Swertiamarin (BioDeep_00000184089)

   

human metabolite blood metabolite natural product


代谢物信息卡片


5-ethenyl-4a-hydroxy-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,3H,4H,4aH,5H,6H-pyrano[3,4-c]pyran-1-one

化学式: C16H22O10 (374.1212912)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

分子结构信息

SMILES: C=CC1C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCCC21O
InChI: InChI=1S/C16H22O10/c1-2-7-14(24-6-8-13(21)23-4-3-16(7,8)22)26-15-12(20)11(19)10(18)9(5-17)25-15/h2,6-7,9-12,14-15,17-20,22H,1,3-5H2

描述信息

同义名列表

4 个代谢物同义名

5-ethenyl-4a-hydroxy-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,3H,4H,4aH,5H,6H-pyrano[3,4-c]pyran-1-one; 4-Ethenyl-4a-hydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,5,6-tetrahydropyrano[3,4-c]pyran-8-one; 5-ethenyl-4a-hydroxy-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3H,4H,5H,6H-pyrano[3,4-c]pyran-1-one; Swertiamarin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

149 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenjuan Ma, Jianglan Long, Linjie Dong, Jian Zhang, Aiting Wang, Yu Zhang, Dan Yan. Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation. Journal of ethnopharmacology. 2024 Apr; 323(?):117752. doi: 10.1016/j.jep.2024.117752. [PMID: 38216099]
  • Takaya Tominaga, Kotomi Ueno, Hikaru Saito, Mayumi Egusa, Katsushi Yamaguchi, Shuji Shigenobu, Hironori Kaminaka. Monoterpene glucosides in Eustoma grandiflorum roots promote hyphal branching in arbuscular mycorrhizal fungi. Plant physiology. 2023 Sep; ?(?):. doi: 10.1093/plphys/kiad482. [PMID: 37655911]
  • Sasidharan Perumal, MadhanaVigneshwari Gopal Samy, Dharaneedharan Subramanian. In vitro and in silico screening of novel typhoid drugs from endangered herb (Enicostema axillare). Journal of biomolecular structure & dynamics. 2023 04; 41(7):2926-2936. doi: 10.1080/07391102.2022.2041488. [PMID: 35174771]
  • Ting Zhang, Miaomiao Wang, Zhaoju Li, Xien Wu, Xiaoli Liu. Transcriptome analysis and exploration of genes involved in the biosynthesis of secoiridoids in Gentiana rhodantha. PeerJ. 2023; 11(?):e14968. doi: 10.7717/peerj.14968. [PMID: 36915654]
  • Sasidharan Perumal, MadhanaVigneshwari Gopal Samy, Dharaneedharan Subramanian. Effect of novel therapeutic medicine swertiamarin from Enicostema axillare in zebrafish infected with Salmonella typhi. Chemical biology & drug design. 2022 12; 100(6):1033-1041. doi: 10.1111/cbdd.14146. [PMID: 36178071]
  • Poomraphie Nuntawong, Taiki Horikawa, Hiroyuki Tanaka, Satoshi Morimoto, Seiichi Sakamoto. Activated Carbon-Based Immunochromatographic Strip Test for the Rapid Qualitative Analysis of Swertiamarin and Sweroside. Journal of AOAC International. 2022 Sep; 105(5):1460-1467. doi: 10.1093/jaoacint/qsac054. [PMID: 35521980]
  • Tao Wang, Shubin Wu, Ibrahim Abdel Aziz Ibrahim, Leilei Fan. Cardioprotective Role of Swertiamarin, a Plant Glycoside Against Experimentally Induced Myocardial Infarction via Antioxidant and Anti-inflammatory Functions. Applied biochemistry and biotechnology. 2022 Aug; ?(?):. doi: 10.1007/s12010-022-04094-1. [PMID: 35960488]
  • Naisargee Patel, Aarushi Zinzuvadia, Mitali Prajapati, Rajeev K Tyagi, Sarat Dalai. Swertiamarin-mediated immune modulation/adaptation confers protection against Plasmodium berghei. Future microbiology. 2022 Aug; 17(?):931-941. doi: 10.2217/fmb-2021-0298. [PMID: 35704297]
  • Mengge Shi, Jie Tang, Tong Zhang, Han Han. Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway. Journal of ethnopharmacology. 2022 Jun; 291(?):115164. doi: 10.1016/j.jep.2022.115164. [PMID: 35278607]
  • Sasidharan Perumal, Madhana V Gopal Samy, Dharaneedharan Subramanian. Developmental toxicity, antioxidant, and marker enzyme assessment of swertiamarin in zebrafish (Danio rerio). Journal of biochemical and molecular toxicology. 2021 Sep; 35(9):e22843. doi: 10.1002/jbt.22843. [PMID: 34251064]
  • Poomraphie Nuntawong, Taiki Horikawa, Akihiro Ochi, Shinji Wada, Yumi Tsuneura, Hiroyuki Tanaka, Seiichi Sakamoto, Satoshi Morimoto. A monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay to quantify swertiamarin and related compounds in Swertia japonica Makino. Phytochemical analysis : PCA. 2021 Jul; 32(4):512-520. doi: 10.1002/pca.2999. [PMID: 33021012]
  • Syed Mudassir Jeelani, Jasvinder Singh, Arti Sharma, Gulzar A Rather, Sheikh Abid Ali, Ajai Prakash Gupta, Shashank Singh, Surrinder K Lattoo. In-vitro cytotoxicity in relation to chemotypic diversity in diploid and tetraploid populations of Gentiana kurroo Royle. Journal of ethnopharmacology. 2021 Jun; 274(?):113966. doi: 10.1016/j.jep.2021.113966. [PMID: 33647427]
  • Kirti Parwani, Farhin Patel, Dhara Patel, Palash Mandal. Protective Effects of Swertiamarin against Methylglyoxal-Induced Epithelial-Mesenchymal Transition by Improving Oxidative Stress in Rat Kidney Epithelial (NRK-52E) Cells. Molecules (Basel, Switzerland). 2021 May; 26(9):. doi: 10.3390/molecules26092748. [PMID: 34067107]
  • Haixia Wang, Huiming Huang, Jingwei Lv, Ning Jiang, Yujiao Li, Xinmin Liu, Hongping Zhao. Iridoid compounds from the aerial parts of Swertia mussotii Franch. with cytotoxic activity. Natural product research. 2021 May; 35(9):1544-1549. doi: 10.1080/14786419.2019.1660332. [PMID: 33938336]
  • Beibei Ma, Tianyu Lou, Tingting Wang, Ruiji Li, Jinhui Liu, Shangyue Yu, Yudong Guo, Zhibin Wang, Jing Wang. Comprehensive metabolism study of swertiamarin in rats using ultra high-performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Apr; 51(4):455-466. doi: 10.1080/00498254.2020.1869856. [PMID: 33356745]
  • Taruna Pandey, Aparna Shukla, Mashu Trivedi, Feroz Khan, Rakesh Pandey. Swertiamarin from Enicostemma littorale, counteracts PD associated neurotoxicity via enhancement α-synuclein suppressive genes and SKN-1/NRF-2 activation through MAPK pathway. Bioorganic chemistry. 2021 03; 108(?):104655. doi: 10.1016/j.bioorg.2021.104655. [PMID: 33548732]
  • Nur Sakinah Muhamad Fadzil, Mahendran Sekar, Siew Hua Gan, Srinivasa Reddy Bonam, Yuan Seng Wu, Jaishree Vaijanathappa, Subban Ravi, Pei Teng Lum, Shivsharan B Dhadde. Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin - A Promising Natural Lead for New Drug Discovery and Development. Drug design, development and therapy. 2021; 15(?):2721-2746. doi: 10.2147/dddt.s299753. [PMID: 34188450]
  • V Jaishree, Shravan Narsimha. Swertiamarin and quercetin combination ameliorates hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced type 2 diabetes mellitus in wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Oct; 130(?):110561. doi: 10.1016/j.biopha.2020.110561. [PMID: 32795923]
  • Shreya Dubey, Monika Kallubai, Rajagopal Subramanyam. Comparative binding of Swertiamarin with human serum albumin and α-1 glycoprotein and its cytotoxicity against neuroblastoma cells. Journal of biomolecular structure & dynamics. 2020 10; 38(17):5266-5276. doi: 10.1080/07391102.2019.1695672. [PMID: 31755370]
  • Prabhjot Kaur, R C Gupta, Abhijit Dey, Tabarak Malik, Devendra Kumar Pandey. Optimization of salicylic acid and chitosan treatment for bitter secoiridoid and xanthone glycosides production in shoot cultures of Swertia paniculata using response surface methodology and artificial neural network. BMC plant biology. 2020 May; 20(1):225. doi: 10.1186/s12870-020-02410-7. [PMID: 32429895]
  • Man Zhang, Xiaoyao Ma, Honglei Xu, Wenbo Wu, Xin He, Xiaoying Wang, Min Jiang, Yuanyuan Hou, Gang Bai. A natural AKT inhibitor swertiamarin targets AKT-PH domain, inhibits downstream signaling, and alleviates inflammation. The FEBS journal. 2020 05; 287(9):1816-1829. doi: 10.1111/febs.15112. [PMID: 31665825]
  • Yuangui Yang, Yanli Zhao, Zhitian Zuo, Ji Zhang, Yao Shi, Yuanzhong Wang. Investigation of a Medical Plant for Hepatic Diseases with Secoiridoids Using HPLC and FT-IR Spectroscopy for a Case of Gentiana rigescens. Molecules (Basel, Switzerland). 2020 Mar; 25(5):. doi: 10.3390/molecules25051219. [PMID: 32182739]
  • Mengge Shi, Kai Xiong, Tong Zhang, Han Han. Pharmacokinetics and metabolic profiles of swertiamarin in rats by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2020 Feb; 179(?):112997. doi: 10.1016/j.jpba.2019.112997. [PMID: 31767226]
  • Yang Yang, Jing Li, Cong Wei, Ying He, Yixin Cao, Yongmin Zhang, Wenji Sun, Boling Qiao, Jiao He. Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jun; 59(?):152782. doi: 10.1016/j.phymed.2018.12.005. [PMID: 31005808]
  • Jianghong Wang, Jiantai He. Swertiamarin decreases lipid accumulation dependent on 3-ketoacyl-coA thiolase. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Apr; 112(?):108668. doi: 10.1016/j.biopha.2019.108668. [PMID: 30784937]
  • Manju Singh, Ram Mohan, Sonali Mishra, Nitu Goyal, Karuna Shanker, Namita Gupta, Birendra Kumar. Ultra performance liquid chromatography coupled with principal component and cluster analysis of Swertia chirayita for adulteration check. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 164(?):302-308. doi: 10.1016/j.jpba.2018.10.054. [PMID: 30412803]
  • Jie Li, Ji Zhang, Zhitian Zuo, Hengyu Huang, Yuanzhong Wang. Quantification and Discrimination of in Vitro Regeneration Swertia nervosa at Different Growth Periods using the UPLC/UV Coupled with Chemometric Method. Journal of AOAC International. 2018 Sep; 101(5):1473-1481. doi: 10.5740/jaoacint.17-0488. [PMID: 29743131]
  • Naisargee Patel, Rajeev K Tyagi, Nikunj Tandel, Neeraj K Garg, Nupur Soni. The Molecular Targets of Swertiamarin and its Derivatives Confer Anti- Diabetic and Anti-Hyperlipidemic Effects. Current drug targets. 2018; 19(16):1958-1967. doi: 10.2174/1389450119666180406113428. [PMID: 29623834]
  • Lu Liu, Guan-Ling Xu, Xiao-Xia Ma, Afsar Khan, Wen-Hong Tan, Zhu-Ya Yang, Zhi-Hong Zhou. Sweritranslactones A-C: Unusual Skeleton Secoiridoid Dimers via [4 + 2] Cycloaddition from Swertiamarin. The Journal of organic chemistry. 2017 12; 82(24):13263-13267. doi: 10.1021/acs.joc.7b02383. [PMID: 29143525]
  • Beibei Xiang, Xiaoxue Li, Yan Wang, Xiaoxuan Tian, Zhen Yang, Lin Ma, Xia Liu, Yong Wang. Cloning and Characterization of Two Iridoid Synthase Homologs from Swertia Mussotii. Molecules (Basel, Switzerland). 2017 Aug; 22(8):. doi: 10.3390/molecules22081387. [PMID: 28829394]
  • Khalid Ghazanfar, Khan Mubashir, Showkat A Dar, Tazeen Nazir, Iqra Hameed, Bashir A Ganai, Seema Akbar, Akbar Masood. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. Journal of complementary & integrative medicine. 2017 Apr; 14(3):. doi: 10.1515/jcim-2017-0002. [PMID: 28731312]
  • Xinying Wu, Ye Gu, Lun Li. The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats. Toxicology letters. 2017 Jan; 265(?):9-16. doi: 10.1016/j.toxlet.2016.11.011. [PMID: 27866977]
  • Tao Wu, Jingjing Li, Yong Li, Hongping Song. Antioxidant and Hepatoprotective Effect of Swertiamarin on Carbon Tetrachloride-Induced Hepatotoxicity via the Nrf2/HO-1 Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 41(6):2242-2254. doi: 10.1159/000475639. [PMID: 28448964]
  • Xin Yu Leong, Punniyakoti Veeraveedu Thanikachalam, Manisha Pandey, Srinivasan Ramamurthy. A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Dec; 84(?):1051-1060. doi: 10.1016/j.biopha.2016.10.044. [PMID: 27780133]
  • Shu Li, Qinglan Wang, Yanyan Tao, Chenghai Liu. Swertiamarin Attenuates Experimental Rat Hepatic Fibrosis by Suppressing Angiotensin II-Angiotensin Type 1 Receptor-Extracellular Signal-Regulated Kinase Signaling. The Journal of pharmacology and experimental therapeutics. 2016 Nov; 359(2):247-255. doi: 10.1124/jpet.116.234179. [PMID: 27543328]
  • Tushar P Patel, Komal Rawal, Sanket Soni, Sarita Gupta. Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Oct; 83(?):785-791. doi: 10.1016/j.biopha.2016.07.028. [PMID: 27490779]
  • Amit Rai, Michimi Nakamura, Hiroki Takahashi, Hideyuki Suzuki, Kazuki Saito, Mami Yamazaki. High-throughput sequencing and de novo transcriptome assembly of Swertia japonica to identify genes involved in the biosynthesis of therapeutic metabolites. Plant cell reports. 2016 Oct; 35(10):2091-111. doi: 10.1007/s00299-016-2021-z. [PMID: 27378356]
  • Yaping Wang, Bashir Ahmad, Baozhong Duan, Rui Zeng, Linfang Huang. Chemical and Genetic Comparative Analysis of Gentiana crassicaulis and Gentiana macrophylla. Chemistry & biodiversity. 2016 Jun; 13(6):776-81. doi: 10.1002/cbdv.201500247. [PMID: 27144464]
  • Hai-lan Fang, Fei-neng Shang, Xian-ying Yang, Cong-long Xia, Bao-zhong Duan. [HPLC Analyzed the Iridoid Glycosides of Qingyedan Commonly Used in Folk Medicine in Yunnan]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jun; 39(6):1337-40. doi: ". [PMID: 30156807]
  • Parthraj R Kshirsagar, Sandeep R Pai, Mansingraj S Nimbalkar, Nikhil B Gaikwad. RP-HPLC analysis of seco-iridoid glycoside swertiamarin from different Swertia species. Natural product research. 2016; 30(7):865-8. doi: 10.1080/14786419.2015.1071366. [PMID: 26299409]
  • Li Zhang, Jun Dang, Li-juan Mei, Yun Shao, Qi-Ian Wang, Xue-juan Liu. [Chemical Constituents from Roots of Gentiana straminea of Tibetan Medicine]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jan; 39(1):103-6. doi: . [PMID: 30080009]
  • Supreet Khanal, Niroj Shakya, Krishna Thapa, Deepak Raj Pant. Phytochemical investigation of crude methanol extracts of different species of Swertia from Nepal. BMC research notes. 2015 Dec; 8(?):821. doi: 10.1186/s13104-015-1753-0. [PMID: 26708007]
  • Xiuhong Wu, Shuhan Tang, Yan Jin, Yan Zhang, Masao Hattori, Xijun Wang, Hailong Zhang, Zhigang Wang. New analytical method for the study of metabolism of swertiamarin in rats after oral administration by UPLC-TOF-MS following DNPH derivatization. Biomedical chromatography : BMC. 2015 Aug; 29(8):1184-9. doi: 10.1002/bmc.3406. [PMID: 25612327]
  • Jibesh Kumar Padhan, Varun Kumar, Hemant Sood, Tiratha Raj Singh, Rajinder S Chauhan. Contents of therapeutic metabolites in Swertia chirayita correlate with the expression profiles of multiple genes in corresponding biosynthesis pathways. Phytochemistry. 2015 Aug; 116(?):38-47. doi: 10.1016/j.phytochem.2015.05.007. [PMID: 26028519]
  • G Dhanavathy. Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas. Journal of endocrinological investigation. 2015 Jun; 38(6):669-84. doi: 10.1007/s40618-015-0243-5. [PMID: 25770453]
  • Ahmed M Mustafa, Giovanni Caprioli, Massimo Ricciutelli, Filippo Maggi, Rosa Marín, Sauro Vittori, Gianni Sagratini. Comparative HPLC/ESI-MS and HPLC/DAD study of different populations of cultivated, wild and commercial Gentiana lutea L. Food chemistry. 2015 May; 174(?):426-33. doi: 10.1016/j.foodchem.2014.11.089. [PMID: 25529701]
  • Ying Lv, Hai-tao Zhang, Yan-fang Wang, Hong Zhu, Ping Long, Zhen-wang Wang, Na Zhang, Chun-hong Zhang. [Preliminary comparative study of swertiamarin and swertisin on three kinds of Digeda-species Mongolian medicinal materials]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Mar; 40(5):804-6. doi: . [PMID: 26087537]
  • Zeyun Li, Edward Welbeck, Li Yang, Chunyong He, Haijun Hu, Ming Song, Kaishun Bi, Zhengtao Wang. A quantitative ¹H nuclear magnetic resonance (qHNMR) method for assessing the purity of iridoids and secoiridoids. Fitoterapia. 2015 Jan; 100(?):187-94. doi: 10.1016/j.fitote.2014.12.001. [PMID: 25510321]
  • Chia-Ming Lu, Lie-Chwen Lin, Tung-Hu Tsai. Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules (Basel, Switzerland). 2014 Dec; 19(12):21560-78. doi: 10.3390/molecules191221560. [PMID: 25532849]
  • Bo Feng, Heyun Zhu, Jiao Guan, Longshan Zhao, Jingkai Gu, Lei Yin, J Paul Fawcett, Wenshu Liu. A rapid and sensitive UFLC-MS/MS method for the simultaneous determination of gentiopicroside and swertiamarin in rat plasma and its application in pharmacokinetics. The Journal of pharmacy and pharmacology. 2014 Oct; 66(10):1369-76. doi: 10.1111/jphp.12266. [PMID: 24780079]
  • S Saravanan, P Pandikumar, N Prakash Babu, V I Hairul Islam, K Thirugnanasambantham, M Gabriel Paulraj, K Balakrishna, S Ignacimuthu. In vivo and in vitro immunomodulatory potential of swertiamarin isolated from Enicostema axillare (Lam.) A. Raynal that acts as an anti-inflammatory agent. Inflammation. 2014 Oct; 37(5):1374-88. doi: 10.1007/s10753-014-9862-9. [PMID: 24736879]
  • Gang Fan, Wei-Zao Luo, Shang-Hua Luo, Yan Li, Xian-Li Meng, Xiang-Dong Zhou, Yi Zhang. Metabolic discrimination of Swertia mussotii and Swertia chirayita known as "Zangyinchen" in traditional Tibetan medicine by (1)H NMR-based metabolomics. Journal of pharmaceutical and biomedical analysis. 2014 Sep; 98(?):364-70. doi: 10.1016/j.jpba.2014.06.014. [PMID: 24992216]
  • Vladimir Mihailović, Jelena Katanić, Danijela Mišić, Vesna Stanković, Mirjana Mihailović, Aleksandra Uskoković, Jelena Arambašić, Slavica Solujić, Milan Mladenović, Nevena Stanković. Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats. Food & function. 2014 Aug; 5(8):1795-803. doi: 10.1039/c4fo00088a. [PMID: 24912992]
  • Shanshan Wang, Shuhan Tang, Yujia Sun, Huiyu Wang, Xijun Wang, Hailong Zhang, Zhigang Wang. Highly sensitive determination of new metabolite in rat plasma after oral administration of swertiamarin by liquid chromatography/time of flight mass spectrometry following picolinoyl derivatization. Biomedical chromatography : BMC. 2014 Jul; 28(7):939-46. doi: 10.1002/bmc.3099. [PMID: 24301427]
  • S Saravanan, V I Hairul Islam, N Prakash Babu, P Pandikumar, K Thirugnanasambantham, M Chellappandian, C Simon Durai Raj, M Gabriel Paulraj, S Ignacimuthu. Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014 Jun; 56(?):70-86. doi: 10.1016/j.ejps.2014.02.005. [PMID: 24582615]
  • S Saravanan, V I Hairul Islam, K Thirugnanasambantham, N Pazhanivel, N Raghuraman, M Gabriel Paulraj, S Ignacimuthu. Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2014 Jun; 63(6):451-62. doi: 10.1007/s00011-014-0717-5. [PMID: 24492951]
  • Huiling Yang, Jianquan Liu, Shilong Chen, Fengzu Hu, Dangwei Zhou. Spatial variation profiling of four phytochemical constituents in Gentiana straminea (Gentianaceae). Journal of natural medicines. 2014 Jan; 68(1):38-45. doi: 10.1007/s11418-013-0763-2. [PMID: 23604973]
  • Yoshihiro Suyama, Shin-Ichiro Kurimoto, Kazuyoshi Kawazoe, Kotaro Murakami, Han-Dong Sun, Shun-Lin Li, Yoshihisa Takaishi, Yoshiki Kashiwada. Rigenolide A, a new secoiridoid glucoside with a cyclobutane skeleton, and three new acylated secoiridoid glucosides from Gentiana rigescens Franch. Fitoterapia. 2013 Dec; 91(?):166-172. doi: 10.1016/j.fitote.2013.08.006. [PMID: 23994629]
  • Gui-li Xu, Hong-liang Li, Jian-chang He, En-fu Feng, Pan-pan Shi, Yue-qiong Liu, Chang-xiao Liu. Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid. Journal of ethnopharmacology. 2013 Aug; 149(1):49-54. doi: 10.1016/j.jep.2013.05.016. [PMID: 23791808]
  • Yao-Li Li, Ming-Ying Shang, Chang-An Geng, Xue-Mei Zhang, Ji-Jun Chen, Shao-Qing Cai. [Simultaneous determination of five constituents in eight Qingyedan species derived from Swertia plants by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 May; 38(9):1394-400. doi: . [PMID: 23944076]
  • Hitesh Vaidya, Ramesh K Goyal, Sukhinder Kaur Cheema. Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-γ gene expression in 3T3-L1 cells. Phytotherapy research : PTR. 2013 Apr; 27(4):624-7. doi: 10.1002/ptr.4763. [PMID: 22718571]
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