Tesmilifene (BioDeep_00000184242)

   

human metabolite blood metabolite


代谢物信息卡片


N,N-Diethyl-2-((4-phenylmethyl)phenoxy)-ethanamine hydrochloride

化学式: C19H25NO (283.193604)
中文名称: DPPE 富马酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCOC1=CC=C(C=C1)CC2=CC=CC=C2
InChI: InChI=1S/C19H25NO/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17/h5-13H,3-4,14-16H2,1-2H3

描述信息

C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist

同义名列表

13 个代谢物同义名

N,N-Diethyl-2-((4-phenylmethyl)phenoxy)-ethanamine hydrochloride; N,N-Diethyl-2-((4-phenylmethyl)phenoxy)ethanamine hydrochloride; N,N-Diethyl-2-(4-(phenylmethyl)phenoxy)ethanamine hydrochloride; N,N-Diethyl-2-((4-phenylmethyl)phenoxy)ethanamine; N,N-Diethyl-2-(4-(phenylmethyl)phenoxy)ethanamine; (2-(4-Benzylphenoxy)ethyl)diethylamine; [2-(4-benzylphenoxy)ethyl]diethylamine; BzPhOEt-diethylammonium chloride; Tesmilifene hydrochloride; DPPE hydrochloride; Tesmilifene; DEPMPE; dppe



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hiromichi Nakahara, Takato Hiranita, Osamu Shibata. A Sigma1 Receptor Agonist Alters Fluidity and Stability of Lipid Monolayers. Langmuir : the ACS journal of surfaces and colloids. 2024 Mar; 40(12):6484-6492. doi: 10.1021/acs.langmuir.4c00053. [PMID: 38470245]
  • Phim-On Khunsuk, Chitsuda Pongma, Tanapat Palaga, Voravee P Hoven. Zwitterionic Polymer-Decorated Lipid Nanoparticles for mRNA Delivery in Mammalian Cells. Biomacromolecules. 2023 12; 24(12):5654-5665. doi: 10.1021/acs.biomac.3c00649. [PMID: 37956106]
  • Lina Zhao, Meina Ren, Yanjiao Wang, Hailong An, Fude Sun. Delivery mechanism of doxorubicin by PEG-DPPE micelles on membrane invasion by dynamic simulations. Physical chemistry chemical physics : PCCP. 2023 Jun; 25(23):16114-16125. doi: 10.1039/d2cp05946k. [PMID: 37278335]
  • Jorge A Ceballos, Sebastián Jaramillo-Isaza, Juan C Calderón, Paulo B Miranda, Marco A Giraldo. Doxorubicin Interaction with Lipid Monolayers Leads to Decreased Membrane Stiffness when Experiencing Compression-Expansion Dynamics. Langmuir : the ACS journal of surfaces and colloids. 2023 Jun; ?(?):. doi: 10.1021/acs.langmuir.3c00250. [PMID: 37320858]
  • Monika Rojewska, Wojciech Smułek, Adam Grzywaczyk, Ewa Kaczorek, Krystyna Prochaska. Study of Interactions between Saponin Biosurfactant and Model Biological Membranes: Phospholipid Monolayers and Liposomes. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041965. [PMID: 36838953]
  • Giulia Elisa G Gonçalves, Samuel Oliveira, Kaio de Souza Gomes, Thais Alves Costa-Silva, Andre Gustavo Tempone, João Henrique Ghilardi Lago, Luciano Caseli. Effect of partial O-methylation in dehydrodieugenol on its antitrypanosomal activity - correlation with the toxicity using cell membrane models. Biophysical chemistry. 2023 Feb; 296(?):106975. doi: 10.1016/j.bpc.2023.106975. [PMID: 36842251]
  • Petra Maleš, Marija Butumović, Ina Erceg, Zlatko Brkljača, Danijela Bakarić. Influence of DPPE surface undulations on melting temperature determination: UV/Vis spectroscopic and MD study. Biochimica et biophysica acta. Biomembranes. 2023 01; 1865(1):184072. doi: 10.1016/j.bbamem.2022.184072. [PMID: 36216096]
  • Trivikram R Molugu, Robin L Thurmond, Todd M Alam, Theodore P Trouard, Michael F Brown. Phospholipid headgroups govern area per lipid and emergent elastic properties of bilayers. Biophysical journal. 2022 11; 121(21):4205-4220. doi: 10.1016/j.bpj.2022.09.005. [PMID: 36088534]
  • H G Sebinelli, I A Borin, P Ciancaglini, M Bolean. Topographical and mechanical properties of liposome surfaces harboring Na,K-ATPase by means of atomic force microscopy. Soft matter. 2019 Apr; 15(13):2737-2745. doi: 10.1039/c9sm00040b. [PMID: 30868144]
  • Lei Liu, Xiaoyuan Xiong, Ming Shen, Dan Ru, Pei Gao, Xiangyu Zhang, Can Huang, Ying Sun, He Li, Yourong Duan. Co-Delivery of Triptolide and Curcumin for Ovarian Cancer Targeting Therapy via mPEG-DPPE/CaP Nanoparticle. Journal of biomedical nanotechnology. 2018 Oct; 14(10):1761-1772. doi: 10.1166/jbn.2018.2633. [PMID: 30041722]
  • Young H Choi, Jung H Suh, Joo H Lee, Il H Cho, Myung G Lee. Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. The Journal of pharmacy and pharmacology. 2010 Aug; 62(8):1084-8. doi: 10.1111/j.2042-7158.2010.01129.x. [PMID: 20663044]
  • Fred Y Xu, Gary Queen, Lorne Brandes, Grant M Hatch. The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breast cancer cells. Proceedings of the Western Pharmacology Society. 2007; 50(?):61-3. doi: NULL. [PMID: 18605231]
  • M A Deli, L Németh, A Falus, C S Abrahám. Effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine on the blood-brain barrier permeability in the rat. European journal of pharmacology. 2000 Jan; 387(1):63-72. doi: 10.1016/s0014-2999(99)00796-7. [PMID: 10633162]
  • L J Brandes, S P Bracken, E W Ramsey. N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine in combination with cyclophosphamide: an active, low-toxicity regimen for metastatic hormonally unresponsive prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1995 Jun; 13(6):1398-403. doi: 10.1200/jco.1995.13.6.1398. [PMID: 7751884]
  • L J Brandes, K J Simons, S P Bracken, R C Warrington. Results of a clinical trial in humans with refractory cancer of the intracellular histamine antagonist, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl, in combination with various single antineoplastic agents. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1994 Jun; 12(6):1281-90. doi: 10.1200/jco.1994.12.6.1281. [PMID: 8201390]
  • L J Brandes, F S LaBella. Histamine and calcium are independently regulated intracellular mediators of lymphocyte mitogenesis. Biochemical and biophysical research communications. 1992 Jan; 182(2):786-93. doi: 10.1016/0006-291x(92)91801-v. [PMID: 1310395]
  • C B Lazier, W C Breckenridge. Comparison of the effects of tamoxifen and of a tamoxifen analogue that does not bind the estrogen receptor on serum lipid profiles in the cockerel. Biochemistry and cell biology = Biochimie et biologie cellulaire. 1990 Jan; 68(1):210-7. doi: 10.1139/o90-027. [PMID: 2350488]
  • G B Glavin, L J Brandes. Antiulcerogenic and antisecretory effects of a novel diphenylmethane derivative and antiestrogen binding site ligand. Canadian journal of physiology and pharmacology. 1988 Sep; 66(9):1139-43. doi: 10.1139/y88-187. [PMID: 2905933]
  • W C Breckenridge, C B Lazier. Tamoxifen-induced modification of serum lipoprotein phospholipids in the cockerel. Lipids. 1987 Jul; 22(7):505-12. doi: 10.1007/bf02540366. [PMID: 3626776]