Pinacidil (BioDeep_00000182437)
human metabolite blood metabolite
代谢物信息卡片
化学式: C13H19N5 (245.164)
中文名称: 吡那地尔
谱图信息:
最多检出来源 Homo sapiens(blood) 27.18%
分子结构信息
SMILES: CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
InChI: InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02D - Arteriolar smooth muscle, agents acting on > C02DG - Guanidine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:91706
- PubChem: 4826
- HMDB: HMDB0256556
- DrugBank: DB06762
- ChEMBL: CHEMBL1159
- Wikipedia: Pinacidil
- MeSH: Pinacidil
- chemspider: 4660
- CAS: 113563-69-2
- CAS: 60560-33-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Francesco Pettini, Ottavia Spiga, Simone Furini, Fabio Fusi. Electrophysiology, molecular modelling, and functional analysis of the effects of dietary quercetin and flavonoid analogues on Kir6.1 channels in rat stomach fundus smooth muscle.
Biochemical pharmacology.
2024 Feb; 220(?):115969. doi:
10.1016/j.bcp.2023.115969
. [PMID: 38086489] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Lamei Yu, Weijian Li, Byung Mun Park, Gi-Ja Lee, Suhn Hee Kim. Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
Peptides.
2019 11; 121(?):170123. doi:
10.1016/j.peptides.2019.170123
. [PMID: 31386893] - Keisuke Iguchi, Masao Saotome, Kanna Yamashita, Prottoy Hasan, Miyuki Sasaki, Yuichiro Maekawa, Yasuhide Watanabe. Pinacidil, a KATP channel opener, stimulates cardiac Na+/Ca2+ exchanger function through the NO/cGMP/PKG signaling pathway in guinea pig cardiac ventricular myocytes.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 08; 392(8):949-959. doi:
10.1007/s00210-019-01642-1
. [PMID: 30919008] - Bradley S Miller, Shoshana R Blumenthal, Alexey Shalygin, Kevin D Wright, Alexander Staruschenko, John D Imig, Andrey Sorokin. Inactivation of p66Shc Decreases Afferent Arteriolar KATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats.
Diabetes.
2018 11; 67(11):2206-2212. doi:
10.2337/db18-0308
. [PMID: 30131395] - M Kocmalova, M Oravec, M Adamkov, V Sadlonova, I Kazimierova, I Medvedova, M Joskova, S Franova, M Sutovska. Potassium ion channels and allergic asthma.
Advances in experimental medicine and biology.
2015; 838(?):35-45. doi:
10.1007/5584_2014_76
. [PMID: 25315623] - N D Filipets, A I Gozhenko. [Comparative assessment of nephroprotective properties of potassium and calcium channel modulators in experimental renal injury].
Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(1):10-2. doi:
. [PMID: 24649595]
- A I Hozhenko, N D Filipets'. [The functional state of the kidneys after adenosine triphosphate-sensitive potassium channels activation in experimental acute hypoxia].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994).
2014; 60(4):22-9. doi:
. [PMID: 25335231]
- Milla Mikkola, Sanna Toivonen, Kaisa Tamminen, Kaija Alfthan, Timo Tuuri, Tero Satomaa, Jari Natunen, Juhani Saarinen, Minna Tiittanen, Milla Lampinen, Leena Valmu, Jukka Partanen, Timo Otonkoski. Lectin from Erythrina cristagalli supports undifferentiated growth and differentiation of human pluripotent stem cells.
Stem cells and development.
2013 Mar; 22(5):707-16. doi:
10.1089/scd.2012.0365
. [PMID: 23106381] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068
. [PMID: 22961681] - Qunhua Bai, Junlin He, Jingfu Qiu, Yang Wang, Shibo Wang, Yun Xiu, Chao Yu. Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine hydroxylase.
Oncology reports.
2012 Oct; 28(4):1376-84. doi:
10.3892/or.2012.1959
. [PMID: 22895566] - Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
10.1124/dmd.111.040758
. [PMID: 21965623] - Guo Hua Liang, Adebowale Adebiyi, M Dennis Leo, Elizabeth M McNally, Charles W Leffler, Jonathan H Jaggar. Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.
American journal of physiology. Heart and circulatory physiology.
2011 Jun; 300(6):H2088-95. doi:
10.1152/ajpheart.01290.2010
. [PMID: 21421823] - Ravinder Sodi, Andrew S Davison, Elizabeth Holmes, Trevor J Hine, Norman B Roberts. The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase.
Clinical biochemistry.
2009 Jun; 42(9):813-8. doi:
10.1016/j.clinbiochem.2009.01.024
. [PMID: 19232334] - Vivek Garg, Jundong Jiao, Keli Hu. Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes.
Cardiovascular research.
2009 Apr; 82(1):51-8. doi:
10.1093/cvr/cvp039
. [PMID: 19181933] - Adebowale Adebiyi, Elizabeth M McNally, Jonathan H Jaggar. Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers.
Molecular pharmacology.
2008 Sep; 74(3):736-43. doi:
10.1124/mol.108.048165
. [PMID: 18511652] - Pedro J Gomez-Pinilla, Pedro J Camello, María J Pozo. Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.
Journal of pineal research.
2008 Apr; 44(3):250-60. doi:
10.1111/j.1600-079x.2007.00520.x
. [PMID: 18339120] - Laura J Sampson, Lowri M Davies, Richard Barrett-Jolley, Nick B Standen, Caroline Dart. Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.
Cardiovascular research.
2007 Oct; 76(1):61-70. doi:
10.1016/j.cardiores.2007.05.020
. [PMID: 17582389] - Martin Broch-Lips, Kristian Overgaard, Helle A Praetorius, Ole Baekgaard Nielsen. Effects of extracellular HCO3(-) on fatigue, pHi, and K+ efflux in rat skeletal muscles.
Journal of applied physiology (Bethesda, Md. : 1985).
2007 Aug; 103(2):494-503. doi:
10.1152/japplphysiol.00049.2007
. [PMID: 17446415] - N N Kurgaliuk, G M Tkachenko. [Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels].
Biomeditsinskaia khimiia.
2006 Nov; 52(6):556-67. doi:
"
. [PMID: 17288247] - Jeffrey M Fish, Daniel R Welchons, Young-Sup Kim, Suk-Ho Lee, Won-Kyung Ho, Charles Antzelevitch. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.
Circulation.
2006 Mar; 113(11):1393-400. doi:
10.1161/circulationaha.105.601690
. [PMID: 16534004] - Juan José Acevedo, Irene Mendoza-Lujambio, José Luis de la Vega-Beltrán, Claudia L Treviño, Ricardo Felix, Alberto Darszon. KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation.
Developmental biology.
2006 Jan; 289(2):395-405. doi:
10.1016/j.ydbio.2005.11.002
. [PMID: 16343479] - Jason M Hoover, Alan D Kaye, Ikhlass N Ibrahim, Aaron M Fields, Todd A Richards. Analysis of responses to kava kava in the feline pulmonary vascular bed.
Journal of medicinal food.
2006; 9(1):62-71. doi:
10.1089/jmf.2006.9.62
. [PMID: 16579730] - Hyeonsook Cheong, Dilli Parasad Paudyal, Jae Yeoul Jun, Cheol Ho Yeum, Pyung Jin Yoon, Chan Guk Park, Man Yoo Kim, Insuk So, Ki Whan Kim, Seok Choi. Effects of pine needle extract on pacemaker currents in interstitial cells of Cajal from the murine small intestine.
Molecules and cells.
2005 Oct; 20(2):235-40. doi:
. [PMID: 16267398]
- Satoshi Nawate, Mitsuhiro Fukao, Ichiro Sakuma, Takamitsu Soma, Kazuhiko Nagai, Osamu Takikawa, Soichi Miwa, Akira Kitabatake. Reciprocal changes in endothelium-derived hyperpolarizing factor- and nitric oxide-system in the mesenteric artery of adult female rats following ovariectomy.
British journal of pharmacology.
2005 Jan; 144(2):178-89. doi:
10.1038/sj.bjp.0706091
. [PMID: 15655506] - Laura J Sampson, Yasunobu Hayabuchi, Nick B Standen, Caroline Dart. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
Circulation research.
2004 Nov; 95(10):1012-8. doi:
10.1161/01.res.0000148634.47095.ab
. [PMID: 15499025] - An S De Vriese, Henk J Blom, Sandra G Heil, Siska Mortier, Leo A J Kluijtmans, Johan Van de Voorde, Norbert H Lameire. Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia.
Circulation.
2004 May; 109(19):2331-6. doi:
10.1161/01.cir.0000129138.08493.4d
. [PMID: 15117854] - István Baczkó, Wayne R Giles, Peter E Light. Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.
British journal of pharmacology.
2004 Mar; 141(6):1059-67. doi:
10.1038/sj.bjp.0705702
. [PMID: 14993099] - Jason M Hoover, Alan D Kaye, Ikhlass N Ibrahim, Aaron M Fields, Todd A Richards. Analysis of responses to St. John's Wort in the feline pulmonary vascular bed.
Journal of herbal pharmacotherapy.
2004; 4(3):47-62. doi:
. [PMID: 15829469]
- H M Tkachenko, N M Kurhaliuk, L S Vovkanych. [Effect of K-ATP channel opener-pinacidil on the liver mitochondria function in rats with different resistance to hypoxia during stress].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2004 Jan; 76(1):56-64. doi:
"
. [PMID: 15909418] - Aaron M Fields, Todd A Richards, Jason A Felton, Shaili K Felton, Erin Z Bayer, Ikhlass N Ibrahim, Alan David Kaye. Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
Journal of alternative and complementary medicine (New York, N.Y.).
2003 Dec; 9(6):909-18. doi:
10.1089/107555303771952253
. [PMID: 14736362] - H M Tkachenko, O O Moĭbenko, N M Kurhaliuk. [Effect of ATP-sensitive potassium channel modulators and intermittent hypoxia on mitochondrial respiration during stress].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2003 Nov; 75(6):115-22. doi:
"
. [PMID: 15143528] - H M Tkachenko, N M Kurhaliuk, L S Vovkanych. [Role of ATP-sensitive potassium channel activators in liver mitochondrial function in rats with different resistance to hypoxia].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2003 Sep; 75(5):69-76. doi:
"
. [PMID: 14681995] - Gerald S Braun, Rüdiger W Veh, Stephan Segerer, Michael F Horster, Stephan M Huber. Developmental expression and functional significance of Kir channel subunits in ureteric bud and nephron epithelia.
Pflugers Archiv : European journal of physiology.
2002 Dec; 445(3):321-30. doi:
10.1007/s00424-002-0906-x
. [PMID: 12466933] - Zhong Zhang, Kristie Rhinehart, Thomas L Pallone. Membrane potential controls calcium entry into descending vasa recta pericytes.
American journal of physiology. Regulatory, integrative and comparative physiology.
2002 Oct; 283(4):R949-57. doi:
10.1152/ajpregu.00251.2002
. [PMID: 12228065] - Chin-Chuan Tsai, Tung-Yuan Lai, Wei-Chan Huang, I-Min Liu, Juei-Tang Cheng. Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.
Life sciences.
2002 Aug; 71(11):1321-30. doi:
10.1016/s0024-3205(02)01852-0
. [PMID: 12106597] - Pedro Gomes, P Soares-Da-Silva. D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.
American journal of physiology. Renal physiology.
2002 Jul; 283(1):F114-23. doi:
10.1152/ajprenal.00244.2001
. [PMID: 12060593] - Tatsuo Fukuse, Toshiki Hirata, Mitsugu Omasa, Hiromi Wada. Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
American journal of respiratory and critical care medicine.
2002 Jun; 165(11):1511-5. doi:
10.1164/rccm.2012034
. [PMID: 12045125] - T Yu, Z Yu, X Liu, S Yang, Y Ye. Myocardial protection with pinacidil induced hyperpolarized arrest during cardiopulmonary bypass.
Chinese medical journal.
2001 Dec; 114(12):1245-8. doi:
NULL
. [PMID: 11793844] - A A Konstas, A Bielfeld-Ackermann, C Korbmacher. Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression.
Pflugers Archiv : European journal of physiology.
2001 Aug; 442(5):752-61. doi:
10.1007/s004240100597
. [PMID: 11512032] - Y Liu, G Ren, B O'Rourke, E Marbán, J Seharaseyon. Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.
Molecular pharmacology.
2001 Feb; 59(2):225-30. doi:
10.1124/mol.59.2.225
. [PMID: 11160857] - W Long, L Zhang, L D Longo. Cerebral artery K(ATP)- and K(Ca)-channel activity and contractility: changes with development.
American journal of physiology. Regulatory, integrative and comparative physiology.
2000 Dec; 279(6):R2004-14. doi:
10.1152/ajpregu.2000.279.6.r2004
. [PMID: 11080063] - M Horie, M Watanuki, K Tsuji, H Ishida, A Ishida-Takahashi, Y Yuzuki, Y Seino, S Sasayama. Blockade of cardiac ATP-sensitive K+ channel by cibenzoline targets its pore-forming subunit.
Journal of cardiovascular pharmacology.
2000 Mar; 35(3):434-42. doi:
10.1097/00005344-200003000-00014
. [PMID: 10710130] - Y Sunaga, N Inagaki, T Gonoi, Y Yamada, H Ishida, Y Seino, S Seino. Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.
European journal of pharmacology.
1999 Sep; 381(1):71-6. doi:
10.1016/s0014-2999(99)00539-7
. [PMID: 10528136] - K Stambaugh, G T Elliott, K A Jacobson, B T Liang. Additive effects of late preconditioning produced by monophosphoryl lipid A and the early preconditioning mediated by adenosine receptors and KATP channel.
Circulation.
1999 Jun; 99(25):3300-7. doi:
10.1161/01.cir.99.25.3300
. [PMID: 10385506] - S R Bareggi, V Gambaro, M Valenti, C Benvenuti. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation.
Arzneimittel-Forschung.
1999 Jan; 49(1):21-5. doi:
10.1055/s-0031-1300352
. [PMID: 10028374] - M A Clark, J A Lawson, J H Ludens. K+ channel blockers: natriuretic potency correlates to vascular ATP-sensitive K+ channel blockade.
Methods and findings in experimental and clinical pharmacology.
1999 Jan; 21(1):25-30. doi:
10.1358/mf.1999.21.1.527015
. [PMID: 10222444] - M J Lalli, D C Johns, M Janecki, Y Liu, B O'Rourke, E Marban. Suppression of KATP currents by gene transfer of a dominant negative Kir6.2 construct.
Pflugers Archiv : European journal of physiology.
1998 Nov; 436(6):957-61. doi:
10.1007/s004240050729
. [PMID: 9799413] - T Mimuro, T Kawata, T Onuki, S Hashimoto, K Tsuchiya, H Nihei, T Koike. The attenuated effect of ATP-sensitive K+ channel opener pinacidil on renal haemodynamics in spontaneously hypertensive rats.
European journal of pharmacology.
1998 Oct; 358(2):153-60. doi:
10.1016/s0014-2999(98)00573-1
. [PMID: 9808264] - E Satoh, M Yamada, C Kondo, V P Repunte, Y Horio, T Iijima, Y Kurachi. Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil.
The Journal of physiology.
1998 Sep; 511 ( Pt 3)(?):663-74. doi:
10.1111/j.1469-7793.1998.663bg.x
. [PMID: 9714850] - T Shindo, M Yamada, S Isomoto, Y Horio, Y Kurachi. SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
British journal of pharmacology.
1998 Jul; 124(5):985-91. doi:
10.1038/sj.bjp.0701927
. [PMID: 9692785] - S R Bareggi, V Gambaro, M Valenti, C Benvenuti. Pharmacodynamics and pharmacokinetics of pinacidil after a single dose of a new slow release tablet in healthy volunteers.
Arzneimittel-Forschung.
1998 Jul; 48(7):730-3. doi:
NULL
. [PMID: 9706373] - B J DeWitt, H C Champion, J R Marrone, D B McNamara, T D Giles, S S Greenberg, P J Kadowitz. Differential effects of L-N5-(1-iminoethyl)-ornithine on tone and endothelium-dependent vasodilator responses.
The American journal of physiology.
1997 Sep; 273(3 Pt 1):L588-94. doi:
10.1152/ajplung.1997.273.3.l588
. [PMID: 9316493] - M Nishimura, H Takahashi, A Nanbu, M Sakamoto, T Nakanishi, M Yoshimura. Cerebral adenosine triphosphate-sensitive K+ channels may be impaired during acute cerebral ischemia in spontaneously hypertensive rats.
Journal of the autonomic nervous system.
1996 May; 58(3):139-46. doi:
10.1016/0165-1838(95)00123-9
. [PMID: 8738306] - J J Ligtenberg, A D Leenaers, T W Van Haeften, A J Smit, W J Sluiter, W D Reitsma. No deterioration of insulin secretion by the potassium channel opener pinacidil in essential hypertension.
Journal of human hypertension.
1996 Apr; 10(4):269-76. doi:
NULL
. [PMID: 8736460] - Y Goodman, M P Mattson. K+ channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity.
Brain research.
1996 Jan; 706(2):328-32. doi:
10.1016/0006-8993(95)01367-9
. [PMID: 8822377] - M Reslerova, R Loutzenhiser. Divergent mechanisms of ATP-sensitive K+ channel-induced vasodilation in renal afferent and efferent arterioles. Evidence of L-type Ca2+ channel-dependent and -independent actions of pinacidil.
Circulation research.
1995 Dec; 77(6):1114-20. doi:
10.1161/01.res.77.6.1114
. [PMID: 7586223] - J H Ludens, M A Clark, M P Smith, S J Humphrey. Renal and vascular effects of chemically distinct ATP-sensitive K+ channel blockers in rats.
Journal of cardiovascular pharmacology.
1995 Mar; 25(3):404-9. doi:
10.1097/00005344-199503000-00009
. [PMID: 7769805] - T P Links, A J Smit, W D Reitsma. Potassium channel modulation: effect of pinacidil on insulin release in healthy volunteers.
Journal of clinical pharmacology.
1995 Mar; 35(3):291-4. doi:
10.1002/j.1552-4604.1995.tb04061.x
. [PMID: 7608319] - B Y Rhim, K W Hong. Relaxation by cromakalim and pinacidil of isolated smooth muscle cells from canine coronary artery-multiple sites of action.
Archives internationales de pharmacodynamie et de therapie.
1994 Jul; 328(1):67-81. doi:
. [PMID: 7893192]
- K Sakamoto, Y Nakamura. Stereoselective disposition and metabolism of pinacidil in rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1994 Apr; 24(4):329-38. doi:
10.3109/00498259409045896
. [PMID: 8059536] - E Bellissant, N P Chau, C Thuillez, J F Giudicelli. Pharmacokinetic-pharmacodynamic modeling between pinacidil or pinacidil-N-oxide plasma levels and systemic and regional hemodynamic effects in healthy volunteers.
Fundamental & clinical pharmacology.
1994; 8(5):437-45. doi:
10.1111/j.1472-8206.1994.tb00823.x
. [PMID: 7875638] - E A Belyaeva, A Szewczyk, B Mikołajek, M J Nałecz, L Wojtczak. Demonstration of glibenclamide-sensitive K+ fluxes in rat liver mitochondria.
Biochemistry and molecular biology international.
1993 Nov; 31(3):493-500. doi:
NULL
. [PMID: 8118425] - T P Links, A J Smit, H J Oosterhuis, W D Reitsma. Potassium channels in hypokalaemic periodic paralysis: a key to the pathogenesis?.
Clinical science (London, England : 1979).
1993 Sep; 85(3):319-25. doi:
10.1042/cs0850319
. [PMID: 8403805] - K Sakamoto, Y Nakamura. Urinary metabolites of pinacidil. II. Species difference in the metabolism of pinacidil.
Xenobiotica; the fate of foreign compounds in biological systems.
1993 Jun; 23(6):649-56. doi:
10.3109/00498259309059402
. [PMID: 8212738] - G H Gelband, J R McCullough. Modulation of rabbit aortic Ca(2+)-activated K+ channels by pinacidil, cromakalim, and glibenclamide.
The American journal of physiology.
1993 May; 264(5 Pt 1):C1119-27. doi:
10.1152/ajpcell.1993.264.5.c1119
. [PMID: 8498475] - K Sakamoto, Y Nakamura. Urinary metabolites of pinacidil: I. Isolation and identification of the metabolites in rat urine.
Xenobiotica; the fate of foreign compounds in biological systems.
1993 Apr; 23(4):391-400. doi:
10.3109/00498259309057027
. [PMID: 8337897] - L R Krusell, L T Jespersen, K Thomsen, O L Pedersen. Proximal renal tubular pressure-natriuresis-relation in essential hypertensives following acute vasodilatation.
Blood pressure.
1993 Mar; 2(1):40-5. doi:
10.3109/08037059309077525
. [PMID: 8193730] - C B Nielsen, E B Pedersen. Effect of pinacidil on renal haemodynamics, tubular function and plasma levels of angiotensin II, aldosterone and atrial natriuretic peptide in healthy man.
European journal of clinical pharmacology.
1993; 45(1):29-35. doi:
10.1007/bf00315346
. [PMID: 8405026] - P Girard, J L Saumet, F Dubois, J P Boissel. Pharmacodynamic model of the haemodynamic effects of pinacidil in normotensive volunteers.
European journal of clinical pharmacology.
1993; 44(2):177-82. doi:
10.1007/bf00315477
. [PMID: 8453963] - M Schwanstecher, C Brandt, S Behrends, U Schaupp, U Panten. Effect of MgATP on pinacidil-induced displacement of glibenclamide from the sulphonylurea receptor in a pancreatic beta-cell line and rat cerebral cortex.
British journal of pharmacology.
1992 Jun; 106(2):295-301. doi:
10.1111/j.1476-5381.1992.tb14331.x
. [PMID: 1393263] - C N Corder, M R Goldberg, P A Alaupovic, M D Price, S S Furste. Lipid and apolipoprotein levels during therapy with pinacidil combined with hydrochlorothiazide.
European journal of clinical pharmacology.
1992; 42(1):65-70. doi:
10.1007/bf00314922
. [PMID: 1541318] - J H Pratt, J K Rothrock, J H Dominguez. Inhibition of aldosterone production by pinacidil in vitro.
Hypertension (Dallas, Tex. : 1979).
1991 Oct; 18(4):529-34. doi:
10.1161/01.hyp.18.4.529
. [PMID: 1655650] - C K Stone, K L Wellington, A Willick, J T Sullebarger, C S Liang. Acute hemodynamic effects of pinacidil in hypertensive patients with and without propranolol pretreatment.
Journal of clinical pharmacology.
1991 Apr; 31(4):333-41. doi:
10.1002/j.1552-4604.1991.tb03714.x
. [PMID: 2037705] - C Thuillez, E Pussard, E Bellissant, C Richer, R Kechrid, J F Giudicelli. Arterial vasodilating profile and biological effects of pinacidil in healthy volunteers.
British journal of clinical pharmacology.
1991 Jan; 31(1):33-9. doi:
10.1111/j.1365-2125.1991.tb03854.x
. [PMID: 2015168] - T R Jones, L Charette, M L Garcia, G J Kaczorowski. Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
The Journal of pharmacology and experimental therapeutics.
1990 Nov; 255(2):697-706. doi:
. [PMID: 1700817]
- J E Nielsen-Kudsk, C B Nielsen, S Mellemkjaer, C Siggaard. Lack of effect of pinacidil on theophylline pharmacokinetics and metabolism in man.
Pharmacology & toxicology.
1990 Aug; 67(2):156-8. doi:
10.1111/j.1600-0773.1990.tb00803.x
. [PMID: 2255669] - W Spinelli, C Follmer, R Parsons, T Colatsky. Effects of cromakalim, pinacidil and nicorandil on cardiac refractoriness and arterial pressure in open-chest dogs.
European journal of pharmacology.
1990 Apr; 179(3):243-52. doi:
10.1016/0014-2999(90)90162-y
. [PMID: 2142089] - K Saku, H Ying, K Arakawa. Effects of pinacidil on serum lipid, lipoprotein, and apolipoprotein levels in patients with mild to moderate hypertension.
Clinical therapeutics.
1990 Mar; 12(2):132-8. doi:
NULL
. [PMID: 2354482] - J C Clapham, S D Longman. Haemodynamic differences between cromakalim and pinacidil: comparison with nifedipine.
European journal of pharmacology.
1989 Nov; 171(1):109-17. doi:
10.1016/0014-2999(89)90434-2
. [PMID: 2693121] - M G Garrino, T D Plant, J C Henquin. Effects of putative activators of K+ channels in mouse pancreatic beta-cells.
British journal of pharmacology.
1989 Nov; 98(3):957-65. doi:
10.1111/j.1476-5381.1989.tb14626.x
. [PMID: 2531623] - A Malmgren, K E Andersson, C Sjögren, P O Andersson. Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability.
The Journal of urology.
1989 Oct; 142(4):1134-8. doi:
10.1016/s0022-5347(17)39012-2
. [PMID: 2795743] - C Damase-Michel, M A Tran, J L Montastruc, J P Moatti, P Montastruc. Effects of pinacidil on the sympatho-adrenal system in dogs.
British journal of pharmacology.
1989 Aug; 97(4):1019-26. doi:
10.1111/j.1476-5381.1989.tb12557.x
. [PMID: 2676058] - R Ayesh, M Al-Waiz, A McBurney, S C Mitchell, J R Idle, J W Ward, R L Smith. Variable metabolism of pinacidil: lack of correlation with the debrisoquine and trimethylamine C- and N-oxidative polymorphisms.
British journal of clinical pharmacology.
1989 Apr; 27(4):423-8. doi:
10.1111/j.1365-2125.1989.tb05389.x
. [PMID: 2719898] - M R Goldberg, F W Rockhold, W L Thompson, K A DeSante. Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension.
Journal of clinical pharmacology.
1989 Jan; 29(1):33-40. doi:
10.1002/j.1552-4604.1989.tb03234.x
. [PMID: 2708546] - T D Plant, M G Garrino, J C Henquin. Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.
Pflugers Archiv : European journal of physiology.
1989; 414 Suppl 1(?):S152-3. doi:
10.1007/bf00582278
. [PMID: 2528721] - S Kimura, S Fujioka, K Fukui, T Tamaki, H Iwao, Y Abe. Effects of an antihypertensive vasodilator, pinacidil, on regional blood flow in conscious spontaneously hypertensive rats.
Journal of pharmacobio-dynamics.
1988 Jun; 11(6):430-7. doi:
10.1248/bpb1978.11.430
. [PMID: 3171884] - A F DeLong, S W Oldham, K A DeSante, G Nell, D P Henry. Disposition of [14C]pinacidil in humans.
Journal of pharmaceutical sciences.
1988 Feb; 77(2):153-6. doi:
10.1002/jps.2600770212
. [PMID: 3361430] - M R Goldberg. Clinical pharmacology of pinacidil, a prototype for drugs that affect potassium channels.
Journal of cardiovascular pharmacology.
1988; 12 Suppl 2(?):S41-7. doi:
10.1097/00005344-198812002-00008
. [PMID: 2466178] - I Ahnfelt-Rønne. Pinacidil: history, basic pharmacology, and therapeutic implications.
Journal of cardiovascular pharmacology.
1988; 12 Suppl 2(?):S1-4. doi:
NULL
. [PMID: 2466172] - A H Weston, K M Bray, S Duty, A D McHarg, D T Newgreen, J S Southerton. In vitro studies on the mode of action of pinacidil.
Drugs.
1988; 36 Suppl 7(?):10-28. doi:
10.2165/00003495-198800367-00004
. [PMID: 2855517] - I Ahnfelt-Rønne. Pinacidil. Preclinical investigations.
Drugs.
1988; 36 Suppl 7(?):4-9. doi:
10.2165/00003495-198800367-00003
. [PMID: 3076134] - M P Cinquegrani, C S Liang. Antihypertensive effects of pinacidil in patients with and without indomethacin pretreatment.
Clinical and experimental hypertension. Part A, Theory and practice.
1988; 10(3):411-31. doi:
10.3109/10641968809033901
. [PMID: 3359658] - A McBurney, P R Farrow, J W Ward. Effects of food on the bioavailability of sustained-release pinacidil in humans.
Journal of pharmaceutical sciences.
1988 Jan; 77(1):68-9. doi:
10.1002/jps.2600770112
. [PMID: 3346824] - A McBurney, J A Henry, J W Ward. Accumulation of pinacidil N-oxide during chronic treatment with pinacidil.
European journal of clinical pharmacology.
1988; 35(1):93-5. doi:
10.1007/bf00555515
. [PMID: 3220100] - P A Abraham, C E Halstenson, G R Matzke, W F Keane. Comparison of antihypertensive, renal hemodynamic, and humoral effects of pinacidil and hydralazine monotherapy.
Journal of clinical hypertension.
1987 Dec; 3(4):439-51. doi:
. [PMID: 3330986]
- R J Solomon, M S Weinberg. Comparative effects of pinacidil and prazosin on blood pressure, weight, plasma volume, the renin-angiotensin-aldosterone system, and the renal kallikrein-kinin system in patients with essential hypertension.
Journal of clinical hypertension.
1987 Dec; 3(4):589-95. doi:
NULL
. [PMID: 3330989] - A McBurney, P R Farrow, J W Ward. Effects of formulation on the pharmacokinetics of orally administered pinacidil in humans.
Journal of pharmaceutical sciences.
1987 Dec; 76(12):940-1. doi:
10.1002/jps.2600761220
. [PMID: 3440941] - S Morimoto, Y Matsumura, Y Sasaki, T Takakuwa, M Kageyama. Diuretic effect induced by intrarenal infusion of pinacidil in anesthetized dogs.
The Journal of pharmacology and experimental therapeutics.
1987 Sep; 242(3):1050-5. doi:
NULL
. [PMID: 3656107]