Q-VD-OPh (BioDeep_00000182792)
human metabolite blood metabolite
代谢物信息卡片
化学式: C26H25F2N3O6 (513.1711333999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
InChI: InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)
描述信息
D009676 - Noxae > D000477 - Alkylating Agents > D000590 - Amino Acid Chloromethyl Ketones
同义名列表
5 个代谢物同义名
5-(2,6-Difluorophenoxy)-3-({1-hydroxy-3-methyl-2-[(quinolin-2-yl)formamido]butylidene}amino)-4-oxopentanoate; 5-(2,6-difluorophenoxy)-3-{3-methyl-2-[(quinolin-2-yl)formamido]butanamido}-4-oxopentanoic acid; 5-(2,6-difluorophenoxy)-3-[3-methyl-2-(quinolin-2-ylformamido)butanamido]-4-oxopentanoic acid; Q-VD-OPh hydrate; Q-VD-OPh
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Trevor L Nydam, Robert Plenter, Swati Jain, Scott Lucia, Alkesh Jani. Caspase Inhibition During Cold Storage Improves Graft Function and Histology in a Murine Kidney Transplant Model.
Transplantation.
2018 09; 102(9):1487-1495. doi:
10.1097/tp.0000000000002218. [PMID: 29757911] - Jason A Powell, Alexander C Lewis, Wenying Zhu, John Toubia, Melissa R Pitman, Craig T Wallington-Beddoe, Paul A B Moretti, Diana Iarossi, Saumya E Samaraweera, Nik Cummings, Hayley S Ramshaw, Daniel Thomas, Andrew H Wei, Angel F Lopez, Richard J D'Andrea, Ian D Lewis, Stuart M Pitson. Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.
Blood.
2017 02; 129(6):771-782. doi:
10.1182/blood-2016-06-720433. [PMID: 27956387] - Yu-Hsin Chiu, Xueyao Jin, Christopher B Medina, Susan A Leonhardt, Volker Kiessling, Brad C Bennett, Shaofang Shu, Lukas K Tamm, Mark Yeager, Kodi S Ravichandran, Douglas A Bayliss. A quantized mechanism for activation of pannexin channels.
Nature communications.
2017 01; 8(?):14324. doi:
10.1038/ncomms14324. [PMID: 28134257] - Takashi Kasukabe, Yoshio Honma, Junko Okabe-Kado, Yusuke Higuchi, Nobuo Kato, Shunichi Kumakura. Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells.
Oncology reports.
2016 Aug; 36(2):968-76. doi:
10.3892/or.2016.4867. [PMID: 27375275] - Mercè Garcia-Belinchón, María Sánchez-Osuna, Laura Martínez-Escardó, Carla Granados-Colomina, Sònia Pascual-Guiral, Victoria Iglesias-Guimarais, Elisenda Casanelles, Judit Ribas, Victor J Yuste. An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death.
The Journal of biological chemistry.
2015 Aug; 290(34):20841-20855. doi:
10.1074/jbc.m115.644179. [PMID: 26124276] - Tuba Ozgocer, Sedat Yildiz, Hulya Elbe, Nigar Vardi. Endotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonates.
Canadian journal of physiology and pharmacology.
2015 Aug; 93(8):603-14. doi:
10.1139/cjpp-2014-0559. [PMID: 26061900] - Grzegorz Raszewski, Marta Kinga Lemieszek, Krzysztof Łukawski, Małgorzata Juszczak, Wojciech Rzeski. Chlorpyrifos and cypermethrin induce apoptosis in human neuroblastoma cell line SH-SY5Y.
Basic & clinical pharmacology & toxicology.
2015 Feb; 116(2):158-67. doi:
10.1111/bcpt.12285. [PMID: 24975276] - Dong Won Lee, Sarah Faubel, Charles L Edelstein. A pan caspase inhibitor decreases caspase-1, IL-1α and IL-1β, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules.
Renal failure.
2015 Feb; 37(1):144-50. doi:
10.3109/0886022x.2014.970194. [PMID: 25310769] - Marta Massanella, Marta Curriu, Jorge Carrillo, Elisabet Gómez, Jordi Puig, Jordi Navarro, Judith Dalmau, Javier Martínez-Picado, Manel Crespo, Cecilia Cabrera, Eugènia Negredo, Bonaventura Clotet, Julià Blanco. Assessing main death pathways in T lymphocytes from HIV infected individuals.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2013 Jul; 83(7):648-58. doi:
10.1002/cyto.a.22299. [PMID: 23650261] - Xiangwen Chen-Deutsch, George P Studzinski. Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance.
Cell cycle (Georgetown, Tex.).
2012 Apr; 11(7):1364-73. doi:
10.4161/cc.19765. [PMID: 22421156] - Marlyn P Langford, David J McGee, Kathy H Ta, Thomas B Redens, Donald E Texada. Multiple caspases mediate acute renal cell apoptosis induced by bacterial cell wall components.
Renal failure.
2011; 33(2):192-206. doi:
10.3109/0886022x.2011.553304. [PMID: 21332342] - Yonnie Wu, David C Henry, Kyle Heim, Jeffrey P Tomkins, Cheng-Yi Kuan. Straw blood cell count, growth, inhibition and comparison to apoptotic bodies.
BMC cell biology.
2008 May; 9(?):26. doi:
10.1186/1471-2121-9-26. [PMID: 18492269] - C Zhu, X Wang, Z Huang, L Qiu, F Xu, N Vahsen, M Nilsson, P S Eriksson, H Hagberg, C Culmsee, N Plesnila, G Kroemer, K Blomgren. Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.
Cell death and differentiation.
2007 Apr; 14(4):775-84. doi:
10.1038/sj.cdd.4402053. [PMID: 17039248] - Vyacheslav Y Melnikov, Sarah Faubel, Britta Siegmund, M Scott Lucia, Danica Ljubanovic, Charles L Edelstein. Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice.
The Journal of clinical investigation.
2002 Oct; 110(8):1083-91. doi:
10.1172/jci15623. [PMID: 12393844]