1-Azabicyclo[2.2.2]octan-2-yl 2-hydroxy-2,2-diphenylacetate (BioDeep_00000183704)

   

human metabolite blood metabolite


代谢物信息卡片


1-Azabicyclo[2.2.2]octan-2-yl 2-hydroxy-2,2-diphenylacetic acid

化学式: C21H23NO3 (337.16778480000005)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1CN2CCC1CC2OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
InChI: InChI=1S/C21H23NO3/c23-20(25-19-15-16-11-13-22(19)14-12-16)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2

描述信息

同义名列表

3 个代谢物同义名

1-Azabicyclo[2.2.2]octan-2-yl 2-hydroxy-2,2-diphenylacetic acid; 1-Azabicyclo[2.2.2]octan-2-yl 2-hydroxy-2,2-diphenylacetate; 1-azabicyclo[2.2.2]octan-2-yl hydroxydiphenylacetate



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Junsuke Uwada, Abu Syed Md Anisuzzaman, Atsushi Nishimune, Hatsumi Yoshiki, Ikunobu Muramatsu. Intracellular distribution of functional M(1) -muscarinic acetylcholine receptors in N1E-115 neuroblastoma cells. Journal of neurochemistry. 2011 Sep; 118(6):958-67. doi: 10.1111/j.1471-4159.2011.07378.x. [PMID: 21740440]
  • Koji Hori, Kimiko Konishi, Koichiro Watanabe, Hiroyuki Uchida, Takashi Tsuboi, Matsuko Moriyasu, Itaru Tominaga, Mitsugu Hachisu. Influence of anticholinergic activity in serum on clinical symptoms of Alzheimer's disease. Neuropsychobiology. 2011; 63(3):147-53. doi: 10.1159/000321591. [PMID: 21228606]
  • Kung-Shing Lee, Atsushi Nishimune, Hatsumi Yoshiki, Abu Syed Md Anisuzzaman, Fumiko Suzuki, Mao-Hsien Wang, Juei-Tang Cheng, Ikunobu Muramatsu. Assessment of novel muscarinic acetylcholine receptors in rat cerebral cortex by a tissue segment binding method. Journal of pharmacological sciences. 2010; 112(4):444-51. doi: 10.1254/jphs.10016fp. [PMID: 20424384]
  • Satin Salehi, Shannon R Long, Philip J Proteau, Theresa M Filtz. Hawthorn (Crataegus monogyna Jacq.) extract exhibits atropine-sensitive activity in a cultured cardiomyocyte assay. Journal of natural medicines. 2009 Jan; 63(1):1-8. doi: 10.1007/s11418-008-0278-4. [PMID: 18696181]
  • Lijun Shi, Caiping Mao, Fanxing Zeng, Yuying Zhang, Zhice Xu. Central cholinergic signal-mediated neuroendocrine regulation of vasopressin and oxytocin in ovine fetuses. BMC developmental biology. 2008 Oct; 8(?):95. doi: 10.1186/1471-213x-8-95. [PMID: 18828925]
  • Christine Thomas, Ute Hestermann, Juergen Kopitz, Konstanze Plaschke, Peter Oster, Martin Driessen, Christoph Mundt, Matthias Weisbrod. Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium. BMC neuroscience. 2008 Sep; 9(?):86. doi: 10.1186/1471-2202-9-86. [PMID: 18793418]
  • Marci L Chew, Benoit H Mulsant, Bruce G Pollock, Mark E Lehman, Andrew Greenspan, Ramy A Mahmoud, Margaret A Kirshner, Denise A Sorisio, Robert R Bies, Georges Gharabawi. Anticholinergic activity of 107 medications commonly used by older adults. Journal of the American Geriatrics Society. 2008 Jul; 56(7):1333-41. doi: 10.1111/j.1532-5415.2008.01737.x. [PMID: 18510583]
  • Abu Syed Md Anisuzzaman, Shigeru Morishima, Fumiko Suzuki, Takashi Tanaka, Hatsumi Yoshiki, Zakia Sultana Sathi, Hironobu Akino, Osamu Yokoyama, Ikunobu Muramatsu. Assessment of muscarinic receptor subtypes in human and rat lower urinary tract by tissue segment binding assay. Journal of pharmacological sciences. 2008 Feb; 106(2):271-9. doi: 10.1254/jphs.fp0071435. [PMID: 18270476]
  • Ray Norbury, Michael J Travis, Kjell Erlandsson, Wendy Waddington, Peter J Ell, Declan G M Murphy. Estrogen therapy and brain muscarinic receptor density in healthy females: a SPET study. Hormones and behavior. 2007 Feb; 51(2):249-57. doi: 10.1016/j.yhbeh.2006.10.007. [PMID: 17173920]
  • Niladri Basu, Anton M Scheuhammer, Kirsti Rouvinen-Watt, Nicole Grochowina, Kate Klenavic, R Douglas Evans, Hing Man Chan. Methylmercury impairs components of the cholinergic system in captive mink (Mustela vison). Toxicological sciences : an official journal of the Society of Toxicology. 2006 May; 91(1):202-9. doi: 10.1093/toxsci/kfj121. [PMID: 16446290]
  • Sabrina Ganzinelli, Tania Borda, Leonor Sterin-Borda. Regulation of m1 muscarinic receptors and nNOS mRNA levels by autoantibodies from schizophrenic patients. Neuropharmacology. 2006 Mar; 50(3):362-71. doi: 10.1016/j.neuropharm.2005.09.013. [PMID: 16289249]
  • Elisabeth Maróstica, Maria Christina W Avellar, Catarina S Porto. Effects of testosterone on muscarinic acetylcholine receptors in the rat epididymis. Life sciences. 2005 Jun; 77(6):656-69. doi: 10.1016/j.lfs.2004.12.031. [PMID: 15921997]
  • T R Renuka, Das V Ani, C S Paulose. Alterations in the muscarinic M1 and M3 receptor gene expression in the brain stem during pancreatic regeneration and insulin secretion in weanling rats. Life sciences. 2004 Sep; 75(19):2269-80. doi: 10.1016/j.lfs.2004.03.034. [PMID: 15350825]
  • Paul S-H Park, Charlene C Ng, Sean Buck, James W Wells, Yu-Ling Cheng, Peter S Pennefather. Characterization of radioligand binding to a transmembrane receptor reconstituted into Lipobeads. FEBS letters. 2004 Jun; 567(2-3):344-8. doi: 10.1016/j.febslet.2004.03.124. [PMID: 15178349]
  • Camila C Cardoso, Renato T S Pereira, Cristiane A Koyama, Catarina S Porto, Fernando M F Abdalla. Effects of estrogen on muscarinic acetylcholine receptors in the rat hippocampus. Neuroendocrinology. 2004; 80(6):379-86. doi: 10.1159/000084202. [PMID: 15741743]
  • Zhi-Zhong Guan, Wen-Feng Yu, Agneta Nordberg. Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells. Neurochemistry international. 2003 Aug; 43(3):243-9. doi: 10.1016/s0197-0186(03)00009-3. [PMID: 12689604]
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  • Leonor Sterin-Borda, Lilian Joensen, Carolina Bayo-Hanza, Mónica Esteva, Enri Borda. Therapeutic use of muscarinic acetylcholine receptor peptide to prevent mice chagasic cardiac dysfunction. Journal of molecular and cellular cardiology. 2002 Dec; 34(12):1645-54. doi: 10.1006/jmcc.2002.2114. [PMID: 12505062]
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