Gestodene (BioDeep_00000018424)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1S,2R,10R,11S,14R,15S)-15-ethyl-14-ethynyl-14-hydroxytetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,12-dien-5-one
化学式: C21H26O2 (310.1932696)
中文名称: 孕二烯酮
谱图信息:
最多检出来源 Homo sapiens(urine) 12.82%
分子结构信息
SMILES: C#CC1(O)C=CC2C3CCC4=CC(=O)CCC4C3CCC21CC
InChI: InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
描述信息
Gestodene is only found in individuals that have used or taken this drug.Gestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol and 75 mcg of gestodene.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
同义名列表
8 个代谢物同义名
(1S,2R,10R,11S,14R,15S)-15-ethyl-14-ethynyl-14-hydroxytetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,12-dien-5-one; 13-Ethyl-17-hydroxy-18,19-dinor-17 alpha-pregna-4,15-dien-20-yn-3-one; 17-alpha-Ethinyl-13-ethyl-17 beta-hydroxy-4,15-gonadien-3-one; Gestodene, ((17alpha)-(+-))-isomer; SH b 3331; Gestodene; SH b 331; Gestoden
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135323
- PubChem: 3033968
- HMDB: HMDB0015668
- DrugBank: DB06730
- ChEMBL: CHEMBL1213583
- Wikipedia: Gestodene
- chemspider: 2298532
- CAS: 60282-87-3
- PMhub: MS000007887
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Albe Carina Swanepoel, Hildegarde Cecilia Roberts, Prashilla Soma, Barend Gerhardus Lindeque, Janette Bester. Hemorheological mechanisms for increased thrombosis in subjects using gestodene.
Microscopy research and technique.
2018 Dec; 81(12):1489-1500. doi:
10.1002/jemt.23149. [PMID: 30365192] - Matheo Augusto Morandi Stumpf, Ana Claudia Garabeli Cavalli Kluthcovsky, Jefferson Matsuiti Okamoto, Gianna Carla Alberti Schrut, Patricia de Oliveira Cajoeiro, Ana Paula Marte Chacra, Ricardo Bizeli. Acute pancreatitis secondary to oral contraceptive-induced hypertriglyceridemia: a case report.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 Nov; 34(11):930-932. doi:
10.1080/09513590.2018.1473365. [PMID: 29782195] - Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano. Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women.
JAMA cardiology.
2018 09; 3(9):877-882. doi:
10.1001/jamacardio.2018.2251. [PMID: 30073300] - Chao Zhang, Haiyan Li, Xin Xiong, Suodi Zhai, Yudong Wei, Shuang Zhang, Yuanyuan Zhang, Lin Xu, Li Liu. An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch.
Drug design, development and therapy.
2017; 11(?):725-731. doi:
10.2147/dddt.s131123. [PMID: 28331292] - Chunxiao Li, Meiying Ning, Xiaodong Yao, Yankun Wang, Ying Liu. Preparation and in vitro/in vivo evaluation of gestodene (GEST) intravaginal ring.
Pakistan journal of pharmaceutical sciences.
2016 Sep; 29(5):1545-1553. doi:
NULL. [PMID: 27731811] - Julia Winkler, Mark Goldammer, Matthias Ludwig, Beate Rohde, Christian Zurth. Pharmacokinetic drug-drug interaction between ethinyl estradiol and gestodene, administered as a transdermal fertility control patch, and two CYP3A4 inhibitors and a CYP3A4 substrate.
European journal of drug metabolism and pharmacokinetics.
2015 Dec; 40(4):389-99. doi:
10.1007/s13318-014-0215-8. [PMID: 24997757] - Sahar M El-Haggar, Tarek M Mostafa. Cardiovascular risk in Egyptian healthy consumers of different types of combined oral contraceptives pills: A comparative study.
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Contraception.
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2009 Aug; 280(2):255-61. doi:
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Metabolism: clinical and experimental.
2002 Sep; 51(9):1216-21. doi:
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Vascular pharmacology.
2002 Aug; 39(3):149-54. doi:
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Vascular pharmacology.
2002 Aug; 39(3):131-6. doi:
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Contraception.
2002 Mar; 65(3):231-6. doi:
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Fertility and sterility.
2002 Jan; 77(1):1-14. doi:
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Endocrine.
2001 Dec; 16(3):217-25. doi:
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Contraception.
2001 Oct; 64(4):243-8. doi:
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Contraception.
2001 Oct; 64(4):235-41. doi:
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Therapeutische Umschau. Revue therapeutique.
2001 Sep; 58(9):527-33. doi:
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Contraception.
2001 Sep; 64(3):145-8. doi:
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Contraception.
2001 Jun; 63(6):303-7. doi:
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European journal of obstetrics, gynecology, and reproductive biology.
2001 Apr; 95(2):193-7. doi:
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Die Pharmazie.
2001 Apr; 56(4):325-8. doi:
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Human reproduction (Oxford, England).
2001 Jan; 16(1):76-81. doi:
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Contraception.
2001 Jan; 63(1):13-8. doi:
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British journal of clinical pharmacology.
2000 Oct; 50(4):333-7. doi:
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American journal of obstetrics and gynecology.
2000 Sep; 183(3):550-60. doi:
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Contraception.
2000 Apr; 61(4):259-63. doi:
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The Journal of clinical endocrinology and metabolism.
1999 Nov; 84(11):4204-8. doi:
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The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
1999 Nov; 4 Suppl 2(?):27-35. doi:
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Contraception.
1999 Nov; 60(5):275-9. doi:
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Fertility and sterility.
1999 Jul; 72(1):115-20. doi:
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Fertility and sterility.
1999 Jun; 71(6):1079-84. doi:
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Contraception.
1999 Apr; 59(4):237-43. doi:
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American journal of obstetrics and gynecology.
1999 Mar; 180(3 Pt 1):539-49. doi:
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Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
1999 Jan; 5(1):60-70. doi:
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Minerva ginecologica.
1998 Dec; 50(12):539-43. doi:
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Acta pharmaceutica Hungarica.
1998 Sep; 68(5):289-93. doi:
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Contraception.
1998 Aug; 58(2):83-91. doi:
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European journal of endocrinology.
1998 Aug; 139(2):167-77. doi:
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American journal of obstetrics and gynecology.
1998 Jul; 179(1):41-6. doi:
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British journal of haematology.
1997 Apr; 97(1):233-8. doi:
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Thrombosis and haemostasis.
1996 Nov; 76(5):729-34. doi:
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1996 Aug; 54(2):71-7. doi:
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