Phenoperidine (BioDeep_00000182330)

   

human metabolite blood metabolite


代谢物信息卡片


Ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylic acid

化学式: C23H29NO3 (367.2147324)
中文名称: 苯哌利定
谱图信息: 最多检出来源 Homo sapiens(blood) 90%

分子结构信息

SMILES: CCOC(=O)C1(CCN(CC1)CCC(C2=CC=CC=C2)O)C3=CC=CC=C3
InChI: InChI=1S/C23H29NO3/c1-2-27-22(26)23(20-11-7-4-8-12-20)14-17-24(18-15-23)16-13-21(25)19-9-5-3-6-10-19/h3-12,21,25H,2,13-18H2,1H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AH - Opioid anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

9 个代谢物同义名

Ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylic acid; ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylate; Hydrochloride, phenoperidine; Phenoperidine hydrochloride; Phenoperidine; Fenoperidine; Operidine; Lealgin; R 1406



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Roy Sheinbaum, Craig Ignacio, Hazim J Safi, Anthony Estrera. Contemporary strategies to preserve renal function during cardiac and vascular surgery. Reviews in cardiovascular medicine. 2003; 4 Suppl 1(?):S21-8. doi: NULL. [PMID: 12556734]
  • A Priou, N Bruder, D Bégou, I Morange, N Graziani, F Grisoli, T Brue. Glycosylated and non-glycosylated prolactin forms are increased after opioid administration as part of surgical anaesthesia. Clinical endocrinology. 1995 Aug; 43(2):213-7. doi: 10.1111/j.1365-2265.1995.tb01917.x. [PMID: 7554317]
  • B Stimmesse, F Lassauge, G Clément, T T Than, C Succi, J P Kantelip, C Pequegnot, P Magnin, F Barale. [Pediatric anesthesia and pharmacokinetics of propofol administered at a constant rate]. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression. 1990 Jan; 31(1):30-1. doi: NULL. [PMID: 2363475]
  • P Kintz, B Godelar, P Mangin, A A Lugnier, A J Chaumont. Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection. Forensic science international. 1989 Dec; 43(3):267-73. doi: 10.1016/0379-0738(89)90154-0. [PMID: 2613140]
  • M Fischler, J C Levron, H Trang, J F Vaxelaire, B Flaisler, G Vourc'h. Pharmacokinetics of phenoperidine in anaesthetized patients undergoing general surgery. British journal of anaesthesia. 1985 Sep; 57(9):872-6. doi: 10.1093/bja/57.9.872. [PMID: 4027103]
  • M Fischler, J C Levron, H Trang, D Brodaty, C Dubois, D Guilmet, G Vourc'h. Pharmacokinetics of phenoperidine in patients undergoing cardiopulmonary bypass. British journal of anaesthesia. 1985 Sep; 57(9):877-82. doi: 10.1093/bja/57.9.877. [PMID: 4027104]
  • C N Isherwood, T N Calvey, N E Williams, K Chan, G R Murray. Elimination of phenoperidine in liver disease. British journal of anaesthesia. 1984 Aug; 56(8):843-7. doi: 10.1093/bja/56.8.843. [PMID: 6743448]
  • C S Waldmann, J R Eason, E Rambohul, G C Hanson. Serum morphine levels. A comparison between continuous subcutaneous infusion and continuous intravenous infusion in postoperative patients. Anaesthesia. 1984 Aug; 39(8):768-71. doi: 10.1111/j.1365-2044.1984.tb06520.x. [PMID: 6476312]
  • L A Milne, N E Williams, T N Calvey, G R Murray, K Chan. Effect of urine pH on the elimination of phenoperidine. British journal of clinical pharmacology. 1983 Jul; 16(1):101-3. doi: 10.1111/j.1365-2125.1983.tb02150.x. [PMID: 6882616]
  • T N Calvey, L A Milne, N E Williams, K Chan, G R Murray. Effect of antacids on the plasma concentration of phenoperidine. British journal of anaesthesia. 1983 Jun; 55(6):535-9. doi: 10.1093/bja/55.6.535. [PMID: 6860522]
  • K Chan, G R Murray, C Rostron, T N Calvey, N E Williams. Quantitative gas-liquid chromatographic method for the determination of phenoperidine in human plasma. Journal of chromatography. 1981 Apr; 223(1):213-8. doi: 10.1016/s0378-4347(00)80089-4. [PMID: 7251768]
  • L Milne, N E Williams, T N Calvey, G R Murray, K Chan. Plasma concentration and metabolism of phenoperidine in man. British journal of anaesthesia. 1980 May; 52(5):537-40. doi: 10.1093/bja/52.5.537. [PMID: 7387808]
  • C A Shanks, A A Somogyi, E J Triggs. Dose-response and plasma concentration-response relationships of pancuronium in man. Anesthesiology. 1979 Aug; 51(2):111-8. doi: 10.1097/00000542-197908000-00004. [PMID: 453610]
  • C Le Guilcher, H Roumane, J P Campion, C Mai Van Dau, B Launois. [Anesthesia in renal transplantation. Place of neuroleptoanalgesia and curarizing agents in renal transplantation]. Anesthesie, analgesie, reanimation. 1978 Jan; 35(1):119-28. doi: NULL. [PMID: 354430]
  • J Verret, C Chaix, P Mugneret, P Rocher, E Gisselmann, G Rifle, B Caillard. [Our experience of anesthesia in the anephric patient]. Anesthesie, analgesie, reanimation. 1976 Jan; 33(1):109-18. doi: NULL. [PMID: 793448]
  • W Delius, L Johansson, S O Nyström, C J Westerholm, B Wranne. Central and peripheral circulation immediately after pulmonary surgery as related to sympathodrenal activity. Acta anaesthesiologica Scandinavica. 1975; 19(1):60-8. doi: 10.1111/j.1399-6576.1975.tb05223.x. [PMID: 1136692]
  • G S Robertson, W F Hamilton. Methoxyflurane and renal function. British journal of anaesthesia. 1973 Jan; 45(1):55-62. doi: 10.1093/bja/45.1.55. [PMID: 4696437]
  • J Latarjet, P Bouletreau, J M Dubernard, J L Sayag, Y D Gilles, J Eyraud, J Artige, J Brunet, G Fraisse, V G Banssillon. [Anesthesia of primates (macaca and baboons) under ketamine and neuroleptanalgesia]. Anesthesie, analgesie, reanimation. 1973 Jan; 30(1):177-90. doi: NULL. [PMID: 4198558]
  • H Andrasch, T Fink, E Schmid. [Elimination of triamterene, an antikaliuretic, and its phenolic metabolite, 2,4,7-triamino-6-p-hydroxyphenylpteridine, in the urine of subjects with normal liver function and in subjects suffering from liver cirrhosis]. Zeitschrift fur Gastroenterologie. 1971; 9(4):240-5. doi: NULL. [PMID: 5164739]
  • U Armato, A J Zuckerman. Investigation of a drug possibly implicated in sporadic jaundice using human liver cells in culture. Lo sperimentale. 1969 Sep; 119(5):399-405. doi: NULL. [PMID: 5002393]
  • A De Blasi, L Appiani, A Brienza, A Gasparetto, C Manni, M Maritano, B Mazzarella, V Morpurgo. [Neuroleptoanalgesia]. Minerva anestesiologica. 1968 Aug; 34(8):933-90. doi: NULL. [PMID: 5736580]