Zotarolimus (BioDeep_00000185140)
human metabolite blood metabolite
代谢物信息卡片
化学式: C52H79N5O12 (965.5724934)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 98.73%
分子结构信息
SMILES: COC1CC(CC(C)C2CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C)C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N3CCCCC3C(=O)O2)OC)CCC1N1C=NN=N1
InChI: InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3
描述信息
同义名列表
3 个代谢物同义名
1,18-dihydroxy-19,30-dimethoxy-12-{1-[3-methoxy-4-(1H-1,2,3,4-tetrazol-1-yl)cyclohexyl]propan-2-yl}-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; 1,18-dihydroxy-19,30-dimethoxy-12-{1-[3-methoxy-4-(1,2,3,4-tetrazol-1-yl)cyclohexyl]propan-2-yl}-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; Zotarolimus
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- David E Kandzari, Ajay J Kirtane, Stephan Windecker, Azeem Latib, Elvin Kedhi, Roxana Mehran, Matthew J Price, Alexandre Abizaid, Daniel I Simon, Stephen G Worthley, Azfar Zaman, James W Choi, Ronald Caputo, Mihir Kanitkar, Brent McLaurin, Srinivasa Potluri, Timothy Smith, Douglas Spriggs, Thaddeus Tolleson, Tamim Nazif, Maria Parke, Lilian C Lee, Te-Hsin Lung, Gregg W Stone. One-Month Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Zotarolimus-Eluting Stents in High-Bleeding-Risk Patients.
Circulation. Cardiovascular interventions.
2020 11; 13(11):e009565. doi:
10.1161/circinterventions.120.009565. [PMID: 33167705] - Ryota Kakizaki, Yoshiyasu Minami, Takehiro Hashikata, Teruyoshi Nemoto, Takuya Hashimoto, Kazuhiro Fujiyoshi, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako. Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation.
Coronary artery disease.
2018 12; 29(8):624-631. doi:
10.1097/mca.0000000000000654. [PMID: 29975201] - Matthew J Price, Richard A Shlofmitz, Douglas J Spriggs, Thomas A Haldis, Paul Myers, Alexandra Popma Almonacid, Akiko Maehara, Michelle Dauler, Yun Peng, Roxana Mehran. Safety and efficacy of the next generation Resolute Onyx zotarolimus-eluting stent: Primary outcome of the RESOLUTE ONYX core trial.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2018 08; 92(2):253-259. doi:
10.1002/ccd.27322. [PMID: 28940882] - Sho Torii, Gaku Nakazawa, Takeshi Ijichi, Ayako Yoshikawa, Yohei Ohno, Yuji Ikari. Comparison of the endothelial coverage in everolimus and zotarolimus-eluting stents in normal, atherosclerotic, and bifurcation rabbit iliac arteries.
Cardiovascular intervention and therapeutics.
2018 Jan; 33(1):55-61. doi:
10.1007/s12928-016-0437-6. [PMID: 27822890] - Matthew J Price, Shigeru Saito, Richard A Shlofmitz, Douglas J Spriggs, Michael Attubato, Brent McLaurin, Alexandra Popma Almonacid, Sandeep Brar, Minglei Liu, Elizabeth Moe, Roxana Mehran. First Report of the Resolute Onyx 2.0-mm Zotarolimus-Eluting Stent for the Treatment of Coronary Lesions With Very Small Reference Vessel Diameter.
JACC. Cardiovascular interventions.
2017 07; 10(14):1381-1388. doi:
10.1016/j.jcin.2017.05.004. [PMID: 28728650] - Yoshitaka Muraoka, Shinjo Sonoda, Kuninobu Kashiyama, Fumihiko Kamezaki, Yuki Tsuda, Masaru Araki, Masahito Tamura, Masaaki Takeuchi, Haruhiko Abe, Masahiro Okazaki, Yutaka Otsuji. Coronary arterial remodeling and out-stent plaque change after drug-eluting stent implantation--comparison between zotarolimus-eluting stents and paclitaxel-eluting stents.
Circulation journal : official journal of the Japanese Circulation Society.
2013; 77(2):363-71. doi:
10.1253/circj.cj-12-0575. [PMID: 23117679] - Jung-Sun Kim, Myeong-Ki Hong, Dong-Ho Shin, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang. Quantitative and qualitative changes in DES-related neointimal tissue based on serial OCT.
JACC. Cardiovascular imaging.
2012 Nov; 5(11):1147-55. doi:
10.1016/j.jcmg.2012.01.024. [PMID: 23153915] - Young-Guk Ko, Dong-Min Kim, Jin Man Cho, So Yeon Choi, Jung Han Yoon, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong. Optical coherence tomography findings of very late stent thrombosis after drug-eluting stent implantation.
The international journal of cardiovascular imaging.
2012 Apr; 28(4):715-23. doi:
10.1007/s10554-011-9905-3. [PMID: 21656060] - Soon Jun Hong, Seung Cheol Choi, Chul Min Ahn, Jae Hyung Park, Jae Sang Kim, Do-Sun Lim. Telmisartan reduces neointima volume and pulse wave velocity 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients.
Heart (British Cardiac Society).
2011 Sep; 97(17):1425-32. doi:
10.1136/hrt.2011.225193. [PMID: 21700754]