Bezafibrate (BioDeep_00000018308)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid
化学式: C19H20ClNO4 (361.1080790000001)
中文名称: 苯扎贝特
谱图信息:
最多检出来源 Mus musculus(blood) 9.68%
分子结构信息
SMILES: CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl
InChI: InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
描述信息
Bezafibrate is only found in individuals that have used or taken this drug. It is an antilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins. [PubChem]Like the other fibrates, bezafibrate is an agonist of PPARα; some studies suggest it may have some activity on PPARγ and PPARδ as well.
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AB - Fibrates
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
同义名列表
68 个代谢物同义名
2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid; 2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid; 2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionate; Boehringer mannheim brand OF bezafibrate; Berlin chemie brand OF bezafibrate; Berlin-chemie brand OF bezafibrate; Synthelabo brand OF bezafibrate; Bezafibrate berlin-chemie brand; Cryopharma brand OF bezafibrate; Azupharma brand OF bezafibrate; Betapharm brand OF bezafibrate; Lakeside brand OF bezafibrate; Merckle brand OF bezafibrate; Bezafibrate cryopharma brand; Bezafibrate synthelabo brand; Bezafibrate azupharma brand; Hennig brand OF bezafibrate; Bezafibrate betapharm brand; Elfar brand OF bezafibrate; Bezafibrate lakeside brand; Bayer brand OF bezafibrate; Roche brand OF bezafibrate; Hexal brand OF bezafibrate; Teva brand OF bezafibrate; Bezafibrate merckle brand; Isis brand OF bezafibrate; Bezafibrate hennig brand; TAD brand OF bezafibrate; Bezafibrate roche brand; Bezafibrate elfar brand; Bezafibrate bayer brand; Bezafibrate hexal brand; Bezafibrate teva brand; Bezafibrate isis brand; Bezafibrate tad brand; Bezafibric acid; PB, Bezafibrat; Bezafibrat PB; Bezafibratum; Sklerofibrat; Bezafibrato; bezafibrate; Reducterol; Beza lande; Beza-lande; Bezatol SR; Beza puren; Regadrin b; Beza-puren; Bezafibrat; Bezafisal; Difaterol; BezaLande; Bezamerck; BezaPuren; Durabezur; Azufibrat; Bezabeta; Befibrat; Solibay; Bezacur; Béfizal; Befizal; Bezalip; Eulitop; Cedur; Lipox; BM15075
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:47612
- PubChem: 39042
- HMDB: HMDB0015465
- DrugBank: DB01393
- ChEMBL: CHEMBL264374
- Wikipedia: Bezafibrate
- MeSH: Bezafibrate
- chemspider: 35728
- CAS: 41859-67-0
- PMhub: MS000006177
- RefMet: Bezafibrate
- medchemexpress: HY-B0637
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo. Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome.
Heart and vessels.
2024 Jun; 39(6):486-495. doi:
10.1007/s00380-024-02363-z. [PMID: 38393377] - Yangyiyan Song, Wen Sun, Wenqiang Li, Wen Li. Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
International immunopharmacology.
2023 Oct; 123(?):110751. doi:
10.1016/j.intimp.2023.110751. [PMID: 37567013] - Masako Iwasaki, Hitoshi Suzuki, Yukako Umezawa, Takeo Koshida, Midori Saito, Hiromitsu Fukuda, Hisatsugu Takahara, Keiichi Matsuzaki, Yusuke Suzuki. Efficacy and safety of pemafibrate in patients with chronic kidney disease: A retrospective study.
Medicine.
2023 Feb; 102(7):e32818. doi:
10.1097/md.0000000000032818. [PMID: 36800602] - Caroline Santana Frientes, Marcelo Luis Marquezi, Juliana Monique Lino Aparecido, Marcelo Santin Cascapera, Patrícia Soares Rogeri, Antônio Herbert Lancha Junior. Effect of Menstrual Cycle Phase on Fuel Oxidation Post HIT in Women Reproductive Age: A Pilot Study.
International journal of environmental research and public health.
2023 02; 20(4):. doi:
10.3390/ijerph20043148. [PMID: 36833845] - Hongyu Chen, Lu Tian, Xiangyu Sun, Rongliang Ma, Meiqin Zhang. New Horizons for Estimating the Time Since Deposition of Fingermarks: Combining Label-Free Physical Visualization and Electrochemical Characterization.
Analytical chemistry.
2023 01; 95(2):889-897. doi:
10.1021/acs.analchem.2c03427. [PMID: 36537841] - Avigdor D Arad, Fred J DiMenna, Hannah D Kittrell, Harry R Kissileff, Jeanine B Albu. Whole body lipid oxidation during exercise is impaired with poor insulin sensitivity but not with obesity per se.
American journal of physiology. Endocrinology and metabolism.
2022 Oct; 323(4):E366-E377. doi:
10.1152/ajpendo.00042.2022. [PMID: 35830686] - Bianca Seminotti, Morgana Brondani, Rafael Teixeira Ribeiro, Guilhian Leipnitz, Moacir Wajner. Disturbance of Mitochondrial Dynamics, Endoplasmic Reticulum-Mitochondria Crosstalk, Redox Homeostasis, and Inflammatory Response in the Brain of Glutaryl-CoA Dehydrogenase-Deficient Mice: Neuroprotective Effects of Bezafibrate.
Molecular neurobiology.
2022 Aug; 59(8):4839-4853. doi:
10.1007/s12035-022-02887-3. [PMID: 35639256] - Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo. Efficacy and Safety of Pemafibrate Versus Bezafibrate to Treat Patients with Hypertriglyceridemia: A Randomized Crossover Study.
Journal of atherosclerosis and thrombosis.
2022 Jun; ?(?):. doi:
10.5551/jat.63659. [PMID: 35768226] - Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Nícolas Manzke Glänzel, Leonardo de Moura Alvorcem, Morgana Brondani, Renata Britto, Mateus Grings, Vanessa Duarte Ortiz, Patrick Turck, Alex Sander da Rosa Araujo, Moacir Wajner, Guilhian Leipnitz. Antioxidant system disturbances and mitochondrial dysfunction induced by 3-methyglutaric acid in rat heart are prevented by bezafibrate.
European journal of pharmacology.
2022 Jun; 924(?):174950. doi:
10.1016/j.ejphar.2022.174950. [PMID: 35430210] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Quetzalli Veloz Corona, Lulu Sanchez Reyes, Armando Valenzuela Peraza, Gerardo Barragán Mejía. Oseltamivir induces favorable response on oxidative damage in the brain of rats treated with Bezafibrate.
The International journal of neuroscience.
2022 Jun; 132(6):574-581. doi:
10.1080/00207454.2020.1828882. [PMID: 32976735] - Yao Jiang, Andrew D Southam, Sandro Trova, Flavio Beke, Bader Alhazmi, Thomas Francis, Anshul Radotra, Alessandro di Maio, Mark T Drayson, Chris M Bunce, Farhat L Khanim. Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing.
British journal of cancer.
2022 02; 126(2):275-286. doi:
10.1038/s41416-021-01570-z. [PMID: 34686779] - Xin Qiao, Yu-Yang Gao, Li-Xia Zheng, Xiao-Jing Ding, Ling-Wen Xu, Juan-Juan Hu, Wei-Zhen Gao, Jing-Yuan Xu. Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate.
European journal of medicinal chemistry.
2021 Nov; 223(?):113730. doi:
10.1016/j.ejmech.2021.113730. [PMID: 34388483] - Nan Shen, Jielu Pan, Hongyu Miao, Haiyan Zhang, Lianjun Xing, Xiao Yu. Fibrates for the treatment of pruritus in primary biliary cholangitis: a systematic review and meta-analysis.
Annals of palliative medicine.
2021 Jul; 10(7):7697-7705. doi:
10.21037/apm-21-1304. [PMID: 34353058] - Martin Lund, Kathrine G Andersen, Robert Heaton, Iain P Hargreaves, Niels Gregersen, Rikke K J Olsen. Bezafibrate activation of PPAR drives disturbances in mitochondrial redox bioenergetics and decreases the viability of cells from patients with VLCAD deficiency.
Biochimica et biophysica acta. Molecular basis of disease.
2021 06; 1867(6):166100. doi:
10.1016/j.bbadis.2021.166100. [PMID: 33549744] - Joost Boeckmans, Alessandra Natale, Matthias Rombaut, Karolien Buyl, Brent Cami, Veerle De Boe, Anja Heymans, Vera Rogiers, Joery De Kock, Tamara Vanhaecke, Robim M Rodrigues. Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists.
Cell biology and toxicology.
2021 04; 37(2):293-311. doi:
10.1007/s10565-020-09544-2. [PMID: 32613381] - Salwa A Ibrahim, Mervat Z Mohamed, Nashwa F El-Tahawy, Aly M Abdelrahman. Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats.
Canadian journal of physiology and pharmacology.
2021 Mar; 99(3):313-320. doi:
10.1139/cjpp-2020-0159. [PMID: 32721217] - Juan M León-Martínez, Esperanza Martínez-Abundis, Manuel González-Ortiz, Karina G Pérez-Rubio. Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial.
Journal of medicinal food.
2021 Feb; 24(2):111-115. doi:
10.1089/jmf.2020.0029. [PMID: 32397850] - Hideaki Shiraishi, Kenji Yamada, Kiyoshi Egawa, Mika Ishige, Fumihiro Ochi, Asami Watanabe, Sanae Kawakami, Kazuyo Kuzume, Kenji Watanabe, Koji Sameshima, Kiyotaka Nakamagoe, Akira Tamaoka, Naoko Asahina, Saki Yokoshiki, Keiko Kobayashi, Takashi Miyakoshi, Koji Oba, Toshiyuki Isoe, Hiroshi Hayashi, Seiji Yamaguchi, Norihiro Sato. Efficacy of bezafibrate for preventing myopathic attacks in patients with very long-chain acyl-CoA dehydrogenase deficiency.
Brain & development.
2021 Feb; 43(2):214-219. doi:
10.1016/j.braindev.2020.07.019. [PMID: 32798077] - Elsemieke de Vries, Ruth Bolier, Jorn Goet, Albert Parés, Jef Verbeek, Marleen de Vree, Joost Drenth, Karel van Erpecum, Karin van Nieuwkerk, Frans van der Heide, Nahid Mostafavi, Jeltje Helder, Cyriel Ponsioen, Ronald Oude Elferink, Henk van Buuren, Ulrich Beuers. Fibrates for Itch (FITCH) in Fibrosing Cholangiopathies: A Double-Blind, Randomized, Placebo-Controlled Trial.
Gastroenterology.
2021 02; 160(3):734-743.e6. doi:
10.1053/j.gastro.2020.10.001. [PMID: 33031833] - Jonathan J Sheard, Andrew D Southam, Hannah L MacKay, Max A Ellington, Martyn D Snow, Farhat L Khanim, Christopher M Bunce, William E Johnson. Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells.
Bioscience reports.
2021 01; 41(1):. doi:
10.1042/bsr20202505. [PMID: 33289496] - Boris Zingerman, Danny Ziv, Netta Feder Krengel, Asher Korzets, Ilan Matok. Cessation of Bezafibrate in patients with chronic kidney disease improves renal function.
Scientific reports.
2020 11; 10(1):19768. doi:
10.1038/s41598-020-76861-1. [PMID: 33188240] - Franck Peiretti, Roberta Montanari, Davide Capelli, Bernadette Bonardo, Cécilia Colson, Ez-Zoubir Amri, Marina Grimaldi, Patrick Balaguer, Keiichi Ito, Robert G Roeder, Giorgio Pochetti, Jean Michel Brunel. A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.
Journal of medicinal chemistry.
2020 11; 63(21):13124-13139. doi:
10.1021/acs.jmedchem.0c01555. [PMID: 33142057] - Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment.
European journal of medicinal chemistry.
2020 Jul; 197(?):112311. doi:
10.1016/j.ejmech.2020.112311. [PMID: 32339855] - Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Nícolas Manzke Glänzel, Leonardo de Moura Alvorcem, Marina Rocha Frusciante, Carlos Severo Dutra Filho, Moacir Wajner, Guilhian Leipnitz. In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver.
Biochimie.
2020 Apr; 171-172(?):187-196. doi:
10.1016/j.biochi.2020.03.007. [PMID: 32169667] - Keiko Takano, Chisato Saeki, Tsunekazu Oikawa, Akihisa Hidaka, Yusuke Mizuno, Jinya Ishida, Kazuki Takakura, Masanori Nakano, Yuichi Torisu, Katsushi Amano, Tomohisa Ishikawa, Mikio Zeniya, Akihito Tsubota, Masayuki Saruta. IgM response is a prognostic biomarker of primary biliary cholangitis treated with ursodeoxycholic acid and bezafibrate.
Journal of gastroenterology and hepatology.
2020 Apr; 35(4):663-672. doi:
10.1111/jgh.14900. [PMID: 31677185] - Hannah Steele, Aurora Gomez-Duran, Angela Pyle, Sila Hopton, Jane Newman, Renae J Stefanetti, Sarah J Charman, Jehill D Parikh, Langping He, Carlo Viscomi, Djordje G Jakovljevic, Kieren G Hollingsworth, Alan J Robinson, Robert W Taylor, Leonardo Bottolo, Rita Horvath, Patrick F Chinnery. Metabolic effects of bezafibrate in mitochondrial disease.
EMBO molecular medicine.
2020 03; 12(3):e11589. doi:
10.15252/emmm.201911589. [PMID: 32107855] - Ru Sun, Chengwu Shen, Shumaila Shafique, Omer Mustapha, Talib Hussain, Ikram Ullah Khan, Yasir Mehmood, Khaleeq Anwer, Yasser Shahzad, Abid Mehmood Yousaf. Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate.
International journal of nanomedicine.
2020; 15(?):705-715. doi:
10.2147/ijn.s235146. [PMID: 32099359] - Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen, Daowen Wang. PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis.
BMC cancer.
2019 Dec; 19(1):1166. doi:
10.1186/s12885-019-6379-5. [PMID: 31791289] - Akira Honda, Atsushi Tanaka, Tetsuji Kaneko, Atsumasa Komori, Masanori Abe, Mie Inao, Tadashi Namisaki, Naoaki Hashimoto, Kazuhito Kawata, Atsushi Takahashi, Masashi Ninomiya, Jong-Hon Kang, Mie Arakawa, Satoshi Yamagiwa, Satoru Joshita, Takeji Umemura, Ken Sato, Akira Kaneko, Kentaro Kikuchi, Jun Itakura, Takako Nomura, Keisuke Kakisaka, Hideki Fujii, Norifumi Kawada, Yasuhiro Takikawa, Tsutomu Masaki, Hiromasa Ohira, Satoshi Mochida, Hitoshi Yoshiji, Satoshi Iimuro, Yasushi Matsuzaki, Hajime Takikawa. Bezafibrate Improves GLOBE and UK-PBC Scores and Long-Term Outcomes in Patients With Primary Biliary Cholangitis.
Hepatology (Baltimore, Md.).
2019 12; 70(6):2035-2046. doi:
10.1002/hep.30552. [PMID: 30737815] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Y H Chen, Z Zhan, P Hu, H Ren, M L Peng. [A new attempt with lipoprotein lipase agonists in the treatment of nonalcoholic steatohepatitis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 Jul; 27(7):533-540. doi:
10.3760/cma.j.issn.1007-3418.2019.07.011. [PMID: 31357780] - Zaza Iakobishvili, Tal Hasin, Robert Klempfner, Nir Shlomo, Ilan Goldenberg, Ronen Brenner, Ran Kornowski, Yariv Gerber. Association of Bezafibrate Treatment With Reduced Risk of Cancer in Patients With Coronary Artery Disease.
Mayo Clinic proceedings.
2019 07; 94(7):1171-1179. doi:
10.1016/j.mayocp.2018.10.026. [PMID: 31272567] - Takashi Yamaguchi, Kohji Shirai, Daiji Nagayama, Shoko Nakamura, Rena Oka, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Yuta Sato, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Naomi Shimizu, Ichiro Tatsuno. Bezafibrate Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Hypertriglyceridemic Patients with Type 2 Diabetes Mellitus.
Journal of atherosclerosis and thrombosis.
2019 Jul; 26(7):659-669. doi:
10.5551/jat.45799. [PMID: 30584220] - Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Mateus Struecker da Rosa, Nícolas Manzke Glänzel, Leonardo de Moura Alvorcem, Moacir Wajner, Guilhian Leipnitz. Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats.
Neurotoxicity research.
2019 May; 35(4):809-822. doi:
10.1007/s12640-019-00019-9. [PMID: 30850947] - Patrícia Duarte, C Marisa R Almeida, Joana P Fernandes, Daniela Morais, Marta Lino, Carlos R Gomes, Maria F Carvalho, Ana P Mucha. Bioremediation of bezafibrate and paroxetine by microorganisms from estuarine sediment and activated sludge of an associated wastewater treatment plant.
The Science of the total environment.
2019 Mar; 655(?):796-806. doi:
10.1016/j.scitotenv.2018.11.285. [PMID: 30577142] - Bernardo Duarte, Diogo Prata, Ana Rita Matos, Maria Teresa Cabrita, Isabel Caçador, João Carlos Marques, Henrique N Cabral, Patrick Reis-Santos, Vanessa F Fonseca. Ecotoxicity of the lipid-lowering drug bezafibrate on the bioenergetics and lipid metabolism of the diatom Phaeodactylum tricornutum.
The Science of the total environment.
2019 Feb; 650(Pt 2):2085-2094. doi:
10.1016/j.scitotenv.2018.09.354. [PMID: 30290350] - Lauren R Waskowicz, Jin Zhou, Dustin J Landau, Elizabeth D Brooks, Andrea Lim, Zollie A Yavarow, Tsubasa Kudo, Haoyue Zhang, Yajun Wu, Stuart Grant, Sarah P Young, Bay Boon Huat, Paul M Yen, Dwight D Koeberl. Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia.
Human molecular genetics.
2019 01; 28(1):143-154. doi:
10.1093/hmg/ddy343. [PMID: 30256948] - Belisa Parmeggiani, Mateus Grings, Nevton Teixeira da Rosa-Junior, Renata Britto, Moacir Wajner, Guilhian Leipnitz. Bezafibrate Prevents Glycine-Induced Increase of Antioxidant Enzyme Activities in Rat Striatum.
Molecular neurobiology.
2019 Jan; 56(1):29-38. doi:
10.1007/s12035-018-1074-0. [PMID: 29675575] - Sara Lemoinne, Albert Pares, Anna Reig, Karima Ben Belkacem, Astrid Donald Kemgang Fankem, Farid Gaouar, Raoul Poupon, Chantal Housset, Christophe Corpechot, Olivier Chazouillères. Primary sclerosing cholangitis response to the combination of fibrates with ursodeoxycholic acid: French-Spanish experience.
Clinics and research in hepatology and gastroenterology.
2018 12; 42(6):521-528. doi:
10.1016/j.clinre.2018.06.009. [PMID: 30100231] - Suhaniya Samarasinghe, Parizad Avari, Karim Meeran, Jaimini Cegla. Management of hypertriglyceridaemic pancreatitis in the acute setting and review of literature.
BMJ case reports.
2018 Nov; 11(1):. doi:
10.1136/bcr-2018-227594. [PMID: 30567142] - Joseph M Chambers, Shahram Jevin Poureetezadi, Amanda Addiego, Manuela Lahne, Rebecca A Wingert. ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny.
eLife.
2018 11; 7(?):. doi:
10.7554/elife.40266. [PMID: 30475208] - Zaza Khuchua, Aleksandr I Glukhov, Arnold W Strauss, Sabzali Javadov. Elucidating the Beneficial Role of PPAR Agonists in Cardiac Diseases.
International journal of molecular sciences.
2018 Nov; 19(11):. doi:
10.3390/ijms19113464. [PMID: 30400386] - Annette Wegner, Dragan Pavlovic, Sebastian Haußmann-Vopel, Christian Lehmann. Impact of lipid modulation on the intestinal microcirculation in experimental sepsis.
Microvascular research.
2018 11; 120(?):41-46. doi:
10.1016/j.mvr.2018.05.009. [PMID: 29859746] - Xiujuan Kong, Zihao Wu, Ziran Ren, Kaiheng Guo, Shaodong Hou, Zhechao Hua, Xuchun Li, Jingyun Fang. Degradation of lipid regulators by the UV/chlorine process: Radical mechanisms, chlorine oxide radical (ClO•)-mediated transformation pathways and toxicity changes.
Water research.
2018 06; 137(?):242-250. doi:
10.1016/j.watres.2018.03.004. [PMID: 29550727] - Isabela Bruna Pires Borges, Marilda Guimarães Silva, Rafael Giovane Misse, Samuel Katsuyuki Shinjo. Lipid-lowering agent-triggered dermatomyositis and polymyositis: a case series and literature review.
Rheumatology international.
2018 Feb; 38(2):293-301. doi:
10.1007/s00296-017-3821-3. [PMID: 29027009] - Ayumi Usui-Ouchi, Yasuo Ouchi, Nobuyuki Ebihara. The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells.
International immunopharmacology.
2017 Nov; 52(?):70-76. doi:
10.1016/j.intimp.2017.08.027. [PMID: 28866026] - Charlotte Koopal, A David Marais, Jan Westerink, Yolanda van der Graaf, Frank L J Visseren. Effect of adding bezafibrate to standard lipid-lowering therapy on post-fat load lipid levels in patients with familial dysbetalipoproteinemia. A randomized placebo-controlled crossover trial.
Journal of lipid research.
2017 11; 58(11):2180-2187. doi:
10.1194/jlr.m076901. [PMID: 28928170] - Jamie L Barger, James M Vann, Nicole L Cray, Thomas D Pugh, Angela Mastaloudis, Shelly N Hester, Steven M Wood, Michael A Newton, Richard Weindruch, Tomas A Prolla. Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.
Aging cell.
2017 08; 16(4):750-760. doi:
10.1111/acel.12608. [PMID: 28556428] - Joanna L Denbigh, David Perez-Guaita, Robbin R Vernooij, Mark J Tobin, Keith R Bambery, Yun Xu, Andrew D Southam, Farhat L Khanim, Mark T Drayson, Nicholas P Lockyer, Royston Goodacre, Bayden R Wood. Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques.
Scientific reports.
2017 06; 7(1):2649. doi:
10.1038/s41598-017-02069-5. [PMID: 28572622] - Lingyao Du, Yuanji Ma, Miao Liu, Libo Yan, Hong Tang. Peroxisome Proliferators Activated Receptor (PPAR) agonists activate hepatitis B virus replication in vivo.
Virology journal.
2017 05; 14(1):96. doi:
10.1186/s12985-017-0765-x. [PMID: 28545573] - Hui Wang, Jia Zhou, Qiong Zhen Liu, Lu Lu Wang, Jing Shang. Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice.
Scientific reports.
2017 05; 7(1):2335. doi:
10.1038/s41598-017-02576-5. [PMID: 28539670] - Ruth Bolier, Elsemieke S de Vries, Albert Parés, Jeltje Helder, E Marleen Kemper, Koos Zwinderman, Ronald P Oude Elferink, Ulrich Beuers. Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial.
Trials.
2017 05; 18(1):230. doi:
10.1186/s13063-017-1966-8. [PMID: 28535810] - V De Marco, K S M Noronha, T C Casado, E R Nakandakare, J C Florio, E Z Santos, C Gilor. Therapy of Canine Hyperlipidemia with Bezafibrate.
Journal of veterinary internal medicine.
2017 May; 31(3):717-722. doi:
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Molecular metabolism.
2017 03; 6(3):256-266. doi:
10.1016/j.molmet.2016.12.007. [PMID: 28271032] - Galit Weinstein, Miriam Lutski, Uri Goldbourt, David Tanne. C-reactive protein is related to future cognitive impairment and decline in elderly individuals with cardiovascular disease.
Archives of gerontology and geriatrics.
2017 Mar; 69(?):31-37. doi:
10.1016/j.archger.2016.11.002. [PMID: 27886564] - Kenji Yamada, Hironori Kobayashi, Ryosuke Bo, Jamiyan Purevsuren, Yuichi Mushimoto, Tomoo Takahashi, Yuki Hasegawa, Takeshi Taketani, Seiji Fukuda, Seiji Yamaguchi. Efficacy of bezafibrate on fibroblasts of glutaric acidemia type II patients evaluated using an in vitro probe acylcarnitine assay.
Brain & development.
2017 Jan; 39(1):48-57. doi:
10.1016/j.braindev.2016.08.004. [PMID: 27591119] - S Haj Ahmed, W Kharroubi, A Zarrouk, F Brahmi, T Nury, G Lizard, M Hammami. Protective effects of bezafibrate against elaidic acid-induced accumulation of lipid droplets in monocytic cells.
Current research in translational medicine.
2017 Jan; 65(1):20-30. doi:
10.1016/j.retram.2016.08.001. [PMID: 28340693] - Airton José Petris, Regina Kazue Tanno de Souza, Maira Sayuri Sakay Bortoletto. [Public sector participation in the supply of dyslipidemia medication in a population-based study].
Ciencia & saude coletiva.
2016 Dec; 21(12):3899-3906. doi:
10.1590/1413-812320152112.08442015. [PMID: 27925129] - Tobias Jakob, Alain J Nordmann, Stefan Schandelmaier, Ignacio Ferreira-González, Matthias Briel. Fibrates for primary prevention of cardiovascular disease events.
The Cochrane database of systematic reviews.
2016 11; 11(?):CD009753. doi:
10.1002/14651858.cd009753.pub2. [PMID: 27849333] - Francesco Alessandro Palermo, Paolo Cocci, Matteo Mozzicafreddo, Augustine Arukwe, Mauro Angeletti, Graziano Aretusi, Gilberto Mosconi. Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes: revealed by computational modeling (docking) and transcriptional regulation of signaling pathways.
Toxicology research.
2016 Mar; 5(2):471-481. doi:
10.1039/c5tx00314h. [PMID: 30090361] - Minho Hong, Ki Duk Song, Hak-Kyo Lee, SunShin Yi, Yong Seok Lee, Tae-Hwe Heo, Hyun Sik Jun, Sung-Jo Kim. Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential.
In vitro cellular & developmental biology. Animal.
2016 Mar; 52(3):349-355. doi:
10.1007/s11626-015-9979-7. [PMID: 26659390] - Lu Lu Wang, Zhi Chao Zhang, Waseem Hassan, Yu Li, Jun Liu, Jing Shang. Amelioration of free fatty acid-induced fatty liver by quercetin-3-O-β-D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling.
Hepatology research : the official journal of the Japan Society of Hepatology.
2016 Feb; 46(2):225-38. doi:
10.1111/hepr.12557. [PMID: 26190035] - Yuan Feng, Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Zhihao Liu, Pengyuan Sun, Xiaobo Yang, Huijun Sun, Jianhua Qin, Kexin Liu. Bezafibrate-mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Jan; 81(?):119-28. doi:
10.1016/j.ejps.2015.10.008. [PMID: 26474691] - Fatima Djouadi, Florence Habarou, Carole Le Bachelier, Sacha Ferdinandusse, Dimitri Schlemmer, Jean François Benoist, Audrey Boutron, Brage S Andresen, Gepke Visser, Pascale de Lonlay, Simon Olpin, Toshiyuki Fukao, Seiji Yamaguchi, Arnold W Strauss, Ronald J A Wanders, Jean Bastin. Mitochondrial trifunctional protein deficiency in human cultured fibroblasts: effects of bezafibrate.
Journal of inherited metabolic disease.
2016 Jan; 39(1):47-58. doi:
10.1007/s10545-015-9871-3. [PMID: 26109258] - Atsushi Shima, Tetsuhiko Yasuno, Kenji Yamada, Miyoko Yamaguchi, Ryuichi Kohno, Seiji Yamaguchi, Hiroshi Kido, Hidetoshi Fukuda. First Japanese Case of Carnitine Palmitoyltransferase II Deficiency with the Homozygous Point Mutation S113L.
Internal medicine (Tokyo, Japan).
2016 ; 55(18):2659-61. doi:
10.2169/internalmedicine.55.6288. [PMID: 27629963] - Chieri Fujino, Yuki Tamura, Satoko Tange, Hiroyuki Nakajima, Seigo Sanoh, Yoko Watanabe, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura. Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.
The Journal of toxicological sciences.
2016; 41(5):677-91. doi:
10.2131/jts.41.677. [PMID: 27665777] - Alexandre Courchesne-Loyer, Valérie St-Pierre, Marie Hennebelle, Christian-Alexandre Castellano, Mélanie Fortier, Daniel Tessier, Stephen C Cunnane. Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans.
Nutrition (Burbank, Los Angeles County, Calif.).
2015 Oct; 31(10):1255-9. doi:
10.1016/j.nut.2015.05.015. [PMID: 26333891] - Ayako Watanabe, Akiko Tanabe, Risa Maruoka, Kiyoko Nakamura, Koji Hatta, Yoshihiro J Ono, Yoshito Terai, Masahide Ohmichi. Fibrates protect against vascular endothelial dysfunction induced by paclitaxel and carboplatin chemotherapy for cancer patients: a pilot study.
International journal of clinical oncology.
2015 Aug; 20(4):829-38. doi:
10.1007/s10147-014-0779-y. [PMID: 25539886] - Nithiwat Vatanavicharn, Kenji Yamada, Yuka Aoyama, Toshiyuki Fukao, Narumon Densupsoontorn, Pipop Jirapinyo, Achara Sathienkijkanchai, Seiji Yamaguchi, Pornswan Wasant. Carnitine-acylcarnitine translocase deficiency: Two neonatal cases with common splicing mutation and in vitro bezafibrate response.
Brain & development.
2015 Aug; 37(7):698-703. doi:
10.1016/j.braindev.2014.10.005. [PMID: 25459972] - Takahisa Hirose, Tamio Teramoto, Kazunori Abe, Takehiko Taneyama. Determinants of Bezafibrate-induced Improvements in LDL Cholesterol in Dyslipidemic Patients with Diabetes.
Journal of atherosclerosis and thrombosis.
2015 Jul; 22(7):676-84. doi:
10.5551/jat.27425. [PMID: 25752494] - Junji Kobayashi. How Does Bezafibrate Affect the Plasma LDL Cholesterol Levels?.
Journal of atherosclerosis and thrombosis.
2015 Jul; 22(7):658-9. doi:
10.5551/jat.ed007. [PMID: 25752495] - Andrew D Southam, Farhat L Khanim, Rachel E Hayden, Julia K Constantinou, Katarzyna M Koczula, Robert H Michell, Mark R Viant, Mark T Drayson, Chris M Bunce. Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids.
Cancer research.
2015 Jun; 75(12):2530-40. doi:
10.1158/0008-5472.can-15-0202. [PMID: 25943877] - Kenichi Hosonuma, Ken Sato, Yuichi Yamazaki, Masatoshi Yanagisawa, Hiroaki Hashizume, Norio Horiguchi, Satoru Kakizaki, Motoyasu Kusano, Masanobu Yamada. A prospective randomized controlled study of long-term combination therapy using ursodeoxycholic acid and bezafibrate in patients with primary biliary cirrhosis and dyslipidemia.
The American journal of gastroenterology.
2015 Mar; 110(3):423-31. doi:
10.1038/ajg.2015.20. [PMID: 25732417] - T Al-Qirim, G Shattat, G A Sheikha, K Sweidan, Y Al-Hiari, A Jarab. Synthesis of novel N-(4-benzoylphenyl)-2-furamide derivatives and their pharmacological evaluation as potent antihyperlipidemic agents in rats.
Drug research.
2015 Mar; 65(3):158-63. doi:
10.1055/s-0034-1375646. [PMID: 24848001] - Mette Cathrine Ørngreen, John Vissing, Pascal Laforét. No effect of bezafibrate in patients with CPTII and VLCAD deficiencies.
Journal of inherited metabolic disease.
2015 Mar; 38(2):373-4. doi:
10.1007/s10545-014-9779-3. [PMID: 25331908] - Jean Bastin, Jean-Paul Bonnefont, Fatima Djouadi, Jean-Louis Bresson. Should the beneficial impact of bezafibrate on fatty acid oxidation disorders be questioned?.
Journal of inherited metabolic disease.
2015 Mar; 38(2):371-2. doi:
10.1007/s10545-014-9775-7. [PMID: 25310995] - Xiyuan Li, Yuan Ding, Yanyan Ma, Yupeng Liu, Qiao Wang, Jinqing Song, Yanling Yang. Very long-chain acyl-coenzyme A dehydrogenase deficiency in Chinese patients: eight case reports, including one case of prenatal diagnosis.
European journal of medical genetics.
2015 Mar; 58(3):134-9. doi:
10.1016/j.ejmg.2015.01.005. [PMID: 25652019] - Martin J A Schackmann, Rob Ofman, Inge M E Dijkstra, Ronald J A Wanders, Stephan Kemp. Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Biochimica et biophysica acta.
2015 Feb; 1851(2):231-7. doi:
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Journal of lipid research.
2015 Feb; 56(2):254-65. doi:
10.1194/jlr.m052464. [PMID: 25510248] - Yuri A Blednov, Jillian M Benavidez, Mendy Black, Laura B Ferguson, Grant L Schoenhard, Alison M Goate, Howard J Edenberg, Leah Wetherill, Victor Hesselbrock, Tatiana Foroud, R Adron Harris. Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.
Alcoholism, clinical and experimental research.
2015 Jan; 39(1):136-45. doi:
10.1111/acer.12610. [PMID: 25516156] - Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
PloS one.
2015; 10(2):e0112655. doi:
10.1371/journal.pone.0112655. [PMID: 25689681] - Qin Yin, Jingjing Li, Yujing Xia, Rong Zhang, Jianrong Wang, Wenxia Lu, Yuqing Zhou, Yuanyuan Zheng, Huerxidan Abudumijiti, Rongxia Chen, Kan Chen, Sainan Li, Tong Liu, Fan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo. Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis.
Drug design, development and therapy.
2015; 9(?):5407-19. doi:
10.2147/dddt.s92041. [PMID: 26491252] - Zvi Ackerman, Galina Skarzinski, Maria Grozovski, Mor Oron-Herman, Ben-Ami Sela. Effects of antihypertensive and triglyceride-lowering agents on hepatic copper concentrations in rats with fatty liver disease.
Basic & clinical pharmacology & toxicology.
2014 Dec; 115(6):545-51. doi:
10.1111/bcpt.12283. [PMID: 24975050] - Milena Marsoni, Fabrizio De Mattia, Massimo Labra, Antonia Bruno, Marcella Bracale, Candida Vannini. Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants.
Ecotoxicology and environmental safety.
2014 10; 108(?):52-7. doi:
10.1016/j.ecoenv.2014.05.029. [PMID: 25042244] - Michael Lever, Christopher J McEntyre, Peter M George, Sandy Slow, Jane L Elmslie, Helen Lunt, Stephen T Chambers, Amber Parry-Strong, Jeremy D Krebs. Extreme urinary betaine losses in type 2 diabetes combined with bezafibrate treatment are associated with losses of dimethylglycine and choline but not with increased losses of other osmolytes.
Cardiovascular drugs and therapy.
2014 Oct; 28(5):459-68. doi:
10.1007/s10557-014-6542-9. [PMID: 25060556] - Helena F Raposo, Patrícia R Patrício, Mariana C Simões, Helena C F Oliveira. Fibrates and fish oil, but not corn oil, up-regulate the expression of the cholesteryl ester transfer protein (CETP) gene.
The Journal of nutritional biochemistry.
2014 Jun; 25(6):669-74. doi:
10.1016/j.jnutbio.2014.02.008. [PMID: 24746832] - Yuko Ohno, Toru Miyoshi, Yoko Noda, Hiroki Oe, Norihisa Toh, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita, Hiroshi Ito. Bezafibrate improves postprandial hypertriglyceridemia and associated endothelial dysfunction in patients with metabolic syndrome: a randomized crossover study.
Cardiovascular diabetology.
2014 Apr; 13(?):71. doi:
10.1186/1475-2840-13-71. [PMID: 24708775] - Yuqing Chen. Lipoprotein glomerulopathy in China.
Clinical and experimental nephrology.
2014 Apr; 18(2):218-9. doi:
10.1007/s10157-013-0873-x. [PMID: 24165683] - Alexandra Rogue, Sébastien Anthérieu, Aurore Vluggens, Thierry Umbdenstock, Nancy Claude, Catherine de la Moureyre-Spire, Richard J Weaver, André Guillouzo. PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells.
Toxicology and applied pharmacology.
2014 Apr; 276(1):73-81. doi:
10.1016/j.taap.2014.02.001. [PMID: 24534255] - Mette Cathrine Ørngreen, Karen Lindhardt Madsen, Nicolai Preisler, Grete Andersen, John Vissing, Pascal Laforêt. Bezafibrate in skeletal muscle fatty acid oxidation disorders: a randomized clinical trial.
Neurology.
2014 Feb; 82(7):607-13. doi:
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Biological & pharmaceutical bulletin.
2014; 37(1):105-12. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):189-211. doi:
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Internal medicine (Tokyo, Japan).
2014; 53(13):1429-33. doi:
10.2169/internalmedicine.53.2250. [PMID: 24990335] - Ragunath Singaravelu, Ran Chen, Rodney K Lyn, Daniel M Jones, Shifawn O'Hara, Yanouchka Rouleau, Jenny Cheng, Prashanth Srinivasan, Neda Nasheri, Rodney S Russell, D Lorne Tyrrell, John Paul Pezacki. Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis.
Hepatology (Baltimore, Md.).
2014 Jan; 59(1):98-108. doi:
10.1002/hep.26634. [PMID: 23897856] - Michela Triolo, Wijtske Annema, Jan Freark de Boer, Uwe J F Tietge, Robin P F Dullaart. Simvastatin and bezafibrate increase cholesterol efflux in men with type 2 diabetes.
European journal of clinical investigation.
2014; 44(3):240-8. doi:
10.1111/eci.12226. [PMID: 24325778] - Kylie R Dunning, Marie R Anastasi, Voueleng J Zhang, Darryl L Russell, Rebecca L Robker. Regulation of fatty acid oxidation in mouse cumulus-oocyte complexes during maturation and modulation by PPAR agonists.
PloS one.
2014; 9(2):e87327. doi:
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PloS one.
2014; 9(4):e96056. doi:
10.1371/journal.pone.0096056. [PMID: 24759758] - Xiang-ping Li, Hai-rong Gong, Shui-ping Zhao, Wen-yu Huang. [The lipid-regulating effect and safety of combined statin and bezafibrate therapy in acute coronary syndrome patients complicating with dyslipidemia].
Zhonghua xin xue guan bing za zhi.
2013 Dec; 41(12):1006-9. doi:
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Menopause (New York, N.Y.).
2013 Dec; 20(12):1264-74. doi:
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