Propargylamine (BioDeep_00000182643)
human metabolite blood metabolite
代谢物信息卡片
Propargylamine monohydrochloride
化学式: C3H5N (55.042197)
中文名称: 炔丙胺, 丙炔胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CCN
InChI: InChI=1S/C3H5N/c1-2-3-4/h1H,3-4H2
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianan Guo, Yujia Zhang, Changjun Zhang, Chuansheng Yao, Jingqi Zhang, Xiaoying Jiang, Zhichao Zhong, Jiamin Ge, Tao Zhou, Renren Bai, Yuanyuan Xie. N-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer's disease.
Bioorganic chemistry.
2021 08; 113(?):105013. doi:
10.1016/j.bioorg.2021.105013. [PMID: 34062405] - Dongyang Ma, Tong Han, Mohammad Karimian, Naser Abbasi, Hori Ghaneialvar, Akram Zangeneh. Immobilized Ag NPs on chitosan-biguanidine coated magnetic nanoparticles for synthesis of propargylamines and treatment of human lung cancer.
International journal of biological macromolecules.
2020 Dec; 165(Pt A):767-775. doi:
10.1016/j.ijbiomac.2020.09.193. [PMID: 32991899] - Silvio Aprile, Rossana Canavesi, Rosanna Matucci, Cristina Bellucci, Erika Del Grosso, Giorgio Grosa. New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 May; 48(5):478-487. doi:
10.1080/00498254.2017.1342288. [PMID: 28608746] - Beatriz Vega, Holger Wondraczek, Leonore Bretschneider, Tuomas Näreoja, Pedro Fardim, Thomas Heinze. Preparation of reactive fibre interfaces using multifunctional cellulose derivatives.
Carbohydrate polymers.
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Organic & biomolecular chemistry.
2015 Feb; 13(6):1778-91. doi:
10.1039/c4ob02094d. [PMID: 25502141] - H M-F Viart, T S Larsen, C Tassone, T L Andresen, M H Clausen. Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.
Chemical communications (Cambridge, England).
2014 Jul; 50(58):7800-2. doi:
10.1039/c4cc00863d. [PMID: 24903342] - Zhongyue Sun, Cuiping Han, Miaomiao Song, Long Wen, Demei Tian, Haibing Li, Lei Jiang. Fabrication of cysteine-responsive biomimetic single nanochannels by a thiol-yne reaction strategy and their application for sensing in urine samples.
Advanced materials (Deerfield Beach, Fla.).
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Bioorganic & medicinal chemistry.
2013 Jan; 21(1):186-95. doi:
10.1016/j.bmc.2012.10.050. [PMID: 23211968] - Suyan Qiu, Sen Gao, Qida Liu, Zhenyu Lin, Bin Qiu, Guonan Chen. Electrochemical impedance spectroscopy sensor for ascorbic acid based on copper(I) catalyzed click chemistry.
Biosensors & bioelectronics.
2011 Jul; 26(11):4326-30. doi:
10.1016/j.bios.2011.04.029. [PMID: 21596552] - Yana Kleiner, Orit Bar-Am, Tamar Amit, Alexandra Berdichevski, Esti Liani, Gila Maor, Irina Reiter, Moussa B H Youdim, Ofer Binah. TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity.
Journal of cardiovascular pharmacology.
2008 Sep; 52(3):268-77. doi:
10.1097/fjc.0b013e3181862441. [PMID: 18806608] - Ernest Adeghate, Péter Sótonyi, Huba Kalász. Chronic experimental diabetes accelerates urinary elimination of deprenyl and its metabolites.
The open medicinal chemistry journal.
2008 Jan; 2(?):1-5. doi:
10.2174/1874104500802010001. [PMID: 19662137] - Orit Bar-Am, Orly Weinreb, Tamar Amit, Moussa B H Youdim. Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2005 Nov; 19(13):1899-901. doi:
10.1096/fj.05-3794fje. [PMID: 16148027] - Orly Weinreb, Tamar Amit, Orit Bar-Am, Orly Chillag-Talmor, Moussa B H Youdim. Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.
Annals of the New York Academy of Sciences.
2005 Aug; 1053(?):348-55. doi:
10.1196/annals.1344.030. [PMID: 16179541] - Moussa B H Youdim, Mati Fridkin, Hailin Zheng. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.
Mechanisms of ageing and development.
2005 Feb; 126(2):317-26. doi:
10.1016/j.mad.2004.08.023. [PMID: 15621213] - Orly Weinreb, Orit Bar-Am, Tamar Amit, Orly Chillag-Talmor, Moussa B H Youdim. Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 Sep; 18(12):1471-3. doi:
10.1096/fj.04-1916fje. [PMID: 15247150] - Kimberly M O'Connell, David B Langley, Eric M Shepard, Anthony P Duff, Heung-Bae Jeon, Gang Sun, Hans C Freeman, J Mitchell Guss, Lawrence M Sayre, David M Dooley. Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.
Biochemistry.
2004 Aug; 43(34):10965-78. doi:
10.1021/bi0492004. [PMID: 15323556] - Chunhua Qiao, Heung-Bae Jeon, Lawrence M Sayre. Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif.
Journal of the American Chemical Society.
2004 Jun; 126(25):8038-45. doi:
10.1021/ja049568o. [PMID: 15212554] - Hisanori Hara, Takashi Uchimura, Naotsugu Akashi, Tomoyoshi Naganuma, Tetsushi Aizawa, Yusuke Nagae, Naoki Masuda. Simultaneous analytical method for the determination of TCH346 and its four metabolites in human plasma by liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2004; 18(4):377-84. doi:
10.1002/rcm.1349. [PMID: 14966843] - Heung-Bae Jeon, Younghee Lee, Chunhua Qiao, He Huang, Lawrence M Sayre. Inhibition of bovine plasma amine oxidase by 1,4-diamino-2-butenes and -2-butynes.
Bioorganic & medicinal chemistry.
2003 Oct; 11(21):4631-41. doi:
10.1016/s0968-0896(03)00521-2. [PMID: 14527560] - Heung-Bae Jeon, Lawrence M Sayre. Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase.
Biochemical and biophysical research communications.
2003 May; 304(4):788-94. doi:
10.1016/s0006-291x(03)00681-8. [PMID: 12727226] - Songbai Zhang, Akihiro Mizutani, Chihiro Hisatsune, Takayasu Higo, Hiroko Bannai, Tomohiro Nakayama, Mitsuharu Hattori, Katsuhiko Mikoshiba. Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.
The Journal of biological chemistry.
2003 Feb; 278(6):4048-56. doi:
10.1074/jbc.m209960200. [PMID: 12444087] - W G Tatton, R M E Chalmers-Redman, W J H Ju, M Mammen, G W Carlile, A W Pong, N A Tatton. Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells.
The Journal of pharmacology and experimental therapeutics.
2002 May; 301(2):753-64. doi:
10.1124/jpet.301.2.753. [PMID: 11961082] - Kenichi Kitani, Chiyoko Minami, Takako Yamamoto, Setsuko Kanai, Gwen O Ivy, Maria-Cristina Carrillo. Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
Annals of the New York Academy of Sciences.
2002 Apr; 959(?):295-307. doi:
10.1111/j.1749-6632.2002.tb02101.x. [PMID: 11976204] - K Kitani, C Minami, T Yamamoto, W Maruyama, S Kanai, G O Ivy, M C Carrillo. Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy.
Annals of the New York Academy of Sciences.
2001 Apr; 928(?):248-60. doi:
10.1111/j.1749-6632.2001.tb05654.x. [PMID: 11795516] - R Pino, G A Lyles. [Effect of activity of semicarbazide-sensitive aminooxidases and cellular glutathione on the cytotoxic effect of allylamine, acrolein, and formaldehyde in human cultured endothelial cells].
Voprosy meditsinskoi khimii.
1997 Nov; 43(6):537-47. doi:
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Biochimica et biophysica acta.
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