Proxyphylline (BioDeep_00000182686)

 

Secondary id: BioDeep_00000858526

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


7-(2-hydroxypropyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C10H14N4O3 (238.1065854)
中文名称: 7-(2-羟丙基)茶碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.63%

分子结构信息

SMILES: CC(CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O
InChI: InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator[1].
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator[1].

同义名列表

7 个代谢物同义名

7-(2-hydroxypropyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 7-(2-Hydroxypropyl)theophylline; Proxyphylline; Proxiphylline; Purophyllin; Spasmolysin; Monophyllin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • T Hasegawa, M Nadai, R Apichartpichean, I Muraoka, T Nabeshima, K Takagi. Pharmacokinetic characteristics of N7-substituted theophylline derivatives and their interaction with quinolone in rats. Journal of pharmaceutical sciences. 1991 Oct; 80(10):962-5. doi: 10.1002/jps.2600801012. [PMID: 1664467]
  • M Ruud-Christensen, A J Aasen, K E Rasmussen, B Salvesen. High-performance liquid chromatographic determination of (R)-and (S)-proxyphylline in human plasma. Journal of chromatography. 1989 Jul; 491(2):355-66. doi: 10.1016/s0378-4347(00)82853-4. [PMID: 2808621]
  • H Magnussen, R Jörres, V Hartmann. Bronchodilator effect of theophylline preparations and aerosol fenoterol in stable asthma. Chest. 1986 Nov; 90(5):722-5. doi: 10.1378/chest.90.5.722. [PMID: 3533455]
  • H Magnussen, M Litt, G Reuss, P Stutz, R Jörres. [Comparison of the bronchodilator and protective effect of methylxanthines]. Deutsche medizinische Wochenschrift (1946). 1986 Jan; 111(1):15-9. doi: 10.1055/s-2008-1068392. [PMID: 3940830]
  • M Kalla, O Richter, D Reinhardt. [Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde. 1985 Aug; 133(8):520-6. doi: NULL. [PMID: 4047067]
  • F V Rasmussen, S Waldorff, L Madsen. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. European journal of respiratory diseases. 1984 Jan; 65(1):20-7. doi: NULL. [PMID: 6705854]
  • M Wenk, B Eggs, F Follath. Simultaneous determination of diprophylline, proxyphylline and theophylline in serum by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1983 Sep; 276(2):341-8. doi: 10.1016/s0378-4347(00)85100-2. [PMID: 6630383]
  • K Selvig. Metabolism of proxyphylline in man: urinary excretion of proxyphylline and its metabolites. Drug metabolism and disposition: the biological fate of chemicals. 1982 May; 10(3):291-2. doi: NULL. [PMID: 6125369]
  • P Bracher, O Brändli. [Pharmacokinetic and clinical effectiveness of rectally administered theophylline]. Respiration; international review of thoracic diseases. 1982; 43(6):458-66. doi: 10.1159/000194518. [PMID: 7178675]
  • J G Ufkes, R S Leeuwin, M Ottenhof, A Zeegers, J Zuidema. Efficacy of theophylline and its N-7-substituted derivatives in experimentally induced bronchial asthma in the guinea-pig. Archives internationales de pharmacodynamie et de therapie. 1981 Oct; 253(2):301-14. doi: . [PMID: 7325766]
  • J Kanto, H Allonen, T Kulmala, R Mäntylä, E Tala. Interaction between proxyphylline and salbutamol. International journal of clinical pharmacology, therapy, and toxicology. 1981 Aug; 19(8):346-9. doi: NULL. [PMID: 7030976]
  • E Tarrus, I Garcia, J Segura. Human metabolism of 7-substituted theophyllines: N3-demethylation and lack of oxidation of proxyphylline. Journal of pharmaceutical sciences. 1981 May; 70(5):542-5. doi: 10.1002/jps.2600700520. [PMID: 6894619]
  • K Selvig. Pharmacokinetics of proxyphylline in adults after intravenous and oral administration. European journal of clinical pharmacology. 1981 Jan; 19(2):149-55. doi: 10.1007/bf00568402. [PMID: 7202475]
  • K Selvig, K S Bjerve. Metabolism of proxyphylline in man. Isolation and identification of metabolites in urine. Drug metabolism and disposition: the biological fate of chemicals. 1980 Nov; 8(6):456-62. doi: NULL. [PMID: 6109616]
  • L S Geisler, H Thiel, O B Förster, H G Rohner. [Effectiveness of proxyphylline in chronic obstructive pulmonary disease (author's transl)]. Deutsche medizinische Wochenschrift (1946). 1980 Jun; 105(25):894-7. doi: 10.1055/s-2008-1070777. [PMID: 7408664]
  • K Katevuo, J Kanto, T Kleimola. The effect of intravenously administered proxyphylline and Baralgin on the contraction of the human gallbladder. International journal of clinical pharmacology and biopharmacy. 1978 Dec; 16(12):585-8. doi: NULL. [PMID: 730425]
  • K Sakai, H Mizusawa, M Sakanashi, K Sakamoto, S Takeo, F Takenaka. [Effects of Theo-Esberiven on the coronary circulation and myocardial metabolisms in dogs (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1978 Jan; 74(1):37-47. doi: 10.1254/fpj.74.37. [PMID: 640535]
  • K Takeda, Y Katano, Y Nakagawa, T Tsukada, M Nakazawa. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture (theoesberiven) on the heart and the coronary circulation. Japanese journal of pharmacology. 1977 Oct; 27(5):709-20. doi: 10.1254/jjp.27.709. [PMID: 592559]