 2009 May; 66(10):1729-40. doi: 10.1007/s00018-009-9145-z. [PMID: 19330287]
  • Anders Haunsø, Dawn Buchanan. Pharmacological characterization of a fluorescent uptake assay for the noradrenaline transporter. Journal of biomolecular screening. 2007 Apr; 12(3):378-84. doi: 10.1177/1087057107299524. [PMID: 17379857]
  • Ryan Wagstaff, Michael Hedrick, Jun Fan, Paul D Crowe, Daniel DiSepio. High-throughput screening for norepinephrine transporter inhibitors using the FLIPRTetra. Journal of biomolecular screening. 2007 Apr; 12(3):436-41. doi: 10.1177/1087057106297994. [PMID: 17438071]
  • Gabor Horvath, Nathalie Schmid, Miryam A Fragoso, Andreas Schmid, Gregory E Conner, Matthias Salathe, Adam Wanner. Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. American journal of respiratory cell and molecular biology. 2007 Jan; 36(1):53-60. doi: 10.1165/rcmb.2006-0230oc. [PMID: 16917073]
  • Jürgen Biermann, Detlef Lang, Valentin Gorboulev, Hermann Koepsell, Aleksandra Sindic, Rita Schröter, Aurelija Zvirbliene, Hermann Pavenstädt, Eberhard Schlatter, Giuliano Ciarimboli. Characterization of regulatory mechanisms and states of human organic cation transporter 2. American journal of physiology. Cell physiology. 2006 Jun; 290(6):C1521-31. doi: 10.1152/ajpcell.00622.2005. [PMID: 16394027]
  • Frank Pietruck, Markus Horbelt, Thorsten Feldkamp, Katrin Engeln, Stefan Herget-Rosenthal, Thomas Philipp, Andreas Kribben. Digital fluorescence imaging of organic cation transport in freshly isolated rat proximal tubules. Drug metabolism and disposition: the biological fate of chemicals. 2006 Mar; 34(3):339-42. doi: 10.1124/dmd.105.006403. [PMID: 16339355]
  • Giuliano Ciarimboli, Katja Struwe, Petra Arndt, Valentin Gorboulev, Hermann Koepsell, Eberhard Schlatter, Jochen R Hirsch. Regulation of the human organic cation transporter hOCT1. Journal of cellular physiology. 2004 Dec; 201(3):420-8. doi: 10.1002/jcp.20081. [PMID: 15389554]
  • Andrew Bahn, Yohannes Hagos, Tanja Rudolph, Gerhard Burckhardt. Mutation of amino acid 475 of rat organic cation transporter 2 (rOCT2) impairs organic cation transport. Biochimie. 2004 Feb; 86(2):133-6. doi: 10.1016/j.biochi.2003.12.001. [PMID: 15016452]
  • E Schlatter, V Mönnich, I Cetinkaya, T Mehrens, G Ciarimboli, J R Hirsch, C Popp, H Koepsell. The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP. The Journal of membrane biology. 2002 Oct; 189(3):237-44. doi: 10.1007/s00232-002-1023-7. [PMID: 12395288]