N6-Methyladenosine (BioDeep_00000018429)

 

Secondary id: BioDeep_00000405736, BioDeep_00000406157

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2R,3S,4R,5R)-2-Hydroxymethyl-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol

化学式: C11H15N5O4 (281.11239900000004)
中文名称: N6-甲基腺苷, N6 -甲基腺苷
谱图信息: 最多检出来源 Homo sapiens(feces) 1.32%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

N6-Methyladenosine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/n6-methyladenosine (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000018429). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O
InChI: InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1

描述信息

N6-Methyladenosine is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological markers for patients with colorectal cancer. tRNA has been shown to be excreted in abnormal amounts in the urine of cancer patients. tRNA from neoplastic tissue had a much more rapid turnover rate than the tRNA from the corresponding normal tissue. Evidence indicates that methylation of tRNA occurs only after synthesis of the intact macromolecule. Because there are no specific enzyme systems to incorporate the modified nucleosides into the macromolecular nucleic acid, these nucleosides once released in the process of tRNA turnover cannot be reutilized, nor are they further degraded, but are excreted in urine. (PMID: 15991285, 3506820) [HMDB]
N6-Methyladenosine is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological markers for patients with colorectal cancer. tRNA has been shown to be excreted in abnormal amounts in the urine of cancer patients. tRNA from neoplastic tissue had a much more rapid turnover rate than the tRNA from the corresponding normal tissue. Evidence indicates that methylation of tRNA occurs only after synthesis of the intact macromolecule. Because there are no specific enzyme systems to incorporate the modified nucleosides into the macromolecular nucleic acid, these nucleosides once released in the process of tRNA turnover cannot be reutilized, nor are they further degraded, but are excreted in urine. (PMID: 15991285, 3506820).
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

同义名列表

17 个代谢物同义名

(2R,3S,4R,5R)-2-Hydroxymethyl-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylamino)-9H-purin-9-yl]oxolane-3,4-diol; 6-methylamino-9-beta-delta-Ribofuranosyl-purine; 6-methylamino-9-beta-D-Ribofuranosyl-purine; 6-Methyladenosine;N-Methyladenosine; 6-Methylaminopurine ribonucleoside; 6-Methylaminopurine D-riboside; 6-Methylaminopurine riboside; N(6)-Monomethyladenosine; 6-Methylaminopurinosine; N(6)-Methyladenosine; N6-Methyladenosine; 6-Methyladenosine; N-Methyladenosine; N(6)MAdo; m6a; N6-methyladenosine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

30 个相关的代谢反应过程信息。

Reactome(30)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cong Chen, Cai Jiang, Ting Lin, Yue Hu, Huijuan Wu, Qing Xiang, Minguang Yang, Sinuo Wang, Xiao Han, Jing Tao. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise. Acta physiologica (Oxford, England). 2024 Jun; 240(6):e14154. doi: 10.1111/apha.14154. [PMID: 38682314]
  • Junjie Pan, Fei Tong, Ning Ren, Lanqi Ren, Yibei Yang, Feng Gao, Qiaoping Xu. Role of N6‑methyladenosine in the pathogenesis, diagnosis and treatment of prostate cancer (Review). Oncology reports. 2024 06; 51(6):. doi: 10.3892/or.2024.8747. [PMID: 38757383]
  • Minggui Song, Jiawen Zhao, Chujun Zhang, Chengchao Jia, Jing Yang, Haonan Zhao, Jingjing Zhai, Beilei Lei, Shiheng Tao, Siqi Chen, Ran Su, Chuang Ma. PEA-m6A: an ensemble learning framework for accurately predicting N6-methyladenosine modifications in plants. Plant physiology. 2024 May; 195(2):1200-1213. doi: 10.1093/plphys/kiae120. [PMID: 38428981]
  • Yi-Hao Min, Wen-Xuan Shao, Qiu-Shuang Hu, Neng-Bin Xie, Shan Zhang, Yu-Qi Feng, Xi-Wen Xing, Bi-Feng Yuan. Simultaneous Detection of Adenosine-to-Inosine Editing and N6-Methyladenosine at Identical RNA Sites through Deamination-Assisted Reverse Transcription Stalling. Analytical chemistry. 2024 May; 96(21):8730-8739. doi: 10.1021/acs.analchem.4c01022. [PMID: 38743814]
  • Tian-Long Wang, Xiao-Juan Miao, Yan-Rong Shuai, Hao-Ping Sun, Xiao Wang, Min Yang, Nan Zhang. FAT1 inhibits the proliferation of DLBCL cells via increasing the m6A modification of YAP1 mRNA. Scientific reports. 2024 05; 14(1):11836. doi: 10.1038/s41598-024-62793-7. [PMID: 38782965]
  • Wanli Ji, Yan Huo, Yifan Zhang, Xiaojing Qian, Yi Ren, Cheng Hu, Jiaqi Zhang. Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis. International immunopharmacology. 2024 May; 132(?):111968. doi: 10.1016/j.intimp.2024.111968. [PMID: 38579565]
  • Ye Zhao, Kun-Jin Han, Yan-Ting Tian, Kai-Hua Jia, Yousry A El-Kassaby, Yue Wu, Jie Liu, Hua-Yu Si, Yu-Han Sun, Yun Li. N6-methyladenosine mRNA methylation positively regulated the response of poplar to salt stress. Plant, cell & environment. 2024 May; 47(5):1797-1812. doi: 10.1111/pce.14844. [PMID: 38314665]
  • Huayue Liu, Mengzhuo Lin, Hui Wang, Xue Li, Die Zhou, Xiaojing Bi, Yunwei Zhang. N6-methyladenosine analysis unveils key mechanisms underlying long-term salt stress tolerance in switchgrass (Panicum virgatum). Plant science : an international journal of experimental plant biology. 2024 May; 342(?):112023. doi: 10.1016/j.plantsci.2024.112023. [PMID: 38320658]
  • Jie Chen, Ziying Guan, Lina Sun, Xinlin Fan, Desen Wang, Xiaoqiang Yu, Lihua Lyu, Guojun Qi. N6-methyladenosine modification of RNA controls dopamine synthesis to influence labour division in ants. Molecular ecology. 2024 Apr; 33(8):e17322. doi: 10.1111/mec.17322. [PMID: 38501589]
  • Jiayao Wang, Jiehao Zhang, Hao Liu, Lingnan Meng, Xianchun Gao, Yihan Zhao, Chen Wang, Xiaoliang Gao, Ahui Fan, Tianyu Cao, Daiming Fan, Xiaodi Zhao, Yuanyuan Lu. N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer. Cancer communications (London, England). 2024 Apr; 44(4):469-490. doi: 10.1002/cac2.12534. [PMID: 38512764]
  • Xiangdong Fan, Yitong Zhang, Ruiying Guo, Kuo Yue, Guy Smagghe, Yongyue Lu, Luoluo Wang. Decoding epitranscriptomic regulation of viral infection: mapping of RNA N6-methyladenosine by advanced sequencing technologies. Cellular & molecular biology letters. 2024 Mar; 29(1):42. doi: 10.1186/s11658-024-00564-y. [PMID: 38539075]
  • Gang Tu, Xuan Wang, Rong Xia, Bowen Song. m6A-TCPred: a web server to predict tissue-conserved human m6A sites using machine learning approach. BMC bioinformatics. 2024 Mar; 25(1):127. doi: 10.1186/s12859-024-05738-1. [PMID: 38528499]
  • Xiaowei Wu, Tingting Su, Songyao Zhang, Yu Zhang, Chui Eng Wong, Jinqi Ma, Yanlin Shao, Changmei Hua, Lisha Shen, Hao Yu. N6-methyladenosine-mediated feedback regulation of abscisic acid perception via phase-separated ECT8 condensates in Arabidopsis. Nature plants. 2024 03; 10(3):469-482. doi: 10.1038/s41477-024-01638-7. [PMID: 38448725]
  • Mengjie Zhu, Nan Wu, Jiayi Zhong, Chen Chen, Wenwen Liu, Yingdang Ren, Xifeng Wang, Huaibing Jin. N6-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector. Cell reports. 2024 Feb; 43(2):113821. doi: 10.1016/j.celrep.2024.113821. [PMID: 38368611]
  • Huan Su, Lijun Meng, Zechao Qu, Wei Zhang, Nan Liu, Peijian Cao, Jingjing Jin. Genome-wide identification of the N6-methyladenosine regulatory genes reveals NtFIP37B increases drought resistance of tobacco (Nicotiana tabacum L.). BMC plant biology. 2024 Feb; 24(1):134. doi: 10.1186/s12870-024-04813-2. [PMID: 38403644]
  • Peng Xu, Kanghui Liu, Shansong Huang, Jialun Lv, Zhengyuan Yan, Han Ge, Quan Cheng, Zetian Chen, Peicheng Ji, Yawei Qian, Bowen Li, Hao Xu, Li Yang, Zekuan Xu, Diancai Zhang. N6-methyladenosine-modified MIB1 promotes stemness properties and peritoneal metastasis of gastric cancer cells by ubiquitinating DDX3X. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024 Jan; ?(?):. doi: 10.1007/s10120-023-01463-5. [PMID: 38252226]
  • Xinbin Zheng, Bo Zhou, Yuzhen Li, Hengren Zhong, Zhengxin Huang, Minhua Gu. Transcriptome-wide N6-methyladenosine methylation profile of atherosclerosis in mice. BMC genomics. 2023 Dec; 24(1):774. doi: 10.1186/s12864-023-09878-1. [PMID: 38097926]
  • Dandan Feng, Pengfei Li, Wei Xiao, Zhuan Pei, Peishun Chen, Mingrui Hu, Zhaoyu Yang, Teng Li, Zian Xia, Hanjin Cui, Haigang Li, Qing Huang, Wei Zhang, Tao Tang, Yang Wang. N6-methyladenosine profiling reveals that Xuefu Zhuyu decoction upregulates METTL14 and BDNF in a rat model of traumatic brain injury. Journal of ethnopharmacology. 2023 Dec; 317(?):116823. doi: 10.1016/j.jep.2023.116823. [PMID: 37348798]
  • Ping Luo, Shiqi Li, Wei Jing, Jiancheng Tu, Xinghua Long. N6-methyladenosine RNA modification in nonalcoholic fatty liver disease. Trends in endocrinology and metabolism: TEM. 2023 12; 34(12):838-848. doi: 10.1016/j.tem.2023.09.002. [PMID: 37758602]
  • Wil Prall, Arsheed H Sheikh, Jeremie Bazin, Jean Bigeard, Marilia Almeida-Trapp, Martin Crespi, Heribert Hirt, Brian D Gregory. Pathogen-induced m6A dynamics affect plant immunity. The Plant cell. 2023 Oct; 35(11):4155-4172. doi: 10.1093/plcell/koad224. [PMID: 37610247]
  • Jingyuan Zhang, Tianming Qiu, Xiaofeng Yao, Xiance Sun. Insights into the role of N6-methyladenosine in ferroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Sep; 165(?):115192. doi: 10.1016/j.biopha.2023.115192. [PMID: 37487443]
  • Xiaoyang Dou, Yu Xiao, Chao Shen, Kitty Wang, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen, Jianjun Chen, Chuan He. RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation. Nature cell biology. 2023 Aug; ?(?):. doi: 10.1038/s41556-023-01213-w. [PMID: 37640841]
  • Ying Lv, Fei Han, Mengxia Liu, Ting Zhang, Guanshen Cui, Jiaojiao Wang, Ying Yang, Yun-Gui Yang, Wenqiang Yang. Characteristics of N6-methyladenosine Modification During Sexual Reproduction of Chlamydomonas reinhardtii. Genomics, proteomics & bioinformatics. 2023 Aug; 21(4):756-768. doi: 10.1016/j.gpb.2022.04.004. [PMID: 35550876]
  • Yini Li, Xiaoyang Dou, Jun Liu, Yu Xiao, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W Ostrow, Chuan He, Shuying Sun. Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nature neuroscience. 2023 08; 26(8):1328-1338. doi: 10.1038/s41593-023-01374-9. [PMID: 37365312]
  • Junliang Li, Jiayuan Wang, Qiuying Pang, Xiufeng Yan. Analysis of N6-methyladenosine reveals a new important mechanism regulating the salt tolerance of sugar beet (Beta vulgaris). Plant science : an international journal of experimental plant biology. 2023 Jul; 335(?):111794. doi: 10.1016/j.plantsci.2023.111794. [PMID: 37459955]
  • Yimeng Cui, Peiwei Wang, Mengli Li, Yujue Wang, Xinmiao Tang, Jingang Cui, Yu Chen, Teng Zhang. Cinnamic acid mitigates left ventricular hypertrophy and heart failure in part through modulating FTO-dependent N6-methyladenosine RNA modification in cardiomyocytes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115168. doi: 10.1016/j.biopha.2023.115168. [PMID: 37453198]
  • Jun Tang, Shuyan Chen, Guifang Jia. Detection, regulation, and functions of RNA N6-methyladenosine modification in plants. Plant communications. 2023 05; 4(3):100546. doi: 10.1016/j.xplc.2023.100546. [PMID: 36627844]
  • Long Cai, Song Cui, Tao Jin, Xiaolong Huang, Haigang Hou, Benyuan Hao, Zhuang Xu, Liang Cai, Yuan Hu, Xue Yang, Lei Zhou, Ting Yu, Yunlu Tian, Xi Liu, Liangming Chen, Shijia Liu, Ling Jiang, Shirong Zhou, Jianmin Wan. The N6-methyladenosine binding proteins YTH03/05/10 coordinately regulate rice plant height. Plant science : an international journal of experimental plant biology. 2023 Apr; 329(?):111546. doi: 10.1016/j.plantsci.2022.111546. [PMID: 36464025]
  • Yu Tian, Haijuan Xiao, Yanhui Yang, Pingping Zhang, Jiahui Yuan, Wei Zhang, Lijie Chen, Yibao Fan, Jinze Zhang, Huan Cheng, Tingwei Deng, Lin Yang, Weiwei Wang, Guoyong Chen, Peiqin Wang, Peng Gong, Xing Niu, Xianbin Zhang. Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma. Molecular cancer. 2023 01; 22(1):5. doi: 10.1186/s12943-022-01706-6. [PMID: 36627693]
  • Li Wang, Chenhui Yang, Qianru Shan, Miao Zhao, Juanjuan Yu, Yong-Fang Li. Transcriptome-wide profiling of mRNA N6-methyladenosine modification in rice panicles and flag leaves. Genomics. 2023 01; 115(1):110542. doi: 10.1016/j.ygeno.2022.110542. [PMID: 36535337]
  • Jiajun Shi, Qianyi Zhang, Xi Yin, Jiahui Ye, Shengqing Gao, Chen Chen, Yaxuan Yang, Baojuan Wu, Yuping Fu, Hongmei Zhang, Zhangding Wang, Bo Wang, Yun Zhu, Hongyan Wu, Yongzhong Yao, Guifang Xu, Qiang Wang, Shouyu Wang, Weijie Zhang. Stabilization of IGF2BP1 by USP10 promotes breast cancer metastasis via CPT1A in an m6A-dependent manner. International journal of biological sciences. 2023; 19(2):449-464. doi: 10.7150/ijbs.76798. [PMID: 36632454]
  • Bao Yuan, Jin Zhou. N6-methyladenosine (m6A) reader IGF2BP1 facilitates clear-cell renal cell carcinoma aerobic glycolysis. PeerJ. 2023; 11(?):e14591. doi: 10.7717/peerj.14591. [PMID: 36691477]
  • Hong Gil Lee, Jiwoo Kim, Pil Joon Seo. N6-methyladenosine-modified RNA acts as a molecular glue that drives liquid-liquid phase separation in plants. Plant signaling & behavior. 2022 12; 17(1):2079308. doi: 10.1080/15592324.2022.2079308. [PMID: 35621186]
  • Man Zhang, Yunping Zeng, Rong Peng, Jie Dong, Yelin Lan, Sujuan Duan, Zhenyi Chang, Jian Ren, Guanzheng Luo, Bing Liu, Kamil Růžička, Kewei Zhao, Hong-Bin Wang, Hong-Lei Jin. N6-methyladenosine RNA modification regulates photosynthesis during photodamage in plants. Nature communications. 2022 12; 13(1):7441. doi: 10.1038/s41467-022-35146-z. [PMID: 36460653]
  • Junfeng Cao, Chaochen Huang, Jun'e Liu, Chenyi Li, Xia Liu, Zishou Zheng, Lipan Hou, Jinquan Huang, Lingjian Wang, Yugao Zhang, Xiaoxia Shangguan, Zhiwen Chen. Comparative Genomics and Functional Studies of Putative m6A Methyltransferase (METTL) Genes in Cotton. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214111. [PMID: 36430588]
  • Xue Chen, Ying Wang, Jia-Nan Wang, Qiu-Chen Cao, Ru-Xu Sun, Hong-Jing Zhu, Ye-Ran Zhang, Jiang-Dong Ji, Qing-Huai Liu. m6A modification of circSPECC1 suppresses RPE oxidative damage and maintains retinal homeostasis. Cell reports. 2022 11; 41(7):111671. doi: 10.1016/j.celrep.2022.111671. [PMID: 36384115]
  • Xiaoyu Huang, Nigara Abuduwaili, Xinting Wang, Miao Tao, Xiaoqian Wang, Gengqing Huang. Cotton (Gossypium hirsutum) VIRMA as an N6-Methyladenosine RNA Methylation Regulator Participates in Controlling Chloroplast-Dependent and Independent Leaf Development. International journal of molecular sciences. 2022 Aug; 23(17):. doi: 10.3390/ijms23179887. [PMID: 36077287]
  • Hao Peng, Binbin Chen, Wei Wei, Siyao Guo, Hui Han, Chunlong Yang, Jieyi Ma, Lu Wang, Sui Peng, Ming Kuang, Shuibin Lin. N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation. Nature metabolism. 2022 08; 4(8):1041-1054. doi: 10.1038/s42255-022-00622-9. [PMID: 35999469]
  • Leilei Zhou, Guangtong Gao, Renkun Tang, Weihao Wang, Yuying Wang, Shiping Tian, Guozheng Qin. m6 A-mediated regulation of crop development and stress responses. Plant biotechnology journal. 2022 08; 20(8):1447-1455. doi: 10.1111/pbi.13792. [PMID: 35178842]
  • Xingyu Tang, Peijie Zheng, Xueyong Li, Hongyan Wu, Dong-Qing Wei, Yuewu Liu, Guohua Huang. Deep6mAPred: A CNN and Bi-LSTM-based deep learning method for predicting DNA N6-methyladenosine sites across plant species. Methods (San Diego, Calif.). 2022 08; 204(?):142-150. doi: 10.1016/j.ymeth.2022.04.011. [PMID: 35477057]
  • Dawei Zhu, Yingting Liu, Junjun Chen, Qi Wang, Yuan Li, Yulan Zhu, Jun Feng, Jingting Jiang. The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma. Journal of translational medicine. 2022 07; 20(1):298. doi: 10.1186/s12967-022-03496-3. [PMID: 35794583]
  • Meng Wu, Fulei Nie, Haibin Liu, Tianyang Zhang, Miaomiao Li, Xiaoming Song, Wei Chen. The evolution of N6-methyladenosine regulators in plants. Methods (San Diego, Calif.). 2022 07; 203(?):268-275. doi: 10.1016/j.ymeth.2021.11.013. [PMID: 34883238]
  • Lili Zhang, Xiaofang Luo, Sen Qiao. METTL14-mediated N6-methyladenosine modification of Pten mRNA inhibits tumour progression in clear-cell renal cell carcinoma. British journal of cancer. 2022 07; 127(1):30-42. doi: 10.1038/s41416-022-01757-y. [PMID: 35249103]
  • Jianzi Lan, Bowen Xu, Xin Shi, Qi Pan, Qing Tao. WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy. Cellular & molecular biology letters. 2022 Jun; 27(1):51. doi: 10.1186/s11658-022-00350-8. [PMID: 35761192]
  • You Wu, Xiaocui Xu, Meijie Qi, Chuan Chen, Mengying Li, Rushuang Yan, Xiaochen Kou, Yanhong Zhao, Wenqiang Liu, Yanhe Li, Xuelian Liu, Meiling Zhang, Chengqi Yi, Hongbin Liu, Junhong Xiang, Hong Wang, Bin Shen, Yawei Gao, Shaorong Gao. N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. Nature cell biology. 2022 06; 24(6):917-927. doi: 10.1038/s41556-022-00915-x. [PMID: 35606490]
  • Linlin Zhang, Weiwei Ke, Xiangxuan Zhao, Zaiming Lu. Resina Draconis extract exerts anti-HCC effects through METTL3-m6A-Survivin axis. Phytotherapy research : PTR. 2022 Jun; 36(6):2542-2557. doi: 10.1002/ptr.7467. [PMID: 35443090]
  • Aolin Li, Congcong Cao, Ying Gan, Xiaofei Wang, Tianyu Wu, Quan Zhang, Yuchen Liu, Lin Yao, Qian Zhang. ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3. Clinical and translational medicine. 2022 06; 12(6):e906. doi: 10.1002/ctm2.906. [PMID: 35678231]
  • Chunguang Lei, Qingzhong Wang. The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders. International journal of molecular sciences. 2022 May; 23(11):. doi: 10.3390/ijms23115922. [PMID: 35682599]
  • Wenxiang Li, Yi Yu, Xuanrong Chen, Qian Fang, Anqi Yang, Xinyu Chen, Lei Wu, Chengyu Wang, Dechuan Wu, Sihong Ye, Dexiang Wu, Genlou Sun. N6-Methyladenosine dynamic changes and differential methylation in wheat grain development. Planta. 2022 May; 255(6):125. doi: 10.1007/s00425-022-03893-4. [PMID: 35567638]
  • Yuanlei Chen, Zeyi Lu, Chao Qi, Chenhao Yu, Yang Li, Wang Huan, Ruyue Wang, Wenqin Luo, Danyang Shen, Lifeng Ding, Liangliang Ren, Haiyun Xie, Dingwei Xue, Mingchao Wang, Kangxin Ni, Liqun Xia, Jun Qian, Gonghui Li. N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. Molecular cancer. 2022 05; 21(1):111. doi: 10.1186/s12943-022-01549-1. [PMID: 35538475]
  • Li Liu, Jiangtu He, Guifeng Sun, Nan Huang, Zhixuan Bian, Chang Xu, Yue Zhang, Zhongqi Cui, Wenqiang Xu, Fenyong Sun, Chengle Zhuang, Qiuhong Man, Song Gu. The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma. Clinical and translational medicine. 2022 05; 12(5):e778. doi: 10.1002/ctm2.778. [PMID: 35522946]
  • Shiyan Wang, Shanshan Gao, Yong Zeng, Lin Zhu, Yulin Mo, Chi Chun Wong, Yi Bao, Peiran Su, Jianning Zhai, Lina Wang, Fraser Soares, Xin Xu, Huarong Chen, Kebria Hezaveh, Xinpei Ci, Aobo He, Tracy McGaha, Catherine O'Brien, Robert Rottapel, Wei Kang, Jianfeng Wu, Gang Zheng, Zongwei Cai, Jun Yu, Housheng Hansen He. N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer. Gastroenterology. 2022 04; 162(4):1183-1196. doi: 10.1053/j.gastro.2021.12.269. [PMID: 34968454]
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