(6'-Acetyloxy-4,5-diamino-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate (BioDeep_00000183357)

   

human metabolite blood metabolite


代谢物信息卡片


3-(Acetyloxy)-4,5-diamino-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-6-yl acetic acid

化学式: C24H18N2O7 (446.11139579999997)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1=CC2=C(C=C1)C1(OC(=O)C3=C1C=CC(N)=C3N)C1=C(O2)C=C(OC(C)=O)C=C1
InChI: InChI=1S/C24H18N2O7/c1-11(27)30-13-3-5-15-19(9-13)32-20-10-14(31-12(2)28)4-6-16(20)24(15)17-7-8-18(25)22(26)21(17)23(29)33-24/h3-10H,25-26H2,1-2H3



数据库引用编号

2 个数据库交叉引用编号

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相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Cristina Calcagno, Mara Novero, Andrea Genre, Paola Bonfante, Luisa Lanfranco. The exudate from an arbuscular mycorrhizal fungus induces nitric oxide accumulation in Medicago truncatula roots. Mycorrhiza. 2012 May; 22(4):259-69. doi: 10.1007/s00572-011-0400-4. [PMID: 21744141]
  • A K Glian'ko, N B Mitanova, A V Stepanov. [Influence of environmental factors on the generation of nitric oxide in the roots of etiolated pea seedlings]. Prikladnaia biokhimiia i mikrobiologiia. 2012 Jan; 48(1):95-102. doi: ". [PMID: 22567891]
  • Juan L Turrion-Gomez, Ernesto P Benito. Flux of nitric oxide between the necrotrophic pathogen Botrytis cinerea and the host plant. Molecular plant pathology. 2011 Aug; 12(6):606-16. doi: 10.1111/j.1364-3703.2010.00695.x. [PMID: 21722298]
  • Jennifer Del Giudice, Yvan Cam, Isabelle Damiani, Franck Fung-Chat, Eliane Meilhoc, Claude Bruand, Renaud Brouquisse, Alain Puppo, Alexandre Boscari. Nitric oxide is required for an optimal establishment of the Medicago truncatula-Sinorhizobium meliloti symbiosis. The New phytologist. 2011 Jul; 191(2):405-417. doi: 10.1111/j.1469-8137.2011.03693.x. [PMID: 21457261]
  • Xuegui Bai, Liming Yang, Meihua Tian, Jinhui Chen, Jisen Shi, Yongping Yang, Xiangyang Hu. Nitric oxide enhances desiccation tolerance of recalcitrant Antiaris toxicaria seeds via protein S-nitrosylation and carbonylation. PloS one. 2011; 6(6):e20714. doi: 10.1371/journal.pone.0020714. [PMID: 21674063]
  • P Leonetti, M T Melillo, T Bleve-Zacheo. Nitric oxide and hydrogen peroxide: two players in the defence response of tomato plants to root-knot nematodes. Communications in agricultural and applied biological sciences. 2011; 76(3):371-81. doi: ". [PMID: 22696948]
  • Alfonso Méndez-Bravo, Carlos Calderón-Vázquez, Enrique Ibarra-Laclette, Javier Raya-González, Enrique Ramírez-Chávez, Jorge Molina-Torres, Angel A Guevara-García, José López-Bucio, Luis Herrera-Estrella. Alkamides activate jasmonic acid biosynthesis and signaling pathways and confer resistance to Botrytis cinerea in Arabidopsis thaliana. PloS one. 2011; 6(11):e27251. doi: 10.1371/journal.pone.0027251. [PMID: 22076141]
  • Anisha David, Sunita Yadav, Satish C Bhatla. Sodium chloride stress induces nitric oxide accumulation in root tips and oil body surface accompanying slower oleosin degradation in sunflower seedlings. Physiologia plantarum. 2010 Dec; 140(4):342-54. doi: 10.1111/j.1399-3054.2010.01408.x. [PMID: 20738803]
  • Guosheng Liu, Yuanyuan Ji, Nazmul H Bhuiyan, Guillaume Pilot, Gopalan Selvaraj, Jitao Zou, Yangdou Wei. Amino acid homeostasis modulates salicylic acid-associated redox status and defense responses in Arabidopsis. The Plant cell. 2010 Nov; 22(11):3845-63. doi: 10.1105/tpc.110.079392. [PMID: 21097712]
  • Huajian Zhang, Suomeng Dong, Meifang Wang, Wei Wang, Wenwen Song, Xianying Dou, Xiaobo Zheng, Zhengguang Zhang. The role of vacuolar processing enzyme (VPE) from Nicotiana benthamiana in the elicitor-triggered hypersensitive response and stomatal closure. Journal of experimental botany. 2010 Aug; 61(13):3799-812. doi: 10.1093/jxb/erq189. [PMID: 20603283]
  • Marta Gil-Ortega, Paula Stucchi, Rocío Guzmán-Ruiz, Victoria Cano, Silvia Arribas, M Carmen González, Mariano Ruiz-Gayo, Maria S Fernández-Alfonso, Beatriz Somoza. Adaptative nitric oxide overproduction in perivascular adipose tissue during early diet-induced obesity. Endocrinology. 2010 Jul; 151(7):3299-306. doi: 10.1210/en.2009-1464. [PMID: 20410199]
  • Syamantak Majumder, M Ilayaraja, Himabindu Reddy Seerapu, Swaraj Sinha, Jamila H Siamwala, Suvro Chatterjee. Chick embryo partial ischemia model: a new approach to study ischemia ex vivo. PloS one. 2010 May; 5(5):e10524. doi: 10.1371/journal.pone.0010524. [PMID: 20479865]
  • Luciano Freschi, Maria Aurineide Rodrigues, Douglas Silva Domingues, Eduardo Purgatto, Marie-Anne Van Sluys, Jose Ronaldo Magalhaes, Werner M Kaiser, Helenice Mercier. Nitric oxide mediates the hormonal control of Crassulacean acid metabolism expression in young pineapple plants. Plant physiology. 2010 Apr; 152(4):1971-85. doi: 10.1104/pp.109.151613. [PMID: 20147491]
  • Adoración Zafra, María Isabel Rodríguez-García, Juan de Dios Alché. Cellular localization of ROS and NO in olive reproductive tissues during flower development. BMC plant biology. 2010 Feb; 10(?):36. doi: 10.1186/1471-2229-10-36. [PMID: 20181244]
  • Min Tong, Liefeng Zhang, Yifan Wang, Hui Jiang, Yong Ren. Fe-chlorophyllin promotes the growth of wheat roots associated with nitric oxide generation. International journal of molecular sciences. 2010; 11(12):5246-55. doi: 10.3390/ijms11125246. [PMID: 21614205]
  • Ruiqiang Chen, Shulan Sun, Chun Wang, Yansha Li, Yan Liang, Fengying An, Chao Li, Haili Dong, Xiaohui Yang, Jian Zhang, Jianru Zuo. The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death. Cell research. 2009 Dec; 19(12):1377-87. doi: 10.1038/cr.2009.117. [PMID: 19806166]
  • Jun Tanaka, Li Qiang, Alexander S Banks, Carrie L Welch, Michihiro Matsumoto, Tadahiro Kitamura, Yukari Ido-Kitamura, Ronald A DePinho, Domenico Accili. Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes. 2009 Oct; 58(10):2344-54. doi: 10.2337/db09-0167. [PMID: 19584310]
  • M Arasimowicz, J Floryszak-Wieczorek, G Milczarek, T Jelonek. Nitric oxide, induced by wounding, mediates redox regulation in pelargonium leaves. Plant biology (Stuttgart, Germany). 2009 Sep; 11(5):650-63. doi: 10.1111/j.1438-8677.2008.00164.x. [PMID: 19689772]
  • Hong-Mei Zhang, Howard Dang, Chih-Ko Yeh, Bin-Xian Zhang. Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. PloS one. 2009 Jun; 4(6):e6048. doi: 10.1371/journal.pone.0006048. [PMID: 19557129]
  • N C C Schachnik, V Peruhype-Magalhães, G M M Paula, F Lucas, V M Freitas, O A Martins-Filho, L M S Dusse. Intracellular nitric oxide assessment in whole blood leukocytes by flow cytometry: optimization and applicability to monitor patients with chronic graft nephropathy. Journal of immunological methods. 2009 Apr; 343(2):103-11. doi: 10.1016/j.jim.2009.01.010. [PMID: 19374002]
  • Somshuvra Mukhopadhyay, Jason Lee, Pravin B Sehgal. Depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole. American journal of physiology. Heart and circulatory physiology. 2008 Nov; 295(5):H1943-55. doi: 10.1152/ajpheart.00642.2008. [PMID: 18775848]
  • Yao Juan Xue, Ling Tao, Zhi Min Yang. Aluminum-induced cell wall peroxidase activity and lignin synthesis are differentially regulated by jasmonate and nitric oxide. Journal of agricultural and food chemistry. 2008 Oct; 56(20):9676-84. doi: 10.1021/jf802001v. [PMID: 18803390]
  • Salma A Abdelmagid, Catherine K L Too. Prolactin and estrogen up-regulate carboxypeptidase-d to promote nitric oxide production and survival of mcf-7 breast cancer cells. Endocrinology. 2008 Oct; 149(10):4821-8. doi: 10.1210/en.2008-0145. [PMID: 18535109]
  • Preeti Dohare, Puja Garg, Uma Sharma, N R Jagannathan, Madhur Ray. Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC complementary and alternative medicine. 2008 Sep; 8(?):55. doi: 10.1186/1472-6882-8-55. [PMID: 18826584]
  • Werner Schmid, Alexander Lee, Jinhi Son, Elisabeth Koller, Ivo Volf. Hypochlorite-oxidized low density lipoproteins reduce production and bioavailability of nitric oxide in RAW 264.7 macrophages by distinct mechanisms. Life sciences. 2008 Jul; 83(1-2):50-8. doi: 10.1016/j.lfs.2008.05.002. [PMID: 18558412]
  • K Seligman, E E Saviani, H C Oliveira, C A F Pinto-Maglio, I Salgado. Floral transition and nitric oxide emission during flower development in Arabidopsis thaliana is affected in nitrate reductase-deficient plants. Plant & cell physiology. 2008 Jul; 49(7):1112-21. doi: 10.1093/pcp/pcn089. [PMID: 18540030]
  • Radhika Desikan, Jakub Horák, Christina Chaban, Virtudes Mira-Rodado, Janika Witthöft, Kirstin Elgass, Christopher Grefen, Man-Kim Cheung, Alfred J Meixner, Richard Hooley, Steven John Neill, John Travers Hancock, Klaus Harter. The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells. PloS one. 2008 Jun; 3(6):e2491. doi: 10.1371/journal.pone.0002491. [PMID: 18560512]
  • Zsuzsanna Kolbert, Bernadett Bartha, László Erdei. Exogenous auxin-induced NO synthesis is nitrate reductase-associated in Arabidopsis thaliana root primordia. Journal of plant physiology. 2008 Jun; 165(9):967-75. doi: 10.1016/j.jplph.2007.07.019. [PMID: 17936409]
  • P Zelníčková, M Faldyna, J Ondráček, H Kovářů, F Kovářů. Ontogeny of reactive nitrogen species production by blood phagocytes in pigs. Physiological research. 2008; 57(1):81-88. doi: 10.33549/physiolres.931141. [PMID: 17223724]
  • Shu-Jing Wu, Jian-Yong Wu. Extracellular ATP-induced NO production and its dependence on membrane Ca2+ flux in Salvia miltiorrhiza hairy roots. Journal of experimental botany. 2008; 59(14):4007-16. doi: 10.1093/jxb/ern242. [PMID: 18977749]
  • Frank Gaupels, Alexandra C U Furch, Torsten Will, Luis A J Mur, Karl-Heinz Kogel, Aart J E van Bel. Nitric oxide generation in Vicia faba phloem cells reveals them to be sensitive detectors as well as possible systemic transducers of stress signals. The New phytologist. 2008; 178(3):634-46. doi: 10.1111/j.1469-8137.2008.02388.x. [PMID: 18312539]
  • Kai Guo, Kai Xia, Zhi-Min Yang. Regulation of tomato lateral root development by carbon monoxide and involvement in auxin and nitric oxide. Journal of experimental botany. 2008; 59(12):3443-52. doi: 10.1093/jxb/ern194. [PMID: 18653694]
  • Carlos Garcia-Mata, Lorenzo Lamattina. Abscisic acid (ABA) inhibits light-induced stomatal opening through calcium- and nitric oxide-mediated signaling pathways. Nitric oxide : biology and chemistry. 2007 Nov; 17(3-4):143-51. doi: 10.1016/j.niox.2007.08.001. [PMID: 17889574]
  • Youry Pii, Massimo Crimi, Giorgia Cremonese, Angelo Spena, Tiziana Pandolfini. Auxin and nitric oxide control indeterminate nodule formation. BMC plant biology. 2007 May; 7(?):21. doi: 10.1186/1471-2229-7-21. [PMID: 17488509]
  • Somshuvra Mukhopadhyay, Fang Xu, Pravin B Sehgal. Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging. American journal of physiology. Heart and circulatory physiology. 2007 Mar; 292(3):H1373-89. doi: 10.1152/ajpheart.00990.2006. [PMID: 17071725]
  • Lonneke M Bevers, Ernst E van Faassen, Thi Danh Vuong, Zhenmin Ni, Peter Boer, Hein A Koomans, Branko Braam, Nosratola D Vaziri, Jaap A Joles. Low albumin levels increase endothelial NO production and decrease vascular NO sensitivity. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 Dec; 21(12):3443-9. doi: 10.1093/ndt/gfl443. [PMID: 16997846]
  • Emmanuel Baudouin, Laurent Pieuchot, Gilbert Engler, Nicolas Pauly, Alain Puppo. Nitric oxide is formed in Medicago truncatula-Sinorhizobium meliloti functional nodules. Molecular plant-microbe interactions : MPMI. 2006 Sep; 19(9):970-5. doi: 10.1094/mpmi-19-0970. [PMID: 16941901]
  • Roy W R Dudley, Gawiyou Danialou, Karuthapillai Govindaraju, Larry Lands, David E Eidelman, Basil J Petrof. Sarcolemmal damage in dystrophin deficiency is modulated by synergistic interactions between mechanical and oxidative/nitrosative stresses. The American journal of pathology. 2006 Apr; 168(4):1276-87; quiz 1404. doi: 10.2353/ajpath.2006.050683. [PMID: 16565501]
  • Inmaculada Concepción Villar, Rocío Vera, Milagros Galisteo, Francisco O'Valle, Miguel Romero, Antonio Zarzuelo, Juan Duarte. Endothelial nitric oxide production stimulated by the bioflavonoid chrysin in rat isolated aorta. Planta medica. 2005 Sep; 71(9):829-34. doi: 10.1055/s-2005-871296. [PMID: 16206037]
  • Urszula Małolepsza, Sylwia Rózalska. Nitric oxide and hydrogen peroxide in tomato resistance. Nitric oxide modulates hydrogen peroxide level in o-hydroxyethylorutin-induced resistance to Botrytis cinerea in tomato. Plant physiology and biochemistry : PPB. 2005 Jun; 43(6):623-35. doi: 10.1016/j.plaphy.2005.04.002. [PMID: 15922611]
  • Cecilia M Creus, Magdalena Graziano, Elda M Casanovas, María A Pereyra, Marcela Simontacchi, Susana Puntarulo, Carlos A Barassi, Lorenzo Lamattina. Nitric oxide is involved in the Azospirillum brasilense-induced lateral root formation in tomato. Planta. 2005 May; 221(2):297-303. doi: 10.1007/s00425-005-1523-7. [PMID: 15824907]
  • Akihiro Tojo, Maristela Lika Onozato, Satoru Fukuda, Kensuke Asaba, Kenjiro Kimura, Toshiro Fujita. Nitric oxide generated by nNOS in the macula densa regulates the afferent arteriolar diameter in rat kidney. Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan. 2004 Dec; 37(4):236-41. doi: 10.1007/s00795-004-0263-2. [PMID: 15614448]
  • Hans Strijdom, Christo Muller, Amanda Lochner. Direct intracellular nitric oxide detection in isolated adult cardiomyocytes: flow cytometric analysis using the fluorescent probe, diaminofluorescein. Journal of molecular and cellular cardiology. 2004 Oct; 37(4):897-902. doi: 10.1016/j.yjmcc.2004.05.018. [PMID: 15380680]
  • Francisco J Corpas, Juan B Barroso, Alfonso Carreras, Miguel Quirós, Ana M León, María C Romero-Puertas, Francisco J Esteban, Raquel Valderrama, José M Palma, Luisa M Sandalio, Manuel Gómez, Luis A del Río. Cellular and subcellular localization of endogenous nitric oxide in young and senescent pea plants. Plant physiology. 2004 Sep; 136(1):2722-33. doi: 10.1104/pp.104.042812. [PMID: 15347796]
  • Shaoyou Chu, H Glenn Bohlen. High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism. American journal of physiology. Renal physiology. 2004 Sep; 287(3):F384-92. doi: 10.1152/ajprenal.00006.2004. [PMID: 15140758]
  • Chad Collmann, Mikael A Carlsson, Bill S Hansson, Alan Nighorn. Odorant-evoked nitric oxide signals in the antennal lobe of Manduca sexta. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Jul; 24(27):6070-7. doi: 10.1523/jneurosci.0710-04.2004. [PMID: 15240798]
  • Xi Huang, Kurt Stettmaier, Christa Michel, Peter Hutzler, Martin J Mueller, Jörg Durner. Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana. Planta. 2004 Apr; 218(6):938-46. doi: 10.1007/s00425-003-1178-1. [PMID: 14716563]
  • Natalia Correa-Aragunde, Magdalena Graziano, Lorenzo Lamattina. Nitric oxide plays a central role in determining lateral root development in tomato. Planta. 2004 Apr; 218(6):900-5. doi: 10.1007/s00425-003-1172-7. [PMID: 14716561]
  • Ruisheng Liu, A Erik G Persson. Angiotensin II stimulates calcium and nitric oxide release from Macula densa cells through AT1 receptors. Hypertension (Dallas, Tex. : 1979). 2004 Mar; 43(3):649-53. doi: 10.1161/01.hyp.0000116222.57000.85. [PMID: 14744924]
  • J Pittner, R Liu, R Brown, M Wolgast, A E G Persson. Visualization of nitric oxide production and intracellular calcium in juxtamedullary afferent arteriolar endothelial cells. Acta physiologica Scandinavica. 2003 Nov; 179(3):309-17. doi: 10.1046/j.1365-201x.2003.01137.x. [PMID: 14616247]
  • Takefumi Mori, Allen W Cowley. Angiotensin II-NAD(P)H oxidase-stimulated superoxide modifies tubulovascular nitric oxide cross-talk in renal outer medulla. Hypertension (Dallas, Tex. : 1979). 2003 Oct; 42(4):588-93. doi: 10.1161/01.hyp.0000091821.39824.09. [PMID: 12975384]
  • Pei-Ju Jih, Yu-Chi Chen, Shih-Tong Jeng. Involvement of hydrogen peroxide and nitric oxide in expression of the ipomoelin gene from sweet potato. Plant physiology. 2003 May; 132(1):381-9. doi: 10.1104/pp.102.015701. [PMID: 12746543]
  • Jeffrey G Dickhout, Takefumi Mori, Allen W Cowley. Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstriction. Circulation research. 2002 Sep; 91(6):487-93. doi: 10.1161/01.res.0000035243.66189.92. [PMID: 12242266]
  • Carlos García-Mata, Lorenzo Lamattina. Nitric oxide and abscisic acid cross talk in guard cells. Plant physiology. 2002 Mar; 128(3):790-2. doi: 10.1104/pp.011020. [PMID: 11891235]
  • H K Lum, Y K C Butt, S C L Lo. Hydrogen peroxide induces a rapid production of nitric oxide in mung bean (Phaseolus aureus). Nitric oxide : biology and chemistry. 2002 Mar; 6(2):205-13. doi: 10.1006/niox.2001.0395. [PMID: 11890745]
  • Yasuko Sakihama, Soichi Nakamura, Hideo Yamasaki. Nitric oxide production mediated by nitrate reductase in the green alga Chlamydomonas reinhardtii: an alternative NO production pathway in photosynthetic organisms. Plant & cell physiology. 2002 Mar; 43(3):290-7. doi: 10.1093/pcp/pcf034. [PMID: 11917083]
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