Methocarbamol (BioDeep_00000018256)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-Hydroxy-3-(2-methoxyphenoxy)propyl carbamic acid

化学式: C11H15NO5 (241.09501799999998)
中文名称: 美索巴莫
谱图信息: 最多检出来源 Homo sapiens(blood) 6.45%

分子结构信息

SMILES: COC1=CC=CC=C1OCC(COC(=O)N)O
InChI: InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)

描述信息

Methocarbamol is only found in individuals that have used or taken this drug. It is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)The mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents > M03BA - Carbamic acid esters
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
D002491 - Central Nervous System Agents

同义名列表

18 个代谢物同义名

2-Hydroxy-3-(2-methoxyphenoxy)propyl carbamic acid; 2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate; Whitehall-robins brand OF methocarbamol; Whitehall robins brand OF methocarbamol; Alpharma brand OF methocarbamol; Bastian brand OF methocarbamol; Schwarz brand OF methocarbamol; Parmed brand OF methocarbamol; Ipsen brand OF methocarbamol; Shire brand OF methocarbamol; Carbamate, guaiphenesin; Guaiphenesin carbamate; methocarbamol; Parabaxin; Lumirelax; Delaxin; Robaxin; Ortoton



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pamela Waller, Izabela Lomnicka, Cam Lucas, Sara Johnson, Levent Dirikolu. The medication violations in racehorses at Louisiana racetracks from 2016 to 2020. Veterinary medicine and science. 2022 03; 8(2):553-560. doi: 10.1002/vms3.724. [PMID: 34989156]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Marissa P Caan, Christopher T Lim, Mark Howard. A Case of Catatonia in a Man With COVID-19. Psychosomatics. 2020 Sep; 61(5):556-560. doi: 10.1016/j.psym.2020.05.021. [PMID: 32605766]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Anderson Martin Santos, Ademar Wong, Fernando Campanhã Vicentini, Orlando Fatibello-Filho. Simultaneous voltammetric sensing of levodopa, piroxicam, ofloxacin and methocarbamol using a carbon paste electrode modified with graphite oxide and β-cyclodextrin. Mikrochimica acta. 2019 02; 186(3):174. doi: 10.1007/s00604-019-3296-x. [PMID: 30771008]
  • Megan Kees, Nicole Beckel, Claire Sharp. Successful treatment of Solanum dulcamara intoxication in a Labrador retriever puppy. The Canadian veterinary journal = La revue veterinaire canadienne. 2015 Dec; 56(12):1283-6. doi: ". [PMID: 26663926]
  • Mohammad Saraji, Taghi Khayamian, Zahra Hashemian. Extraction of methocarbamol from human plasma with a polypyrrole/multiwalled carbon nanotubes composite decorated with magnetic nanoparticles as an adsorbent followed by electrospray ionization ion mobility spectrometry detection. Journal of separation science. 2014 Dec; 37(23):3518-25. doi: 10.1002/jssc.201400614. [PMID: 25243817]
  • S A Helmy, H M El-Bedaiwy. Simultaneous determination of paracetamol and methocarbamol in human plasma By HPLC using UV detection with time programming: application to pharmacokinetic study. Drug research. 2014 Jul; 64(7):363-7. doi: 10.1055/s-0033-1358703. [PMID: 24258704]
  • M J Rumpler, P Colahan, R A Sams. The pharmacokinetics of methocarbamol and guaifenesin after single intravenous and multiple-dose oral administration of methocarbamol in the horse. Journal of veterinary pharmacology and therapeutics. 2014 Feb; 37(1):25-34. doi: 10.1111/jvp.12068. [PMID: 23859819]
  • Nada S Abdelwahab, Maha M Abdelrahman. Simultaneous determination of methocarbamol and Ibuprofen by first derivative synchronous fluorescence spectroscopic method in their binary mixture and spiked human plasma. Journal of fluorescence. 2014 Jan; 24(1):129-35. doi: 10.1007/s10895-013-1276-9. [PMID: 23912962]
  • Kendon Kuo, Adesola Odunayo. Adjunctive therapy with intravenous lipid emulsion and methocarbamol for permethrin toxicity in 2 cats. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2013 Jul; 23(4):436-41. doi: 10.1111/vec.12070. [PMID: 23855545]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Mohammad Bagher Gholivand, Mehdi Khodadadian. Rationally designed molecularly imprinted polymers for selective extraction of methocarbamol from human plasma. Talanta. 2011 Sep; 85(3):1680-8. doi: 10.1016/j.talanta.2011.06.066. [PMID: 21807239]
  • Mohamed Walash, Fathalla Belal, Manal Eid, Samah Abo EL Abass. Spectrofluorometric determination of methocarbamol in pharmaceutical preparations and human plasma. Journal of fluorescence. 2011 Mar; 21(2):555-61. doi: 10.1007/s10895-010-0742-x. [PMID: 20936330]
  • Enass M Ghoneim, Hanaa S El-Desoky. Electrochemical determination of methocarbamol on a montmorillonite-Ca modified carbon paste electrode in formulation and human blood. Bioelectrochemistry (Amsterdam, Netherlands). 2010 Oct; 79(2):241-7. doi: 10.1016/j.bioelechem.2010.06.005. [PMID: 20619752]
  • Wuyi Zha, Zhimeng Zhu. Determination of methocarbamol concentration in human plasma by high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Mar; 878(9-10):831-5. doi: 10.1016/j.jchromb.2010.01.025. [PMID: 20171150]
  • M R Koupai-Abyazani, B Esaw, B Laviolette. Determination of methocarbamol in equine serum and urine by high-performance liquid chromatography with ultraviolet detection and atmospheric pressure ionization-mass spectrometric confirmation. Journal of analytical toxicology. 1997 Jul; 21(4):301-5. doi: 10.1093/jat/21.4.301. [PMID: 9248949]
  • N Weng, J W Lee, J D Hulse. Development and validation of a high-performance liquid chromatographic method for the determination of methocarbamol in human plasma. Journal of chromatography. B, Biomedical applications. 1994 Apr; 654(2):287-92. doi: 10.1016/0378-4347(94)00010-7. [PMID: 8044291]
  • S Alessi-Severini, R T Coutts, F Jamali, F M Pasutto. High-performance liquid chromatographic analysis of methocarbamol enantiomers in biological fluids. Journal of chromatography. 1992 Nov; 582(1-2):173-9. doi: 10.1016/0378-4347(92)80316-i. [PMID: 1491037]
  • W W Muir, R A Sams, S Ashcraft. The pharmacology and pharmacokinetics of high-dose methocarbamol in horses. Equine veterinary journal. Supplement. 1992 Feb; ?(11):41-4. doi: 10.1111/j.2042-3306.1992.tb04771.x. [PMID: 9109959]
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  • D A Sica, T J Comstock, J Davis, L Manning, R Powell, A Melikian, G Wright. Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. European journal of clinical pharmacology. 1990; 39(2):193-4. doi: 10.1007/bf00280060. [PMID: 2253675]
  • R Obach, J Pruñonosa, A Menargues, M Nomen, J Vallès. Pharmacokinetics and bioavailability of methocarbamol in rats. Biopharmaceutics & drug disposition. 1988 Sep; 9(5):501-11. doi: 10.1002/bod.2510090508. [PMID: 3224164]
  • W W Muir, R A Sams, S Ashcraft. Pharmacologic and pharmacokinetic properties of methocarbamol in the horse. American journal of veterinary research. 1984 Nov; 45(11):2256-60. doi: NULL. [PMID: 6524718]
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  • D J CAMPBELL, R SHERBANIUK, J RIGBY. FALSE POSITIVE REACTION DUE TO METHOCARBAMOL IN THE SCREENING TEST FOR VANILMANDELIC ACID (VMA). Clinical chemistry. 1964 May; 10(?):447-50. doi: 10.1093/clinchem/10.5.447. [PMID: 14185803]
  • E B TRUITT, A M MORGAN, H M NACHMAN. Potentiation of salicylate plasma levels and analgesic action by methocarbamol. Southern medical journal. 1961 Mar; 54(?):318-21. doi: 10.1097/00007611-196103000-00020. [PMID: 13778276]
  • E G HUF, F K COLES, L L EUBANK. Comparative plasma levels of mephenesin, mephenesin carbamate and methocarbamol. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1959 Nov; 102(?):276-7. doi: 10.3181/00379727-102-25218. [PMID: 14403806]
  • J C HONET, T V CASEY, J W RUNYAN. False-positive urinary test for 5-hydroxyindoleacetic acid due to methocarbamol and mephenesin carbamate. The New England journal of medicine. 1959 Jul; 261(4):188-90. doi: 10.1056/nejm195907232610407. [PMID: 13667004]
  • A M MORGAN, E H TRUITT, J M LITTLE. Plasma levels of mephenesin, mephenesin carbamate, guaiacol glyceryl ether, and methocarbamol (AHR-85) after oral and intravenous administration in the dog. Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 1957 Jun; 46(6):374-7. doi: 10.1002/jps.3030460613. [PMID: 13491400]