9-Hydroxynon-2-enal (BioDeep_00000183450)
human metabolite blood metabolite
代谢物信息卡片
9-Hydroxynon-2-enal
化学式: C9H16O2 (156.115)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: OCCCCCCC=CC=O
InChI: InChI=1S/C9H16O2/c10-8-6-4-2-1-3-5-7-9-11/h4,6,8,11H,1-3,5,7,9H2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Andrzej M Woyda-Ploszczyca, Wieslawa Jarmuszkiewicz. Hydroxynonenal, a lipid peroxidation end product, stimulates uncoupling protein activity in Acanthamoeba castellanii mitochondria; the sensitivity of the inducible activity to purine nucleotides depends on the membranous ubiquinone redox state.
Journal of bioenergetics and biomembranes.
2012 Oct; 44(5):525-38. doi:
10.1007/s10863-012-9456-x. [PMID: 22798183] - Juan Sebastian Danobeitia, Jamie M Sperger, Matthew S Hanson, Elisa E Park, Peter J Chlebeck, Drew A Roenneburg, Mallory L Sears, Jolien X Connor, Alice Schwarznau, Luis A Fernandez. Early activation of the inflammatory response in the liver of brain-dead non-human primates.
The Journal of surgical research.
2012 Aug; 176(2):639-48. doi:
10.1016/j.jss.2011.10.042. [PMID: 22440934] - Concetta Finocchiaro, Olivia Segre, Maurizio Fadda, Taira Monge, Mara Scigliano, Marina Schena, Marco Tinivella, Elisa Tiozzo, Maria G Catalano, Mariateresa Pugliese, Nicoletta Fortunati, Manuela Aragno, Giuliana Muzio, Marina Maggiora, Manuela Oraldi, Rosa A Canuto. Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study.
The British journal of nutrition.
2012 Jul; 108(2):327-33. doi:
10.1017/s0007114511005551. [PMID: 22114792] - Julie Jortay, Maximin Senou, Michel Abou-Samra, Laurence Noel, Annie Robert, Marie-Christine Many, Sonia M Brichard. Adiponectin and skeletal muscle: pathophysiological implications in metabolic stress.
The American journal of pathology.
2012 Jul; 181(1):245-56. doi:
10.1016/j.ajpath.2012.03.035. [PMID: 22658482] - Xiongwei Zhu, Rudy J Castellani, Paula I Moreira, Gjumrakch Aliev, Justin C Shenk, Sandra L Siedlak, Peggy L R Harris, Hisashi Fujioka, Lawrence M Sayre, Pamela A Szweda, Luke I Szweda, Mark A Smith, George Perry. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Free radical biology & medicine.
2012 Feb; 52(3):699-704. doi:
10.1016/j.freeradbiomed.2011.11.004. [PMID: 22137893] - Sarah Engeham, Kennedy Mdaki, Kirsty Jewell, Ruth Austin, Alexander N Lehner, Simon C Langley-Evans. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet.
Journal of nutrition and metabolism.
2012; 2012(?):989037. doi:
10.1155/2012/989037. [PMID: 22536494] - Janelle N Fawver, Hayley E Schall, Rachel D Petrofes Chapa, Xiongwei Zhu, Ian V J Murray. Amyloid-β metabolite sensing: biochemical linking of glycation modification and misfolding.
Journal of Alzheimer's disease : JAD.
2012; 30(1):63-73. doi:
10.3233/jad-2012-112114. [PMID: 22406446] - Rakhee Agarwal, Leah Hennings, Tonya M Rafferty, Lynda G Letzig, Sandra McCullough, Laura P James, Lee Ann MacMillan-Crow, Jack A Hinson. Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.
The Journal of pharmacology and experimental therapeutics.
2012 Jan; 340(1):134-42. doi:
10.1124/jpet.111.184192. [PMID: 22001257] - Jean-Pierre Louboutin, David S Strayer. Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications.
TheScientificWorldJournal.
2012; 2012(?):482575. doi:
10.1100/2012/482575. [PMID: 22448134] - Eugenia Murawska-Ciałowicz, Wojciech Bal, Lidia Januszewska, Marcin Zawadzki, Joanna Rychel, Jolanta Zuwała-Jagiełło. Oxidative stress level in the testes of mice and rats during nickel intoxication.
TheScientificWorldJournal.
2012; 2012(?):395741. doi:
10.1100/2012/395741. [PMID: 22448131] - Noah M Walton, Rick Shin, Katsunori Tajinda, Carrie L Heusner, Jeffrey H Kogan, Shinichi Miyake, Qian Chen, Kouichi Tamura, Mitsuyuki Matsumoto. Adult neurogenesis transiently generates oxidative stress.
PloS one.
2012; 7(4):e35264. doi:
10.1371/journal.pone.0035264. [PMID: 22558133] - Prajitha Thampi, Haripriya Vittal Rao, Sayak K Mitter, Jun Cai, Haoyu Mao, Hong Li, Soojung Seo, Xiaoping Qi, Alfred S Lewin, Carl Romano, Michael E Boulton. The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium.
PloS one.
2012; 7(4):e34468. doi:
10.1371/journal.pone.0034468. [PMID: 22509307] - Jean-François Lesgards, Cyrielle Gauthier, Juan Iovanna, Nicolas Vidal, Alain Dolla, Pierre Stocker. Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes.
Chemico-biological interactions.
2011 Mar; 190(1):28-34. doi:
10.1016/j.cbi.2010.12.028. [PMID: 21216240] - Tomislava Lovaković, Marija Poljak-Blazi, Gunars Duburs, Ana Cipak, Marina Cindrić, Brigita Vigante, Egils Bisenieks, Morana Jaganjac, Lidija Mrakovcić, Azra Dedić, Neven Zarković. Growth modulation of human cells in vitro by mild oxidative stress and 1,4-dihydropyridine derivative antioxidants.
Collegium antropologicum.
2011 Mar; 35(1):137-41. doi:
". [PMID: 21661362] - Kamal A Amin, Hamdy H Kamel, Mohamed A Abd Eltawab. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet.
Lipids in health and disease.
2011 Jan; 10(?):6. doi:
10.1186/1476-511x-10-6. [PMID: 21235803] - Qing Yuan, Shanjuan Hong, Shu Han, Li Zeng, Fang Liu, Guoshan Ding, Yindong Kang, Jingyan Mao, Ming Cai, Youhua Zhu, Quan-Xing Wang. Preconditioning with physiological levels of ethanol protect kidney against ischemia/reperfusion injury by modulating oxidative stress.
PloS one.
2011; 6(10):e25811. doi:
10.1371/journal.pone.0025811. [PMID: 22022451] - Shilpa Chakravarty, Syed Ibrahim Rizvi. Day and Night GSH and MDA Levels in Healthy Adults and Effects of Different Doses of Melatonin on These Parameters.
International journal of cell biology.
2011; 2011(?):404591. doi:
10.1155/2011/404591. [PMID: 21647290] - Julie Jortay, Maximin Senou, Aurélie Delaigle, Laurence Noel, Tohru Funahashi, Norikazu Maeda, Marie C Many, Sonia M Brichard. Local induction of adiponectin reduces lipopolysaccharide-triggered skeletal muscle damage.
Endocrinology.
2010 Oct; 151(10):4840-51. doi:
10.1210/en.2009-1462. [PMID: 20702578] - Baohai Shao, Subramaniam Pennathur, Ioanna Pagani, Michael N Oda, Joseph L Witztum, John F Oram, Jay W Heinecke. Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway.
The Journal of biological chemistry.
2010 Jun; 285(24):18473-84. doi:
10.1074/jbc.m110.118182. [PMID: 20378541] - Ki-Yeon Yoo, Hua Li, In Koo Hwang, Jung Hoon Choi, Choong Hyun Lee, Dae Young Kwon, Shi Yong Ryu, Young Sup Kim, Il-Jun Kang, Hyung-Cheul Shin, Moo-Ho Won. Zizyphus attenuates ischemic damage in the gerbil hippocampus via its antioxidant effect.
Journal of medicinal food.
2010 Jun; 13(3):557-63. doi:
10.1089/jmf.2009.1254. [PMID: 20521981] - Jean-Pierre Louboutin, Beverly A S Reyes, Lokesh Agrawal, Christina R Maxwell, Elisabeth J Van Bockstaele, David S Strayer. Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120--protection by gene delivery of antioxidant enzymes.
Neurobiology of disease.
2010 May; 38(2):313-25. doi:
10.1016/j.nbd.2010.02.007. [PMID: 20219678] - Gaetano Serviddio, Francesco Bellanti, Anna Maria Giudetti, Gabriele Vincenzo Gnoni, Antonio Petrella, Rosanna Tamborra, Antonino Davide Romano, Tiziana Rollo, Gianluigi Vendemiale, Emanuele Altomare. A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.
The Journal of pharmacology and experimental therapeutics.
2010 Mar; 332(3):922-32. doi:
10.1124/jpet.109.161612. [PMID: 20008062] - Michela Guglielmotto, Luca Giliberto, Elena Tamagno, Massimo Tabaton. Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors.
Frontiers in aging neuroscience.
2010; 2(?):3. doi:
10.3389/neuro.24.003.2010. [PMID: 20552043] - Fiore Cattaruzza, Ian Spreadbury, Marcela Miranda-Morales, Eileen F Grady, Stephen Vanner, Nigel W Bunnett. Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.
American journal of physiology. Gastrointestinal and liver physiology.
2010 Jan; 298(1):G81-91. doi:
10.1152/ajpgi.00221.2009. [PMID: 19875705] - Grace Ellis, Erica Fang, Mukesh Maheshwari, Emily Roltsch, Leigh Holcomb, Danna Zimmer, Daniel Martinez, Ian V J Murray. Lipid oxidation and modification of amyloid-β (Aβ) in vitro and in vivo.
Journal of Alzheimer's disease : JAD.
2010; 22(2):593-607. doi:
10.3233/jad-2010-100960. [PMID: 20847409] - Nadeene Parker, Antonio J Vidal-Puig, Vian Azzu, Martin D Brand. Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2.
Biochimica et biophysica acta.
2009 Dec; 1787(12):1451-7. doi:
10.1016/j.bbabio.2009.06.005. [PMID: 19539600] - Michel Havaux, Brigitte Ksas, Agnieszka Szewczyk, Dominique Rumeau, Fabrice Franck, Stefano Caffarri, Christian Triantaphylidès. Vitamin B6 deficient plants display increased sensitivity to high light and photo-oxidative stress.
BMC plant biology.
2009 Nov; 9(?):130. doi:
10.1186/1471-2229-9-130. [PMID: 19903353] - Shahid P Baba, Oleg A Barski, Yonis Ahmed, Timothy E O'Toole, Daniel J Conklin, Aruni Bhatnagar, Sanjay Srivastava. Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue.
Diabetes.
2009 Nov; 58(11):2486-97. doi:
10.2337/db09-0375. [PMID: 19651811] - Arpita Basu, Marci Wilkinson, Kavitha Penugonda, Brandi Simmons, Nancy M Betts, Timothy J Lyons. Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects.
Nutrition journal.
2009 Sep; 8(?):43. doi:
10.1186/1475-2891-8-43. [PMID: 19785767] - Klaus Dittmann, Claus Mayer, Rainer Kehlbach, Marie-Christine Rothmund, H Peter Rodemann. Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
2009 Sep; 92(3):379-82. doi:
10.1016/j.radonc.2009.06.003. [PMID: 19560222] - Juliana B R Corrêa Soares, Diego Menezes, Marcos A Vannier-Santos, Antonio Ferreira-Pereira, Giulliana T Almeida, Thiago M Venancio, Sergio Verjovski-Almeida, Vincent K Zishiri, David Kuter, Roger Hunter, Timothy J Egan, Marcus F Oliveira. Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.
PLoS neglected tropical diseases.
2009 Jul; 3(7):e477. doi:
10.1371/journal.pntd.0000477. [PMID: 19597543] - Raymond Q Migrino, Richard Christenson, Aniko Szabo, Megan Bright, Seth Truran, Parameswaran Hari. Prognostic implication of late gadolinium enhancement on cardiac MRI in light chain (AL) amyloidosis on long term follow up.
BMC medical physics.
2009 May; 9(?):5. doi:
10.1186/1756-6649-9-5. [PMID: 19416541] - Ravichandran Srividhya, Kamelija Zarkovic, Marina Stroser, Georg Waeg, Neven Zarkovic, Periandavan Kalaiselvi. Mitochondrial alterations in aging rat brain: effective role of (-)-epigallo catechin gallate.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2009 May; 27(3):223-31. doi:
10.1016/j.ijdevneu.2009.01.003. [PMID: 19429387] - Massimo Collino, Manuela Aragno, Sara Castiglia, Chiara Tomasinelli, Christoph Thiemermann, Giuseppe Boccuzzi, Roberto Fantozzi. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta.
Diabetes.
2009 Jan; 58(1):235-42. doi:
10.2337/db08-0691. [PMID: 18840784] - Annette Maczurek, Klaus Hager, Marlene Kenklies, Matt Sharman, Ralph Martins, Jürgen Engel, David A Carlson, Gerald Münch. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.
Advanced drug delivery reviews.
2008 Oct; 60(13-14):1463-70. doi:
10.1016/j.addr.2008.04.015. [PMID: 18655815] - Natalia Felitsyn, Colin McLeod, Albert L Shroads, Peter W Stacpoole, Lucia Notterpek. The heme precursor delta-aminolevulinate blocks peripheral myelin formation.
Journal of neurochemistry.
2008 Sep; 106(5):2068-79. doi:
10.1111/j.1471-4159.2008.05552.x. [PMID: 18665889] - Rabia Alghazeer, Hongliang Gao, Nazlin K Howell. Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells).
Toxicology letters.
2008 Aug; 180(3):202-11. doi:
10.1016/j.toxlet.2008.06.859. [PMID: 18625293] - Vian Azzu, Nadeene Parker, Martin D Brand. High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation.
The Biochemical journal.
2008 Jul; 413(2):323-32. doi:
10.1042/bj20080321. [PMID: 18426390] - Anil D'souza, Biji T Kurien, Rosalie Rodgers, Jaideep Shenoi, Sadamu Kurono, Hiroyuki Matsumoto, Kenneth Hensley, Swapan K Nath, R Hal Scofield. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE.
BMC medical genetics.
2008 Jul; 9(?):62. doi:
10.1186/1471-2350-9-62. [PMID: 18606005] - Sridevi Devaraj, Janice Wang-Polagruto, John Polagruto, Carl L Keen, Ishwarlal Jialal. High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome.
Metabolism: clinical and experimental.
2008 Jun; 57(6):867-70. doi:
10.1016/j.metabol.2008.02.016. [PMID: 18502272] - Nadeene Parker, Charles Affourtit, Antonio Vidal-Puig, Martin D Brand. Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria.
The Biochemical journal.
2008 May; 412(1):131-9. doi:
10.1042/bj20080006. [PMID: 18251717] - Nadeene Parker, Antonio Vidal-Puig, Martin D Brand. Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential.
Bioscience reports.
2008 Apr; 28(2):83-8. doi:
10.1042/bsr20080002. [PMID: 18384278] - Ingrid Emerit. Clastogenic factors as potential biomarkers of increased superoxide production.
Biomarker insights.
2007 Dec; 2(?):429-38. doi:
10.1177/117727190700200010. [PMID: 19662223] - Dikran Toroser, William C Orr, Rajindar S Sohal. Carbonylation of mitochondrial proteins in Drosophila melanogaster during aging.
Biochemical and biophysical research communications.
2007 Nov; 363(2):418-24. doi:
10.1016/j.bbrc.2007.08.193. [PMID: 17884014] - Karim S Echtay. Mitochondrial uncoupling proteins--what is their physiological role?.
Free radical biology & medicine.
2007 Nov; 43(10):1351-71. doi:
10.1016/j.freeradbiomed.2007.08.011. [PMID: 17936181] - Bárbara Macedo, Ana Rita Batista, José Barbas do Amaral, Maria João Saraiva. Biomarkers in the assessment of therapies for familial amyloidotic polyneuropathy.
Molecular medicine (Cambridge, Mass.).
2007 Nov; 13(11-12):584-91. doi:
10.2119/2007-00068.macedo. [PMID: 17932549] - Enrico Brignardello, Cristina Runzo, Manuela Aragno, Maria Graziella Catalano, Maurizio Cassader, Paolo Cavallo Perin, Giuseppe Boccuzzi. Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients.
Diabetes care.
2007 Nov; 30(11):2922-7. doi:
10.2337/dc07-1110. [PMID: 17704347] - Kazuyo Toyoda, Ritsuko Nagae, Mitsugu Akagawa, Kosuke Ishino, Takahiro Shibata, Sohei Ito, Noriyuki Shibata, Tomoko Yamamoto, Makio Kobayashi, Yoshinari Takasaki, Tsukasa Matsuda, Koji Uchida. Protein-bound 4-hydroxy-2-nonenal: an endogenous triggering antigen of antI-DNA response.
The Journal of biological chemistry.
2007 Aug; 282(35):25769-78. doi:
10.1074/jbc.m703039200. [PMID: 17588942] - Jagadeesan Nair, Silvio De Flora, Alberto Izzotti, Helmut Bartsch. Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions.
Mutation research.
2007 Aug; 621(1-2):95-105. doi:
10.1016/j.mrfmmm.2007.02.013. [PMID: 17412369] - Subir Kumar Das, D M Vasudevan. Alcohol-induced oxidative stress.
Life sciences.
2007 Jun; 81(3):177-87. doi:
10.1016/j.lfs.2007.05.005. [PMID: 17570440] - Lina Holmquist, Grant Stuchbury, Katrin Berbaum, Sonja Muscat, Simon Young, Klaus Hager, Jürgen Engel, Gerald Münch. Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.
Pharmacology & therapeutics.
2007 Jan; 113(1):154-64. doi:
10.1016/j.pharmthera.2006.07.001. [PMID: 16989905] - Moti L Tiku, Haritha Narla, Mohit Jain, Praveen Yalamanchili. Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation.
Arthritis research & therapy.
2007; 9(4):R76. doi:
10.1186/ar2274. [PMID: 17686167] - Brian S Rogers, Robert C A Symons, Keiichi Komeima, Jikui Shen, Weihong Xiao, Mara E Swaim, Yuan Yuan Gong, Shu Kachi, Peter A Campochiaro. Differential sensitivity of cones to iron-mediated oxidative damage.
Investigative ophthalmology & visual science.
2007 Jan; 48(1):438-45. doi:
10.1167/iovs.06-0528. [PMID: 17197565] - Vittorio Calabrese, Rukhsana Sultana, Giovanni Scapagnini, Eleonora Guagliano, Maria Sapienza, Rita Bella, Jaroslaw Kanski, Giovanni Pennisi, Cesare Mancuso, Anna Maria Giuffrida Stella, D A Butterfield. Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease.
Antioxidants & redox signaling.
2006 Nov; 8(11-12):1975-86. doi:
10.1089/ars.2006.8.1975. [PMID: 17034343] - Biji T Kurien, R Hal Scofield. Lipid peroxidation in systemic lupus erythematosus.
Indian journal of experimental biology.
2006 May; 44(5):349-56. doi:
". [PMID: 16708886] - Qin Shi, France Vaillancourt, Véronique Côté, Hassan Fahmi, Patrick Lavigne, Hassan Afif, John A Di Battista, Julio C Fernandes, Mohamed Benderdour. Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal.
Arthritis research & therapy.
2006; 8(6):R159. doi:
10.1186/ar2066. [PMID: 17042956] - Sudesh Vasdev, Vicki Gill, Pawan K Singal. Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms.
Vascular health and risk management.
2006; 2(3):263-76. doi:
10.2147/vhrm.2006.2.3.263. [PMID: 17326332] - Naoyuki Iso-O, Hiroshi Noto, Masumi Hara, Masako Togo, Ken Karasawa, Noriko Ohashi, Eisei Noiri, Yoshiaki Hashimoto, Takashi Kadowaki, Satoshi Kimura, Tsuyoshi Watanabe, Kazuhisa Tsukamoto. Adenovirus-mediated gene transfer and lipoprotein-mediated protein delivery of plasma PAF-AH ameliorates proteinuria in rat model of glomerulosclerosis.
Molecular therapy : the journal of the American Society of Gene Therapy.
2006 Jan; 13(1):118-26. doi:
10.1016/j.ymthe.2005.08.011. [PMID: 16213192] - Rahul Shah, Karel Raska, Moti L Tiku. The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage: a pathogenic role in osteoarthritis.
Arthritis and rheumatism.
2005 Sep; 52(9):2799-807. doi:
10.1002/art.21239. [PMID: 16145669] - Martin J J Ronis, Angelica Butura, Brante P Sampey, Kartik Shankar, Ronald L Prior, Sohelia Korourian, Emanuele Albano, Magnus Ingelman-Sundberg, Dennis R Petersen, Thomas M Badger. Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition.
Free radical biology & medicine.
2005 Sep; 39(5):619-30. doi:
10.1016/j.freeradbiomed.2005.04.011. [PMID: 16085180] - Bohus Obert, Erica E Benson, Steve Millam, Anna Pret'ová, David H Bremner. Moderation of morphogenetic and oxidative stress responses in flax in vitro cultures by hydroxynonenal and desferrioxamine.
Journal of plant physiology.
2005 May; 162(5):537-47. doi:
10.1016/j.jplph.2004.06.002. [PMID: 15940871] - Karim S Echtay, Julian L Pakay, Telma C Esteves, Martin D Brand. Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage.
BioFactors (Oxford, England).
2005; 24(1-4):119-30. doi:
10.1002/biof.5520240114. [PMID: 16403971] - Joseph Lunec, Eugene Halligan, Nalini Mistry, Katherine Karakoula. Effect of vitamin E on gene expression changes in diet-related carcinogenesis.
Annals of the New York Academy of Sciences.
2004 Dec; 1031(?):169-83. doi:
10.1196/annals.1331.016. [PMID: 15753143] - Martin D Brand, Charles Affourtit, Telma C Esteves, Katherine Green, Adrian J Lambert, Satomi Miwa, Julian L Pakay, Nadeene Parker. Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins.
Free radical biology & medicine.
2004 Sep; 37(6):755-67. doi:
10.1016/j.freeradbiomed.2004.05.034. [PMID: 15304252] - Yukiko Minamiyama, Shigekazu Takemura, Shinya Toyokuni, Susumu Imaoka, Yoshihiko Funae, Kazuhiro Hirohashi, Toshikazu Yoshikawa, Shigeru Okada. CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats.
Free radical biology & medicine.
2004 Sep; 37(5):703-12. doi:
10.1016/j.freeradbiomed.2004.05.022. [PMID: 15288127] - Taro Yamashita, Yukio Ando, Masaaki Nakamura, Konen Obayashi, Hisayasu Terazaki, Katsuki Haraoka, Sun Xu Guo, Mitsuharu Ueda, Makoto Uchino. Inhibitory effect of α-tocopherol on methylmercury-induced oxidative steress.
Environmental health and preventive medicine.
2004 May; 9(3):111-7. doi:
10.1007/bf02898069. [PMID: 21432319] - Dorota Sanocka, Maciej Kurpisz. Reactive oxygen species and sperm cells.
Reproductive biology and endocrinology : RB&E.
2004 Mar; 2(?):12. doi:
10.1186/1477-7827-2-12. [PMID: 15038829] - Hossein A Ghanbari, Kasra Ghanbari, Peggy L R Harris, Paul K Jones, Zvezdana Kubat, Rudolph J Castellani, Benjamin L Wolozin, Mark A Smith, George Perry. Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients.
Aging cell.
2004 02; 3(1):41-4. doi:
10.1111/j.1474-9728.2004.00083.x. [PMID: 14965355] - Norman J Haughey, Roy G Cutler, Anita Tamara, Justin C McArthur, Diana L Vargas, Carlos A Pardo, Jadwiga Turchan, Avindra Nath, Mark P Mattson. Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia.
Annals of neurology.
2004 Feb; 55(2):257-67. doi:
10.1002/ana.10828. [PMID: 14755730] - Martin D Brand, Julie A Buckingham, Telma C Esteves, Katherine Green, Adrian J Lambert, Satomi Miwa, Michael P Murphy, Julian L Pakay, Darren A Talbot, Karim S Echtay. Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.
Biochemical Society symposium.
2004; ?(71):203-13. doi:
10.1042/bss0710203. [PMID: 15777023] - Ji Eun Lee, Takayuki Nakagawa, Tomoko Kita, Tae Soo Kim, Fukuichiro Iguchi, Tsuyoshi Endo, Atsushi Shiga, Sang Heun Lee, Juichi Ito. Mechanisms of apoptosis induced by cisplatin in marginal cells in mouse stria vascularis.
ORL; journal for oto-rhino-laryngology and its related specialties.
2004; 66(3):111-8. doi:
10.1159/000079329. [PMID: 15316230] - Naomi Osakabe, Megumi Yamagishi, Midori Natsume, Akiko Yasuda, Toshihiko Osawa. Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats.
Experimental biology and medicine (Maywood, N.J.).
2004 Jan; 229(1):33-9. doi:
10.1177/153537020422900104. [PMID: 14709774] - Michael P Murphy, Karim S Echtay, Frances H Blaikie, Jordi Asin-Cayuela, Helena M Cocheme, Katherine Green, Julie A Buckingham, Ellen R Taylor, Fiona Hurrell, Gillian Hughes, Satomi Miwa, Christopher E Cooper, Dimitri A Svistunenko, Robin A J Smith, Martin D Brand. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.
The Journal of biological chemistry.
2003 Dec; 278(49):48534-45. doi:
10.1074/jbc.m308529200. [PMID: 12972420] - Anca D Dobrian, Suzanne D Schriver, Terrie Lynch, Russell L Prewitt. Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity.
American journal of physiology. Renal physiology.
2003 Oct; 285(4):F619-28. doi:
10.1152/ajprenal.00388.2002. [PMID: 12799306] - Manuela Aragno, Juan Carlos Cutrin, Raffaella Mastrocola, Maria-Giulia Perrelli, Francesca Restivo, Giuseppe Poli, Oliviero Danni, Giuseppe Boccuzzi. Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: attenuation by dehydroepiandrosterone.
Kidney international.
2003 Sep; 64(3):836-43. doi:
10.1046/j.1523-1755.2003.00152.x. [PMID: 12911533] - Karim S Echtay, Telma C Esteves, Julian L Pakay, Mika B Jekabsons, Adrian J Lambert, Manuel Portero-Otín, Reinald Pamplona, Antonio J Vidal-Puig, Steven Wang, Stephen J Roebuck, Martin D Brand. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.
The EMBO journal.
2003 Aug; 22(16):4103-10. doi:
10.1093/emboj/cdg412. [PMID: 12912909] - Mario Umberto Dianzani. 4-hydroxynonenal from pathology to physiology.
Molecular aspects of medicine.
2003 Aug; 24(4-5):263-72. doi:
10.1016/s0098-2997(03)00021-9. [PMID: 12893004] - Jovana Gasic-Milenkovic, Claudia Loske, Gerald Münch. Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y.
Journal of Alzheimer's disease : JAD.
2003 Feb; 5(1):25-30. doi:
10.3233/jad-2003-5104. [PMID: 12590163] - Joanne E Carter, Ai Q Truong-Tran, Dion Grosser, Lien Ho, Richard E Ruffin, Peter D Zalewski. Involvement of redox events in caspase activation in zinc-depleted airway epithelial cells.
Biochemical and biophysical research communications.
2002 Oct; 297(4):1062-70. doi:
10.1016/s0006-291x(02)02292-1. [PMID: 12359264] - John W Crabb, June O'Neil, Masaru Miyagi, Karen West, Henry F Hoff. Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues.
Protein science : a publication of the Protein Society.
2002 Apr; 11(4):831-40. doi:
10.1110/ps.4400102. [PMID: 11910026] - Takafumi Wataya, Akihiko Nunomura, Mark A Smith, Sandra L Siedlak, Peggy L R Harris, Shun Shimohama, Luke I Szweda, Matthew A Kaminski, Jesus Avila, Donald L Price, Don W Cleveland, Lawrence M Sayre, George Perry. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
The Journal of biological chemistry.
2002 Feb; 277(7):4644-8. doi:
10.1074/jbc.m110913200. [PMID: 11733539] - Rudy J Castellani, George Perry, Sandra L Siedlak, Akihiko Nunomura, Shun Shimohama, Jing Zhang, Thomas Montine, Lawrence M Sayre, Mark A Smith. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.
Neuroscience letters.
2002 Feb; 319(1):25-8. doi:
10.1016/s0304-3940(01)02514-9. [PMID: 11814645] - M Aragno, S Parola, E Brignardello, R Manti, S Betteto, E Tamagno, O Danni, G Boccuzzi. Oxidative stress and eicosanoids in the kidneys of hyperglycemic rats treated with dehydroepiandrosterone.
Free radical biology & medicine.
2001 Oct; 31(8):935-42. doi:
10.1016/s0891-5849(01)00669-4. [PMID: 11595378] - X R Lu, W Y Ong, B Halliwell. The phospholipase A2 inhibitor quinacrine prevents increased immunoreactivity to cytoplasmic phospholipase A2 (cPLA2) and hydroxynonenal (HNE) in neurons of the lateral septum following fimbria-fornix transection.
Experimental brain research.
2001 Jun; 138(4):500-8. doi:
10.1007/s002210100737. [PMID: 11465749] - O B Suhr, K Lång, L Wikström, I Anan, Y Ando, M El-Salhy, G Holmgren, K Tashima. Scavenger treatment of free radical injury in familial amyloidotic polyneuropathy: a study on Swedish transplanted and non-transplanted patients.
Scandinavian journal of clinical and laboratory investigation.
2001 Feb; 61(1):11-8. doi:
10.1080/00365510151067884. [PMID: 11300606]
