2-Amino-5-[[1-[carboxymethyl(2-hydroxypropanoyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid (BioDeep_00000183426)
human metabolite blood metabolite
代谢物信息卡片
2-Amino-4-({1-[N-(carboxymethyl)-2-hydroxypropanamido]-1-oxo-3-sulphanylpropan-2-yl}-C-hydroxycarbonimidoyl)butanoic acid
化学式: C13H21N3O8S (379.10493060000005)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC(C(=O)N(CC(=O)O)C(=O)C(CS)NC(=O)CCC(C(=O)O)N)O
InChI: InChI=1S/C13H21N3O8S/c1-6(17)11(21)16(4-10(19)20)12(22)8(5-25)15-9(18)3-2-7(14)13(23)24/h6-8,17,25H,2-5,14H2,1H3,(H,15,18)(H,19,20)(H,23,24)
描述信息
同义名列表
8 个代谢物同义名
2-Amino-4-({1-[N-(carboxymethyl)-2-hydroxypropanamido]-1-oxo-3-sulphanylpropan-2-yl}-C-hydroxycarbonimidoyl)butanoic acid; 2-Amino-4-({1-[N-(carboxymethyl)-2-hydroxypropanamido]-1-oxo-3-sulphanylpropan-2-yl}-C-hydroxycarbonimidoyl)butanoate; 2-Amino-4-({1-[N-(carboxymethyl)-2-hydroxypropanamido]-1-oxo-3-sulfanylpropan-2-yl}-C-hydroxycarbonimidoyl)butanoate; 2-Amino-5-[[1-[carboxymethyl(2-hydroxypropanoyl)amino]-1-oxo-3-sulphanylpropan-2-yl]amino]-5-oxopentanoic acid; 2-Amino-5-[[1-[carboxymethyl(2-hydroxypropanoyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid; 2-Amino-5-[[1-[carboxymethyl(2-hydroxypropanoyl)amino]-1-oxo-3-sulphanylpropan-2-yl]amino]-5-oxopentanoate; 2-amino-4-({1-[N-(carboxymethyl)-2-hydroxypropanamido]-1-oxo-3-sulfanylpropan-2-yl}carbamoyl)butanoic acid; 2-Amino-5-[[1-[carboxymethyl(2-hydroxypropanoyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Journal of clinical investigation.
2012 Jun; 122(6):2306-15. doi:
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Journal of proteome research.
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The Biochemical journal.
2012 Apr; 443(1):213-22. doi:
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2012 Apr; 63(7):2449-64. doi:
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Experimental cell research.
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The American journal of pathology.
2011 Dec; 179(6):2810-21. doi:
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The Indian journal of medical research.
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2011 Jul; 26(7):1843-59. doi:
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Functional & integrative genomics.
2011 Jun; 11(2):293-305. doi:
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Planta.
2011 Jun; 233(6):1173-84. doi:
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BMC genomics.
2011 Apr; 12(?):190. doi:
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International journal of toxicology.
2011 Mar; 30(2):253-8. doi:
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Brain and nerve = Shinkei kenkyu no shinpo.
2011 Mar; 63(3):223-31. doi:
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The Journal of biological chemistry.
2011 Jan; 286(2):1374-80. doi:
10.1074/jbc.m110.144097. [PMID: 21056979] - Rosa Lozano-Durán, Tábata Rosas-Díaz, Ana P Luna, Eduardo R Bejarano. Identification of host genes involved in geminivirus infection using a reverse genetics approach.
PloS one.
2011; 6(7):e22383. doi:
10.1371/journal.pone.0022383. [PMID: 21818318] - Masanari Itokawa, Makoto Arai, Tomoe Ichikawa, Mitsuhiro Miyashita, Takeo Yoshikawa, Yuji Okazaki, Toshio Miyata. [Molecular pathophysiology of schizophrenia and preventive strategy in pubertal period].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica.
2011; 113(7):672-8. doi:
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PloS one.
2011; 6(9):e24863. doi:
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Journal of biomedicine & biotechnology.
2011; 2011(?):354801. doi:
10.1155/2011/354801. [PMID: 22131803] - Rodrigo Lorenzi, Michael Everton Andrades, Rafael Calixto Bortolin, Ryoji Nagai, Felipe Dal-Pizzol, José Cláudio Fonseca Moreira. Glycolaldehyde induces oxidative stress in the heart: a clue to diabetic cardiomyopathy?.
Cardiovascular toxicology.
2010 Dec; 10(4):244-9. doi:
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Plant physiology.
2010 Dec; 154(4):1697-709. doi:
10.1104/pp.110.164152. [PMID: 20959419] - Hélène Zuber, Jean-Claude Davidian, Grégoire Aubert, Delphine Aimé, Maya Belghazi, Raphaël Lugan, Dimitri Heintz, Markus Wirtz, Rüdiger Hell, Richard Thompson, Karine Gallardo. The seed composition of Arabidopsis mutants for the group 3 sulfate transporters indicates a role in sulfate translocation within developing seeds.
Plant physiology.
2010 Oct; 154(2):913-26. doi:
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Diabetes research and clinical practice.
2010 Sep; 89(3):262-7. doi:
10.1016/j.diabres.2010.05.005. [PMID: 20605248] - Hattem El-Shabrawi, Bhumesh Kumar, Tanushri Kaul, Malireddy K Reddy, Sneh L Singla-Pareek, Sudhir K Sopory. Redox homeostasis, antioxidant defense, and methylglyoxal detoxification as markers for salt tolerance in Pokkali rice.
Protoplasma.
2010 Sep; 245(1-4):85-96. doi:
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PloS one.
2010 Jul; 5(7):e11630. doi:
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Plant & cell physiology.
2010 Jun; 51(6):997-1006. doi:
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Archives of general psychiatry.
2010 Jun; 67(6):589-97. doi:
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2010 Apr; 231(5):1113-25. doi:
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Diabetes.
2010 Mar; 59(3):670-8. doi:
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European journal of pharmacology.
2010 Feb; 628(1-3):255-60. doi:
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Molecular biology reports.
2010 Feb; 37(2):729-35. doi:
10.1007/s11033-009-9578-3. [PMID: 19513813] - Ananda Mustafiz, Khirod K Sahoo, Sneh L Singla-Pareek, Sudhir K Sopory. Metabolic engineering of glyoxalase pathway for enhancing stress tolerance in plants.
Methods in molecular biology (Clifton, N.J.).
2010; 639(?):95-118. doi:
10.1007/978-1-60761-702-0_6. [PMID: 20387042] - Brandon Louie, Srinivas Rajamahanty, Paul Pyo, Muhammad Choudhury, Sensuke Konno. Mode of cytotoxic action of nephrotoxic agents: oxidative stress and glutathione-dependent enzyme.
BJU international.
2010 Jan; 105(2):264-8. doi:
10.1111/j.1464-410x.2009.08657.x. [PMID: 19493264] - Reiko Inagi, Takanori Kumagai, Toshiro Fujita, Masaomi Nangaku. The role of glyoxalase system in renal hypoxia.
Advances in experimental medicine and biology.
2010; 662(?):49-55. doi:
10.1007/978-1-4419-1241-1_6. [PMID: 20204770] - Marta Kalousová, Marie Jáchymová, Alexandra Germanová, Ales Antonín Kubena, Vladimír Tesar, Tomás Zima. Genetic predisposition to advanced glycation end products toxicity is related to prognosis of chronic hemodialysis patients.
Kidney & blood pressure research.
2010; 33(1):30-6. doi:
10.1159/000285845. [PMID: 20185929] - Cinzia Antognelli, Angela Gambelunghe, Chiara Del Buono, Nicola Murgia, Vincenzo N Talesa, Giacomo Muzi. Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses.
Chemico-biological interactions.
2009 Nov; 182(1):13-21. doi:
10.1016/j.cbi.2009.08.002. [PMID: 19679115] - Mohammad Anwar Hossain, Masayuki Fujita. Purification of glyoxalase I from onion bulbs and molecular cloning of its cDNA.
Bioscience, biotechnology, and biochemistry.
2009 Sep; 73(9):2007-13. doi:
10.1271/bbb.90194. [PMID: 19734676] - Eszter Karg, Ferenc Papp, Noemi Tassi, Tamás Janáky, Gyula Wittmann, Sándor Túri. Enhanced methylglyoxal formation in the erythrocytes of hemodialyzed patients.
Metabolism: clinical and experimental.
2009 Jul; 58(7):976-82. doi:
10.1016/j.metabol.2009.02.032. [PMID: 19394056] - Takanori Kumagai, Masaomi Nangaku, Ichiro Kojima, Ryoji Nagai, Julie R Ingelfinger, Toshio Miyata, Toshiro Fujita, Reiko Inagi. Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.
American journal of physiology. Renal physiology.
2009 Apr; 296(4):F912-21. doi:
10.1152/ajprenal.90575.2008. [PMID: 19211689] - Suping Zhou, Roger Sauvé, Theodore W Thannhauser. Proteome changes induced by aluminium stress in tomato roots.
Journal of experimental botany.
2009; 60(6):1849-57. doi:
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Journal of experimental botany.
2009; 60(12):3545-57. doi:
10.1093/jxb/erp198. [PMID: 19671579] - Sneh L Singla-Pareek, Sudesh K Yadav, Ananda Mustafiz, S K Sopory. Role of the glyoxalase pathway in delaying plant senescence under stress conditions.
SEB experimental biology series.
2009; 62(?):171-85. doi:
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Journal of diabetes and its complications.
2008 Jul; 22(4):267-72. doi:
10.1016/j.jdiacomp.2007.06.010. [PMID: 18413187] - Yuki Kitamura, Michi Kawase, Shinji Ohmori. Formate excretion in urine of rats fed dimethylaminoazobenzene-rich diets: the possibility of formate formation from D-lactate.
Acta medica Okayama.
2008 Jun; 62(3):193-203. doi:
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Journal of plant physiology.
2008 May; 165(8):813-24. doi:
10.1016/j.jplph.2007.07.013. [PMID: 17920727] - Frances M Dupont. Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics.
BMC plant biology.
2008 Apr; 8(?):39. doi:
10.1186/1471-2229-8-39. [PMID: 18419817] - Takanori Kumagai, Masaomi Nangaku, Reiko Inagi. Pathophysiological role of the glyoxalase system in renal hypoxic injury.
Annals of the New York Academy of Sciences.
2008 Apr; 1126(?):265-7. doi:
10.1196/annals.1433.029. [PMID: 18448828] - Marta Kalousová, Alexandra Germanová, Marie Jáchymová, Oto Mestek, Vladimír Tesar, Tomás Zima. A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients.
Annals of the New York Academy of Sciences.
2008 Apr; 1126(?):268-71. doi:
10.1196/annals.1433.012. [PMID: 18079478] - Sudesh Kumar Yadav, Sneh L Singla-Pareek, Sudhir K Sopory. An overview on the role of methylglyoxal and glyoxalases in plants.
Drug metabolism and drug interactions.
2008; 23(1-2):51-68. doi:
10.1515/dmdi.2008.23.1-2.51. [PMID: 18533364] - Simon Conn, Chris Curtin, Annie Bézier, Chris Franco, Wei Zhang. Purification, molecular cloning, and characterization of glutathione S-transferases (GSTs) from pigmented Vitis vinifera L. cell suspension cultures as putative anthocyanin transport proteins.
Journal of experimental botany.
2008; 59(13):3621-34. doi:
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Journal of experimental botany.
2008; 59(14):3885-901. doi:
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American journal of physiology. Renal physiology.
2007 Oct; 293(4):F1157-65. doi:
10.1152/ajprenal.00411.2006. [PMID: 17609286] - A Gambelunghe, C Antognelli, C Del Buono, R Piccinini, B Ugolini, M dell'Omo, N Murgia, V N Talesa, G Muzi. [Crystalline silica can induce oxidative stress by inhibiting glyoxalase system in bronchial epithelial cells].
Giornale italiano di medicina del lavoro ed ergonomia.
2007 Jul; 29(3 Suppl):397-9. doi:
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Multiple sclerosis (Houndmills, Basingstoke, England).
2007 May; 13(4):446-53. doi:
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Cancer journal (Sudbury, Mass.).
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