Procaterol (BioDeep_00000018238)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(propan-2-yl)amino]butyl]-1,2-dihydroquinolin-2-one

化学式: C16H22N2O3 (290.16303419999997)
中文名称: 5-(1-羟基-2-异丙胺基丁基)-8-羧基喹诺酮
谱图信息: 最多检出来源 Homo sapiens(urine) 77.42%

分子结构信息

SMILES: CCC(C(C1=C2C=CC(=O)NC2=C(C=C1)O)O)NC(C)C
InChI: InChI=1S/C16H22N2O3/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20)

描述信息

Procaterol is only found in individuals that have used or taken this drug. It is a long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation. [PubChem]Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists

同义名列表

17 个代谢物同义名

8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(propan-2-yl)amino]butyl]-1,2-dihydroquinolin-2-one; (R*,s*)-(+-)-8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone; Procaterol monohydrochloride, (r*,r*)-(+-)-isomer; Procaterol monohydrochloride, (r*,r*)-(-)-isomer; Procaterol monohydrochloride, (r*,s*)-(+)-isomer; Procaterol monohydrochloride, (r*,s*)-(-)-isomer; Procaterol monohydrochloride, (r*,r*)-(+)-isomer; Procaterol, (r*,r*)-(+-)-isomer; Procaterol, (r*,s*)-(-)-isomer; Monohydrochloride, procaterol; Procaterol monohydrochloride; Hydrochloride, procaterol; Procaterol hydrochloride; PROCATEROL; Pro-air; Pro air; ProAir



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dexian Kong, Qizhao Zhuang, Yejian Han, Lanping Xu, Zeming Wang, Lili Jiang, Jinwei Su, Chun-Hua Lu, Yuwu Chi. Simultaneous voltammetry detection of dopamine and uric acid in human serum and urine with a poly(procaterol hydrochloride) modified glassy carbon electrode. Talanta. 2018 Aug; 185(?):203-212. doi: 10.1016/j.talanta.2018.03.078. [PMID: 29759190]
  • Haruka Kogiso, Yukiko Ikeuchi, Masako Sumiya, Shigekuni Hosogi, Saori Tanaka, Chikao Shimamoto, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari. Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca2+ Modulation of cAMP-Stimulated Ciliary Beatings via PDE1. International journal of molecular sciences. 2018 Feb; 19(3):. doi: 10.3390/ijms19030658. [PMID: 29495403]
  • Dexian Kong, Lili Jiang, Yijun Liu, Zeming Wang, Libin Han, Rixin Lv, Jiandi Lin, Chun-Hua Lu, Yuwu Chi, Guonan Chen. Electrochemical investigation and determination of procaterol hydrochloride on poly(glutamic acid)/carboxyl functionalized multiwalled carbon nanotubes/polyvinyl alcohol modified glassy carbon electrode. Talanta. 2017 Nov; 174(?):436-443. doi: 10.1016/j.talanta.2017.06.047. [PMID: 28738604]
  • Haruka Kogiso, Shigekuni Hosogi, Yukiko Ikeuchi, Saori Tanaka, Chikao Shimamoto, Hitoshi Matsumura, Takashi Nakano, Koh-Ichi Sano, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari. A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia. Pflugers Archiv : European journal of physiology. 2017 09; 469(9):1215-1227. doi: 10.1007/s00424-017-1988-9. [PMID: 28477148]
  • Nanna Krogh, Vibeke Backer, Sebastian Rzeppa, Peter Hemmersbach, Morten Hostrup. Pharmacokinetics of nebulized and oral procaterol in asthmatic and non-asthmatic subjects in relation to doping analysis. Drug testing and analysis. 2016 Oct; 8(10):1056-1064. doi: 10.1002/dta.1935. [PMID: 26990656]
  • K Kusano, M Nomura, K Toju, Y Ishikawa, Y Minamijima, S Yamashita, S Nagata. Pharmacokinetics of procaterol in thoroughbred horses. Journal of veterinary pharmacology and therapeutics. 2016 Jun; 39(3):264-70. doi: 10.1111/jvp.12272. [PMID: 26538319]
  • Kohei Tahara, Hiromasa Tomida, Yousuke Ito, Suguru Tachikawa, Risako Onodera, Hiroyuki Tanaka, Yuichi Tozuka, Hirofumi Takeuchi. Pulmonary liposomal formulations encapsulated procaterol hydrochloride by a remote loading method achieve sustained release and extended pharmacological effects. International journal of pharmaceutics. 2016 May; 505(1-2):139-46. doi: 10.1016/j.ijpharm.2016.03.031. [PMID: 27012982]
  • Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism. Journal of separation science. 2016 May; 39(9):1766-75. doi: 10.1002/jssc.201501026. [PMID: 26935589]
  • Jia-Ming Liu, Qitong Huang, Zhen-Bo Liu, Li-Hong Zhang, Zhi-Yong Zheng, Chang-Qing Lin. Design of highly sensitive phosphorescence sensor for determination of procaterol hydrochloride based on inhibition of KClO3 oxidation fluorescein isothiocyanate. Luminescence : the journal of biological and chemical luminescence. 2015 Jun; 30(4):382-7. doi: 10.1002/bio.2743. [PMID: 25044504]
  • Norihito Yokoe, Etsuro Yamaguchi, Masaki Nishimura, Hiroyuki Tanaka, Ayumu Takahashi, Kenji Baba, Masahiko Gosho, Shoshiro Okada. UGT1A1*28 is associated with greater decrease in serum K⁺ levels following oral intake of procaterol. The Journal of asthma : official journal of the Association for the Care of Asthma. 2015 Apr; 52(3):240-5. doi: 10.3109/02770903.2014.957766. [PMID: 25171434]
  • Zongbao Chen, Yan Cai, Lin Zhang, Lan Zhang. Capillary electrochromatography of three β2-agonists in human urine using a lauryl methacrylate-based monolithic column. Journal of separation science. 2012 May; 35(9):1138-45. doi: 10.1002/jssc.201101005. [PMID: 22689490]
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  • H Kobayashi, M Masuda, E Kashiyama, N Koga, Y Yasuda, T Shibutani, K Endo, T Funaki, T Miyamoto. Pharmacokinetic study of the oral administration of procaterol hydrochloride hydrate 50 µg in healthy adult Japanese men. International journal of clinical pharmacology and therapeutics. 2010 Nov; 48(11):744-50. doi: 10.5414/cpp48744. [PMID: 20979933]
  • Daniele Di Corcia, Veronica Morra, Marco Pazzi, Marco Vincenti. Simultaneous determination of beta2-agonists in human urine by fast-gas chromatography/mass spectrometry: method validation and clinical application. Biomedical chromatography : BMC. 2010 Apr; 24(4):358-66. doi: 10.1002/bmc.1300. [PMID: 19642085]
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  • Tadashi Kohyama, Yasuhiro Yamauchi, Hajime Takizawa, Susumu Itakura, Sumiko Kamitani, Masashi Desaki, Shin Kawasaki, Takahide Nagase. Procaterol inhibits lung fibroblast migration. Inflammation. 2009 Dec; 32(6):387-92. doi: 10.1007/s10753-009-9147-x. [PMID: 19728063]
  • Richard J Bloomer, Robert E Canale, Megan M Blankenship, Kelley G Hammond, Kelsey H Fisher-Wellman, Brian K Schilling. Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study. Lipids in health and disease. 2009 Aug; 8(?):32. doi: 10.1186/1476-511x-8-32. [PMID: 19656409]
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  • Somsak Sirichai, Proespichaya Khanatharana. Rapid analysis of clenbuterol, salbutamol, procaterol, and fenoterol in pharmaceuticals and human urine by capillary electrophoresis. Talanta. 2008 Sep; 76(5):1194-8. doi: 10.1016/j.talanta.2008.05.026. [PMID: 18761177]
  • Masaru Kishida, Hiroki Nakazono, Rei Kuroiwa, Hidenori Dokai, Junko Nakazato, Hiroaki Nakamura, Itsuo Suzuki, Noriaki Shinomiya. [Therapy with nebulized beta2 agonists (procaterol) in asthmatic children: pulmonary function and plasma levels after inhalation]. Arerugi = [Allergy]. 2007 Nov; 56(11):1372-7. doi: NULL. [PMID: 18059150]
  • T-W Yu, R R-L Chen, C-S Gau. Production of an extremly low dose procaterol HCl preparation by fluidized-bed coating method: in vitro and in vivo evaluation. Drug development and industrial pharmacy. 2006 Jul; 32(6):651-60. doi: 10.1080/03639040600623317. [PMID: 16885120]
  • Katsumi Ikezono, Masayuki Kamata, Toyoki Mori. Adrenal influences on the inhibitory effects of procaterol, a selective Beta-two-adrenoceptor agonist, on antigen-induced airway microvascular leakage and bronchoconstriction in Guinea pigs. Pharmacology. 2005 Mar; 73(4):209-15. doi: 10.1159/000083299. [PMID: 15650321]
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  • Hiroaki Kume, Masashi Kondo, Yasushi Ito, Ryujiro Suzuki, Kenichi Yamaki, Kenzo Takagi. Effects of sustained-release tulobuterol on asthma control and beta-adrenoceptor function. Clinical and experimental pharmacology & physiology. 2002 Dec; 29(12):1076-83. doi: 10.1046/j.1440-1681.2002.03777.x. [PMID: 12390295]
  • Kouichi Kaidoh, Yasuhiko Igawa, Hiroo Takeda, Yoshinobu Yamazaki, Satoshi Akahane, Hiroshi Miyata, Yukiyoshi Ajisawa, Osamu Nishizawa, Karl-Erik Andersson. Effects of selective beta2 and beta3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats. The Journal of urology. 2002 Sep; 168(3):1247-52. doi: 10.1097/01.ju.0000023414.15425.5a. [PMID: 12187276]
  • Takao Fujisawa, Yoshiko Kato, Akihiko Terada, Kosei Iguchi, Hitoshi Kamiya. Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils. The Journal of asthma : official journal of the Association for the Care of Asthma. 2002 Feb; 39(1):21-7. doi: 10.1081/jas-120000803. [PMID: 11883736]
  • S L Huang, W Wang, D S Ou-Yang, H H Zhou. Determination of procaterol in human plasma by gas chromatography/electron impact ionization mass spectrometry. Acta pharmacologica Sinica. 2000 Jun; 21(6):564-6. doi: NULL. [PMID: 11360692]
  • T J Visser, E A van der Wouden, A van Waarde, P Doze, P H Elsinga, W Vaalburg. Synthesis and biodistribution of [11c]procaterol, a beta2-adrenoceptor agonist for positron emission tomography. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2000 Apr; 52(4):857-63. doi: 10.1016/s0969-8043(99)00267-5. [PMID: 10800722]
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