Pirlindole (BioDeep_00000182474)

   

human metabolite blood metabolite


代谢物信息卡片


12-methyl-1,4-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-9(16),10,12,14-tetraene

化学式: C15H18N2 (226.1469908)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1=CC2=C(C=C1)N3CCNC4C3=C2CCC4
InChI: InChI=1S/C15H18N2/c1-10-5-6-14-12(9-10)11-3-2-4-13-15(11)17(14)8-7-16-13/h5-6,9,13,16H,2-4,7-8H2,1H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
D000970 - Antineoplastic Agents

同义名列表

7 个代谢物同义名

12-methyl-1,4-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-9(16),10,12,14-tetraene; 1,10-Trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino(1,2-a)indole; Pirlindole hydrochloride; Pyrlindole; Pirlindole; Pirlindol; Pyrazidol



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S Nag, L Lehmann, G Kettschau, T Heinrich, A Thiele, A Varrone, B Gulyas, C Halldin. Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B). Bioorganic & medicinal chemistry. 2012 May; 20(9):3065-71. doi: 10.1016/j.bmc.2012.02.056. [PMID: 22436387]
  • Marco Antonioli, Joanna Rybka, Livia A Carvalho. Neuroimmune endocrine effects of antidepressants. Neuropsychiatric disease and treatment. 2012; 8(?):65-83. doi: 10.2147/ndt.s16409. [PMID: 22347798]
  • I V Zarubina, F N Narmanbetova, E F Agadzhanian, P D Shabanov. [Efficacy of bemithyl and pyrazidol in patients with cerebroasthenia due to brain injury]. Klinicheskaia meditsina. 2005; 83(11):59-62. doi: ". [PMID: 16404942]
  • I V Zarubina, N A Kuritsyna, P D Shabanov. Cerebroprotective effect of combined treatment with pyrazidol and bemitil in craniocerebral trauma. Bulletin of experimental biology and medicine. 2004 Jul; 138(1):58-62. doi: 10.1023/b:bebm.0000046939.59393.ac. [PMID: 15514724]
  • André Boland, Jean Gérardy, Danielle Mossay, Vincent Seutin. Pre- and post-treatment with pirlindole and dehydropirlindole protects cultured brain cells against nitric oxide-induced death. European journal of pharmacology. 2003 Apr; 466(1-2):21-30. doi: 10.1016/s0014-2999(03)01539-5. [PMID: 12679138]
  • P Chiap, A Ceccato, R Gora, Ph Hubert, J Géczy, J Crommen. Automated determination of pirlindole enantiomers in plasma by on-line coupling of a pre-column packed with restricted access material to a chiral liquid chromatographic column. Journal of pharmaceutical and biomedical analysis. 2002 Jan; 27(3-4):447-55. doi: 10.1016/s0731-7085(01)00647-1. [PMID: 11755746]
  • I A Goroshinskaia, A Iu Vinogradov, A I Lukash. [The effect of pyrazidole on the middle molecule level during various modes of hypobaric hypoxia]. Voprosy meditsinskoi khimii. 1994 Jul; 40(4):19-21. doi: NULL. [PMID: 7975372]
  • I A Goroshinskaia, L V Mogil'nitskaia. [Lipid peroxidation intensity during periodic hypoxia and the protective effect of pyrazidole]. Biokhimiia (Moscow, Russia). 1994 Jul; 59(7):974-82. doi: ". [PMID: 7948422]
  • I A Goroshinskaia, L A Nemashkalova, A A Khodakova, I V Sorokina. [The effect of pyrazidol on animal status and on the monoamine level in periodic hypobaric hypoxia]. Fiziologicheskii zhurnal imeni I.M. Sechenova. 1993 Oct; 79(10):67-73. doi: NULL. [PMID: 8167669]
  • I A Goroshinskaia, L V Mogil'nitskaia, L A Nemashkalova, A A Khodakova. [Status of cell membrane enzymes in hypoxia and the protective effect of pyrazidole]. Biokhimiia (Moscow, Russia). 1993 Jan; 58(1):62-9. doi: NULL. [PMID: 8471666]
  • I A Goroshinskaia, L A Nemashkalova, A A Khodakova, K B Sherstnev. [Effects of pyrazidol on resistance of animals to hypobaric hypoxia]. Biulleten' eksperimental'noi biologii i meditsiny. 1992 Sep; 114(9):268-9. doi: NULL. [PMID: 1477352]
  • A E Medvedev, D I Rajgorodskaya, V Z Gorkin, I B Fedotova, A F Semiokhina. The role of lipid peroxidation in the possible involvement of membrane-bound monoamine oxidases in gamma-aminobutyric acid and glucosamine deamination in rat brain. Focus on chemical pathogenesis of experimental audiogenic epilepsy. Molecular and chemical neuropathology. 1992 Feb; 16(1-2):187-201. doi: 10.1007/bf03159969. [PMID: 1520403]
  • I A Goroshinskaia, E Z Tsvetnenko, A A Khodakova, N P Miliutina, A A Ananian, E E Nikolaeva, V L Kesel'man. [The use of pyrazidol during treatment using hyperbaric oxygenation therapy]. Anesteziologiia i reanimatologiia. 1991 Jan; ?(1):53-4. doi: NULL. [PMID: 1862967]
  • I V Borisova, V I Popova. [The determination of pyrazidol in blood and urine]. Sudebno-meditsinskaia ekspertiza. 1989 Oct; 32(4):49-50. doi: NULL. [PMID: 2617560]
  • E A Baumanis, I A Birska, G O Reĭkman, I E Kirule, V I Shvedov. [Mechanism of the qualitative modification of mitochondrial monoamine oxidase activity by pyrazidol]. Voprosy meditsinskoi khimii. 1987 Nov; 33(6):90-6. doi: ". [PMID: 3445553]
  • B Saletu, J Grünberger. On acute and chronic CNS effects of antidepressants in normals: neurophysiological, behavioral and pharmacokinetic studies with pirlindol. Methods and findings in experimental and clinical pharmacology. 1985 Mar; 7(3):137-51. doi: NULL. [PMID: 4010387]
  • J Ostrowski, J Theumer, W Gärtner, K Resag, H Passing. Determination of pirlindole in plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1984 Jul; 309(1):115-23. doi: 10.1016/0378-4347(84)80011-0. [PMID: 6480758]
  • I V Verevkina, V V Asnina, V Z Gorkin, M D Mashkovskiĭ. [Selective inhibition by pyrazidol of monoamine oxidase type A in different human and animal tissues]. Voprosy meditsinskoi khimii. 1983 Sep; 29(5):118-23. doi: NULL. [PMID: 6649522]
  • T T Sorokina, R A Evsegneev. [Anorexia nervosa as a manifestation of endogenous depression in puberty]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1983; 83(8):1195-8. doi: ". [PMID: 6624346]
  • N A Avdulov, B Iu Zaslavskiĭ, L M Mikheeva, A V Val'dman. [Comparison of membranotropic and relative hydrophobic properties of antidepressants with different chemical structure]. Biulleten' eksperimental'noi biologii i meditsiny. 1982 Sep; 94(9):66-7. doi: ". [PMID: 7171827]