VASICINONE (BioDeep_00000184916)

   

human metabolite blood metabolite natural product


代谢物信息卡片


1H-Pyrrolo[2,1-b]quinazolin-9-one, 3-hydroxy-2,3-dihydro-

化学式: C11H10N2O2 (202.07422400000002)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 9.3%

分子结构信息

SMILES: c1ccc2c(c1)c(=O)n1CC[C@@H](c1n2)O
InChI: InChI=1S/C11H10N2O2/c14-9-5-6-13-10(9)12-8-4-2-1-3-7(8)11(13)15/h1-4,9,14H,5-6H2

描述信息

同义名列表

4 个代谢物同义名

1H-Pyrrolo[2,1-b]quinazolin-9-one, 3-hydroxy-2,3-dihydro-; 3-hydroxy-1H,2H,3H,9H-pyrrolo[2,1-b]quinazolin-9-one; 3-hydroxy-1H,2H,3H-pyrrolo[2,1-b]quinazolin-9-one; Vasicinone



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

37 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Syeda Tehreem, Saeedur Rahman, Muhammad Salman Bhatti, Reaz Uddin, Muhammad Noman Khan, Saba Tauseef, Hesham R El-Seedi, Abdullatif Bin Muhsinah, Jalal Uddin, Syed Ghulam Musharraf. A UPLC-DAD-Based Bio-Screening Assay for the Evaluation of the Angiotensin Converting Enzyme Inhibitory Potential of Plant Extracts and Compounds: Pyrroquinazoline Alkaloids from Adhatoda vasica as a Case Study. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226971. [PMID: 34834066]
  • Renren Bai, Chuansheng Yao, Zhichao Zhong, Jiamin Ge, Ziqiang Bai, Xiangyang Ye, Tian Xie, Yuanyuan Xie. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation. European journal of medicinal chemistry. 2021 Mar; 213(?):113165. doi: 10.1016/j.ejmech.2021.113165. [PMID: 33454546]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Da-Tong Ju, Kalaiselvi Sivalingam, Wei-Wen Kuo, Tsung-Jung Ho, Ruey-Lin Chang, Li-Chin Chung, Cecilia Hsuan Day, Vijaya Padma Viswanadha, Po-Hsiang Liao, Chih-Yang Huang. Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model. Nutrients. 2019 Jul; 11(7):. doi: 10.3390/nu11071655. [PMID: 31331066]
  • Bharat Singh, Pooran M Sahu, Ram A Sharma. Effect of elicitors on the production of pyrroloquinazoline alkaloids by stimulating anthranilate synthase activity in Adhatoda vasica Nees cell cultures. Planta. 2017 Dec; 246(6):1125-1137. doi: 10.1007/s00425-017-2757-x. [PMID: 28819874]
  • Wei Liu, Yongli Wang, Dan-dan He, Shu-ping Li, Yu-dan Zhu, Bo Jiang, Xue-mei Cheng, Zheng--tao Wang, Chang-hong Wang. Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Nov; 22(12):1088-95. doi: 10.1016/j.phymed.2015.08.005. [PMID: 26547531]
  • Chaitali Sarkar, Sankhadip Bose, Sugato Banerjee. Evaluation of hepatoprotective activity of vasicinone in mice. Indian journal of experimental biology. 2014 Jul; 52(7):705-11. doi: ". [PMID: 25059038]
  • Bharat Singh, Ram Avtar Sharma. Anti-inflammatory and antimicrobial properties of pyrroloquinazoline alkaloids from Adhatoda vasica Nees. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Mar; 20(5):441-5. doi: 10.1016/j.phymed.2012.12.015. [PMID: 23357363]
  • Deepak Kumar Jha, Likun Panda, P Lavanya, Sudha Ramaiah, Anand Anbarasu. Detection and confirmation of alkaloids in leaves of Justicia adhatoda and bioinformatics approach to elicit its anti-tuberculosis activity. Applied biochemistry and biotechnology. 2012 Nov; 168(5):980-90. doi: 10.1007/s12010-012-9834-1. [PMID: 22899014]
  • Bin Liu. [Study on chemical constituents of Peganum multisectum]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Nov; 34(11):1719-21. doi: . [PMID: 22506396]
  • Adil Astulla, Kazumasa Zaima, Yosuke Matsuno, Yusuke Hirasawa, Wiwied Ekasari, Aty Widyawaruyanti, Noor Cholies Zaini, Hiroshi Morita. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. Journal of natural medicines. 2008 Oct; 62(4):470-2. doi: 10.1007/s11418-008-0259-7. [PMID: 18523842]
  • B Avula, S Begum, S Ahmed, M I Choudhary, I A Khan. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis. Die Pharmazie. 2008 Jan; 63(1):20-2. doi: . [PMID: 18271297]
  • Chaitali Das, Rajlakshmi Poi, Ashim Chowdhury. HPTLC determination of vasicine and vasicinone in Adhatoda vasica. Phytochemical analysis : PCA. 2005 Mar; 16(2):90-2. doi: 10.1002/pca.817. [PMID: 15881115]
  • D S Samiulla, V V Vaidyanathan, P C Arun, G Balan, M Blaze, S Bondre, G Chandrasekhar, A Gadakh, R Kumar, G Kharvi, H O Kim, S Kumar, J A Malikayil, M Moger, M K Mone, P Nagarjuna, C Ogbu, D Pendhalkar, A V S Raja Rao, G Venkateshwar Rao, V K Sarma, S Shaik, G V R Sharma, S Singh, C Sreedhar, R Sonawane, U Timmanna, L W Hardy. Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery. Molecular diversity. 2005; 9(1-3):131-9. doi: 10.1007/s11030-005-1297-7. [PMID: 15789560]
  • P E Phillips. The virus hypothesis in systemic lupus erythematosus. Annals of internal medicine. 1975 Nov; 83(5):709-15. doi: 10.7326/0003-4819-83-5-709. [PMID: 938]