Pridopidine (BioDeep_00000182607)
human metabolite blood metabolite
代谢物信息卡片
化学式: C15H23NO2S (281.1449418)
中文名称: 4-[3-(甲磺酰基)苯基]-1-丙基哌啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1CCC(CC1)C1=CC=CC(=C1)S(C)(=O)=O
InChI: InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3
描述信息
C78272 - Agent Affecting Nervous System
Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 9795739
- HMDB: HMDB0256771
- DrugBank: DB11947
- ChEMBL: CHEMBL596802
- Wikipedia: Pridopidine
- chemspider: 7971505
- CAS: 346688-38-8
- medchemexpress: HY-10684
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tangui Maurice. Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders.
Expert opinion on drug discovery.
2021 04; 16(4):373-389. doi:
10.1080/17460441.2021.1838483. [PMID: 33070647] - Igor D Grachev, Philipp M Meyer, Georg A Becker, Marcus Bronzel, Doug Marsteller, Gina Pastino, Ole Voges, Laura Rabinovich, Helena Knebel, Franziska Zientek, Michael Rullmann, Bernhard Sattler, Marianne Patt, Thilo Gerhards, Maria Strauss, Andreas Kluge, Peter Brust, Juha-Matti Savola, Mark F Gordon, Michal Geva, Swen Hesse, Henryk Barthel, Michael R Hayden, Osama Sabri. Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study.
European journal of nuclear medicine and molecular imaging.
2021 04; 48(4):1103-1115. doi:
10.1007/s00259-020-05030-3. [PMID: 32995944] - Tom H Johnston, Michal Geva, Lilach Steiner, Aric Orbach, Spyros Papapetropoulos, Juha-Matti Savola, Ian J Reynolds, Paula Ravenscroft, Michael Hill, Susan H Fox, Jonathan M Brotchie, Ralph Laufer, Michael R Hayden. Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.
Movement disorders : official journal of the Movement Disorder Society.
2019 05; 34(5):708-716. doi:
10.1002/mds.27565. [PMID: 30575996] - Laura Rabinovich-Guilatt, Lilach Steiner, Hussein Hallak, Gina Pastino, Pierandrea Muglia, Ofer Spiegelstein. Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease.
British journal of clinical pharmacology.
2017 Oct; 83(10):2214-2224. doi:
10.1111/bcp.13317. [PMID: 28449367] - L Rabinovich-Guilatt, K E Siegler, A Schultz, A Halabi, A Rembratt, O Spiegelstein. The effect of mild and moderate renal impairment on the pharmacokinetics of pridopidine, a new drug for Huntington's disease.
British journal of clinical pharmacology.
2016 Feb; 81(2):246-55. doi:
10.1111/bcp.12792. [PMID: 26407011] - Kristoffer Sahlholm, Jurgen W A Sijbesma, Bram Maas, Chantal Kwizera, Daniel Marcellino, Nisha K Ramakrishnan, Rudi A J O Dierckx, Philip H Elsinga, Aren van Waarde. Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses.
Psychopharmacology.
2015 Sep; 232(18):3443-53. doi:
10.1007/s00213-015-3997-8. [PMID: 26159455] - P Lindskov Krog, O Osterberg, P Gundorf Drewes, Å Rembratt, A Schultz, W Timmer. Pharmacokinetic and tolerability profile of pridopidine in healthy-volunteer poor and extensive CYP2D6 metabolizers, following single and multiple dosing.
European journal of drug metabolism and pharmacokinetics.
2013 Mar; 38(1):43-51. doi:
10.1007/s13318-012-0100-2. [PMID: 22948856] - A Helldén, G Panagiotidis, P Johansson, N Waters, S Waters, J Tedroff, L Bertilsson. The dopaminergic stabilizer pridopidine is to a major extent N-depropylated by CYP2D6 in humans.
European journal of clinical pharmacology.
2012 Sep; 68(9):1281-6. doi:
10.1007/s00228-012-1248-z. [PMID: 22399238]