Ribonolactone (BioDeep_00000018383)

 

Secondary id: BioDeep_00000002968, BioDeep_00000405480, BioDeep_00000600497, BioDeep_00001869006

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-one

化学式: C5H8O5 (148.0371718)
中文名称: D-(+)-核糖酸-1,4-内酯, 核糖酸-1,4-内酯
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.41%

分子结构信息

SMILES: C(C1C(C(C(=O)O1)O)O)O
InChI: InChI=1S/C5H8O5/c6-1-2-3(7)4(8)5(9)10-2/h2-4,6-8H,1H2/t2-,3-,4+/m1/s1

描述信息

Ribonolactone, also known as D-ribono-1,4-lactone is a five-membered form of ribonolactone having D-configuration. It has a role as a metabolite. It is a ribonolactone and a butan-4-olide. It derives from a D-ribonic acid. Ribonolactone belongs to the class of organic compounds known as pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms. Ribonolactone is a metabolite normally not detectable in human biofluids; however, it has been found in the urine of patients with neuroblastoma.
Ribonolactone is a metabolite normally not detectable in human biofluids; however, it has been found in the urine of patients with neuroblastoma. (PMID 699273) [HMDB]
D-Ribonolactone is sugar lactone and an inhibitor of β-galactosidase of Escherichia coli with a Ki of 26 mM[1].

同义名列表

35 个代谢物同义名

(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-one; delta-(+)-Ribonic acid gamma-lactone; D-(+)-Ribonic acid gamma-lactone; delta-(+)-Ribonic acid g-lactone; D(+)-Ribonic acid gamma-lactone; delta-(+)-Ribonone-1.4-lactone; delta-ribopentono-1,4-Lactone; gamma-Lactone OF ribonic acid; D-(+)-Ribonate gamma-lactone; D-(+)-Ribonic acid g-lactone; D-(+)-Ribonic acid γ-lactone; gamma-Lactone-ribonic acid; delta-ribono-gamma-Lactone; D-(+)-Ribonone-1.4-lactone; D-Ribonic acid-1,4-lactone; D-Ribopentono-1,4-lactone; gamma-Lactone OF ribonate; D-(+)-Ribonate γ-lactone; delta-ribono-1,4-Lactone; D-(+)-Ribonate g-lactone; D-Arabinono-1,4-lactone; D-Ribono-gamma-lactone; D-Ribonate-1,4-lactone; gamma-Lactone-ribonate; Ribono-gamma-lactone; D-ribono-1,4-Lactone; delta-Ribonolactone; D-Ribono-g-lactone; D-Ribono-γ-lactone; Deoxyribonolactone; Ribono-g-lactone; Ribono-γ-lactone; D-Ribonolactone; ribonolactone; D-Ribosone



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Silvana Casati, Paola Rota, Pietro Allevi, Alessandra Mingione, Roberta Ottria, Pierangela Ciuffreda. Clarifying the Use of Benzylidene Protecting Group for D-(+)-Ribono-1,4-Lactone, an Essential Building Block in the Synthesis of C-Nucleosides. Molecules (Basel, Switzerland). 2021 Oct; 26(21):. doi: 10.3390/molecules26216447. [PMID: 34770855]
  • Christelle Cronje, Gavin M George, Alisdair R Fernie, Jan Bekker, Jens Kossmann, Rolene Bauer. Manipulation of L-ascorbic acid biosynthesis pathways in Solanum lycopersicum: elevated GDP-mannose pyrophosphorylase activity enhances L-ascorbate levels in red fruit. Planta. 2012 Mar; 235(3):553-64. doi: 10.1007/s00425-011-1525-6. [PMID: 21979413]
  • Beata A Wolucka. Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy. The FEBS journal. 2008 Jun; 275(11):2691-711. doi: 10.1111/j.1742-4658.2008.06395.x. [PMID: 18422659]
  • Won-Ki Huh, Yong Bhum Song, Young-Seok Lee, Cheol Woong Ha, Seong-Tae Kim, Sa-Ouk Kang. D-Erythroascorbic acid activates cyanide-resistant respiration in Candida albicans. Biochemical and biophysical research communications. 2008 May; 369(2):401-6. doi: 10.1016/j.bbrc.2008.02.029. [PMID: 18282465]
  • Katsumi Amako, Kazuyo Fujita, Taka-aki Shimohata, Etsuko Hasegawa, Ritsuko Kishimoto, Kiyoshi Goda. NAD+-specific D-arabinose dehydrogenase and its contribution to erythroascorbic acid production in Saccharomyces cerevisiae. FEBS letters. 2006 Nov; 580(27):6428-34. doi: 10.1016/j.febslet.2006.10.058. [PMID: 17097644]
  • N Smirnoff. L-ascorbic acid biosynthesis. Vitamins and hormones. 2001; 61(?):241-66. doi: 10.1016/s0083-6729(01)61008-2. [PMID: 11153268]