Protoapigenone (BioDeep_00000182681)

   

human metabolite blood metabolite natural product


代谢物信息卡片


5,7-dihydroxy-2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-4H-chromen-4-one

化学式: C15H10O6 (286.047736)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(C=CC1=O)(C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-1-3-15(20,4-2-8)13-7-11(19)14-10(18)5-9(17)6-12(14)21-13/h1-7,17-18,20H

描述信息

同义名列表

4 个代谢物同义名

5,7-dihydroxy-2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-4H-chromen-4-one; 5,7-dihydroxy-2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)chromen-4-one; Protoapigenone; WYC02



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anhua Wei, Daonian Zhou, Guanghua Wu. Determination of protoapigenone in rat plasma by high-performance liquid chromatography with UV detection and its application in pharmacokinetic studies. Biomedical chromatography : BMC. 2013 Nov; 27(11):1452-6. doi: 10.1002/bmc.2942. [PMID: 23813346]
  • Miklós Poór, Yin Li, Sándor Kunsági-Máté, Zsófia Varga, Attila Hunyadi, Balázs Dankó, Fang-Rong Chang, Yang-Chang Wu, Tamás Kőszegi. Protoapigenone derivatives: albumin binding properties and effects on HepG2 cells. Journal of photochemistry and photobiology. B, Biology. 2013 Jul; 124(?):20-6. doi: 10.1016/j.jphotobiol.2013.04.002. [PMID: 23648796]
  • Yun-Ju Chen, Hsin-Pao Chen, Yu-Jen Cheng, Yu-Heng Lin, Kuang-Wen Liu, Yun-Ju Chen, Ming-Feng Hou, Yang-Chang Wu, Yi-Chen Lee, Shyng-Shiou Yuan. The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway. Life sciences. 2013 Jun; 92(22):1081-92. doi: 10.1016/j.lfs.2013.04.007. [PMID: 23624232]
  • Chao-Ping Tung, Fang-Rong Chang, Yang-Chang Wu, Da-Wei Chuang, Attila Hunyadi, Shih-Tung Liu. Inhibition of the Epstein-Barr virus lytic cycle by protoapigenone. The Journal of general virology. 2011 Aug; 92(Pt 8):1760-1768. doi: 10.1099/vir.0.031609-0. [PMID: 21490247]
  • Isabelle Pouny, Chantal Etiévant, Laurence Marcourt, Isabelle Huc-Dumas, Muriel Batut, Frédéric Girard, Michel Wright, Georges Massiot. Protoflavonoids from ferns impair centrosomal integrity of tumor cells. Planta medica. 2011 Mar; 77(5):461-6. doi: 10.1055/s-0030-1250407. [PMID: 20945277]
  • X H Huang, P C Xiong, C M Xiong, Y L Cai, A H Wei, J P Wang, X F Liang, J L Ruan. In vitro and in vivo antitumor activity of Macrothelypteris torresiana and its acute/subacute oral toxicity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Oct; 17(12):930-4. doi: 10.1016/j.phymed.2010.03.006. [PMID: 20381325]
  • Chien-Chih Chiu, Hsueh-Wei Chang, Da-Wei Chuang, Fang-Rong Chang, Yu-Ching Chang, Yu-Shan Cheng, Ming-Tz Tsai, Wan-Yu Chen, Su-Shuo Lee, Chih-Kuang Wang, Jeff Yi-Fu Chen, Hui-Min Wang, Chao-Chieh Chen, Yin-Chang Liu, Yang-Chang Wu. Fern plant-derived protoapigenone leads to DNA damage, apoptosis, and G(2)/m arrest in lung cancer cell line H1299. DNA and cell biology. 2009 Oct; 28(10):501-6. doi: 10.1089/dna.2009.0852. [PMID: 19630532]
  • Hsueh-Ling Chang, Jinu-Huang Su, Yao-Tsung Yeh, Yi-Chen Lee, Huey-May Chen, Yang-Chang Wu, Shyng-Shiou F Yuan. Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo. Cancer letters. 2008 Aug; 267(1):85-95. doi: 10.1016/j.canlet.2008.03.007. [PMID: 18430509]
  • Fang-Rong Chang, Ken-ichiro Hayashi, Nam-Hai Chua, Shuichi Kamio, Zih-You Huang, Hiroshi Nozaki, Yang-Chang Wu. The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists. Journal of natural products. 2005 Jul; 68(7):971-3. doi: 10.1021/np050121i. [PMID: 16038533]