15R-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid (BioDeep_00000018507)

   

human metabolite Endogenous


代谢物信息卡片


(5Z,8Z,11Z,13E,15R,17Z)-15-hydroxyicosa-5,8,11,13,17-pentaenoic acid

化学式: C20H30O3 (318.2195)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(endogenous) 2.78%

分子结构信息

SMILES: CCC=CCC(O)C=CC=CCC=CCC=CCCCC(=O)O
InChI: InChI=1S/C20H30O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h3-5,8-11,13-14,17,19,21H,2,6-7,12,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,13-3-,17-14+/t19-/m1/s1

描述信息

15R-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid is also known as 15R-HEPE. 15R-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid is considered to be practically insoluble (in water) and acidic. 15R-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid is an eicosanoid lipid molecule

同义名列表

7 个代谢物同义名

(5Z,8Z,11Z,13E,15R,17Z)-15-hydroxyicosa-5,8,11,13,17-pentaenoic acid; (5Z,8Z,11Z,13E,15R,17Z)-15-Hydroxyicosapentaenoic acid; 15R-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid; (5Z,8Z,11Z,13E,15R,17Z)-15-Hydroxyicosapentaenoate; 15R-Hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoate; (+/-)15-HEPE; 15R-HEPE



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Kento Sawane, Takahiro Nagatake, Koji Hosomi, So-Ichiro Hirata, Jun Adachi, Yuichi Abe, Junko Isoyama, Hidehiko Suzuki, Ayu Matsunaga, Satoshi Fukumitsu, Kazuhiko Aida, Takeshi Tomonaga, Makoto Arita, Jun Kunisawa. Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice. Nutrients. 2019 11; 11(12):. doi: 10.3390/nu11122868. [PMID: 31766714]
  • Yana Y Toporkova, Svetlana S Gorina, Fakhima K Mukhitova, Mats Hamberg, Tatyana M Ilyina, Lucia S Mukhtarova, Alexander N Grechkin. Identification of CYP443D1 (CYP74 clan) of Nematostella vectensis as a first cnidarian epoxyalcohol synthase and insights into its catalytic mechanism. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2017 Oct; 1862(10 Pt A):1099-1109. doi: 10.1016/j.bbalip.2017.07.015. [PMID: 28774820]
  • Rima Chattopadhyay, Alexander Tinnikov, Elena Dyukova, Nikhlesh K Singh, Sivareddy Kotla, James A Mobley, Gadiparthi N Rao. 12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction. Journal of lipid research. 2015 Mar; 56(3):562-577. doi: 10.1194/jlr.m055566. [PMID: 25556764]
  • Charles B Stephensen, Patrice Armstrong, John W Newman, Theresa L Pedersen, Jillian Legault, Gertrud U Schuster, Darshan Kelley, Susanna Vikman, Jaana Hartiala, Rami Nassir, Michael F Seldin, Hooman Allayee. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. Journal of lipid research. 2011 May; 52(5):991-1003. doi: 10.1194/jlr.p012864. [PMID: 21296957]
  • Nguyen Dang Hung, Mee Ree Kim, Dai-Eun Sok. Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis. British journal of pharmacology. 2011 Mar; 162(5):1119-35. doi: 10.1111/j.1476-5381.2010.01117.x. [PMID: 21091644]
  • Hiroyasu Inoue. [Endogenous ligands for PPARs]. Nihon rinsho. Japanese journal of clinical medicine. 2005 Apr; 63(4):578-83. doi: ". [PMID: 15828223]
  • . . . . doi: . [PMID: 11034610]