3',6'-Dihydroxy-4,5-diaminospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one (BioDeep_00000183278)
human metabolite blood metabolite
代谢物信息卡片
3,6-Dihydroxy-4,5-diaminospiro[isobenzofuran-1(3H),9-[9H]xanthene]-3-one
化学式: C20H14N2O5 (362.0902674)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C(C=C1O)OC3=C(C24C5=C(C(=C(C=C5)N)N)C(=O)O4)C=CC(=C3)O
InChI: InChI=1S/C20H14N2O5/c21-14-6-5-13-17(18(14)22)19(25)27-20(13)11-3-1-9(23)7-15(11)26-16-8-10(24)2-4-12(16)20/h1-8,23-24H,21-22H2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Adelaide Del Viscovo, Agnese Secondo, Alba Esposito, Fernando Goglia, Maria Moreno, Lorella M T Canzoniero. Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells.
American journal of physiology. Endocrinology and metabolism.
2012 Jun; 302(11):E1419-30. doi:
10.1152/ajpendo.00389.2011. [PMID: 22414808] - Klaus Uhlenhut, Petra Högger. Pitfalls and limitations in using 4,5-diaminofluorescein for evaluating the influence of polyphenols on nitric oxide release from endothelial cells.
Free radical biology & medicine.
2012 Jun; 52(11-12):2266-75. doi:
10.1016/j.freeradbiomed.2012.03.006. [PMID: 22565032] - Alak Manna, Piu Saha, Avijit Sarkar, Debanjan Mukhopadhyay, Ajay K Bauri, Deepak Kumar, Padma Das, Subrata Chattopadhyay, Mitali Chatterjee. Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line.
PloS one.
2012; 7(5):e36938. doi:
10.1371/journal.pone.0036938. [PMID: 22590637] - Eva Rieckeheer, Robert H G Schwinger, Wilhelm Bloch, Klara Brixius. Hawthorn special extract WS® 1442 increases red blood cell NO-formation without altering red blood cell deformability.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Dec; 19(1):20-4. doi:
10.1016/j.phymed.2011.08.059. [PMID: 21899992] - Faouzi Horchani, Marianne Prévot, Alexandre Boscari, Edouard Evangelisti, Eliane Meilhoc, Claude Bruand, Philippe Raymond, Eric Boncompagni, Samira Aschi-Smiti, Alain Puppo, Renaud Brouquisse. Both plant and bacterial nitrate reductases contribute to nitric oxide production in Medicago truncatula nitrogen-fixing nodules.
Plant physiology.
2011 Feb; 155(2):1023-36. doi:
10.1104/pp.110.166140. [PMID: 21139086] - Joana P N Ribeiro, Luís M Magalhães, Marcela A Segundo, Salette Reis, José L F C Lima. Fully automatic flow method for the determination of scavenging capacity against nitric oxide radicals.
Analytical and bioanalytical chemistry.
2010 Aug; 397(7):3005-14. doi:
10.1007/s00216-010-3883-5. [PMID: 20563794] - Frank Helle, Bjarne M Iversen, Christos Chatziantoniou. Losartan increases NO release in afferent arterioles during regression of L-NAME-induced renal damage.
American journal of physiology. Renal physiology.
2010 May; 298(5):F1170-7. doi:
10.1152/ajprenal.00056.2009. [PMID: 20219827] - Kapuganti J Gupta, Werner M Kaiser. Production and scavenging of nitric oxide by barley root mitochondria.
Plant & cell physiology.
2010 Apr; 51(4):576-84. doi:
10.1093/pcp/pcq022. [PMID: 20185408] - M Cristina Palmieri, Christian Lindermayr, Hermann Bauwe, Clara Steinhauser, Joerg Durner. Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation.
Plant physiology.
2010 Mar; 152(3):1514-28. doi:
10.1104/pp.109.152579. [PMID: 20089767] - Emilia Bramanti, Valeria Angeli, Maria Franzini, Cecilia Vecoli, Riccardo Baldassini, Aldo Paolicchi, Renata Barsacchi, Alfonso Pompella. Exogenous vs. endogenous gamma-glutamyltransferase activity: Implications for the specific determination of S-nitrosoglutathione in biological samples.
Archives of biochemistry and biophysics.
2009 Jul; 487(2):146-52. doi:
10.1016/j.abb.2009.05.012. [PMID: 19467221] - Luisa Ederli, Lara Reale, Laura Madeo, Francesco Ferranti, Chris Gehring, Marco Fornaciari, Bruno Romano, Stefania Pasqualini. NO release by nitric oxide donors in vitro and in planta.
Plant physiology and biochemistry : PPB.
2009 Jan; 47(1):42-8. doi:
10.1016/j.plaphy.2008.09.008. [PMID: 18990582] - Josée Nina Bouchard, Hideo Yamasaki. Heat stress stimulates nitric oxide production in Symbiodinium microadriaticum: a possible linkage between nitric oxide and the coral bleaching phenomenon.
Plant & cell physiology.
2008 Apr; 49(4):641-52. doi:
10.1093/pcp/pcn037. [PMID: 18308760] - Theresa A John, Basil O Ibe, J Usha Raj. Regulation of endothelial nitric oxide synthase: involvement of protein kinase G 1 beta, serine 116 phosphorylation and lipid structures.
Clinical and experimental pharmacology & physiology.
2008 Feb; 35(2):148-58. doi:
10.1111/j.1440-1681.2007.04801.x. [PMID: 17892503] - Luciano Cesar Pontes Azevedo, Mariano Janiszewski, Vera Pontieri, Marcelo de Almeida Pedro, Estevão Bassi, Paulo José Ferreira Tucci, Francisco Rafael Martins Laurindo. Platelet-derived exosomes from septic shock patients induce myocardial dysfunction.
Critical care (London, England).
2007; 11(6):R120. doi:
10.1186/cc6176. [PMID: 17996049] - V I Kirpatovskii, A V Kazachenko, E Yu Plotnikov, T A Kon'kova, V V Drozhzheva, D B Zorov. Effects of ischemic and hypoxic preconditioning on the state of mitochondria and function of ischemic kidneys.
Bulletin of experimental biology and medicine.
2007 Jan; 143(1):105-9. doi:
10.1007/s10517-007-0028-8. [PMID: 18019025] - Klara Brixius, Sonja Willms, Andreas Napp, Paschalios Tossios, Dennis Ladage, Wilhelm Bloch, Uwe Mehlhorn, Robert H G Schwinger. Crataegus special extract WS 1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177.
Cardiovascular drugs and therapy.
2006 Jun; 20(3):177-84. doi:
10.1007/s10557-006-8723-7. [PMID: 16779533] - Ruisheng Liu, Oscar A Carretero, YiLin Ren, Jeffrey L Garvin. Increased intracellular pH at the macula densa activates nNOS during tubuloglomerular feedback.
Kidney international.
2005 May; 67(5):1837-43. doi:
10.1111/j.1523-1755.2005.00282.x. [PMID: 15840031] - Eita Sasaki, Hirotatsu Kojima, Hiroaki Nishimatsu, Yasuteru Urano, Kazuya Kikuchi, Yasunobu Hirata, Tetsuo Nagano. Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs.
Journal of the American Chemical Society.
2005 Mar; 127(11):3684-5. doi:
10.1021/ja042967z. [PMID: 15771488] - Hans Strijdom, Christo Muller, Amanda Lochner. Direct intracellular nitric oxide detection in isolated adult cardiomyocytes: flow cytometric analysis using the fluorescent probe, diaminofluorescein.
Journal of molecular and cellular cardiology.
2004 Oct; 37(4):897-902. doi:
10.1016/j.yjmcc.2004.05.018. [PMID: 15380680] - Shaoyou Chu, H Glenn Bohlen. High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism.
American journal of physiology. Renal physiology.
2004 Sep; 287(3):F384-92. doi:
10.1152/ajprenal.00006.2004. [PMID: 15140758] - Andrew Y Zhang, Ya-Fei Chen, David X Zhang, Fu-Xian Yi, Jenson Qi, Patricia Andrade-Gordon, Lawrence de Garavilla, Pin-Lan Li, Ai-Ping Zou. Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney.
American journal of physiology. Renal physiology.
2003 Oct; 285(4):F792-8. doi:
10.1152/ajprenal.00342.2002. [PMID: 12783779] - Peter Lorenz, Sanjoy Roychowdhury, Mario Engelmann, Gerald Wolf, Thomas F W Horn. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells.
Nitric oxide : biology and chemistry.
2003 Sep; 9(2):64-76. doi:
10.1016/j.niox.2003.09.005. [PMID: 14623172] - Sergey V Brodsky, Shujuan Gao, Hong Li, Michael S Goligorsky. Hyperglycemic switch from mitochondrial nitric oxide to superoxide production in endothelial cells.
American journal of physiology. Heart and circulatory physiology.
2002 Nov; 283(5):H2130-9. doi:
10.1152/ajpheart.00196.2002. [PMID: 12384491] - Ae Ra Kim, Yani Zou, Hyung Suk Kim, Jae Sue Choi, Gregory Youngnam Chang, You Jung Kim, Hae Young Chung. Selective peroxynitrite scavenging activity of 3-methyl-1,2-cyclopentanedione from coffee extract.
The Journal of pharmacy and pharmacology.
2002 Oct; 54(10):1385-92. doi:
10.1211/002235702760345473. [PMID: 12396301] - Michael Graham Espey, Katrina M Miranda, Douglas D Thomas, David A Wink. Ingress and reactive chemistry of nitroxyl-derived species within human cells.
Free radical biology & medicine.
2002 Sep; 33(6):827-34. doi:
10.1016/s0891-5849(02)00978-4. [PMID: 12208370] - Takefumi Mori, Jeffrey G Dickhout, Allen W Cowley. Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct.
Hypertension (Dallas, Tex. : 1979).
2002 Feb; 39(2 Pt 2):465-9. doi:
10.1161/hy02t2.102908. [PMID: 11882591] - K L Rhinehart, T L Pallone. Nitric oxide generation by isolated descending vasa recta.
American journal of physiology. Heart and circulatory physiology.
2001 Jul; 281(1):H316-24. doi:
10.1152/ajpheart.2001.281.1.h316. [PMID: 11406499] - V A Tyurin, S X Liu, Y Y Tyurina, N B Sussman, C A Hubel, J M Roberts, R N Taylor, V E Kagan. Elevated levels of S-nitrosoalbumin in preeclampsia plasma.
Circulation research.
2001 Jun; 88(11):1210-5. doi:
10.1161/hh1101.092179. [PMID: 11397789] - M Broillet, O Randin, J Chatton. Photoactivation and calcium sensitivity of the fluorescent NO indicator 4,5-diaminofluorescein (DAF-2): implications for cellular NO imaging.
FEBS letters.
2001 Mar; 491(3):227-32. doi:
10.1016/s0014-5793(01)02206-2. [PMID: 11240132]