Pyrazofurin (BioDeep_00000182736)

   

human metabolite blood metabolite natural product


代谢物信息卡片


3-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-5-carboxamide

化学式: C9H13N3O6 (259.08043180000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
InChI: InChI=1S/C9H13N3O6/c10-9(17)4-6(15)3(11-12-4)8-7(16)5(14)2(1-13)18-8/h2,5,7-8,13-16H,1H2,(H2,10,17)(H,11,12)

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors

同义名列表

4 个代谢物同义名

3-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-5-carboxamide; 3(5)-Ribofuranosyl- 4-hydroxypyrazol-5(3)-carboxamide; Pyrazofurin; Pyrazomycin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J Cinatl, B Morgenstern, G Bauer, P Chandra, H Rabenau, H W Doerr. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet (London, England). 2003 Jun; 361(9374):2045-6. doi: 10.1016/s0140-6736(03)13615-x. [PMID: 12814717]
  • W Watanabe, K Sudo, S Asawa, K Konno, T Yokota, S Shigeta. Use of lactate dehydrogenase to evaluate the anti-viral activity against influenza A virus. Journal of virological methods. 1995 Feb; 51(2-3):185-91. doi: 10.1016/0166-0934(94)00103-n. [PMID: 7738138]
  • K Ishii. Isolation of thymidine-requiring variants from rat nerve-like cells. Cell structure and function. 1990 Apr; 15(2):93-7. doi: 10.1247/csf.15.93. [PMID: 2162741]
  • T J McMillan, T Kalebic, G R Stark, I R Hart. High frequency of double drug resistance in the B16 melanoma cell line. European journal of cancer (Oxford, England : 1990). 1990; 26(5):565-7. doi: 10.1016/0277-5379(90)90077-7. [PMID: 2144741]
  • B Lerch. On the inhibition of plant virus multiplication by ribavirin. Antiviral research. 1987 Jun; 7(5):257-70. doi: 10.1016/0166-3542(87)90010-6. [PMID: 2821895]
  • E Giulotto, C Knights, G R Stark. Hamster cells with increased rates of DNA amplification, a new phenotype. Cell. 1987 Mar; 48(5):837-45. doi: 10.1016/0092-8674(87)90080-8. [PMID: 3815526]
  • K Bhalla, S Grant. Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis. Cancer chemotherapy and pharmacology. 1987; 19(3):226-32. doi: 10.1007/bf00252977. [PMID: 3581416]
  • J M Karle, K H Cowan, C A Chisena, R L Cysyk. Uracil nucleotide synthesis in a human breast cancer cell line (MCF-7) and in two drug-resistant sublines that contain increased levels of enzymes of the de novo pyrimidine pathway. Molecular pharmacology. 1986 Aug; 30(2):136-41. doi: NULL. [PMID: 2874477]
  • J M Karle, L W Anderson, D D Dietrick, R L Cysyk. Effect of inhibitors of the de novo pyrimidine biosynthetic pathway on serum uridine levels in mice. Cancer research. 1981 Dec; 41(12 Pt 1):4952-5. doi: NULL. [PMID: 6171344]
  • J D Moyer, J T Oliver, R E Handschumacher. Salvage of circulating pyrimidine nucleosides in the rat. Cancer research. 1981 Aug; 41(8):3010-7. doi: NULL. [PMID: 7248957]
  • J F Worzalla, M J Sweeney. Pyrazofurin inhibition of purine biosynthesis via 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate formyltransferase. Cancer research. 1980 May; 40(5):1482-5. doi: NULL. [PMID: 7370986]
  • D P Suttle, G R Stark. Coordinate overproduction of orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in hamster cells resistant to pyrazofurin and 6-azauridine. The Journal of biological chemistry. 1979 Jun; 254(11):4602-7. doi: . [PMID: 220255]
  • T Ohnuma, J Roboz, M L Shapiro, J F Holland. Pharmacological and biochemical effects of pyrazofurin in humans. Cancer research. 1977 Jul; 37(7 Pt 1):2043-9. doi: NULL. [PMID: 861933]