Tenocyclidine (BioDeep_00000184217)

   

human metabolite blood metabolite


代谢物信息卡片


1-(1-(2-Thienyl)cyclohexyl)piperidine, tritium-labeled

化学式: C15H23NS (249.1551118)
中文名称: 替诺环定
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
InChI: InChI=1S/C15H23NS/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16/h7-8,13H,1-6,9-12H2

描述信息

D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
D020011 - Protective Agents

同义名列表

14 个代谢物同义名

1-(1-(2-Thienyl)cyclohexyl)piperidine, tritium-labeled; 1-(1-(2-Thienyl)cyclohexyl)piperidine hydrochloride; 1-[1-(Thiophen-2-yl)cyclohexyl]piperidine; N-(1-(2-Thiophenyl)cyclohexyl)piperidine; 1-(1-(2-Thienyl)cyclohexyl)piperidine; (3H)Thienylcyclohexylpiperidine; Thienyl cyclohexylpiperidine; Thienylcyclohexylpiperidine; Tenocyclidine hydrochloride; 2-Thienylphencyclidine; Tenocyclidine-TCP; Tenocyclidinum; TENOCYCLIDINE; Tenociclidina



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Maja Jelena Petek, Ana Lucić Vrdoljak, Gordan Mrsić. Qualitative GC-MS assessment of TCP and TAMORF elimination in rats. Arhiv za higijenu rada i toksikologiju. 2010 Mar; 61(1):61-7. doi: 10.2478/10004-1254-61-2010-1985. [PMID: 20338869]
  • Maja Jelena Petek, Suzana Berend, Nevenka Kopjar, Davor Zeljezić, Marin Mladinić, Bozica Radić, Ana Lucić Vrdoljak. Tenocyclidine treatment in soman-poisoned rats--intriguing results on genotoxicity versus protection. Acta biochimica Polonica. 2008; 55(1):97-105. doi: 10.18388/abp.2008_3155. [PMID: 18324340]
  • Robert N Pechnick, Catherine J Bresee, Russell E Poland. The role of antagonism of NMDA receptor-mediated neurotransmission and inhibition of the dopamine reuptake in the neuroendocrine effects of phencyclidine. Life sciences. 2006 Mar; 78(17):2006-11. doi: 10.1016/j.lfs.2005.09.018. [PMID: 16288927]
  • Fernanda Gumilar, Hugo R Arias, Guillermo Spitzmaul, Cecilia Bouzat. Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants. Neuropharmacology. 2003 Dec; 45(7):964-76. doi: 10.1016/s0028-3908(03)00247-8. [PMID: 14573389]
  • M D Simpson, P Slater, J F Deakin, C G Gottfries, I Karlsson, B Grenfeldt, T J Crow. Absence of basal ganglia amino acid neuron deficits in schizophrenia in three collections of brains. Schizophrenia research. 1998 May; 31(2-3):167-75. doi: 10.1016/s0920-9964(98)00020-6. [PMID: 9689721]
  • G Hoizey, R Vistelle, D Lamiable, H Millart, B Gourdier, P d'Arbigny. Determination of gacyclidine enantiomers in human plasma by gas chromatography-mass spectrometry using selected-ion monitoring. Journal of chromatography. B, Biomedical sciences and applications. 1997 Dec; 704(1-2):167-74. doi: 10.1016/s0378-4347(97)00465-9. [PMID: 9518146]
  • R D Brinton, P Proffitt, J Tran, R Luu. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Experimental neurology. 1997 Oct; 147(2):211-20. doi: 10.1006/exnr.1997.6619. [PMID: 9344546]
  • B Foucaud, S Gambs, N Schmid, J P Behr, M Goeldner. A photoaffinity probe for the polyamine site regulating the NMDA receptor. European journal of pharmacology. 1995 May; 289(3):471-7. doi: 10.1016/0922-4106(95)90156-6. [PMID: 7556416]
  • T Hayashi, K Yamada, T Hasegawa, S Ishihara, T Kameyama, T Morimasa, T Kaneyuki, T Shohmori, T Nabeshima. Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography (1): Changes in the [3H]QNB binding. Japanese journal of pharmacology. 1994 Apr; 64(4):303-6. doi: 10.1254/jjp.64.303. [PMID: 8057532]
  • R Haring, D E Pellegrini-Giampietro, S R Zukin, R S Zukin, M A Scheideler. High efficiency reconstitution of a phencyclidine/MK-801 receptor binding site solubilized from rat forebrain membranes. Molecular pharmacology. 1991 Nov; 40(5):666-73. doi: ". [PMID: 1658603]
  • P C Contreras, A E Jacobson, K C Rice, J M Farah. Phencyclidine increased release of beta-endorphin from anterior lobe of the pituitary. The Journal of pharmacology and experimental therapeutics. 1991 Sep; 258(3):837-41. doi: . [PMID: 1653842]
  • K Ohi, M Takashima, T Nishikawa, K Takahashi. N-methyl-D-aspartate receptor participates in neuronal transmission of photic information through the retinohypothalamic tract. Neuroendocrinology. 1991 Apr; 53(4):344-8. doi: 10.1159/000125740. [PMID: 1675438]
  • B Foucaud, G Gombos. Identification and characterization of a high-affinity glutamate-controlled TCP binding site in rat brain postsynaptic densities. European journal of pharmacology. 1990 Dec; 189(6):355-62. doi: 10.1016/0922-4106(90)90032-s. [PMID: 1981559]
  • A A Reid, M V Mattson, B R de Costa, A Thurkauf, A E Jacobson, J A Monn, K C Rice, R B Rothman. Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain. Neuropharmacology. 1990 Sep; 29(9):811-7. doi: 10.1016/0028-3908(90)90154-j. [PMID: 1963480]
  • A Thurkauf, B de Costa, M V Mattson, C P France, M T Price, J W Olney, J H Woods, A E Jacobson, K C Rice. Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines. Journal of medicinal chemistry. 1990 Aug; 33(8):2211-5. doi: 10.1021/jm00170a027. [PMID: 2374147]
  • W F Hood, R P Compton, J B Monahan. N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site. Journal of neurochemistry. 1990 Mar; 54(3):1040-6. doi: 10.1111/j.1471-4159.1990.tb02355.x. [PMID: 1968086]
  • J A Monn, A Thurkauf, M V Mattson, A E Jacobson, K C Rice. Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site. Journal of medicinal chemistry. 1990 Mar; 33(3):1069-76. doi: 10.1021/jm00165a029. [PMID: 2155320]
  • G Massicotte, M Kessler, G Lynch, M Baudry. N-Methyl-D-aspartate and quisqualate/DL-alpha-amino-3-hydroxy-5- methylisoxazole-4-propionic acid receptors: differential regulation by phospholipase C treatment. Molecular pharmacology. 1990 Feb; 37(2):278-85. doi: ". [PMID: 2154675]
  • R P Compton, W F Hood, J B Monahan. Evidence for a functional coupling of the NMDA and glycine recognition sites in synaptic plasma membranes. European journal of pharmacology. 1990 Jan; 188(1):63-70. doi: 10.1016/0922-4106(90)90248-v. [PMID: 2155123]
  • W F Hood, J W Thomas, R P Compton, J B Monahan. Guanine nucleotide modulation of [3H]TCP binding to the NMDA receptor complex. European journal of pharmacology. 1990 Jan; 188(1):43-9. doi: 10.1016/0922-4106(90)90246-t. [PMID: 2155121]
  • F R DePietro, J C Byrd. Effects of membrane fluidity on [3H]TCP binding to PCP receptors. Journal of molecular neuroscience : MN. 1990; 2(1):45-52. doi: 10.1007/bf02896925. [PMID: 2175211]
  • M Zorbas, S M Owens, L M Plunkett, H Bui. The pharmacokinetics of [3H]1-[1-(2-thienyl)cyclohexyl]piperidine (TCP) in Sprague-Dawley rats. Drug metabolism and disposition: the biological fate of chemicals. 1989 Nov; 17(6):641-5. doi: NULL. [PMID: 2575500]
  • J B Monahan, V M Corpus, W F Hood, J W Thomas, R P Compton. Characterization of a [3H]glycine recognition site as a modulatory site of the N-methyl-D-aspartate receptor complex. Journal of neurochemistry. 1989 Aug; 53(2):370-5. doi: 10.1111/j.1471-4159.1989.tb07344.x. [PMID: 2545816]
  • A A Reid, J A Monn, A E Jacobson, K C Rice, R B Rothman. Characterization of NMDA-coupled and dopamine reuptake carrier coupled [3H]-TCP binding sites in guinea pig brain. NIDA research monograph. 1989; 95(?):530-1. doi: NULL. [PMID: 2561850]