Pentisomide (BioDeep_00000182225)
human metabolite blood metabolite
代谢物信息卡片
化学式: C19H33N3O (319.26234880000004)
中文名称: 喷替索胺
谱图信息:
最多检出来源 Homo sapiens(blood) 99.37%
分子结构信息
SMILES: CC(C)CC(CCN(C(C)C)C(C)C)(C(N)=O)C1=CC=CC=N1
InChI: InChI=1S/C19H33N3O/c1-14(2)13-19(18(20)23,17-9-7-8-11-21-17)10-12-22(15(3)4)16(5)6/h7-9,11,14-16H,10,12-13H2,1-6H3,(H2,20,23)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
8 个代谢物同义名
2-{2-[bis(propan-2-yl)amino]ethyl}-4-methyl-2-(pyridin-2-yl)pentanimidate; 2-{2-[bis(propan-2-yl)amino]ethyl}-4-methyl-2-(pyridin-2-yl)pentanamide; alpha-[2-(diisopropylamino)ethyl]-alpha-isobutylpyridine-2-acetamide; 2-[2-(diisopropylamino)ethyl]-4-methyl-2-(pyridin-2-yl)pentanamide; 2-(2-(Diisopropylamino)ethyl)-4-methyl-2-(2-pyridyl)pentamide; Penticainide; Propisomide; Pentisomide
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 65847
- HMDB: HMDB0256288
- ChEMBL: CHEMBL141837
- chemspider: 59259
- CAS: 78833-03-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- C Mewis, V Kühlkamp, I Lindena, T Risler, K Ress. Quantitation of pentisomide and its metabolite by high-pressure liquid chromatography in human serum.
Journal of chromatographic science.
1996 Apr; 34(4):161-5. doi:
10.1093/chromsci/34.4.161. [PMID: 8901131] - M Hachisu, H Chen, T Soneda, K Fujishima, T Ishizuka, F Konno. Antiarrhythmic effect related to the plasma concentration of pentisomide in vivo and the antiarrhythmic-concentration relationship in vitro.
Drugs under experimental and clinical research.
1995; 21(4):145-51. doi:
NULL. [PMID: 8529527] - D Berdaï, F Demotes-Mainard, F Philip, G Vinçon, R Montels, J Necciari, B Bannwarth. Influence of food and body weight on the pharmacokinetics of penticainide.
Fundamental & clinical pharmacology.
1994; 8(5):453-7. doi:
10.1111/j.1472-8206.1994.tb00825.x. [PMID: 7875640] - T A Plomp, M J Buijs. High-performance liquid chromatographic method for the simultaneous determination of pentisomide and its major metabolite N-desisopropylpentisomide in plasma, urine and tissues using solid-phase extraction.
Journal of chromatography.
1993 Jan; 612(1):123-35. doi:
10.1016/0378-4347(93)80375-e. [PMID: 8454692] - D W Holt, S Walker, A Johnston, R W Jones, N L Howse, A Darragh, E Caffrey. The effect of age on the pharmacokinetics of pentisomide.
Biopharmaceutics & drug disposition.
1991 Nov; 12(8):627-31. doi:
10.1002/bdd.2510120808. [PMID: 1801967] - G Vergara, G Inama, M Guarnerio, F Rando, V Oldani, F Furlanello. Electropharmacological test with pentisomide (CM 7857) in patients with sustained ventricular tachycardia.
Giornale italiano di cardiologia.
1990 Jun; 20(6):543-8. doi:
NULL. [PMID: 2227224] - K Hashimoto, M Ishii, K Watanabe. Relationships between ventricular arrhythmias and plasma concentrations of ME3202 (CM7857) in dogs.
Journal of cardiovascular pharmacology.
1989 Jul; 14(1):121-6. doi:
10.1097/00005344-198907000-00021. [PMID: 2475703] - S G Priori, O Bonazzi, M Facchini, T Varisco, P J Schwartz. Antiarrhythmic efficacy of penticainide and comparison with disopyramide, flecainide, propafenone and mexiletine by acute oral drug testing.
The American journal of cardiology.
1987 Nov; 60(13):1068-72. doi:
10.1016/0002-9149(87)90354-7. [PMID: 3118693] - E Aliot, A Munoz, K Khalife, J Necciari, J P Gagnol, J M Gilgenkrantz. Electrophysiologic effects and pharmacokinetics of intravenous penticainide (CM 7857).
European heart journal.
1987 Jun; 8(6):618-23. doi:
10.1093/oxfordjournals.eurheartj.a062331. [PMID: 3622542] - S Walker, R J Flanagan, D W Holt. HPLC measurement of penticainide and desalkylpenticainide in biological fluids.
Biomedical chromatography : BMC.
1987 Feb; 2(1):34-7. doi:
10.1002/bmc.1130020110. [PMID: 3508092] - H Davi, A Carayon, D Berthet, W Cautreels, R Dommisse, M D Zannad. Identification of urinary metabolites of penticainide in the rat, dog, baboon and man.
Biomedical & environmental mass spectrometry.
1986 Oct; 13(10):559-68. doi:
10.1002/bms.1200131008. [PMID: 2947651] - G Houin, J P Jeanniot, P Ledudal, J Barré, J P Tillement. Liquid-chromatographic determination of propisomide and its mono-N-dealkylated metabolite in plasma and urine.
Clinical chemistry.
1985 Jul; 31(7):1222-4. doi:
10.1093/clinchem/31.7.1222. [PMID: 4006195] - J Necciari, D Mery, Y Sales, D Berthet, W Cautreels. Determination of propisomide, a new antiarrhythmic agent, in biological samples by gas chromatography with a thermionic detector.
Journal of chromatography.
1985 May; 341(1):202-7. doi:
10.1016/s0378-4347(00)84029-3. [PMID: 4019687] - R Zini, J Barre, G Defer, J P Jeanniot, G Houin, J P Tillement. Protein binding of propisomide.
Journal of pharmaceutical sciences.
1985 May; 74(5):530-3. doi:
10.1002/jps.2600740507. [PMID: 4020629]