Ritipenem (BioDeep_00000182961)
human metabolite blood metabolite
代谢物信息卡片
3-[(C-Hydroxycarbonimidoyloxy)methyl]-6-(1-hydroxyethyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
化学式: C10H12N2O6S (288.04160520000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1C2N(C1=O)C(=C(S2)COC(=O)N)C(=O)O)O
InChI: InChI=1S/C10H12N2O6S/c1-3(13)5-7(14)12-6(9(15)16)4(19-8(5)12)2-18-10(11)17/h3,5,8,13H,2H2,1H3,(H2,11,17)(H,15,16)
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M Matsuoka, N Imado, T Maki, K Banno, T Sato. Simultaneous determination of an active metabolite and open-ring metabolites by high performance liquid chromatography and pharmacokinetic studies of a penem antibiotic, FCE22891, in dogs.
Journal of pharmaceutical and biomedical analysis.
1998 Jun; 17(2):255-66. doi:
10.1016/s0731-7085(97)00189-1. [PMID: 9638578] - I Poggesi, R Spinelli, E Frigerio, M Strolin Benedetti, L Carra, D Sassella, R Rimoldi. A study of the pharmacokinetics and tolerability of ritipenem acoxil in healthy volunteers following multiple oral dosing.
The Journal of antimicrobial chemotherapy.
1997 Aug; 40(2):291-4. doi:
10.1093/jac/40.2.291. [PMID: 9301999] - M Matsuoka, T Maki, K Banno, T Sato. Liquid chromatographic analysis of penem antibiotic FCE22101 in biological fluids with a liquid-liquid extraction procedure.
Journal of chromatography. B, Biomedical applications.
1996 Oct; 685(2):273-9. doi:
10.1016/s0378-4347(96)00197-1. [PMID: 8953168] - M J Iatropoulos, A J Newman, A D Dayan, M Brughera, G Scampini, G Mazue. Urinary bladder hyperplasia in the rat: non-specific pathogenetic considerations using a beta-lactam antibiotic.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
1994 Oct; 46(4-5):265-74. doi:
10.1016/s0940-2993(11)80098-9. [PMID: 7894235] - C Efthymiopoulos, M Strolin Benedetti, D Sassella, A Boobis, D Davies. Pharmacokinetics of [14C]FCE 22891, a penem antibiotic, following oral administration to healthy volunteers.
Antimicrobial agents and chemotherapy.
1992 Sep; 36(9):1958-63. doi:
10.1128/aac.36.9.1958. [PMID: 1416887] - R Méndez, A Negro, J Martín-Villacorta. High-performance liquid chromatographic methods for the determination of the penems SCH 29482 and FCE 22101 in human serum and urine.
Journal of chromatography.
1992 Aug; 579(1):115-21. doi:
10.1016/0378-4347(92)80369-2. [PMID: 1447337] - A M Lovering, A P MacGowan, D A Lewis, D S Reeves. Pharmacokinetics and metabolism of FCE 22101 following its administration as the oral pro-drug FCE 22891.
The Journal of antimicrobial chemotherapy.
1992 Feb; 29(2):179-85. doi:
10.1093/jac/29.2.179. [PMID: 1506334] - R Battaglia, M Strolin Benedetti, E Fontana. Effect of cilastatin on the urinary metabolism of FCE 22101 in the rat.
The Journal of antimicrobial chemotherapy.
1992 Jan; 29(1):84-6. doi:
10.1093/jac/29.1.84. [PMID: 1737730] - S R Norrby, L A Burman, D Sassella, R Corigli, G Cassinelli, G Franceschi, K Dornbusch. Pharmacokinetics in healthy subjects of FCE 22101 and its acetoxymethyl ester, FCE 22891: effect of co-administration of imipenem/cilastatin on the renal metabolism of FCE 22101.
The Journal of antimicrobial chemotherapy.
1990 Mar; 25(3):371-83. doi:
10.1093/jac/25.3.371. [PMID: 2338416] - M Brughera, G Scampini, M L Ferrari, A Nava, G Mazué. Toxicological profile of FCE 22101 and its orally available ester FCE 22891.
The Journal of antimicrobial chemotherapy.
1989 Mar; 23 Suppl C(?):129-35. doi:
10.1093/jac/23.suppl_c.129. [PMID: 2732134] - C Della Bruna, D Jabes, R Rossi, G Younes, P Castellani. FCE 22101 and FCE 22891: in-vitro antibacterial activity at concentrations simulating human plasma levels following intravenous, intramuscular and oral administration.
The Journal of antimicrobial chemotherapy.
1989 Mar; 23 Suppl C(?):119-28. doi:
10.1093/jac/23.suppl_c.119. [PMID: 2659570] - A M Lovering, L O White, D A Lewis, A P MacGowan, K R Routh, D M Pickin, D S Reeves. Pharmacokinetics of FCE 22101 in man following different modes of administration.
The Journal of antimicrobial chemotherapy.
1989 Mar; 23 Suppl C(?):179-95. doi:
10.1093/jac/23.suppl_c.179. [PMID: 2732141] - M Strolin Benedetti, G Goldaniga, L Montesanti, R Battaglia, G Vicario. Disposition of 14C-labelled FCE 22101 in animals.
The Journal of antimicrobial chemotherapy.
1989 Mar; 23 Suppl C(?):165-71. doi:
10.1093/jac/23.suppl_c.165. [PMID: 2732138] - D Sassella, G Cassinelli, R Corigli, P Dewland, V Hutt, H Lode, R C Ballard. Urinary recovery and tolerability of FCE 22101 following single intravenous administration under restricted and high fluid intake.
The Journal of antimicrobial chemotherapy.
1989 Mar; 23 Suppl C(?):197-203. doi:
10.1093/jac/23.suppl_c.197. [PMID: 2732142] - M Strolin Benedetti, R Battaglia, G Vicario, R Roncucci. Urinary metabolites of 14C-labelled FCE 22101 in animals.
The Journal of antimicrobial chemotherapy.
1989 Mar; 23 Suppl C(?):173-7. doi:
10.1093/jac/23.suppl_c.173. [PMID: 2732140] - M G Jannuzzo, M Mandelli, M S Benedetti, E Moro, M Carnovali, R Vaiani, D Sassella. Pharmacokinetics and tolerance of a new penem antibiotic, FCE 22101, in healthy volunteers after a single intravenous dose.
European journal of clinical pharmacology.
1989; 36(6):633-5. doi:
10.1007/bf00637750. [PMID: 2776823] - S E Schliamser, K A Broholm, A L Liljedahl, S R Norrby. Comparative neurotoxicity of benzylpenicillin, imipenem/cilastatin and FCE 22101, a new injectible penem.
The Journal of antimicrobial chemotherapy.
1988 Nov; 22(5):687-95. doi:
10.1093/jac/22.5.687. [PMID: 3209527] - G Cassinelli, R Corigli, P Orezzi, G Ventrella, A Bedeschi, E Perrone, D Borghi, G Franceschi. Structure determination of the primary renal metabolite of the penem FCE 22101.
The Journal of antibiotics.
1988 Jul; 41(7):984-7. doi:
10.7164/antibiotics.41.984. [PMID: 3417570] - J M Webberley, R Wise, J M Andrews, J P Ashby, D Wallbridge. The pharmacokinetics and tissue penetration of FCE 22101 following intravenous and oral administration.
The Journal of antimicrobial chemotherapy.
1988 Apr; 21(4):445-50. doi:
10.1093/jac/21.4.445. [PMID: 3378958] - S E Schliamser. Neurotoxicity of beta-lactam antibiotics. Experimental kinetic and neurophysiological studies.
Scandinavian journal of infectious diseases. Supplementum.
1988; 55(?):1-61. doi:
10.3109/inf.1988.20.suppl-55.01. [PMID: 3241957] - A J Baskerville, D Felmingham, R N Grüneberg. A high performance liquid chromatography method for the determination of FCE 22101, a novel penem antimicrobial, in serum.
Drugs under experimental and clinical research.
1988; 14(10):645-8. doi:
NULL. [PMID: 3246208] - P Van der Auwera, F Ernst, P Grenier, Y Glupczynski, M Husson, J Klastersky. In-vitro activity of two new carbapenems FCE 22101 and CGP 31608 in comparison with imipenem.
The Journal of antimicrobial chemotherapy.
1987 Aug; 20(2):179-89. doi:
10.1093/jac/20.2.179. [PMID: 3478328] - R Wise, J M Andrews, G Danks. Comparison of in vitro activity of FCE 22101, a new penem, with those of other beta-lactam antibiotics.
Antimicrobial agents and chemotherapy.
1983 Dec; 24(6):909-14. doi:
10.1128/aac.24.6.909. [PMID: 6607032]