Thiazolidine-4-carboxylic acid (BioDeep_00000184345)

   

human metabolite blood metabolite


代谢物信息卡片


Thiazolidine-4-carboxylic acid, sodium salt

化学式: C4H7NO2S (133.0197)
中文名称: 噻莫西酸
谱图信息: 最多检出来源 Homo sapiens(not specific) 0.99%

分子结构信息

SMILES: C1C(NCS1)C(=O)O
InChI: InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)

描述信息

C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C2131 - Differentiation Inhibitor
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D020011 - Protective Agents > D000975 - Antioxidants
D020011 - Protective Agents > D000931 - Antidotes
D000970 - Antineoplastic Agents

同义名列表

25 个代谢物同义名

Thiazolidine-4-carboxylic acid, sodium salt; Thiazolidine-4-carboxylic acid, (R)-isomer; Acide DL thiazolidine carboxylique-4; 1,3-thiazolidine-4-carboxylic acid; Acide thiazolidine-4-carboxylique; Thiazolidine-4-carboxylic acid; DL-Thiazolidinecarboxylic acid; 4-Thiazolidinecarboxylic acid; THIAZOLIDINECARBOXYLIC ACID; DL-Thiazolidinecarboxylate; Thiazolidine-4-carboxylate; 4-Thiazolidinecarboxylate; Thiazolidinecarboxylate; 4-Carboxythiazolidine; gamma-Thiaproline; DL-Thiaproline; L-Thioproline; Timonacicum; Thiaproline; Timonacico; Timonacic; Heparegen; Norgamem; Hepacom; Timonacic



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • K S Alshallash, I A Elnaggar, A N Abd El-Wahed, A Fahmy, A M Tawfeeq, E M Hammad, A A Almashad, A I Elmezien, A E Hamdy, I M Taha. Using chitosan nanoparticles and N-acetyl thiazolidine 4-carboxylic acid for olive trees efficiency raising, improving fruits properties and oil quality. Brazilian journal of biology = Revista brasleira de biologia. 2023; 83(?):e273643. doi: 10.1590/1519-6984.273643. [PMID: 37729315]
  • Yun Zhai, Heping Cui, Khizar Hayat, Shahzad Hussain, Muhammad Usman Tahir, Shibin Deng, Qiang Zhang, Xiaoming Zhang, Chi-Tang Ho. Transformation between 2-Threityl-thiazolidine-4-carboxylic Acid and Xylose-Cysteine Amadori Rearrangement Product Regulated by pH Adjustment during High-Temperature Instantaneous Dehydration. Journal of agricultural and food chemistry. 2020 Sep; 68(39):10884-10892. doi: 10.1021/acs.jafc.0c04287. [PMID: 32902964]
  • Jenelle A Patterson, Hai He, Jacob S Folz, Qiang Li, Mark A Wilson, Oliver Fiehn, Steven D Bruner, Arren Bar-Even, Andrew D Hanson. Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli. The Biochemical journal. 2020 05; 477(9):1745-1757. doi: 10.1042/bcj20200198. [PMID: 32301498]
  • Takashi Tsuji, Morio Matsumoto, Masaya Nakamura, Takeshi Miyamoto, Mitsuru Yagi, Nobuyuki Fujita, Eijiro Okada, Narihito Nagoshi, Osahiko Tsuji, Kota Watanabe. Metabolite profiling of plasma in patients with ossification of the posterior longitudinal ligament. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. 2018 Nov; 23(6):878-883. doi: 10.1016/j.jos.2018.07.001. [PMID: 30075996]
  • Gregorio Barba-Espin, Eduardo Nicolas, Maria Soledad Almansa, Elena Cantero-Navarro, Alfonso Albacete, José Antonio Hernández, Pedro Díaz-Vivancos. Role of thioproline on seed germination: interaction ROS-ABA and effects on antioxidative metabolism. Plant physiology and biochemistry : PPB. 2012 Oct; 59(?):30-6. doi: 10.1016/j.plaphy.2011.12.002. [PMID: 22244306]
  • Hyun Woo Jeong, Joo-Won Lee, Woo Sik Kim, Sung Sik Choe, Kyung-Hee Kim, Ho Seon Park, Hyun Jung Shin, Gha Young Lee, Dongkyu Shin, Hanjae Lee, Jun Hee Lee, Eun Bok Choi, Hyeon Kyu Lee, Heekyoung Chung, Seung Bum Park, Kyong Soo Park, Hyo-Soo Kim, Seonggu Ro, Jae Bum Kim. A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma. Diabetes. 2011 Feb; 60(2):496-506. doi: 10.2337/db09-1145. [PMID: 21270261]
  • Yoshio Fujita, Peter M Moyle, Suzanne Hieu, Pavla Simerska, Istvan Toth. Investigation toward multi-epitope vaccine candidates using native chemical ligation. Biopolymers. 2008; 90(5):624-32. doi: 10.1002/bip.21002. [PMID: 18979543]
  • Guang-Yong Li, Hye-Young Lee, Ho-Sang Shin, Hyeon-Young Kim, Cheol-Hong Lim, Byung-Hoon Lee. Identification of gene markers for formaldehyde exposure in humans. Environmental health perspectives. 2007 Oct; 115(10):1460-6. doi: 10.1289/ehp.10180. [PMID: 17938736]
  • Ho-Sang Shin, Hye-Sil Ahn, Byung-Hoon Lee. Determination of thiazolidine-4-carboxylates in urine by chloroformate derivatization and gas chromatography-electron impact mass spectrometry. Journal of mass spectrometry : JMS. 2007 Sep; 42(9):1225-32. doi: 10.1002/jms.1255. [PMID: 17610311]
  • Duhee Bang, Stephen B H Kent. A one-pot total synthesis of crambin. Angewandte Chemie (International ed. in English). 2004 May; 43(19):2534-8. doi: 10.1002/anie.200353540. [PMID: 15127445]
  • John E Moulder, Brian L Fish, Kevin R Regner, Eric P Cohen, Thomas J Raife. Retinoic acid exacerbates experimental radiation nephropathy. Radiation research. 2002 Feb; 157(2):199-203. doi: 10.1667/0033-7587(2002)157[0199:raeern]2.0.co;2. [PMID: 11835684]
  • L M Reese, K O Cutler, C E Deutch. Sensitivity of Escherichia coli to proline analogues during osmotic stress and anaerobiosis. Letters in applied microbiology. 1996 Mar; 22(3):202-5. doi: 10.1111/j.1472-765x.1996.tb01143.x. [PMID: 8852348]
  • M Tsuda, Y Kurashima, H Kosaka, H Ohshima, T Sugimura, H Esumi. Marked increase in urinary excretion of nitrate and N-nitrosothioproline in the osteogenic disordered syndrome rats, lacking ascorbic acid biosynthesis, by administration of lipopolysaccharide and thioproline. Carcinogenesis. 1995 Nov; 16(11):2653-7. doi: 10.1093/carcin/16.11.2653. [PMID: 7586182]
  • L Włodek, A Grabowska, J Marcinkiewicz. The modulation of IL-2 dependent proliferation of CTLL-2 cells by 2-methyl-thiazolidine-2,4-dicarboxylic acid. Immunopharmacology. 1995 Jun; 30(1):51-8. doi: 10.1016/0162-3109(95)00004-d. [PMID: 7591713]
  • Y Q Zhao, M Kinuta, T Abe, W B Yao, T Ubuka. A method for determination of total glutathione and total cysteine as S-carboxymethyl derivatives by using an amino acid analyzer, and its application to samples from rat liver, kidney and blood after intraperitoneal administration of 2-(4-carboxy-D-gluco-tetrahydroxybutyl)thiazolidine-4-carboxylic acid. Acta medica Okayama. 1995 Feb; 49(1):35-42. doi: 10.18926/amo/30413. [PMID: 7762408]
  • L Wlodek, H Rommelspacher. Ethanol-induced changes in the content of thiol compounds and of lipid peroxidation in livers and brains from mice: protection by thiazolidine derivatives. Alcohol and alcoholism (Oxford, Oxfordshire). 1994 Nov; 29(6):649-57. doi: 10.1093/oxfordjournals.alcalc.a045599. [PMID: 7695779]
  • B Lubec, A Rokitansky, M Hayde, C Aufricht, U Wagner, W R Mallinger, H Höger, G Lubec. Thiaproline reduces glomerular basement membrane thickness and collagen accumulation in the db/db mouse. Nephron. 1994; 66(3):333-6. doi: 10.1159/000187832. [PMID: 8190187]
  • M Otsuka, Y Sakashita, N Arakawa, M Tsuda. Studies on endogenous formation of N-nitroso compounds in the guinea pig supplemented with proline or thioproline and sodium nitrate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1992 Sep; 30(9):765-9. doi: 10.1016/0278-6915(92)90078-y. [PMID: 1427514]
  • M A Recasens, B Possompes, C Astre, B Saint Aubert, H Joyeux. Thiazolidine-4-carboxylate and 2-phenylthiazolidine-4-carboxylate are active as cysteine precursors but have no effect on growth of a methionine-dependent tumor in rats. The Journal of nutrition. 1992 Jan; 122(1):19-27. doi: 10.1093/jn/122.1.19. [PMID: 1729469]
  • K Boudjema, S L Lindell, J H Southard, F O Belzer. Changes in glutathione concentration in hypothermically perfused dog kidneys. The Journal of laboratory and clinical medicine. 1991 Feb; 117(2):131-7. doi: NULL. [PMID: 1993854]
  • M Tsuda, Y Kurashima. Nitrite-trapping capacity of thioproline in the human body. IARC scientific publications. 1991; ?(105):123-8. doi: NULL. [PMID: 1855835]
  • N Frank, M Tsuda, H Ohgaki, E Frei, T Kato, S Sato. Detoxifying potential of thioproline against N-nitroso compounds, N-nitrosodimethylamine and N-nitrosocimetidine. Cancer letters. 1990 Apr; 50(3):167-72. doi: 10.1016/0304-3835(90)90260-5. [PMID: 2322930]
  • J Alary, G Carrera, G De Saint Blanquat, F Anglade, C Escrieut. Reversed-phase ion-pair high-performance liquid chromatographic determination of 2-carboxythiazolidine-4-carboxylic acid in plasma. Journal of chromatography. 1989 Nov; 496(2):485-92. doi: 10.1016/s0378-4347(00)82599-2. [PMID: 2613851]
  • M Miwa, M Tsuda, Y Kurashima, H Hara, Y Tanaka, K Shinohara. Macrophage-mediated N-nitrosation of thioproline and proline. Biochemical and biophysical research communications. 1989 Mar; 159(2):373-8. doi: 10.1016/0006-291x(89)90001-6. [PMID: 2930520]
  • M Tsuda, N Frank, S Sato, T Sugimura. Marked increase in the urinary level of N-nitrosothioproline after ingestion of cod with vegetables. Cancer research. 1988 Jul; 48(14):4049-52. doi: NULL. [PMID: 3383197]
  • S Böhler. [L-thiazolidine-4-carboxylic acid as a source of cysteine in parenteral nutrition]. Infusionstherapie (Basel, Switzerland). 1988 Apr; 15(2):52-7. doi: NULL. [PMID: 3135273]
  • J C Roberts, H T Nagasawa, R T Zera, R F Fricke, D J Goon. Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids. Journal of medicinal chemistry. 1987 Oct; 30(10):1891-6. doi: 10.1021/jm00393a034. [PMID: 3656363]
  • T Tahira, M Tsuda, K Wakabayashi, M Nagao, T Sugimura. Kinetics of nitrosation of thioproline, the precursor of a major nitroso compound in human urine, and its role as a nitrite scavenger. Gan. 1984 Oct; 75(10):889-94. doi: NULL. [PMID: 6510636]
  • K Hemminki. Urinary excretion products of formaldehyde in the rat. Chemico-biological interactions. 1984 Feb; 48(2):243-8. doi: 10.1016/0009-2797(84)90125-x. [PMID: 6697422]
  • H Ohshima, M Friesen, I O'Neill, H Bartsch. Presence in human urine of a new N-nitroso compound, N-nitrosothiazolidine 4-carboxylic acid. Cancer letters. 1983 Sep; 20(2):183-90. doi: 10.1016/0304-3835(83)90047-2. [PMID: 6667458]
  • M F Harmand, P Blanquet. Pharmacokinetics and metabolism of [35S]-Thiazolidine carboxylic acid in the rat. I. Elimination and distribution. European journal of drug metabolism and pharmacokinetics. 1982 Oct; 7(4):323-7. doi: 10.1007/bf03189636. [PMID: 7166184]
  • S Nasca, V Galichet, J C Jardillier, E Garbe, P Coninx. Thioproline toxicity. Lancet (London, England). 1981 Apr; 1(8223):778. doi: 10.1016/s0140-6736(81)92648-9. [PMID: 6110977]
  • J Lankelma, P G Penders, A Leyva, H M Pinedo. Determination of thioproline in plasma using high performance liquid chromatography. Cancer letters. 1981 Mar; 12(1-2):131-7. doi: 10.1016/0304-3835(81)90048-3. [PMID: 7272996]
  • R Coccia, C Blarzino, C Foppoli, C Cini. Oxidation of D-thiazolidine-4-carboxylic acid by hog kidney D-aminoacid oxidase. The Italian journal of biochemistry. 1979 Jul; 28(4):252-60. doi: NULL. [PMID: 42631]