Protionamide (BioDeep_00000182679)
human metabolite blood metabolite
代谢物信息卡片
2-propylpyridine-4-carboimidothioic acid
化学式: C9H12N2S (180.07211519999998)
中文名称: 丙硫异烟胺
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: CCCC1=NC=CC(=C1)C(=S)N
InChI: InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
描述信息
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AD - Thiocarbamide derivatives
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:32066
- PubChem: 666418
- HMDB: HMDB0256869
- DrugBank: DB12667
- ChEMBL: CHEMBL1378024
- Wikipedia: Prothionamide
- MeSH: Prothionamide
- chemspider: 579891
- CAS: 14222-60-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xubin Zheng, Erwin M Jongedijk, Yi Hu, Johanna Kuhlin, Rongrong Zheng, Katarina Niward, Jakob Paues, Biao Xu, Lina Davies Forsman, Thomas Schön, Judith Bruchfeld, Jan-Willem C Alffenaar. Development and validation of a simple LC-MS/MS method for simultaneous determination of moxifloxacin, levofloxacin, prothionamide, pyrazinamide and ethambutol in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Nov; 1158(?):122397. doi:
10.1016/j.jchromb.2020.122397. [PMID: 33091676] - Shengyuan Wu, Liai Lan, Jingjing Jiang, Xianting Ding, Chih-Ming Ho, Yuefen Lou, Guorong Fan. Simultaneous determination of the potent anti-tuberculosis regimen-Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC-MS/MS method coupled with 96-well format plate.
Journal of pharmaceutical and biomedical analysis.
2019 May; 168(?):44-54. doi:
10.1016/j.jpba.2019.02.006. [PMID: 30784889] - S Thee, A J Garcia-Prats, P R Donald, A C Hesseling, H S Schaaf. A review of the use of ethionamide and prothionamide in childhood tuberculosis.
Tuberculosis (Edinburgh, Scotland).
2016 Mar; 97(?):126-36. doi:
10.1016/j.tube.2015.09.007. [PMID: 26586647] - Sang-In Park, Jaeseong Oh, Kyungho Jang, Jangsoo Yoon, Seol Ju Moon, Jong Sun Park, Jae Ho Lee, Junghan Song, In-Jin Jang, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4429-35. doi:
10.1128/aac.00354-15. [PMID: 25987620] - Seung Heon Lee, Kyung-Ah Seo, Young Min Lee, Hyun-Kyung Lee, Je Hyeong Kim, Chol Shin, Jong-Ryul Ghim, Jae-Gook Shin, Dong Hyun Kim. Low Serum Concentrations of Moxifloxacin, Prothionamide, and Cycloserine on Sputum Conversion in Multi-Drug Resistant TB.
Yonsei medical journal.
2015 Jul; 56(4):961-7. doi:
10.3349/ymj.2015.56.4.961. [PMID: 26069117] - Weijie Zhao, Zhenyong Guo, Meiqin Zheng, Jinfu Zhang, Bin Wang, Peng Li, Lei Fu, Shuo Liu. Activity of linezolid-containing regimens against multidrug-resistant tuberculosis in mice.
International journal of antimicrobial agents.
2014 Feb; 43(2):148-53. doi:
10.1016/j.ijantimicag.2013.10.010. [PMID: 24290060] - Vikas Trivedi, Vivek Upadhyay, Gaurang Shah, Manish Yadav, Pranav S Shrivastav, Mallika Sanyal. Ex vivo conversion of prodrug prothionamide to its metabolite prothionamide sulfoxide with different extraction techniques and their estimation in human plasma by LC-MS/MS.
Bioanalysis.
2013 Jan; 5(2):185-200. doi:
10.4155/bio.12.301. [PMID: 23330561] - H W Lee, D W Kim, J H Park, S-D Kim, M-S Lim, P B Phapale, E-H Kim, S K Park, Y-R Yoon. Pharmacokinetics of prothionamide in patients with multidrug-resistant tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2009 Sep; 13(9):1161-6. doi:
NULL. [PMID: 19723408] - H Bartels, R Bartels. Simple, rapid and sensitive determination of protionamide in human serum by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Apr; 707(1-2):338-41. doi:
10.1016/s0378-4347(97)00584-7. [PMID: 9613970] - A Drowart, S Chanteau, K Huygen, M De Cock, J L Cartel, J De Bruyn, P Launois, J C Yernault, J P Van Vooren. Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1993 Mar; 61(1):29-34. doi:
. [PMID: 8326178] - C Hoose, K Eberhardt, W Hartmann, W Wosniok. [Short- and long-term results of tuberculosis therapy with a fixed combination of isoniazide, prothionamide and diaminodiphenylsulfone combined with rifampicin].
Pneumologie (Stuttgart, Germany).
1990 Feb; 44 Suppl 1(?):458-9. doi:
NULL. [PMID: 2114630] - G A Ellard, K U Kiran, J N Stanley. Long-term prothionamide compliance: a study carried out in India using a combined formulation containing prothionamide, dapsone and isoniazid.
Leprosy review.
1988 Jun; 59(2):163-75. doi:
10.5935/0305-7518.19880021. [PMID: 3246926] - P J Jenner, S E Smith. Plasma levels of ethionamide and prothionamide in a volunteer following intravenous and oral dosages.
Leprosy review.
1987 Mar; 58(1):31-7. doi:
10.5935/0305-7518.19870004. [PMID: 3600145] - J N Stanley, J M Pearson, G A Ellard. Ethionamide, prothionamide and thiacetazone self-administration. Studies of patient compliance using isoniazid-marked formulations.
Leprosy review.
1986 Mar; 57(1):9-18. doi:
10.5935/0305-7518.19860003. [PMID: 2422517] - P J Jenner, G A Ellard, P J Gruer, V R Aber. A comparison of the blood levels and urinary excretion of ethionamide and prothionamide in man.
The Journal of antimicrobial chemotherapy.
1984 Mar; 13(3):267-77. doi:
10.1093/jac/13.3.267. [PMID: 6725176] - T A Iakovleva, V T Dolgikh, L V Poluéktov. [Use of the antioxidant ionol to prevent damage to the heart from prolonged administration of antitubercular preparations].
Biulleten' eksperimental'noi biologii i meditsiny.
1983 Oct; 96(10):59-62. doi:
. [PMID: 6626733] - J H Peters, G R Gordon, J F Murray. Disposition of prothionamide in rats and armadillos.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1983 Mar; 51(1):54-63. doi:
NULL. [PMID: 6602784] - J H Peters, G R Gordon, J F Murray, V F Simmon. Mutagenic activity of antileprosy drugs and their derivatives.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1983 Mar; 51(1):45-53. doi:
NULL. [PMID: 6683259] - P J Jenner, G A Ellard. High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids.
Journal of chromatography.
1981 Sep; 225(1):245-51. doi:
10.1016/s0378-4347(00)80269-8. [PMID: 7298753] - G Opl. [Epidemiology, diagnosis, and treatment of renal tuberculosis. A report of 213 cases].
Wiener medizinische Wochenschrift (1946).
1980 Jun; 130(12):417-20. doi:
NULL. [PMID: 7424028] - N V Tatarinova, V I Chikanov. [Blood serum ethambutol concentration in tuberculosis under different regimens of treatment].
Problemy tuberkuleza.
1978 Dec; ?(12):62-5. doi:
NULL. [PMID: 740642] - J Heising, J Seiferth. [Therapy of urogenital tuberculosis].
Deutsche medizinische Wochenschrift (1946).
1978 May; 103(18):767-8. doi:
10.1055/s-0028-1104507. [PMID: 648344] - E Freerksen. [Research in the campaign against leprosy (author's transl)].
MMW, Munchener medizinische Wochenschrift.
1977 Sep; 119(35):1115-8. doi:
NULL. [PMID: 408667] - M Rossi, K Rübamen. Determination of prothionamide and its sulphoxide metabolite in physiological fluids by quantitative thin-layer chromatography.
Journal of chromatography.
1977 Feb; 132(3):562-5. doi:
10.1016/s0021-9673(00)82924-6. [PMID: 885951]