(6'-Acetyloxy-4,5-dichloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate (BioDeep_00000183447)
human metabolite blood metabolite
代谢物信息卡片
3-(Acetyloxy)-4,5-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-6-yl acetic acid
化学式: C24H14Cl2O7 (484.0116554)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1=CC2=C(C=C1)C1(OC(=O)C3=C1C=CC(Cl)=C3Cl)C1=C(O2)C=C(OC(C)=O)C=C1
InChI: InChI=1S/C24H14Cl2O7/c1-11(27)30-13-3-5-15-19(9-13)32-20-10-14(31-12(2)28)4-6-16(20)24(15)17-7-8-18(25)22(26)21(17)23(29)33-24/h3-10H,1-2H3
描述信息
同义名列表
5 个代谢物同义名
3-(Acetyloxy)-4,5-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-6-yl acetic acid; (6-Acetyloxy-4,5-dichloro-3-oxospiro[2-benzofuran-1,9-xanthene]-3-yl) acetic acid; 3-(acetyloxy)-4,5-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-6-yl acetate; (6-Acetyloxy-4,5-dichloro-3-oxospiro[2-benzofuran-1,9-xanthene]-3-yl) acetate; 3-(acetyloxy)-4,5-dichloro-3-oxospiro[2-benzofuran-1,9-xanthene]-6-yl acetate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Petra Ondrackova, Pavel Alexa, Jan Matiasovic, Jiri Volf, Martin Faldyna. Interaction of porcine neutrophils with different strains of enterotoxigenic Escherichia coli.
Veterinary microbiology.
2012 Nov; 160(1-2):108-16. doi:
10.1016/j.vetmic.2012.05.010. [PMID: 22704243] - Andres A Caro, Luke W Adlong, Samuel J Crocker, Michael W Gardner, Emily F Luikart, Liz U Gron. Effect of garlic-derived organosulfur compounds on mitochondrial function and integrity in isolated mouse liver mitochondria.
Toxicology letters.
2012 Oct; 214(2):166-74. doi:
10.1016/j.toxlet.2012.08.017. [PMID: 22960305] - Young Jun Kim, Soung-Jin Houng, Jae Hoon Kim, Young-Rok Kim, Hong Geun Ji, Sung-Joon Lee. Nanoemulsified green tea extract shows improved hypocholesterolemic effects in C57BL/6 mice.
The Journal of nutritional biochemistry.
2012 Feb; 23(2):186-91. doi:
10.1016/j.jnutbio.2010.11.015. [PMID: 21447439] - Muhammad Khan, Chuan Ding, Azhar Rasul, Fei Yi, Ting Li, Hongwen Gao, Rong Gao, Lili Zhong, Kun Zhang, Xuedong Fang, Tonghui Ma. Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.
International journal of biological sciences.
2012; 8(4):533-47. doi:
10.7150/ijbs.3753. [PMID: 22532787] - Haider Raza, Annie John. Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells.
PloS one.
2012; 7(4):e36325. doi:
10.1371/journal.pone.0036325. [PMID: 22558435] - Fernando Warleta, Cristina Sánchez Quesada, María Campos, Yosra Allouche, Gabriel Beltrán, José J Gaforio. Hydroxytyrosol protects against oxidative DNA damage in human breast cells.
Nutrients.
2011 10; 3(10):839-57. doi:
10.3390/nu3100839. [PMID: 22254082] - Cecilia Morgantini, Andrea Natali, Beatrice Boldrini, Satoshi Imaizumi, Mohamad Navab, Alan M Fogelman, Ele Ferrannini, Srinivasa T Reddy. Anti-inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes.
Diabetes.
2011 Oct; 60(10):2617-23. doi:
10.2337/db11-0378. [PMID: 21852676] - Andreina Bruno, Liboria Siena, Stefania Gerbino, Maria Ferraro, Pascal Chanez, Marco Giammanco, Mark Gjomarkaj, Elisabetta Pace. Apigenin affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line.
European journal of cancer (Oxford, England : 1990).
2011 Sep; 47(13):2042-51. doi:
10.1016/j.ejca.2011.03.034. [PMID: 21550230] - Anna Stachurska, Magdalena Kozakowska, Alicja Jozkowicz, Jozef Dulak, Agnieszka Loboda. Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells--the involvement of SP-1 and HIFs transcription factors.
Toxicology letters.
2011 Jul; 204(2-3):118-26. doi:
10.1016/j.toxlet.2011.04.022. [PMID: 21554934] - Alexandra Rogue, Carine Lambert, Rozenn Jossé, Sebastien Antherieu, Catherine Spire, Nancy Claude, André Guillouzo. Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytes.
PloS one.
2011 Apr; 6(4):e18816. doi:
10.1371/journal.pone.0018816. [PMID: 21533120] - Avnesh S Thakor, Ramasamy Paulmurugan, Paul Kempen, Cristina Zavaleta, Robert Sinclair, Tarik F Massoud, Sanjiv S Gambhir. Oxidative stress mediates the effects of Raman-active gold nanoparticles in human cells.
Small (Weinheim an der Bergstrasse, Germany).
2011 Jan; 7(1):126-36. doi:
10.1002/smll.201001466. [PMID: 21104804] - J Michael Berg, Shu Ho, Wonjoong Hwang, Rema Zebda, Kyle Cummins, Manuel P Soriaga, Robert Taylor, Bing Guo, Christie M Sayes. Internalization of carbon black and maghemite iron oxide nanoparticle mixtures leads to oxidant production.
Chemical research in toxicology.
2010 Dec; 23(12):1874-82. doi:
10.1021/tx100307h. [PMID: 21067130] - Emiliano Panieri, Gabriele Toietta, Marina Mele, Valentina Labate, Sofia Chiatamone Ranieri, Salvatore Fusco, Valentina Tesori, Annalisa Antonini, Giuseppe Maulucci, Marco De Spirito, Tommaso Galeotti, Giovambattista Pani. Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage.
Aging.
2010 Aug; 2(8):487-503. doi:
10.18632/aging.100183. [PMID: 20739737] - Shinji Itoh, Akinobu Taketomi, Norifumi Harimoto, Eiji Tsujita, Tatsuya Rikimaru, Ken Shirabe, Mitsuo Shimada, Yoshihiko Maehara. Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines.
Journal of clinical biochemistry and nutrition.
2010 Jul; 47(1):81-90. doi:
10.3164/jcbn.10-24. [PMID: 20664735] - Jung-Ran Noh, Gil-Tae Gang, Yong-Hoon Kim, Keum-Jin Yang, Chul-Ho Lee, O-Su Na, Gi-Ju Kim, Won-Keun Oh, Young-Don Lee. Desalinated underground seawater of Jeju Island (Korea) improves lipid metabolism in mice fed diets containing high fat and increases antioxidant potential in t-BHP treated HepG2 cells.
Nutrition research and practice.
2010 Feb; 4(1):3-10. doi:
10.4162/nrp.2010.4.1.3. [PMID: 20198202] - Ming-Kuei Tsai, Yun-Lian Lin, Yi-Tsau Huang. Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats.
Toxicology and applied pharmacology.
2010 Jan; 242(2):155-64. doi:
10.1016/j.taap.2009.10.002. [PMID: 19822164] - Harman D Kaur, Mohinder P Bansal. Studies on HDL associated enzymes under experimental hypercholesterolemia: possible modulation on selenium supplementation.
Lipids in health and disease.
2009 Dec; 8(?):55. doi:
10.1186/1476-511x-8-55. [PMID: 20015371] - Josep M Lluis, Laura Llacuna, Claudia von Montfort, Cristina Bárcena, Carlos Enrich, Albert Morales, José C Fernandez-Checa. GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.
PloS one.
2009 Nov; 4(11):e8059. doi:
10.1371/journal.pone.0008059. [PMID: 19956670] - Meetha Medhora, Yuenmu Chen, Stephanie Gruenloh, Daniel Harland, Sreedhar Bodiga, Jacek Zielonka, Debebe Gebremedhin, Ying Gao, John R Falck, Siddam Anjaiah, Elizabeth R Jacobs. 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology.
2008 May; 294(5):L902-11. doi:
10.1152/ajplung.00278.2007. [PMID: 18296498] - P Zelníčková, M Faldyna, J Ondráček, H Kovářů, F Kovářů. Ontogeny of reactive nitrogen species production by blood phagocytes in pigs.
Physiological research.
2008; 57(1):81-88. doi:
10.33549/physiolres.931141. [PMID: 17223724] - Feng Wen, Da Xing, Lingrui Zhang. Hydrogen peroxide is involved in high blue light-induced chloroplast avoidance movements in Arabidopsis.
Journal of experimental botany.
2008; 59(10):2891-901. doi:
10.1093/jxb/ern147. [PMID: 18550599] - Ryan J Mailloux, Robin Bériault, Joseph Lemire, Ranji Singh, Daniel R Chénier, Robert D Hamel, Vasu D Appanna. The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.
PloS one.
2007 Aug; 2(8):e690. doi:
10.1371/journal.pone.0000690. [PMID: 17668068] - Lorella Navazio, Barbara Baldan, Roberto Moscatiello, Anna Zuppini, Sheridan L Woo, Paola Mariani, Matteo Lorito. Calcium-mediated perception and defense responses activated in plant cells by metabolite mixtures secreted by the biocontrol fungus Trichoderma atroviride.
BMC plant biology.
2007 Jul; 7(?):41. doi:
10.1186/1471-2229-7-41. [PMID: 17663762] - Sutapa Mukherjee, Madhumita Roy, Subhabrata Dey, Rathindra K Bhattacharya. A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn.
Journal of clinical biochemistry and nutrition.
2007 Jul; 41(1):32-42. doi:
10.3164/jcbn.2007005. [PMID: 18392098] - V A Kolla, A Vavasseur, A S Raghavendra. Hydrogen peroxide production is an early event during bicarbonate induced stomatal closure in abaxial epidermis of Arabidopsis.
Planta.
2007 May; 225(6):1421-9. doi:
10.1007/s00425-006-0450-6. [PMID: 17160388] - Francesco Marotta, Masatoshi Harada, Khean-Lee Goh, Aldo Lorenzetti, Paolo Marandola, Emilio Minelli. In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells.
Annals of hepatology.
2007 Apr; 6(2):111-6. doi:
10.1016/s1665-2681(19)31942-8. [PMID: 17519835] - Steven W Mills, Shaylyn H Montgomery, Douglas W Morck. Evaluation of the effects of short-chain fatty acids and extracellular pH on bovine neutrophil function in vitro.
American journal of veterinary research.
2006 Nov; 67(11):1901-7. doi:
10.2460/ajvr.67.11.1901. [PMID: 17078753] - Duk Jae Kim, Jung-Min Koh, Oksun Lee, Na Jung Kim, Young-Sun Lee, Yang Soon Kim, Joong-Yeol Park, Ki-Up Lee, Ghi Su Kim. Homocysteine enhances apoptosis in human bone marrow stromal cells.
Bone.
2006 Sep; 39(3):582-90. doi:
10.1016/j.bone.2006.03.004. [PMID: 16644300] - Manabu T Moryama, Chizue Domiki, Katsuhito Miyazawa, Tatsuro Tanaka, Koji Suzuki. Effects of oxalate exposure on Madin-Darby canine kidney cells in culture: renal prothrombin fragment-1 mRNA expression.
Urological research.
2005 Dec; 33(6):470-5. doi:
10.1007/s00240-005-0510-6. [PMID: 16320015] - Ionara R Siqueira, Helena Cimarosti, Cíntia Fochesatto, Domingos S Nunes, Christianne Salbego, Elaine Elisabetsky, Carlos A Netto. Neuroprotective effects of Ptychopetalum olacoides Bentham (Olacaceae) on oxygen and glucose deprivation induced damage in rat hippocampal slices.
Life sciences.
2004 Aug; 75(15):1897-906. doi:
10.1016/j.lfs.2004.06.001. [PMID: 15302233] - Mette Ree Holthe, Anne Cathrine Staff, Lillian Nordboe Berge, Torstein Lyberg. Leukocyte adhesion molecules and reactive oxygen species in preeclampsia.
Obstetrics and gynecology.
2004 May; 103(5 Pt 1):913-22. doi:
10.1097/01.aog.0000124806.39111.ba. [PMID: 15121565] - Noureddine Bouaïcha, Imed Maatouk. Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes.
Toxicology letters.
2004 Mar; 148(1-2):53-63. doi:
10.1016/j.toxlet.2003.12.005. [PMID: 15019088] - Ozgur Kutuk, Mazhar Adli, Giuseppe Poli, Huveyda Basaga. Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts.
BioFactors (Oxford, England).
2004; 20(1):1-10. doi:
10.1002/biof.5520200101. [PMID: 15096656] - John R Pepperell, D Marshall Porterfield, David L Keefe, Harold R Behrman, Peter J S Smith. Control of ascorbic acid efflux in rat luteal cells: role of intracellular calcium and oxygen radicals.
American journal of physiology. Cell physiology.
2003 Sep; 285(3):C642-51. doi:
10.1152/ajpcell.00587.2002. [PMID: 12724141] - David A Allen, Steven Harwood, Mira Varagunam, Martin J Raftery, Muhammad M Yaqoob. High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 May; 17(8):908-10. doi:
10.1096/fj.02-0130fje. [PMID: 12670885] - Alexandre T Rotta, Björn Gunnarsson, Bradley P Fuhrman, Budi Wiryawan, Lynn J Hernan, David M Steinhorn. Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2003 Apr; 4(2):233-8. doi:
10.1097/01.pcc.0000059729.21375.d0. [PMID: 12749658] - E Osano, J Kishi, Y Takahashi. Phagocytosis of titanium particles and necrosis in TNF-alpha-resistant mouse sarcoma L929 cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2003 Feb; 17(1):41-7. doi:
10.1016/s0887-2333(02)00127-3. [PMID: 12537961] - Hang Xie, Gerry R Huff, William E Huff, Janice M Balog, Narayan C Rath. Effects of ovotransferrin on chicken macrophages and heterophil-granulocytes.
Developmental and comparative immunology.
2002 Nov; 26(9):805-15. doi:
10.1016/s0145-305x(02)00028-9. [PMID: 12377220] - Ji Hoon Yu, Joo Weon Lim, Wan Namkung, Hyeyoung Kim, Kyung Hwan Kim. Suppression of cerulein-induced cytokine expression by antioxidants in pancreatic acinar cells.
Laboratory investigation; a journal of technical methods and pathology.
2002 Oct; 82(10):1359-68. doi:
10.1097/01.lab.0000032377.09626.c7. [PMID: 12379770] - H Xie, N C Rath, G R Huff, J M Balog, W E Huff. Inflammation-induced changes in serum modulate chicken macrophage function.
Veterinary immunology and immunopathology.
2001 Aug; 80(3-4):225-35. doi:
10.1016/s0165-2427(01)00260-4. [PMID: 11457476]