2-[[4-[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]-4-methylidenepentanedioic acid (BioDeep_00000183595)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H23N7O6 (457.171)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 9.82%
分子结构信息
SMILES: C=C(CC(C(=O)O)NC(=O)C1=CC=C(C=C1)NCC2CNC3=C(N2)C(=O)NC(=N3)N)C(=O)O
InChI: InChI=1S/C20H23N7O6/c1-9(18(30)31)6-13(19(32)33)25-16(28)10-2-4-11(5-3-10)22-7-12-8-23-15-14(24-12)17(29)27-20(21)26-15/h2-5,12-13,22,24H,1,6-8H2,(H,25,28)(H,30,31)(H,32,33)(H4,21,23,26,27,29)
描述信息
同义名列表
5 个代谢物同义名
2-[(4-{[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methyl]amino}phenyl)formamido]-4-methylidenepentanedioic acid; 2-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-methylidenepentanedioic acid; 2-[(4-{[(4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-methylidenepentanedioate; 2-[[4-[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]-4-methylidenepentanedioic acid; 2-[[4-[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]-4-methylidenepentanedioate
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Adriana Lima Mello, Selma Freire de Carvalho da Cunha, Maria Cristina Foss-Freitas, Helio Vannucchi. Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults.
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Thrombosis and haemostasis.
2012 Sep; 108(3):533-42. doi:
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Mini reviews in medicinal chemistry.
2012 Sep; 12(10):997-1006. doi:
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BMC medical genetics.
2012 Aug; 13(?):74. doi:
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American journal of hypertension.
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DNA and cell biology.
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DNA and cell biology.
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Neuromolecular medicine.
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PloS one.
2012; 7(3):e33290. doi:
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. [PMID: 22479380] - Zhen Yang, Xie-Fu Zhang, Hong-Xiang Liu, Yong-Shun Hao, Chun-Lin Zhao. MTHFR C677T polymorphism and colorectal cancer risk in Asians, a meta-analysis of 21 studies.
Asian Pacific journal of cancer prevention : APJCP.
2012; 13(4):1203-8. doi:
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. [PMID: 22799306] - Laura Kevere, Santa Purvina, Daiga Bauze, Marcis Zeibarts, Raisa Andrezina, Arnis Rizevs, Sergejs Jelisejevs, Linda Piekuse, Madara Kreile, Indulis Purvins. Elevated serum levels of homocysteine as an early prognostic factor of psychiatric disorders in children and adolescents.
Schizophrenia research and treatment.
2012; 2012(?):373261. doi:
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. [PMID: 23091720] - Bruna Lancia Zampieri, Joice Matos Biselli, Eny Maria Goloni-Bertollo, Hélio Vannucchi, Valdemir Melechco Carvalho, José Antônio Cordeiro, Erika Cristina Pavarino. Maternal risk for Down syndrome is modulated by genes involved in folate metabolism.
Disease markers.
2012; 32(2):73-81. doi:
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. [PMID: 22377700] - Emel Ergul, Ali Sazci, Ihsan Kara. Methylenetetrahydrofolate reductase gene polymorphisms in Turkish children with attention-deficit/hyperactivity disorder.
Genetic testing and molecular biomarkers.
2012 Jan; 16(1):67-9. doi:
10.1089/gtmb.2011.0062
. [PMID: 21819229] - Xianhui Qin, Jianping Li, Yan Zhang, Wei Ma, Fangfang Fan, Binyan Wang, Houxun Xing, Genfu Tang, Xiaobin Wang, Xin Xu, Xiping Xu, Yong Huo. Prevalence and associated factors of diabetes and impaired fasting glucose in Chinese hypertensive adults aged 45 to 75 years.
PloS one.
2012; 7(8):e42538. doi:
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Nutrition and cancer.
2012; 64(4):550-8. doi:
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. [PMID: 22519865] - Rubina Tabassum, Alok Jaiswal, Ganesh Chauhan, Om Prakash Dwivedi, Saurabh Ghosh, Raman K Marwaha, Nikhil Tandon, Dwaipayan Bharadwaj. Genetic variant of AMD1 is associated with obesity in urban Indian children.
PloS one.
2012; 7(4):e33162. doi:
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JAMA.
2011 Dec; 306(23):2610-1. doi:
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. [PMID: 22187282] - H Li, W L Xu, H L Shen, Q Y Chen, L L Hui, L L Long, X L Zhu. Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population.
Genetics and molecular research : GMR.
2011 Dec; 10(4):3738-46. doi:
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American journal of human genetics.
2011 Dec; 89(6):688-700. doi:
10.1016/j.ajhg.2011.10.013
. [PMID: 22100073] - Asma Ezzaher, Dhouha Haj Mouhamed, Anwar Mechri, Asma Omezzine, Fadoua Neffati, Wahiba Douki, Ali Bouslama, Lotfi Gaha, Mohamed Fadhel Najjar. Hyperhomocysteinemia in Tunisian bipolar I patients.
Psychiatry and clinical neurosciences.
2011 Dec; 65(7):664-71. doi:
10.1111/j.1440-1819.2011.02284.x
. [PMID: 22176285] - Mohammad Reza Safarinejad, Nayyer Shafiei, Shiva Safarinejad. Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men.
Medical oncology (Northwood, London, England).
2011 Dec; 28 Suppl 1(?):S398-412. doi:
10.1007/s12032-010-9723-9
. [PMID: 21046286] - Yih-Hsin Chang, Wen-Mei Fu, Yu-Hui Wu, Chih-Jung Yeh, Chien-Ning Huang, Ming-Yuh Shiau. Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Taiwanese patients with Type 2 diabetic mellitus.
Clinical biochemistry.
2011 Dec; 44(17-18):1370-4. doi:
10.1016/j.clinbiochem.2011.09.020
. [PMID: 22008727] - Susan M Wernimont, Andrew G Clark, Patrick J Stover, Martin T Wells, Augusto A Litonjua, Scott T Weiss, J Michael Gaziano, Katherine L Tucker, Andrea Baccarelli, Joel Schwartz, Valentina Bollati, Patricia A Cassano. Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.
BMC medical genetics.
2011 Nov; 12(?):150. doi:
10.1186/1471-2350-12-150
. [PMID: 22103680] - Laurel E Murphy, James L Mills, Anne M Molloy, Cong Qian, Tonia C Carter, Helena Strevens, Dag Wide-Swensson, Aleksander Giwercman, Richard J Levine. Folate and vitamin B12 in idiopathic male infertility.
Asian journal of andrology.
2011 Nov; 13(6):856-61. doi:
10.1038/aja.2011.96
. [PMID: 21857689] - Fahri Uçar, Sükrü Celik, Burcu Yücel, Mehmet Sönmez, Figen Celep, Nergiz Erkut. MTHFR C677T polymorphism and its relationship to myocardial infarction in the Eastern Black Sea region of Turkey.
Archives of medical research.
2011 Nov; 42(8):709-12. doi:
10.1016/j.arcmed.2011.12.007
. [PMID: 22222489] - Pietro Cavalli, Gabriele Tonni, Enrico Grosso, Carlo Poggiani. Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy.
Birth defects research. Part A, Clinical and molecular teratology.
2011 Nov; 91(11):962-5. doi:
10.1002/bdra.22853
. [PMID: 21956977] - Yeltekin Demirel, Sezai Dogan, Ahmet Uludag, Coskun Silan, Sinem Atik, Fatma Silan, Ozturk Ozdemir. Combined effect of Factor V Leiden, MTHFR, and angiotensin-converting enzyme (insertion/deletion) gene mutations in hypertensive adult individuals: a population-based study from Sivas and Canakkale, Turkey.
Genetic testing and molecular biomarkers.
2011 Nov; 15(11):785-91. doi:
10.1089/gtmb.2011.0044
. [PMID: 21699409] - A Oussalah, J-L Guéant, L Peyrin-Biroulet. Meta-analysis: hyperhomocysteinaemia in inflammatory bowel diseases.
Alimentary pharmacology & therapeutics.
2011 Nov; 34(10):1173-84. doi:
10.1111/j.1365-2036.2011.04864.x
. [PMID: 21967576] - A M Pavlovic, T Pekmezovic, R Obrenovic, I Novakovic, G Tomic, M Mijajlovic, N Sternic. Increased total homocysteine level is associated with clinical status and severity of white matter changes in symptomatic patients with subcortical small vessel disease.
Clinical neurology and neurosurgery.
2011 Nov; 113(9):711-5. doi:
10.1016/j.clineuro.2011.07.004
. [PMID: 21802199] - Marianna Zsom, Tibor Fülöp, Lajos Zsom, Akos Baráth, Zoltán Maróti, Emoke Endreffy. Genetic polymorphisms and the risk of progressive renal failure in elderly Hungarian patients.
Hemodialysis international. International Symposium on Home Hemodialysis.
2011 Oct; 15(4):501-8. doi:
10.1111/j.1542-4758.2011.00593.x
. [PMID: 22111818] - Asuri N Prasad, Charles A Rupar, Chitra Prasad. Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy.
Brain & development.
2011 Oct; 33(9):758-69. doi:
10.1016/j.braindev.2011.05.014
. [PMID: 21778025] - Tao Huang, Katherine L Tucker, Yu-Chi Lee, Jimmy W Crott, Laurence D Parnell, Jian Shen, Caren E Smith, Jose M Ordovas, Duo Li, Chao-Qiang Lai. Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population.
Public health nutrition.
2011 Oct; 14(10):1805-12. doi:
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. [PMID: 21338559] - Barbara Faganel Kotnik, Iztok Grabnar, Petra Bohanec Grabar, Vita Dolžan, Janez Jazbec. Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma.
European journal of clinical pharmacology.
2011 Oct; 67(10):993-1006. doi:
10.1007/s00228-011-1046-z
. [PMID: 21509569] - Matteo Nicola Dario Di Minno, Salvatore Pezzullo, Vittorio Palmieri, Antonio Coppola, Armando D'Angelo, Francesca Sampietro, Viviana Cavalca, Elena Tremoli, Giovanni Di Minno. Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis.
Thrombosis research.
2011 Oct; 128(4):e43-8. doi:
10.1016/j.thromres.2011.05.017
. [PMID: 21669453] - Aleksandra Lesiak, Mary Norval, Karolina Wodz-Naskiewicz, Rafal Pawliczak, Michal Rogowski-Tylman, Anna Sysa-Jedrzejowska, Michal Sobjanek, Adam Wlodarkiewicz, Joanna Narbutt. An enhanced risk of basal cell carcinoma is associated with particular polymorphisms in the VDR and MTHFR genes.
Experimental dermatology.
2011 Oct; 20(10):800-4. doi:
10.1111/j.1600-0625.2011.01328.x
. [PMID: 21732987] - Franziska Marti, Peter Vollenweider, Pedro-Manuel Marques-Vidal, Vincent Mooser, Gérard Waeber, Fred Paccaud, Murielle Bochud. Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study.
BMC public health.
2011 Sep; 11(?):733. doi:
10.1186/1471-2458-11-733
. [PMID: 21943240] - Rizwan Masud, Irfan Zia Qureshi. Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.
Molecular and cellular biochemistry.
2011 Sep; 355(1-2):289-97. doi:
10.1007/s11010-011-0866-6
. [PMID: 21567207] - Johan Hultdin, Bethany Van Guelpen, Anna Winkvist, Göran Hallmans, Lars Weinehall, Birgitta Stegmayr, Torbjörn K Nilsson. Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke.
Clinical chemistry and laboratory medicine.
2011 Sep; 49(9):1555-62. doi:
10.1515/cclm.2011.234
. [PMID: 21631392] - C Mislanova, O Martsenyuk, B Huppertz, M Obolenskaya. Placental markers of folate-related metabolism in preeclampsia.
Reproduction (Cambridge, England).
2011 Sep; 142(3):467-76. doi:
10.1530/rep-10-0484
. [PMID: 21690209] - Chan Woo Park, Ae Ra Han, Joanne Kwak-Kim, So Yeon Park, Jung Yeol Han, Mi Kyoung Koong, In Ok Song, Kwang Moon Yang. The role of methylenetetrahydrofolate reductase C677T polymorphism on the peripheral blood natural killer cell proportion in women with unexplained recurrent miscarriages.
Clinical and experimental reproductive medicine.
2011 Sep; 38(3):168-73. doi:
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. [PMID: 22384438] - Natalia Ubeda, Leticia Reyes, Antonio González-Medina, Elena Alonso-Aperte, Gregorio Varela-Moreiras. Physiologic changes in homocysteine metabolism in pregnancy: a longitudinal study in Spain.
Nutrition (Burbank, Los Angeles County, Calif.).
2011 Sep; 27(9):925-30. doi:
10.1016/j.nut.2010.10.017
. [PMID: 21367581] - Nadia Ferlazzo, Gaetano Gorgone, Daniela Caccamo, Monica Currò, Salvatore Condello, Francesco Pisani, Fabrizio Vernieri, Paolo Maria Rossini, Riccardo Ientile. The 894G > T (Glu298Asp) variant in the endothelial NOS gene and MTHFR polymorphisms influence homocysteine levels in patients with cognitive decline.
Neuromolecular medicine.
2011 Sep; 13(3):167-74. doi:
10.1007/s12017-011-8148-8
. [PMID: 21607713] - Koumudi Godbole, Panjalingam Gayathri, Smita Ghule, Batchu Venkatanaga Sasirekha, Amruta Kanitkar-Damle, Nilam Memane, Seshadri Suresh, Jayesh Sheth, Giriraj Ratan Chandak, Chittaranjan S Yajnik. Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.
Birth defects research. Part A, Clinical and molecular teratology.
2011 Sep; 91(9):848-56. doi:
10.1002/bdra.20841
. [PMID: 21770021] - Timo Mühlhaus, Julia Weiss, Dorothea Hemme, Frederik Sommer, Michael Schroda. Quantitative shotgun proteomics using a uniform ¹⁵N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii.
Molecular & cellular proteomics : MCP.
2011 Sep; 10(9):M110.004739. doi:
10.1074/mcp.m110.004739
. [PMID: 21610104] - Ann I Scher, Holly Wu, Jack W Tsao, Henk J Blom, Preethy Feit, Remington L Nevin, Karen A Schwab. MTHFR C677T genotype as a risk factor for epilepsy including post-traumatic epilepsy in a representative military cohort.
Journal of neurotrauma.
2011 Sep; 28(9):1739-45. doi:
10.1089/neu.2011.1982
. [PMID: 21787169] - Glenn Tisman, April Garcia. Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.
Journal of medical case reports.
2011 Aug; 5(?):413. doi:
10.1186/1752-1947-5-413
. [PMID: 21867542] - Erika R F Siqueira, Cláudia P M S Oliveira, Maria T C Muniz, Filipe Silva, Leila M M B Pereira, Flair J Carrilho. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil.
Nutrition journal.
2011 Aug; 10(?):86. doi:
10.1186/1475-2891-10-86
. [PMID: 21854603] - S C Choo, S P Loh, G L Khor, M N Sabariah, R Rozita. MTHFR C677T polymorphism, homocysteine and B-vitamins status in a sample of Chinese and Malay subjects in Universiti Putra Malaysia.
Malaysian journal of nutrition.
2011 Aug; 17(2):249-58. doi:
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. [PMID: 22303578] - Chris J McNeil, John H Beattie, M-J Gordon, Lynn P Pirie, Susan J Duthie. Differential effects of nutritional folic acid deficiency and moderate hyperhomocysteinemia on aortic plaque formation and genome-wide DNA methylation in vascular tissue from ApoE-/- mice.
Clinical epigenetics.
2011 Aug; 2(2):361-8. doi:
10.1007/s13148-011-0022-x
. [PMID: 22704348] - Ji Zhang, Diane E Handy, Yufang Wang, Guylaine Bouchard, Jacob Selhub, Joseph Loscalzo, Martin C Carey. Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice.
Hepatology (Baltimore, Md.).
2011 Aug; 54(2):697-706. doi:
10.1002/hep.24428
. [PMID: 21567442] - J P Mena, M Salazar-Páramo, L González-López, J I Gámez-Nava, L Sandoval-Ramirez, J D Sánchez, L E Figuera, F J Muñoz-Valle, M Vazquez del Mercado, I P Dávalos. Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases.
The pharmacogenomics journal.
2011 Aug; 11(4):287-91. doi:
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